Cohort profile: the Halland osteoarthritis (HALLOA) cohort–from knee pain to osteoarthritis: a longitudinal observational study in Sweden by Ann Bremander, Maria L E Andersson, S Bergman, Katarina Aili, Emma Haglund

“…It is also important to study the development of chronic pain in OA, to get tools to identify individuals at risk and to be able to offer them treatment.Trial registration number ClinicalTrials.gov (NCT04928170).…”
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The mechanisms of efficacy and safety of Ginkgo biloba extract in acute ischemic stroke: a real-world study by Xiangqian Huang, Xiaoming Zhang, Jiahao Song, Duo Lan, Mengqi Wang, Xunming Ji, Da Zhou, Ran Meng

“…Abstract Background and purpose Although Ginkgo biloba extract (GBE) has been shown to be effective in treating acute ischemic stroke (AIS) in several clinical trials, concerns regarding adverse events, such as bleeding, have been raised. …”
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C-28 linker length modulates the activity of second-generation HIV-1 maturation inhibitors by K. C. Yuvraj, Aradhana Singh, Sayantani Datta, Ritika Das, Pranjal Raj Saxena, Subash Chapagain, T. J. Nitz, Carl Wild, Ritu Gaur

“…Bevirimat (BVM), a first-in-class MI, displayed sub-optimal efficacy in clinical trials due to presence of SP1:V7A polymorphism in the Gag protein.This polymorphism is inherently present in HIV-1 subtype C and conferred resistance to BVM. …”
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The Potential of Virtual Reality for Inducing Neuroplasticity in Children with Amblyopia by María B. Coco-Martin, David P. Piñero, Luis Leal-Vega, Carlos J. Hernández-Rodríguez, Joaquin Adiego, Ainhoa Molina-Martín, Dolores de Fez, Juan F. Arenillas

“…More studies are needed to confirm these promising therapies in controlled randomized clinical trials, with special emphasis on the definition of the most adequate planning for obtaining an effective recovery of the visual and binocular function.…”
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THE USE OF ARTIFICIAL INTELLIGENCE ON COLPOSCOPY IMAGES AND SEGMENTAL VOLUMES, CONSTRUCTED FROM MRI AND CT IMAGES, IN THE DIAGNOSIS AND STAGING OF PRECANCERS, CERVICAL CANCERS AND... by Hlescu Cristian Stefan, Tudor Florin Ursuleanu, Roxana Grigorovici, Andreea Roxana Luca, Ramona Elena Teiu, Maria Paula Comanescu, Alina Ionela Calin, Alexandru Grigorovici

“…Selection criteria will adhere to inclusion and exclusion parameters defined in the clinical trial protocol, and all patient data will be handled ethically and in accordance with written and informed consent approved by the Ethics Committee. …”
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Vitamin D Supplementation Ameliorates Metabolic Dysfunction in Patients with PCOS: A SystematicReview of RCTs and Insight into the Underlying Mechanism by Shan Guo, Reshef Tal, Haoyu Jiang, Tao Yuan, Ying Liu

“…Literature research was conducted in Pubmed, Embase, Web of Science, Clinical Trials, and Cochrane Library to identify relevant randomized controlled trials (RCTs) up to March 2020. …”
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Cross-Cultural Adaptation and Validation of “Malocclusion Impact Questionnaire” into Moroccan Arabic by Farid Bourzgui, Samir Diouny, Hadam Mkhantar, Zineb Serhier, Mohamed Bennani Othmani

“…The Moroccan Arabic version of the MIQ was found to be reliable, whereas it has unacceptable validity according to ICON, and hence, it is unlikely to be a useful measure in orthodontic clinical trials for Moroccan adolescents.…”
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An Assessment of Usual Salt Intake among Older Normotensive Adults in Atonsu, a Suburb of Kumasi in the Ashanti Region of Ghana by Rufai Safianu, Jacob Plange-Rhule

“…Experimental and epidemiological studies as well as studies involving clinical trials show the existence of adverse effect of salt consumption on the blood pressure of adults. …”
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The Role of Quercetin, a Flavonoid in the Management of Pathogenesis Through Regulation of Oxidative Stress, Inflammation, and Biological Activities by Hajed Obaid A. Alharbi, Mohammad Alshebremi, Ali Yousif Babiker, Arshad Husain Rahmani

“…It is important to conduct more clinical trials to gain a deeper understanding of the disease-preventive potential, mechanisms of action, safety, and optimal therapeutic dosages. …”
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Therapeutic potential of phytocompounds of Bacopa monnieri (L.) Wettst (literature review) by O.O. Nikitina, D.S. Tsyba

“…The extract was not toxic to humans. Numerous clinical trials show the effectiveness of the use of extracts in the treatment of anhedonia, depression, Alzheimer's disease, Parkinson's disease, dementia and hyperactivity. …”
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Bimatoprost Intracameral Implant (Durysta®): A New Era in Glaucoma Management Through Sustained-Release Innovation by Vagiakis I, Papadopoulou EP, Amaxilati E, Tsiropoulos GN, Konstas AG, Panos GD

“…This review evaluates its pharmacology, efficacy, and safety, using data from pivotal clinical trials and recent real-world studies. The implant achieves IOP reductions comparable to topical prostaglandin analogs, with benefits for patient adherence and fewer common side effects. …”
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Clinical implications of Delphian lymph node metastasis in papillary thyroid carcinoma: a single-institution study, systemic review and meta-analysis by Bin Wang, Xing-zhu Wen, Wei Zhang, Ming Qiu

“…Trial registration The clinical study was retrospectively registered to UMIN clinical trials registry (the registry number: UMIN000033835).…”
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Contemplating the Bibliometric Data Onto Sepsis and Gut Microbiome: Mapping Trends, Collaborations, and Global Contributions by Zhang Li, Wang Yi, Li Ping, Li Xiang, Yu Xiangyou

“…The prominence of the United States in the field underscores the need for welldesigned clinical trials and prospective cohort studies to advance therapeutic strategies. …”
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Cognitive Training and Transcranial Direct Current Stimulation for Mild Cognitive Impairment in Parkinson’s Disease: A Randomized Controlled Trial by Blake J. Lawrence, Natalie Gasson, Andrew R. Johnson, Leon Booth, Andrea M. Loftus

“…The trial was registered with the Australian New Zealand Clinical Trials Registry (ANZCTR: 12614001039673). While controlling for moderator variables, Generalized Linear Mixed Models (GLMMs) showed that when compared to the control group, the intervention groups demonstrated variable statistically significant improvements across executive function, attention/working memory, memory, language, activities of daily living (ADL), and quality of life (QOL; Hedge’s g range = 0.01 to 1.75). …”
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Daratumumab for autoimmune diseases: a systematic review by Martin Krusche, Ina Kötter, Lennard Ostendorf, Nikolas Ruffer, Marie-Therese Holzer, Tobias B. Huber

“…Therefore, systematic clinical trials of this therapeutic approach are needed.…”
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Patient experiences of an ankle fracture and the most important factors in their recovery: a qualitative interview study by Rebecca Samantha Kearney, Rebecca McKeown, David R Ellard, Zi Heng Liew

“…Thematic content analysis was used to identify themes in the data.Setting Individuals were recruited from a sample of participants of a UK-based clinical trial of immobilisation methods for ankle fracture (ISRCTN15537280 at the pre-results stage at time of writing). …”
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Biological Evaluation of Platinum(II) Sulfonamido Complexes: Synthesis, Characterization, Cytotoxicity, and Biological Imaging by Charini Maladeniya, Taniya Darshani, Sameera R. Samarakoon, Frank R. Fronczek, W. M. C. Sameera, Inoka C. Perera, Theshini Perera

“…Platinum-based compounds are actively used in clinical trials as anticancer agents. In this study, two novel platinum complexes, (C1 = [PtCl2(N(SO2quin)dpa)], C2 = [PtCl2(N(SO2azobenz)dpa)]) containing quinoline and azobenzene appended dipicolylamine sulfonamide ligands were synthesized in good yield. …”
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Current Pharmacological Management of Gastroesophageal Reflux Disease by Yao-Kuang Wang, Wen-Hung Hsu, Sophie S. W. Wang, Chien-Yu Lu, Fu-Chen Kuo, Yu-Chung Su, Sheau-Fang Yang, Chiao-Yun Chen, Deng-Chyang Wu, Chao-Hung Kuo

“…Newer formulations of PPI with faster and longer duration of action and potassium-competitive acid blocker, a newer acid suppressant, have also been investigated in clinical trials. In this review, we summarize the current and developing therapeutic agents for GERD treatment.…”
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Terminalia arjuna in Chronic Stable Angina: Systematic Review and Meta-Analysis by Navjot Kaur, Nusrat Shafiq, Harish Negi, Avaneesh Pandey, Srinivas Reddy, Harpreet Kaur, Neelima Chadha, Samir Malhotra

“…Further, well-controlled multicentric clinical trials need to be conducted in large number of patients to explore the therapeutic potential of Terminalia arjuna if any.…”
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Laparoscopy Combined with Enhanced Recovery Pathway in Ileocecal Resection for Crohn’s Disease: A Randomized Study by Yibin Zhu, Jianjian Xiang, Wei Liu, Qian Cao, Wei Zhou

“…This study is registered at ClinicalTrials.gov (NCT02777034).…”
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