Histone Deacetylases Inhibitors in the Treatment of Retinal Degenerative Diseases: Overview and Perspectives by Hua Zhang, Xufeng Dai, Yan Qi, Ying He, Wei Du, Ji-jing Pang

“…Several HDACis have been approved for clinical trials to treat cancer. Studies have shown that HDACis have neuroprotective effects in nervous system damage. …”
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Antitumor Responses of Invariant Natural Killer T Cells by Jennie B. Altman, Adriana D. Benavides, Rupali Das, Hamid Bassiri

“…Finally, we review the successes and failures of clinical trials employing iNKT cell-based immunotherapies and explore the future prospects for the use of such strategies.…”
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Systematic Review of the Relationship between Acute and Late Gastrointestinal Toxicity after Radiotherapy for Prostate Cancer by Matthew Sean Peach, Timothy N. Showalter, Nitin Ohri

“…While numerous strategies to prevent gastrointestinal injury have been studied, clinical trials concentrating on late toxicity have been difficult to carry out. …”
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Metformin Ameliorates D-Galactose-Induced Senescent Human Bone Marrow-Derived Mesenchymal Stem Cells by Enhancing Autophagy by Pingting Ye, Lei Feng, Dan Zhang, Ruihao Li, Yixuan Wen, Xiaohan Tong, Shuo Shi, Chunyan Dong

“…Human bone marrow-derived mesenchymal stem cells (hBMSCs) are promising candidates for stem cell therapy in clinical trials. Applications of hBMSCs in clinical therapy are limited by cellular senescence due to long-term ex vivo expansion. …”
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Hypothermia improves neuronal network recovery in a human-derived in vitro model of oxygen-deprivation. by Eva J H F Voogd, Marloes Thijs, Marloes R Levers, Jeannette Hofmeijer, Monica Frega

“…Mild therapeutic hypothermia showed potential neuroprotective properties during and after cerebral hypoxia or ischemia in experimental animal studies. However, in clinical trials, where hypothermia is mainly applied after reperfusion, results were divergent and neurophysiological effects unclear. …”
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How close is autophagy-targeting therapy for Alzheimer's disease to clinical use? A summary of autophagy modulators in clinical studies by Sofia Miranda Fernandes, Johanna Mayer, Per Nilsson, Makoto Shimozawa

“…We accessed clinicaltrials.gov provided by the United States National Institutes of Health to identify completed and ongoing clinical trials. Additionally, we discuss the limitations and challenges of these therapies.…”
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Advanced In Vitro Models for Preclinical Drug Safety: Recent Progress and Prospects by Dileep G. Nair, Ralf Weiskirchen

“…Differences in physiology between humans and animals or cell lines contribute to the failure of many drug programs during clinical trials. The use of advanced in vitro systems that closely mimic human physiology, such as organ-on-a-chip models like gut–liver-on-a-chip, can be crucial in improving drug efficacy while minimizing toxicity. …”
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Relapsed childhood T-cell acute lymphoblastic leukemia and lymphoblastic lymphoma by Andrew D. Hughes, Petri Pölönen, David T. Teachey

“…Many immunotherapies are under investigation in clinical trials for patients with T-ALL/LBL and early results are very promising. …”
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The Role of Organelle Stresses in Diabetes Mellitus and Obesity: Implication for Treatment by Yi-Cheng Chang, Siow-Wey Hee, Meng-Lun Hsieh, Yung-Ming Jeng, Lee-Ming Chuang

“…Further results from clinical trials are eagerly awaited.…”
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Verteporfin Photodynamic Therapy Combined with Intravitreal Ranibizumab for Polypoidal Choroidal Vasculopathy Controversy Concerning Long-Term Followup by Maribel Fernández, María Gil, Francisco Gomez-Ulla, Pablo Charlón

“…These data need to be confirmed in large, prospective, and controlled clinical trials which are randomized and carried out over a long period.…”
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Submacular Injection of Ranibizumab as a New Surgical Treatment for Refractory Diabetic Macular Edema by Samir M. El-Baha, Ahmed M. Abdel Hadi, Mahmoud A. Abouhussein

“…The study has been registered in Contact ClinicalTrials.gov PRS Identifier: NCT03975088.…”
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The Effects of Uncomplicated Cataract Surgery on Retinal Layer Thickness by Ali Kurt, Raşit Kılıç

“…This study was registered with Australian New Zealand Clinical Trials Registry (ANZCTR): ACTRN12618000763246.…”
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A Comprehensive Review of the Development and Therapeutic Use of Antivirals in Flavivirus Infection by Aarti Tripathi, Shailendra Chauhan, Renu Khasa

“…Various approaches have been extensively utilized in clinical trials for antiviral development, targeting virus entry, replication, polyprotein synthesis and processing, and egress pathways exploiting virus as well as host proteins. …”
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Multimodal MRI Neuroimaging Biomarkers for Cognitive Normal Adults, Amnestic Mild Cognitive Impairment, and Alzheimer's Disease by Ai-Ling Lin, Angela R. Laird, Peter T. Fox, Jia-Hong Gao

“…Further developments of these techniques and the establishment of promising neuroimaging biomarkers will enhance our ability to diagnose aMCI and AD in their early stages and improve the assessment of therapeutic efficacy in these diseases in future clinical trials.…”
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Extended Peritoneal Dialysis and Renal Recovery in HIV-Infected Patients with Prolonged AKI: A Report of 2 Cases by Donlawat Saengpanit, Pongpratch Puapatanakul, Piyaporn Towannang, Talerngsak Kanjanabuch

“…Its efficacy in providing fluid and small solute removal has also been demonstrated in clinical trials and is equivalent to hemodialysis (HD). …”
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Brain-Derived Neurotrophic Factor and Nerve Growth Factor Therapeutics for Brain Injury: The Current Translational Challenges in Preclinical and Clinical Research by Serena-Kaye Sims, Brynna Wilken-Resman, Crystal J. Smith, Ashley Mitchell, Lilly McGonegal, Catrina Sims-Robinson

“…However, the translation of these studies into clinical trials has been limited. Preclinical experiments have largely failed to result in significant impacts in clinical research. …”
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Comparative Analysis of the Efficiency of Medicinal Plants for the Treatment and Prevention of COVID-19 by Viktor Kamkin, Aidana Kamarova, Baurzhan Shalabayev, Assyltas Kussainov, Marat Anuarbekov, Serik Abeuov

“…It is advisable to conduct further clinical trials for the treatment and rehabilitation of COVID-19 using preparations from this plant.…”
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Possible factors responsible for increased risk of tendon injuries during strength training in adult patients: systematic review by Zbigniew Wroński, Burim Gjinovci, Mario Klasic

“…Material and methods: A search was conducted in June and July 2023 in PubMed/Medline, EMBASE, Science Direct, PEDro, and Cochrane databases. Clinical trials, meta-analyses, randomized controlled trials, reviews, and systematic reviews published within the last ten years were included if they considered strength and resistance training as risk factors for tendon injuries. …”
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Update on Nonsurgical Lung Volume Reduction Procedures by J. Alberto Neder, Denis E. O’Donnell

“…ELVR procedures are currently available in selected Canadian research centers as part of ethically approved clinical trials. If a decision is made to offer an ELVR procedure, one-way valves are the first option in the presence of complete lobar exclusion and no significant collateral ventilation. …”
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Effects of using wearable devices to monitoring physical activity in pulmonary rehabilitation programs for chronic respiratory diseases: A systematic review protocol. by Thaianne Rangel Agra Oliveira, Ana Tereza do Nascimento Sales Figueiredo Fernandes, Thayla Amorim Santino, Fernanda Elizabeth Pereira da Silva Menescal, Patrícia Angélica de Miranda Silva Nogueira

“…We will include baseline data from randomized clinical trials reporting the use of wearable devices for monitoring physical activity in protocols for pulmonary rehabilitation programs for chronic respiratory diseases. …”
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