Combined Effect of Lentinan and Cisplatin on Cytokines IL-6, TNF-α, and TGF-β in Tumor Therapy by Xu-dong Liu, Min Li, Wan-xiang Li, Qing-yu Wang, Hong-xia Zhang

“…Many cytokines have shown positive effect on different malignancies in clinical trials. Studies have shown that such cytokines as IL6, TNF-α, and TGF-β play a quite important role in the formation of tumor microenvironment. …”
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Functional Multipotency of Stem Cells: What Do We Need from Them in the Heart? by Pablo Díez Villanueva, Ricardo Sanz-Ruiz, Alberto Núñez García, María Eugenia Fernández Santos, Pedro L. Sánchez, Francisco Fernández-Avilés

“…After more than ten years of human research in the field of cardiac regenerative medicine, application of stem cells in different phases of ischemic heart disease has come to age. Randomized clinical trials have demonstrated that stem cell therapy can improve cardiac recovery after the acute phase of myocardial ischemia and in patients with chronic ischemic heart disease, and several efficacy phase III trials with clinical endpoints are on their way. …”
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Prediction of hemolytic peptides and their hemolytic concentration by Anand Singh Rathore, Nishant Kumar, Shubham Choudhury, Naman Kumar Mehta, Gajendra P. S. Raghava

“…Abstract Peptide-based drugs often fail in clinical trials due to their toxicity or hemolytic activity against red blood cells (RBCs). …”
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The Effect of Antihypertensive Drugs on Endothelial Function as Assessed by Flow-Mediated Vasodilation in Hypertensive Patients by Michiaki Miyamoto, Kazuhiko Kotani, Shun Ishibashi, Nobuyuki Taniguchi

“…A PubMed-based search found 38 clinical trial papers published from January 1999 to June 2011. …”
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PPAR Agonists and Cardiovascular Disease in Diabetes by Anna C. Calkin, Merlin C. Thomas

“…Many of these potentially anti-atherosclerotic effects are thought to be mediated by transrepression of nuclear factor-kB, STAT, and activator protein-1 dependent pathways. In recent clinical trials, PPAR𝛼 agonists have been shown to be effective in the primary prevention of cardiovascular events, while their cardiovascular benefit in patients with established cardiovascular disease remains equivocal. …”
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A SYSTEMATIC REVIEW OF THE USE OF TULATHROMYCIN IN VETERINARY MEDICINE by Carmen (Pop) Moldovan, Alexandra Dreancă, Oana Rotar, Mihai Madru, Ioan Marcus

“…Additionally, the review examines the dosage regimens, administration routes, and potential side effects reported in clinical trials. Data regarding antimicrobial resistance to tulathromycin is discrepant due to several sources that display negative results regarding the sole use of this macrolide and its off-label use. …”
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Update of Immunomodulatory Therapy for Inflammatory Bowel Disease by Charles N Bernstein

“…Newer immunomodulatory agents have been designed for specific targets. and in particular monoclonal antibodies that block the effects of interleukin-1, tumour necrosis factor-alpha and the T cell receptor are available for clinical trials. We are in an era of expanding therapeutic approaches to these diseases, including the refined use of readily available agent, the development of newer, more targeted agents and a broader understanding of how agents may be effectively used simultaneously or sequentially.…”
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Successfully Climbing the “STAIRs”: Surmounting Failed Translation of Experimental Ischemic Stroke Treatments by Michael P. Kahle, Gregory J. Bix

“…It is important for preclinical stroke researchers to frequently consider and revisit these concepts, especially since promising experimental stroke treatments continue to fail in human clinical trials. Therefore, this paper will focus on considerations for several key aspects of preclinical stroke studies including the selection and execution of the animal stroke model, drug/experimental treatment administration, and outcome measures to improve experimental validity and translation potential. …”
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Stem Cells for Cardiac Repair: Status, Mechanisms, and New Strategies by Ren Mingliang, Zhang Bo, Wang Zhengguo

“…It is expected to replace and repair damaged myocardium. But many clinical trials have shown that the stem cell therapy of heart failure is modest or not effective. …”
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Design of Upper limb Rehabilitation Training System for Stroke Patients Based on Goalkeeper Virtual Reality Game by Xingping YANG, Zhuoming CHEN, Zhao GAO

“…After clinical application, it was found that virtual reality rehabilitation training system can significantly improve the upper limb motor function of stroke patients compared with conventional therapy, and the system had good application feedback and strong operability.Conclusion:The upper limb motor training system of virtual reality game can improve the upper limb motor function of stroke patients, and the system has good clinical compliance and operability. Large-scale clinical trials are needed to further verify its efficacy and function.…”
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Intravenous γ Globulin for Intractable Abdominal Pain due to IgA Vasculitis by George Naifa, George Totikidis, Sonia Alexiadou, Christina Kolona, Elpis Mantadakis

“…Given the toxicity and/or need for long-term administration of other second-line immunosuppressive therapies in corticosteroid-resistant IgA vasculitis, such as rituximab, cyclosporine, cyclophosphamide, azathioprine, or colchicine, we propose that IVIg may be a useful and safe treatment option, although randomized controlled clinical trials are needed in order to clarify its role in the treatment of abdominal pain in IgA vasculitis.…”
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Helicobacter pylori-Induced Chronic Gastritis and Assessing Risks for Gastric Cancer by Gonzalo Carrasco, Alejandro H. Corvalan

“…This trial is registered with ClinicalTrials.gov NCT01774266.…”
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Mirror therapy to reduce phantom limb pain. Systematic review by Jesús Sánchez Lozano, Sandra Martínez Pizarro

“…After eliminating duplicates and applying the inclusion criteria, 5 clinical trials remained. The sample was 250 patients. …”
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Liver Protective Effect of Fenofibrate in NASH/NAFLD Animal Models by Ali Mahmoudi, Seyed Adel Moallem, Thomas P. Johnston, Amirhossein Sahebkar

“…In recent decades, several medications related to other metabolic disorders have been evaluated in preclinical studies and in clinical trials due to the correlation of NAFLD with other metabolic diseases. …”
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DNA Vaccination: Using the Patient's Immune System to Overcome Cancer by Georg Eschenburg, Alexander Stermann, Robert Preissner, Hellmuth-Alexander Meyer, Holger N. Lode

“…Using the patient's own immune system by activation of humoral and cellular immune responses to target the cancer cells has shown first promising results in clinical trials and may allow reduced toxicity standard therapy regimen in the future. …”
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Long COVID and gut microbiome: insights into pathogenesis and therapeutics by Raphaela I. Lau, Qi Su, Siew C. Ng

“…Altered gut microbiome has been proposed as one of the plausible mechanisms involved in the pathogenesis of PACS; extensive studies have emerged to bridge the gap between the persistent symptoms and the dysbiosis of gut microbiome. Recent clinical trials have indicated that gut microbiome modulation using probiotics, prebiotics, and fecal microbiota transplantation (FMT) led to improvements in multiple symptoms related to PACS, including fatigue, memory loss, difficulty in concentration, gastrointestinal upset, and disturbances in sleep and mood. …”
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An Update on the Potential of Mesenchymal Stem Cell Therapy for Cutaneous Diseases by Yanyun Li, Ziyu Ye, Weiqin Yang, Qunzhou Zhang, Jincheng Zeng

“…In this review, we highlight the mechanisms underlying MSC-mediated immunomodulation and tissue repair/regeneration and present the latest development of MSC-based clinical trials on cutaneous diseases.…”
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Treatment with the CCR5 antagonist OB-002 reduces lung pathology, but does not prevent disease in a Syrian hamster model of SARS-CoV-2 infection. by Bryce M Warner, Robert Vendramelli, Amrit S Boese, Jonathan Audet, Nikesh Tailor, Courtney Meilleur, Nathan Glowach, Marnie Willman, Thang Truong, Estella Moffat, Kevin Tierney, Beata Kosak, Irfan Dhanidina, Jarret Engstrom, Bozena Korczak, Ian McGowan, Carissa Embury-Hyatt, Darwyn Kobasa

“…Since the emergence of SARS-CoV-2 and the COVID-19 pandemic, a wide range of treatment options have been evaluated in preclinical studies and clinical trials, with several being approved for use in humans. …”
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Therapeutic Potential of Dietary Phenolic Acids by Venkata Saibabu, Zeeshan Fatima, Luqman Ahmad Khan, Saif Hameed

“…Based on the available information in the literature, it is suggested that use of PAs as drugs is very promising; however more research and clinical trials are necessary before these bioactive molecules can be made for treatment. …”
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Black Pepper (Piper nigrum) for Tobacco Withdrawal: A Case Report by Jeremy Weleff, Samyukta Dore, Akhil Anand, Brian S. Barnett

“…Existing treatments for tobacco use disorder are limited in efficacy and there is a strong need for identifying effective novel treatments. Small clinical trials indicate that black pepper (Piper nigrum) essential oil may be helpful for treating nicotine withdrawal and craving. …”
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