GH Therapy in Non–Growth Hormone-Deficient Children by Chiara Guzzetti, Anastasia Ibba, Valeria Incandela, Sandro Loche

“…Recently, long-acting formulations of rhGH have been approved and licensed for GHD, and clinical trials are ongoing for other conditions. In this paper, we review the rhGH therapy in children with conditions other than GHD.…”
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Unlocking the therapeutic potential of microalgal astaxanthin a super antioxidant in oral cancer and associated ailments by Ashokkumar Veeramuthu

“…Therefore, future research should aim at refining dosage strategies, investigating delivery mechanisms, and executing comprehensive clinical trials to validate its efficacy. Astaxanthin emerges as a game-changer in oral health, poised to enhance outcomes and alleviate suffering in oral diseases.…”
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Clinical and Microbiological Efficacy of Adjunctive Systemic Quinolones to Mechanical Therapy in Periodontitis: A Systematic Review of the Literature by Carlos-M. Ardila, Jader-Alexander Bedoya-García

“…MeSH terms and keywords were utilized to explore publications in all idioms. Only randomized clinical trials (RCTs) that met the selection criteria were included. …”
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Optical Coherence Tomography in Huntington's Disease—A Potential Future Biomarker for Neurodegeneration? by Clancy Cerejo, Nicolas De Cleene, Elias Mandler, Katarina Schwarzová, Samuel Labrecque, Philipp Mahlknecht, Florian Krismer, Atbin Djamshidian, Klaus Seppi, Beatrice Heim

“…Lately, there have been multiple ongoing clinical trials targeting therapeutic agents for preventing disease onset or slowing disease progression in HD. …”
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The Effects of Dipeptidyl Peptidase-4 Inhibitors on Cardiovascular Disease Risks in Type 2 Diabetes Mellitus by Pegah Yousefzadeh, Xiangbing Wang

“…Long-term outcome clinical trials are under way to investigate the effects of the DPP-4 inhibitors on the elevated CV risks in patients with T2DM. …”
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New insights into anti-depression effects of bioactive phytochemicals by Ruohan Zhao, Jingwen Wang, Sookja Kim Chung, Baojun Xu

“…In this literature review, we describe the pharmacological actions, experimental models, and clinical trials of the antidepressant effects of various phytochemicals. …”
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Promoting Articular Cartilage Regeneration through Microenvironmental Regulation by Kai Liu, Bingjun Zhang, Xiaoling Zhang

“…By searching relevant research articles and clinical trials in PubMed according to the keywords of articular cartilage, microenvironment, OA, mechanical force, hypoxia, cytokine, and cell senescence. …”
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The Role of Vascular Endothelial Growth Factor in Metastatic Prostate Cancer to the Skeleton by Emma Roberts, Davina A. F. Cossigny, Gerald M. Y. Quan

“…Due to the multifaceted effect VEGF has on tumour angiogenesis, tumour cell proliferation, and bone destruction, therapies targeting the VEGF pathways have shown promising clinical application and are being investigated in clinical trials.…”
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Current status and innovative developments of CAR-T-cell therapy for the treatment of breast cancer by Hany E. Marei, Khaled Bedair, Anwarul Hasan, Layla Al-Mansoori, Sara Caratelli, Giuseppe Sconocchia, Alice Gaiba, Carlo Cenciarelli

“…We discuss in detail the role of tumor-associated antigens in breast cancer, current clinical trials, barriers to the intended therapeutic effects of CAR-T cell therapy, and potential ways to increase treatment efficacy. …”
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Enhancing caregiver resilience: A systematic review of interventions for chronic disease management by Saeedeh Mohammadi Saber, Behzad Rahimian

“…Additional rigorous clinical trials are necessary to fortify the current limited evidence base for interventions targeting caregiver resilience.…”
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Antibiotics in the Treatment of Periodontitis: A Systematic Review of the Literature by Chaima Hammami, Wafa Nasri

“…Seven randomized clinical trials were included in our review. Their data were extracted using a grid established for this purpose. …”
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The Nasal Route as a Potential Pathway for Delivery of Erythropoietin in the Treatment of Acute Ischemic Stroke in Humans by Julio Cesar García-Rodríguez, Iliana Sosa Teste

“…However, it will be necessary to initiate clinical trials in stroke patients using intranasal delivery in order to obtain the clinical evidence of its neuroprotectant capacity in the treatment of patients with acute stroke and other neurodegenerative disorders. …”
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The Genus <i>Chiliadenus</i>: A Comprehensive Review of Taxonomic Aspects, Traditional Uses, Phytochemistry and Pharmacological Activities by Lucinda Villaescusa Castillo, Francisco Zaragozá García, Cristina Zaragozá Arnáez

“…However, the lack of comparative studies among <i>Chiliadenus</i> species and the scarcity of in vivo studies and clinical trials hinder the full realization of its therapeutic potential. …”
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Targeted Anticancer Immunotoxins and Cytotoxic Agents with Direct Killing Moieties by Koji Kawakami, Oumi Nakajima, Ryuichi Morishita, Ryozo Nagai

“…Such targetable agents, including RFB4(dsFv)-PE38 (BL22), IL13-PE38QQR, and Tf-CRM107, are being tested in clinical trials. Several agents using unique technology such as a cleavable adapter or immunoliposomes with antibodies are also in the preclinical stage. …”
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Stroke Prevention: Managing Modifiable Risk Factors by Silvia Di Legge, Giacomo Koch, Marina Diomedi, Paolo Stanzione, Fabrizio Sallustio

“…The results of recent clinical trials investigating new anticoagulants (factor Xa inhibitors and direct thrombin inhibitors) clearly indicate alternative strategies in stroke prevention for patients with atrial fibrillation. …”
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Health Status Measurement Instruments in Chronic Obstructive Pulmonary Disease by Yves Lacasse, Eric Wong, Gordon Guyatt, Roger S Goldstein

“…Generic questionnaires should not be used alone in clinical trials as evaluative instruments because of their inability to detect change over time. …”
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Early mobilization post-myocardial infarction: A scoping review. by Haroon Munir, Jake Fromowitz, Michael Goldfarb

“…More robust evidence from randomized clinical trials is required to inform clinicians and influence practice.…”
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Biological Evaluation of Garcinia kola Heckel by Abdulrahman Mahmoud Dogara, Saber W. Hamad, Harmand A. Hama, Sarwan W. Bradosty, Soran Kayfi, Sawsan S. Al-Rawi, Abubakar Abdullahi Lema

“…However, the safety and efficacy of G. kola have not been wholly assessed in humans, and further well-designed clinical trials are needed to corroborate preclinical findings. …”
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Error fields: personalized robotic movement training that augments one’s more likely mistakes by Naveed Reza Aghamohammadi, Moria Fisher Bittmann, Verena Klamroth-Marganska, Robert Riener, Felix C. Huang, James L. Patton

“…This study reports results from a clinical trial registered on ClinicalTrials.gov with ID: NCT02720341.…”
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Potential Use of Euphorbia hirta for Dengue: A Systematic Review of Scientific Evidence by Sashini D. Perera, Uthpala A. Jayawardena, Chanika D. Jayasinghe

“…Hence, well-controlled clinical trials and contemporary pharmacological approaches including activity guided fractionation and elucidation of the mode of action are encouraged to establish the use of E. hirta for dengue.…”
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