Autologous Stem Cell Therapy in Critical Limb Ischemia: A Meta-Analysis of Randomized Controlled Trials by Baocheng Xie, Houlong Luo, Yusheng Zhang, Qinghui Wang, Chenhui Zhou, Daohua Xu

“…A systematic literature search was performed in the SinoMed, PubMed, Embase, ClinicalTrials.gov, and Cochrane Controlled Trials Register databases from building database to January 2018. …”
Get full text

Unveiling the Emerging Role of Xanthine Oxidase in Acute Pancreatitis: Beyond Reactive Oxygen Species by Chenxia Han, Yaling Wu, Juan Rong, Qing Xia, Dan Du

“…This review summarized the benefits and contradictions of using XO inhibitors in animal models, offered mechanisms other than ROS, and discussed the difficulties faced in clinical trials. We hope to provide a perspective on the future worthwhile basic and clinical research on XO by analyzing its chemical and biological characteristics, as well as the progress of its regulatory mechanisms in AP.…”
Get full text

Diagnostic Model of In-Hospital Mortality in Patients with Acute ST-Segment Elevation Myocardial Infarction Used Artificial Intelligence Methods by Yong Li

“…We registered this study with the registration number ChiCTR1900027129 (the WHO International Clinical Trials Registry Platform (ICTRP) on 1 November 2019).…”
Get full text

Effect of acupuncture on patients with major psychiatric disorder and related symptoms caused by earthquake exposure: Protocol for a scoping review of clinical studies. by Hui-Ju Kwon, Jungtae Leem, Da-Woon Kim, Chan-Young Kwon, Sang-Ho Kim

“…These results will be helpful for developing disaster site-specific research protocols for future clinical trials on this topic.…”
Get full text

Adverse Effects of Carbetocin versus Oxytocin in the Prevention of Postpartum Haemorrhage after Caesarean Section: A Randomized Controlled Trial by D. Mannaerts, L. Van der Veeken, H. Coppejans, Y. Jacquemyn

“…The study was registered in the International Journal of Clinical Trials (ISRCTN 95504420, 2/2017).…”
Get full text

Relationship of Retinal Vessel Caliber with Age-Related Macular Degeneration by Sara Toulouie, Sean Chang, Julia Pan, Kiersten Snyder, Glenn Yiu

“…This trial is registered with ClinicalTrials.gov Identifier: NCT00000145.…”
Get full text

Risk Factors of Periprocedural Bradycardia during Primary Percutaneous Coronary Intervention in Patients with Acute ST-Elevation Myocardial Infarction by Yong Li, Shuzheng Lyu

“…We registered this study with WHO International Clinical Trials Registry Platform (ICTRP) (registration number: ChiCTR1900023214; registered date: 16 May 2019).…”
Get full text

Acute Putrescine Supplementation with Schwann Cell Implantation Improves Sensory and Serotonergic Axon Growth and Functional Recovery in Spinal Cord Injured Rats by J. Bryan Iorgulescu, Samik P. Patel, Jack Louro, Christian M. Andrade, Andre R. Sanchez, Damien D. Pearse

“…Schwann cell (SC) transplantation exhibits significant potential for spinal cord injury (SCI) repair and its use as a therapeutic modality has now progressed to clinical trials for subacute and chronic human SCI. Although SC implants provide a receptive environment for axonal regrowth and support functional recovery in a number of experimental SCI models, axonal regeneration is largely limited to local systems and the behavioral improvements are modest without additional combinatory approaches. …”
Get full text

Nanosuspension Innovations: Expanding Horizons in Drug Delivery Techniques by Shery Jacob, Fathima Sheik Kather, Sai H. S. Boddu, Mahesh Attimarad, Anroop B. Nair

“…This article summarizes key stabilizers, polymers, surfactants, and excipients used in NS formulations, along with ongoing clinical trials and recent patents. Furthermore, a comprehensive analysis of various methods for NS preparation is provided. …”
Get full text

The effect of azithromycin treatment on respiratory morbidity in children with down syndrome by Inbal Golan-Tripto, Omer Dor, Noga Arwas, Itai Hazan, Guy Hazan, Aviv Goldbart

“…Conclusion The significant reduction in respiratory LOS suggests the potential benefits of Azithromycin in children with DS, and emphasizes the need for larger clinical trials to determine optimal use and long-term effects in this vulnerable population.…”
Get full text

Results comparison of cervical cancer early detection using cerviray ® with VIA test by Ali Budi Harsono, Hadi Susiarno, Dodi Suardi, Kemala Isnainiasih Mantilidewi, Viko Duvadilan Wibowo, Yudi Mulyana Hidayat

“…Trial registration Clinical Trials.gov Identifier NCT06518070 Retrospectively registered.…”
Get full text

Icatibant for Angiotensin-Converting Enzyme Inhibitor-Induced Angioedema in Intubated Patients: Case Series and Literature Review by Erin K. Yeung, Haritha Saikumar, Jose Castaneda-Nerio, Sandra G. Adams, Mark Wong

“…The suggested benefit of icatibant in intubated ACEI-induced angioedema patients should be verified by randomized clinical trials and cost-benefit analyses should be performed at individual institutions.…”
Get full text

Effects of starter cultures on the metabolite profile, antioxidant activities, and anti-aging properties of tapuy lees by Edward Kevin B. Bragais, Paul Mark B. Medina

“…Future studies should focus on clinical trials in humans to validate these findings and further explore the potential of tapuy lees as a natural, sustainable source of bioactive compounds.…”
Get full text

Evaluation of Faecal Microbiota Following Probiotics in Infants of Mothers with Gestational Diabetes Mellitus Trial: Protocol for Double-Blind Placebo-Controlled Randomized Trial by Gayatri Athalye-Jape, Chandra Prakash Rath, Harshad Panchal, Archita Mishra, Dorothy Graham, Sanjay Patole

“…The secondary outcomes will include the quantification of faecal short-chain fatty acids at birth and at four months, as well as growth and developmental assessments at four, twelve, and twenty-four months. (3) Trial registration: This trial protocol is registered (ACTRN12624000930583p) in the Australian Clinical Trials registry (ANZCTR).…”
Get full text

Uninephrectomy and sodium‐glucose cotransporter 2 inhibitor administration delay the onset of hyperglycemia by Yuri Sakai Ishizaki, Masao Kikuchi, Koichi Kaikita, Shouichi Fujimoto

“…SGLT2 inhibitors have demonstrated efficacy in suppressing CKD progression in clinical trials, but their mechanisms are not fully understood. …”
Get full text

Mindfulness-based (non-contact) boxing therapy (MBBT) for depression and anxiety: A feasibility study. by Johny Bozdarov, Brett D M Jones, Madeha Umer, Daniel M Blumberger, Ishrat M Husain

“…Further well-designed randomized clinical trials are warranted to confirm the clinical benefits of MBBT.…”
Get full text

Antisecretory factor in severe traumatic brain injury (AFISTBI): protocol for an exploratory randomized placebo-controlled trial by Linus Réen, David Cederberg, Niklas Marklund, Edward Visse, Peter Siesjö

“…Trial registration ClinicalTrials.gov NCT04117672. Registered on September 17, 2017. …”
Get full text

Advances in synaptic PET imaging and intervention with synapse-targeted small-molecular drugs for dementia diagnosis and therapy by Xiuhong Lu, Bin Ji, Gang Huang, Hong Ding

“…Repeated failure of dementia clinical trials with therapeutic drugs targeting abnormal protein aggregates has caused researchers to shift their focus to synaptic functions and increased the importance of clinically available imaging for synaptic density and the development of synapse-targeted intervention. …”
Get full text

Life-Threatening Adenovirus Infections in the Setting of the Immunocompromised Allogeneic Stem Cell Transplant Patients by Cedar J. Fowler, Jennifer Dunlap, Darcy Troyer, Peter Stenzel, Elliot Epner, Richard T. Maziarz

“…Recent developments has yielded an assay that can be used in the early detection and for serial determinations of adenovirus in patients with advanced GVHD, as well as a new therapeutic agent currently undergoing clinical trials.…”
Get full text

Assessing chemical exposure risk in breastfeeding infants: An explainable machine learning model for human milk transfer prediction by Xiaojie Huang, Jiajia Chen, Peineng Liu

“…Ethical challenges in clinical trials necessitate the use of in vitro predictive models to assess chemical exposure risks in breastfeeding infants. …”
Get full text