The Organotypic Longitudinal Spinal Cord Slice Culture for Stem Cell Study by Joanna Sypecka, Sylwia Koniusz, Maria Kawalec, Anna Sarnowska

“…The urgent need for an appropriate in vitro model for spinal cord regeneration results from a greater number of clinical trials concerning regenerative medicine in the spinal cord injury and from still insufficient knowledge of the molecular mechanisms involved in the neuroreparative processes. …”
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Targeting gut microbiota in osteoporosis: impact of the microbial-based functional food ingredients by Pauline Duffuler, Khushwant S. Bhullar, Jianping Wu

“…Moreover, additional animal studies and clinical trials are needed to understand the interactions between gut microbiota and bone metabolism before further applications.…”
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Fractional Radiofrequency Microneedling as a Monotherapy in Acne Scar Management: A Systematic Review of Current Evidence by Niaz G, Ajeebi Y, Alshamrani HM, Khalmurad M, Lee K

“…We systematically reviewed all available literature on FRM techniques used for acne scarring by searching the PubMed and EBSCO databases up to July 2024. 16 studies involving 481 patients, comprising six prospective studies, six randomized clinical trials, three retrospective studies, and one comparative trial, were included. …”
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PET in neurotherapeutic discovery and development by Melissa Chassé, Neil Vasdev

“…Examples highlight the preclinical and clinical uses of PET for studying biomarker function, drug candidate PK/PD, target occupancy/engagement, dosing regimen determination, clinical trial patient selection, and quantifying biomarker changes in response to treatments.…”
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Natural products as anticancer agents and enhancing their efficacy by a mechanism-based precision approach by Stephen Safe

“…Many of the compounds perform poorly in clinical trials due to pharmacokinetic consideration and limited uptake (e.g., curcumin) and these are issues that can be addressed. …”
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Gamma delta T cells in acute myeloid leukemia: biology and emerging therapeutic strategies by Venkata Lokesh Battula, Abhishek Maiti, Adishwar Rao, Akriti Agrawal, Gautam Borthakur

“…Insights from murine models and clinical data in humans show improved overall survival, leukemia-free survival, reduced risk of relapse, enhanced graft-versus-leukemia effect, and decreased graft-versus-host disease in patients with AML who have higher reconstitution of γδ T cells following allogeneic hematopoietic stem cell transplantation. Clinical trials leveraging γδ T cell biology have used unmodified and modified allogeneic cells as well as bispecific engagers and monoclonal antibodies. …”
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Comprehensive analysis of adverse events associated with onasemnogene abeparvovec (Zolgensma) in spinal muscular atrophy patients: insights from FAERS database by Wenwen Zhang, Yizhen Yin, Dan Yang, Mengyuan Liu, Caixia Ye, Ruiling Yan, Ruiman Li

“…Information on its adverse drug reactions is mainly from clinical trials and real-world studies with extensive sample sizes are lacking. …”
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Transient loss of consciousness without cerebral origin following injection of Sinopharm vaccine by Bakhtiar Ebrahimirad, Hero Payandeh

“…Background: The Sinopharm vaccine has been widely administered in Iran during COVID-19 pandemic. Clinical trials have identified several side effects associated with the Sinopharm vaccine, including pain at the injection site, fatigue, headache, and lethargy. …”
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A modern approach to the treatment of acute low back pain: a proposal of a new treatment algorithm by Robert Rupiński, Urszula Grata-Borkowska, Jarosław Drobnik

“…Several randomized clinical trials have demonstrated the efficacy of this method in reducing pain and disability to a degree comparable to high-dose NSAID therapy. …”
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Exploring TNFR1: from discovery to targeted therapy development by Yingying Li, Ruiwei Ye, Haorui Dai, Jiayi Lin, Yue Cheng, Yonghong Zhou, Yiming Lu

“…This review emphasizes the emerging field of targeted therapies aimed at selectively modulating TNFR1 activity, identifying promising therapeutic strategies that exploit TNFR1 as a drug target through an evaluation of current clinical trials and preclinical studies. In conclusion, this study contributes novel insights into the biological functions of TNFR1 and presents potential therapeutic strategies for clinical application, thereby having substantial scientific and clinical significance.…”
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Control of atropoisomerism: an access to valuable compounds by Choppin, Sabine, Wencel-Delord, Joanna, Colobert, Françoise

“…Atropoisomerism is well-known in biaryls, however this phenomenon is encountered in many pharmaceutically relevant compounds such as heterobiaryl, diarylamines, benzamides and anilides.Currently four FDA-approved drugs are atropostable and many others are in clinical trials. It is also important to note that almost 30% of recent FDA-approved small molecules are “proatropisomeric” and interact with a target in a specific chiral conformation.Given this vivid interest in C–C but also C–N atropisomerically stable compounds, this account will detail the new atropoisomeric strategies we developed and their applications in the synthesis of relevant molecules and ligands.…”
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Efficacy and safety of laquinimod versus placebo in relapsing-remitting multiple sclerosis: a systematic review and meta-analysis of randomized controlled trials by Malik Waleed Zeb Khan, Aizaz Ali, Amna Hussain, Safeena Khan, Ammara Tahir, Muhammad Haris Khan, Touba Azeem, Abdul Moeez, Arysha Monis, Aban Masaud Mian, Fazia Khattak, Moosa Ali, Jibran Ikram

“…Methods An extensive electronic search was conducted across PubMed, Embase, Cochrane Database of Systematic Reviews, and ClinicalTrials.gov to identify suitable studies. Risk of bias was assessed using Cochrane’s Risk of Bias tool. …”
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Liquid biopsy in cancer management: Integrating diagnostics and clinical applications by Shashwat Pandey, Preeti Yadav

“…Further research, clinical trials, and regulatory harmonization will be vital in realizing its full potential in precision cancer care.…”
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Comprehensive review of preclinical evaluation strategies for COVID-19 vaccine candidates: assessing immunogenicity, toxicology, and safety profiles by Delaram Doroud, Mojtaba Daneshi, Fatemeh Kazemi-Lomedash, Zohre Eftekhari

“…This guidance is essential for researchers and manufacturers to design effective vaccines that can progress to clinical trials safely. …”
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Emerging targeted therapies in oral oncology: Focus on EGFR inhibition by Vishnu Priya Veeraraghavan, Shikhar Daniel, Arun Kumar Dasari, Kaladhar Reddy Aileni, Chaitra patil, Santosh R. Patil

“…Small-molecule tyrosine kinase inhibitors (TKIs) and monoclonal antibodies (mAbs) targeting EGFR have shown promise in preclinical studies and clinical trials. However, challenges, such as the development of resistance mechanisms and treatment-related toxicities, pose obstacles to their clinical utility. …”
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Decremental response in patients with amyotrophic lateral sclerosis during repetitive nerve stimulation and its relationships with impaired homeostasis by Jinghong Zhang, Yang Li, Qiang Shi

“…Independent factors contributing to decremental response need to be considered in drug development and clinical trials targeting NMJ in patients with ALS.…”
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How you ask matters: evidence-based assessment connecting decentering, reappraisal, and self-reported wellbeing in a post-secondary sample by Yiyi Wang, Joanne M. Chung, Norman A. S. Farb, Norman A. S. Farb

“…This research contributes not only to our understanding of Wellbeing, but also informs its optimal assessment in longitudinal research such as clinical trials and experience sampling studies.…”
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Ferric Carboxymaltose as Treatment in Women with Iron-Deficiency Anemia by Melvin H. Seid, Angelia D. Butcher, Ashwin Chatwani

“…This trial is registered with ClinicalTrials.gov, NCT00548860.…”
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DNA alterations in ovarian adult granulosa cell tumours: A scoping review protocol. by Sven Karstensen, Karsten Kaiser, Caroline Moos, Tim Svenstrup Poulsen, Kirsten Jochumsen, Claus Høgdall, Finn Lauszus, Estrid Høgdall

“…<h4>Discussion</h4>This scoping review will identify knowledge and gaps in the current understanding of the molecular landscape of aGCT, clinical trials on actionable variations and priorities for future research. …”
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Protocol of an Efficacy Study on Nursing Consultation in Weight Management and Metabolic Syndrome Based on the Carbohydrate–Insulin Theory in Individuals with First-Episode Psychos... by Lander Madaria, Claudia Aymerich, Ana Catalan, Miguel Angel Gonzalez-Torres

“…This study was retrospectively registered on Clinical Trials—NCT06650943.…”
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