Treatment Interruption and Regimen Change in Firstgeneration versus Second-generation Tyrosine Kinase Inhibitors used as First-line Therapy for Chronic Myeloid Leukemia by Melea A. Ward, Gang Fang, Kristy L. Richards, Christine M. Walko, Stephanie R. Earnshaw, Laura E. Happe, Susan J. Blalock

“…**Background:** Research has shown that treatment interruptions are associated with worse failure-free survival in chronic myeloid leukemia (CML); however they are commonly used in clinical trials to manage adverse events. **Objectives:** This study assessed the comparative rates of treatment interruption and regimen change between patients initiating first-line therapy with a first-generation tyrosine kinase inhibitor (1GTKI) imatinib versus second-generation TKI (2GTKI), dasatinib or nilotinib, for the treatment of CML in clinical practice. …”
Get full text

Beliefs about HIV cure: A qualitative study of people living with HIV in Soweto, South Africa by Fatima Laher, Naledi Mahlangu, Mbalenhle Sibiya

“…Background: Rare cases of HIV cure exist. Clinical trials of HIV cure are also underway. However, little is documented about how potential cures are perceived by African people living with HIV, although they are key stakeholders. …”
Get full text

Chimerism in Myeloid Malignancies following Stem Cell Transplantation Using FluBu4 with and without Busulfan Pharmacokinetics versus BuCy by Shatha Farhan, Michael Bazydlo, Klodiana Neme, Nancy Mikulandric, Edward Peres, Nalini Janakiraman

“…This will need to be examined in larger retrospective multicenter studies and prospective clinical trials.…”
Get full text

Traditional Uses, Bioactive Compounds, and Pharmacological Investigations of Calendula arvensis L.: A Comprehensive Review by Aya Khouchlaa, Aicha El Baaboua, Hamza El Moudden, Fatima Lakhdar, Saad Bakrim, Naoual El Menyiy, Omar Belmehdi, Hicham Harhar, Nasreddine El Omari, Abdelaali Balahbib, Moon Nyeo Park, Gokhan Zengin, Bonglee Kim, Abdelhakim Bouyahya

“…Nevertheless, pharmacokinetic validation and toxicological examinations are required to detect any possible toxicity for future clinical trials.…”
Get full text

A randomized, double‐blind, placebo‐controlled, multiple dose, parallel study to investigate the effects of a cathepsin S inhibitor in celiac disease by Darren Bentley, Marie Mannino, Marianne Manchester, Priscila Camillo Teixeira, Bernhard Reis, Malcolm Boyce, Sandra Nagel

“…This randomized, double‐blind, placebo‐controlled, parallel‐group, single‐center study tested the effects of the cathepsin S inhibitor RO5459072 on the immune response to a 13‐day gluten challenge in 19 participants with celiac disease (ClinicalTrials.gov: NCT02679014). Nine participants in the RO5459072 arm received 100 mg study drug b.i.d. (200 mg daily); 10 received a placebo. …”
Get full text

INTRAVENOUS VITAMIN C (IVC) TREATMENT OUTCOME OF COVID 19 PATIENTS ADMITTED IN HOSPITAL: A SYSTEMATIC REVIEW by Auria Ekanti Pratiwi, Oki Suwarsa, Achadiyani, Nur Atik

“…Hence, further research and evaluation in clinical trials are needed.…”
Get full text

Psychometric validation of the continuum beliefs of mental illness scale (CB-MIS) and its associations with stigma by Lina-Jolien Peter, Thomas McLaren, Samuel Tomczyk, Holger Muehlan, Silke Schmidt, Georg Schomerus

“…Trial registration German Clinical Trials Register: DRKS00023557. Registered 11/12/2020. …”
Get full text

The PTP1B Inhibitor Trodusquemine (MSI-1436) Improves Glucose Uptake in Equine Metabolic Syndrome Affected Liver through Anti-Inflammatory and Antifibrotic Activity by Lynda Bourebaba, Anna Serwotka-Suszczak, Nabila Bourebaba, Magdalena Zyzak, Krzysztof Marycz

“…Taken together, the presented data suggest that the PTP1B inhibition strategy and the use of its specific inhibitor MSI-1436 represents a promising option for the improvement of liver tissue integrity and homeostasis in the course of EMS and adds more insights for ongoing clinical trials for human MetS management.…”
Get full text

The Role of Platelet Concentrates and Growth Factors in Facial Rejuvenation: A Systematic Review with Case Series by Giuseppina Malcangi, Angelo Michele Inchingolo, Alessio Danilo Inchingolo, Laura Ferrante, Giulia Latini, Irma Trilli, Paola Nardelli, Marialuisa Longo, Andrea Palermo, Francesco Inchingolo, Gianna Dipalma

“…<i>Materials and Methods</i>: A comprehensive literature search was performed on PubMed, Web of Science, and Scopus, focusing on human clinical trials published between February 2019 and February 2024 related to PRP and facial esthetics. …”
Get full text

Virtual reality technology improves the gait and balance function of the elderly: a meta-analysis of randomized controlled trials by Junyu Chen, Shuxia Yan, Haiyan Yin, Dan Lin, Ziqi Mei, Zichun Ding, Meng Wang, Yamei Bai, Guihua Xu

“…Material and methods Two authors independently searched EMBASE, PubMed, Web of Science, ClinicalTrials, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang and Weipu databases up to October 20, 2023 for randomized controlled trials (RCTs) on the application of VR in improving the gait and balance function in the elderly. …”
Get full text

Controversial Roles of Regenerating Family Proteins in Tissue Repair and Tumor Development by Luting Yu, Qingyun Wu, Shenglong Jiang, Jia Liu, Junli Liu, Guoguang Chen

“…Successively, short peptides derived from Reg3δ and Reg3α have been employed in clinical trials, showing favorable therapeutic effects in patients with type I and type II diabetes. …”
Get full text

Functional MRI-guided microsurgery of intracranial arteriovenous malformations: study protocol for a randomised controlled trial by Shuo Wang, Yuanli Zhao, Jun Wu, Bing Zhao, Yong Cao

“…Study findings will be disseminated in the printed media.Trial registration number ClinicalTrials.gov NCT01758211.…”
Get full text

Patient-reported outcomes of zirconia dental implants: a systematic review and future directions by Behrouz Arefnia, Omid Fakheran, Norbert Jakse, Michael Payer

“…The identified studies were subjected to preidentified inclusion criteria. Only controlled clinical trials published in English were considered without limitations on the year of publication. …”
Get full text

Drug Repositioning for Gynecologic Tumors: A New Therapeutic Strategy for Cancer by Kouji Banno, Miho Iida, Megumi Yanokura, Haruko Irie, Kenta Masuda, Yusuke Kobayashi, Eiichiro Tominaga, Daisuke Aoki

“…Such drug discovery can be performed at low cost and in the short term based on the results of previous clinical trials. New drugs for gynecologic tumors may be found by drug repositioning. …”
Get full text

Riboflavin- and Hypericin-Mediated Antimicrobial Photodynamic Therapy as Alternative Treatments for Oral Candidiasis: A Systematic Review by Maciej Łopaciński, Jakub Fiegler-Rudol, Wojciech Niemczyk, Dariusz Skaba, Rafał Wiench

“…<b>Conclusions</b>: Riboflavin- and hypericin-mediated aPDT present promising, biocompatible alternatives for managing antifungal resistance in Candida infections. Further clinical trials and standardized protocols are essential to optimize outcomes and confirm efficacy in broader clinical settings.…”
Get full text

What are the perceived influences on asthma self-management at the workplace? A qualitative study by Adrian Loerbroks, Katherina Heinrichs, Patricia Vu-Eickmann, Stefan Hummel, Jalal Gholami

“…Support by colleagues, line managers, and the employer, for example, practical, emotional, or structural support, was perceived to exert effects on symptom prevention, acute symptom management, and communication (ie, self-disclosure of one’s condition).Conclusions Perceived JDL and social support were experienced as influencing successful implementation of asthma SMB at the workplace.Trial registration number German Clinical Trials Register no: DRKS00011309.…”
Get full text

Infant outcomes after exposure to Tdap vaccine in pregnancy: an observational study by Helen Petousis-Harris, Tony Walls, Patricia Graham, Nicola Austin, Linda Hill

“…We have not found any adverse events attributable to vaccine exposure.Conclusions These data add to the growing pool of evidence that the administration of Tdap vaccine during pregnancy is an appropriate strategy for reducing the burden of pertussis in infants.Clinical trial registration Australia New Zealand Clinical Trials Registry ACTRN12613001045707.…”
Get full text

Cardiac Outpouchings: Definitions, Differential Diagnosis, and Therapeutic Approach by Riccardo Scagliola, Gian Marco Rosa, Sara Seitun

“…The material reviewed was obtained by the following search engines: MEDLINE (PubMed), EMBASE, Google Scholar, and Clinical Trials databases, from January 1966 until March 2021. …”
Get full text

Left Bundle Branch Area Pacing versus Right Ventricular Pacing in Patients with Atrioventricular Block: An Observational Cohort Study by Zhongxiu Chen, Yuanning Xu, Lingyun Jiang, Ran Zhang, Hongsen Zhao, Ran Liu, Lei Zhang, Yajiao Li, Xingbin Liu

“…This study is registered with ClinicalTrials.gov NCT05722379.…”
Get full text

Case report: Near-complete response to neratinib-based treatment in HR-positive HER2-amplified metastatic breast cancer refractory to trastuzumab deruxtecan by Ünal Metin Tokat, Ashkan Adibi, Ashkan Adibi, Esranur Aydın, Şevval Nur Bilgiç, Eylül Özgü, Onur Tutar, Mutlu Demiray

“…Furthermore, we demonstrated that triplet combination could induce a remarkable response in the T-DXd–refractory setting, which could be explored in future clinical trials in HR+ and HER2-activated (by RNA or protein overexpression, amplification, and mutation) patients. …”
Get full text