Efficacy of Keyhole Approach to Carpal Tunnel Syndrome under Ambulatory Strategy by Rodrigo Ramos-Zúñiga, César J. García-Mercado, Iván Segura-Durán, Luis A. Zepeda-Gutiérrez

“…This trial is registered with Clinical Trials Protocol Identifier NCT03062722.…”
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Pembrolizumab for the Treatment of Locally Advanced Cutaneous Squamous Cell Carcinoma: Patient Selection and Special Considerations by Stewart M, Geiger JL

“…Pembrolizumab, approved by the FDA in 2020 for recurrent or metastatic cSCC not amenable to curative surgery or radiation, has shown promising results in clinical trials. Immunotherapy is also being explored in neoadjuvant settings, with ongoing trials evaluating its potential to improve outcomes for high-risk patients with recurrent or metastatic disease. …”
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Caffeine as an Active Molecule in Cosmetic Products for Hair Loss: Its Mechanisms of Action in the Context of Hair Physiology and Pathology by Ewelina Szendzielorz, Radoslaw Spiewak

“…Nevertheless, the metabolic activity of caffeine and its ability to enter and accumulate in the hair follicles combined with the results of available clinical trials seem to indicate that caffeine could indeed prove as an effective and safe option in the management of hair loss.…”
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Parenterally Administered Norovirus GII.4 Virus-Like Particle Vaccine Formulated with Aluminum Hydroxide or Monophosphoryl Lipid A Adjuvants Induces Systemic but Not Mucosal Immune... by Suvi Heinimäki, Maria Malm, Timo Vesikari, Vesna Blazevic

“…NoV vaccine candidates currently in clinical trials are based on noninfectious highly immunogenic virus-like particles (VLPs) delivered intramuscularly (IM). …”
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Combination Olanzapine and Samidorphan for the Management of Schizophrenia and Bipolar 1 Disorder in Adults: A Narrative Review by Hannah W. Haddad, Elena Boardman, Brooke Williams, Rama Mouhaffel, Adam M. Kaye, Alan D. Kaye

“…Clinical trial patients reported improvements in symptoms of psychosis, reduced weight gain, and overall satisfaction with their treatment. …”
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Mitochondrial DNA: A New Predictor of Diabetic Kidney Disease by Yajing Huang, Jingwei Chi, Fanxiang Wei, Yue Zhou, Yihai Cao, Yangang Wang

“…However, large-scale, long-term follow-up clinical trials are still needed to determine the threshold range. …”
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A class of constrained optimal control problems arising in an immunotherapy cancer remission process by Yineng Ouyang, Zhaotao Liang, Zhihui Ma, Lei Wang, Zhaohua Gong, Jun Xie, Kuikui Gao

“…These results provide a theoretical framework that can guide clinical trials in immunotherapy.…”
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Tirosin Kinase Inhibitors in Chronic Graft versus Host Disease: From Bench to Bedside by Jacopo Olivieri, Sabrina Coluzzi, Imma Attolico, Attilio Olivieri

“…While the exact mechanisms leading to such efficacy are still under investigation, use of TKIs in the context of clinical trials should be promoted, aiming to evaluate the biological changes induced in vivo by TKIs and to assess the long term outcome of these patients. …”
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Potentials of Curcumin as an Antidepressant by S.K. Kulkarni, Ashish Dhir, Kiran Kumar Akula

“…The present review attempts to discuss the pharmacological profile along with molecular mechanisms of the antidepressant effect of curcumin in animal models of depression. A need for clinical trials in order to explore the antidepressant efficacy and safety profile of curcumin is emphasized.…”
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Promising Neuroprotective Effects of Dracocephalum Species: Mechanistic Perspectives by Marjan Talebi, Alireza Ghassempour, Afsoon Feizi, Seyed Abdulmajid Ayatollahi, Mehrdad Faizi

“…These findings suggest that Dracocephalum spp. and their phytochemicals have neuroprotective effects by targeting the regulation of various pathways. Therefore, clinical trials should be performed to confirm the in vitro and animal findings. …”
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Is there a risk of esketamine misuse in clinical practice? by Carlos Roncero, Milton Merizalde-Torres, Néstor Szerman, Marta Torrens, Pablo Vega, Pilar Andres-Olivera, Francisco Javier Álvarez

“…In 2019, intranasal esketamine gained approval as a promising therapy for those individuals grappling with treatment-resistant depression. Both clinical trials and real-world studies have underscored its efficacy in alleviating and remitting depressive symptoms, with sustained benefits observed for nearly 4.5 years. …”
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The Impacts of Educational Asthma Interventions in Schools: A Systematic Review of the Literature by Ana Carla Carvalho Coelho, Laís Souza Barretto Cardoso, Carolina de Souza-Machado, Adelmir Souza-Machado

“…A systematic review was conducted for controlled clinical trials investigating the effectiveness of educational asthma interventions for students, asthmatic or nonasthmatic, families, and school staff. …”
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Analysis of restoration in atrophic scar by intradermal autologous dermal tissue: a pilot study by Sudhir Singh, Adarsh L. Singh, Deepika Singh

“…It is important to continue conducting research and clinical trials to establish the benefits and limitations of autologous dermal tissue transplantation for depressed scars. …”
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An sveir model for assessing potential impact of an imperfect anti-SARS vaccine by Abba B. Gumel, C. Connell McCluskey, James Watmough

“…Owing to the recent ongoing clinical trials ofsome candidate anti-SARS vaccines, this study aims to assess, via mathematical modelling, the potential impact of a SARS vaccine,assumed to be imperfect, in curtailing future outbreaks. …”
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The potential impact of a prophylactic vaccine for Ebola in Sierra Leone by Erin N. Bodine, Connor Cook, Mikayla Shorten

“…A prophylactic vaccine for ebolavirus (rVSV-ZEBOV) has been developed, and clinical trials show near-perfect efficacy. We have developed an ordinary differential equations model that simulates an EVD epidemic and takes into account (1) transmission through contact with infectious EVD individuals and deceased EVD bodies, (2) the heterogeneity of the risk of becoming infected with EVD, and (3) the increased survival rate of infected EVD patients due to greater access to trained healthcare providers. …”
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Finite Element Modelling Based Studies for Dental Implants: Systematic Review by Shahad Mohammed Shakir, Saja Ali Muhsin, Raad Al Marza

“…Finite element methods not only give speedy and reliable data on the patients under investigation, but they also act as essential guidance for many clinical trials. To have a better understanding of the finite element modelling method. …”
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Minimally invasive lateral, posterior, and posterolateral sacroiliac joint fusion for low back pain: a systematic review and meta-analysis by Kai Xu, Ya-Ling Li, Song-Hua Xiao, Yong-Wei Pan

“…Methods The PubMed, Web of Science, Embase, Cochrane Library, and ClinicalTrials.gov databases were comprehensively searched for studies up to 31 August 2024. …”
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Aaron Temkin BECK: After Cricitical Thinking to A Creative Psychotherapy Theory] by Mehmet DÝNÇ

“…Numerous controlled clinical trials have now demonstrated that cognitive therapy is effective in a variety of psychiatric conditions including depression, bulimia nervosa, hypochondriasis, social phobia, obsessive-compulsive disorder, substance abuse, body dysmorphic disorder, and post-traumatic stress disorder. …”
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Immunotherapy for Metastatic Melanoma with Right Atrial Involvement in a Patient with Rheumatoid Arthritis by Zachary Benson, Sarah Gordon, Patricia Nicolato, Andrew Poklepovic

“…Patients with preexisting autoimmune diseases or prior immune-related adverse events from therapy are largely excluded from clinical trials. Concerns exist that immunotherapy in these patients could worsen autoimmune disease or increase the risk of developing additional immune-related adverse events on therapy. …”
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NGcGM3 Ganglioside: A Privileged Target for Cancer Vaccines by Luis E. Fernandez, Mariano R. Gabri, Marcelo D. Guthmann, Roberto E. Gomez, Silvia Gold, Leonardo Fainboim, Daniel E. Gomez, Daniel F. Alonso

“…N-glycolyl (NGc) gangliosides, and particularly NGcGM3, have received attention as a privileged target for cancer therapy. Many clinical trials have been performed with the anti-NGc-containing gangliosides anti-idiotype monoclonal antibody racotumomab (formerly known as 1E10) and the conjugated NGcGM3/VSSP vaccine for immunotherapy of melanoma, breast, and lung cancer. …”
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