Marginal Strength of Collarless Metal Ceramic Crown by Sikka Swati, R. Chowdhary, P. S. Patil

“…Hence, it may be subjected to more clinical trials.…”
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Targeting KRAS: from metabolic regulation to cancer treatment by Yanyan Shi, Huiling Zheng, Tianzhen Wang, Shengpu Zhou, Shiqing Zhao, Mo Li, Baoshan Cao

“…We also focus on advances in KRAS inhibitor discovery and related treatment strategies in colorectal, pancreatic, and non-small cell lung cancer, including current clinical trials. Therefore, this review provides an overview of the current understanding of metabolic mechanisms associated with KRAS mutation and related therapeutic strategies, aiming to facilitate the understanding of current challenges in KRAS-driven cancer and to support the investigation of therapeutic strategies.…”
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Effect of amniotic fluid on hair follicle growth by Gamze Tumentemur, Elif Ganime Aygun, Bulut Yurtsever, Didem Cakirsoy, Ercument Ovali

“…These findings support further evaluation of hAF in clinical trials to validate its potential for hair regeneration therapies.…”
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Progress in Therapy Development for Amyotrophic Lateral Sclerosis by Kalina Venkova-Hristova, Alexandar Christov, Zarine Kamaluddin, Peter Kobalka, Kenneth Hensley

“…This review will discuss experimental therapeutics that have been tested in murine ALS models, with an emphasis on those that have progressed to human clinical trials. Reasons will be considered for the frequent failure of preclinical successes to translate into positive clinical outcomes. …”
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Post-chemoradiotherapy adjuvant chemotherapy of rectal cancer by E. V. Ledin, A. V. Kochatkov

“…The meta-analysis (2015) of 4 randomized third-phase clinical trials (EORTC 22921, I-CNR-RT, PROCTORSCRIPT, CHRONICLE) demonstrated the lack of significant of 5-fluorouracil-based adjuvant chemotherapy. …”
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The Effect of Artichoke Leaf Extract on Alanine Aminotransferase and Aspartate Aminotransferase in the Patients with Nonalcoholic Steatohepatitis by Vajiheh Rangboo, Mostafa Noroozi, Roza Zavoshy, Seyed Amirmansoor Rezadoost, Asghar Mohammadpoorasl

“…This study sheds light on the potential hepatoprotective activity and hypolipidemic effect of Cynara scolymus in management of NASH. This clinical trial is registered in the IRCT, Iranian Registry of Clinical Trials, by number IRCT2014070218321N1.…”
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A Randomised Controlled Trial of Efficacy of Cognitive Rehabilitation in Multiple Sclerosis: A Cognitive, Behavioural, and MRI Study by J. Campbell, D. Langdon, M. Cercignani, W. Rashid

“…This study supports the hypothesis that home-based, computerised, cognitive rehabilitation may be effective in improving cognitive performance in patients with MS. Clinical trials registration is ISRCTN54901925.…”
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Efficacy of different preoperative antiseptics in preventing a risk of surgical site infections: a systematic review and meta‑analysis of randomized controlled trials by Lutao Yang, Shunxin Liao, Qing Cao, Sanjay Rastogi

“…Results: This meta-analysis included 10 587 surgical patients from 18 randomized clinical trials to determine the effectiveness of chlorhexidine in alcohol (CHA; 0.5%, 2%–2.5%, and 4%) with aqueous or alcoholic iodine in preventing postoperative SSIs. …”
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Triphenylmethane derivatives have high in vitro and in vivo activity against the main causative agents of cutaneous leishmaniasis. by Renata Celi Carvalho de Souza Pietra, Lucas Fonseca Rodrigues, Eliane Teixeira, Levi Fried, Benjamin Lefkove, Ana Rabello, Jack Arbiser, Lucas Antônio Miranda Ferreira, Ana Paula Fernandes

“…These results demonstrated that TPM present significant anti-leishmanial activities and provide a rationale for human clinical trials of GV and other TPM. TPM are inexpensive and safe, thus using them for treatment of CL may have a major impact on public health.…”
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BEST PROSTHESIS FOR UNICOMPARTMENTAL KNEE ARTHROSIS: FIXED OR MOBILE? by Fabrício Luz Cardoso, Deusimar Cristian dos Santos Gomez, Fabrício Roberto Severino, Patrícia Maria Moraes de Barros de Fucs

“…A systematic keyword search was executed in the PubMed, EMBASE, and Cochrane databases, employing a filter for randomized clinical trials and without language limitations. The search yielded 113 articles from March 28, 2024, including 83 from PubMed, 12 from EMBASE, and 18 from the Cochrane Library. …”
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Role of Opioid Ligands in the Irritable Bowel Syndrome by Enrico Corazziari

“…Fedotozine has been shown to increase the threshold of perception to colonic distension in experimental conditions and to affect favourably symptoms of IBS in clinical trials.…”
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Stem Cell-Based Therapies for Liver Diseases: State of the Art and New Perspectives by Anna Chiara Piscaglia, Mariachiara Campanale, Antonio Gasbarrini, Giovanni Gasbarrini

“…Aim of this paper is to critically analyze the possible sources of SCs suitable for liver repopulation and the results of the clinical trials that have been published until now.…”
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Adjuvant Hormonal Therapy in Postmenopausal Women with Breast Cancer: Physician’s Choices by Asim Jamal Shaikh, Shiyam Kumar, Sajjad Raza, Maria Mehboob, Osama Ishtiaq

“…Physicians show disagreement over the choice and duration of hormonal therapy in this patient population. Clinical trials leading to firm recommendations to set standards from which patients benefit the most are needed.…”
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Drugs from poisonous plants: Ethnopharmacological relevance to modern perspectives by Bhagya Lakhmi Rajbongshi, Ashis K. Mukherjee

“…This review accentuates the need for rigorous scientific investigations, prior to clinical trials to validate their traditional uses, which would reveal the pharmacological interventions that will eventually advance human health and well-being.…”
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A voice-based algorithm can predict type 2 diabetes status in USA adults: Findings from the Colive Voice study. by Abir Elbéji, Mégane Pizzimenti, Gloria Aguayo, Aurélie Fischer, Hanin Ayadi, Franck Mauvais-Jarvis, Jean-Pierre Riveline, Vladimir Despotovic, Guy Fagherazzi

“…We analyzed pre-specified text recordings from 607 US participants from the Colive Voice study registered on ClinicalTrials.gov (NCT04848623). Using hybrid BYOL-S/CvT embeddings, we constructed gender-specific algorithms to predict T2D status, evaluated through cross-validation based on accuracy, specificity, sensitivity, and Area Under the Curve (AUC). …”
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Metabolic plasticity in pancreatic cancer: The mitochondrial connection by Noemi Ghiglione, Damiano Abbo, Anastasia Bushunova, Andrea Costamagna, Paolo Ettore Porporato, Miriam Martini

“…Major Conclusion: Targeting mitochondrial metabolism holds promise for advancing PDAC therapeutics. Ongoing clinical trials underscore the therapeutic potential of modulating key regulators of mitochondrial dynamics and mitophagy. …”
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Childhood trauma and subclinical PTSD symptoms predict adverse effects and worse outcomes across two mindfulness-based programs for active depression. by Nicholas K Canby, Elizabeth A Cosby, Roman Palitsky, Deanna M Kaplan, Josie Lee, Golnoosh Mahdavi, Adrian A Lopez, Roberta E Goldman, Kristina Eichel, Jared R Lindahl, Willoughby B Britton

“…., abuse and neglect) were examined as predictors of depression treatment outcomes and participant attrition using secondary analyses of two MBP clinical trials (N = 52 and 104, respectively). Study 2 also examined meditation-related side effects (MRSE) and MRAE as outcomes and current subclinical and past PTSD symptoms as predictors. …”
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A Case Report of EGFR-TKIs Resistant Secondary MET Gene Amplified 
Lung Squamous Cell Carcinoma and Literature Review by Yalan LIU, Peng CHEN, Xinfu LIU

“…Drugs that target secondary MET amplification are still in clinical trials. This paper retrospectively analyzed the clinical data of a female patient with EGFR-TKIs resistant secondary MET amplified squamous cell lung cancer, and reviewed relevant literature to explore how to optimize the treatment of lung squamous cell carcinoma patients with EGFR mutation, so as to provide clinical reference for the diagnosis and treatment of such patients.…”
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Canadian Expert Panel Recommendations on the Management of CNS Symptoms Related to Efavirenz by M John Gill, Anita Rachlis, Sharon Walmsley, Mark Halman, The Efavirenz Consensus Working Group

“…In routine practice, the discontinuation rate of efavirenz due to adverse effects appears higher than that described in clinical trials. To minimize early treatment interruption and maximize the benefit of long term viral suppression that can be achieved with efavirenz therapy, health care providers and patients have identified that there is a need for information, education about and practical tools for the management of efavirenz-related side effects. …”
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The effectiveness of orthodontic treatment with clear aligners in different thicknesses by Saniye Merve Cengiz, Merve Goymen

“…Trial registration: The trial was registered on https://ClinicalTrials.gov retrospectively with the registration number of NCT06504498, on 16/07/2024.…”
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