A Bayesian tool for optimizing sample size in phase I dose-finding trials for head and neck cancer by Sivakamavalli Jeyachandran

“…The development of effective cancer treatments relies heavily on the successful execution of clinical trials, particularly Phase I trials, which are crucial for determining optimal drug dosages. …”
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Combination of Anti-VEGF and Laser Photocoagulation for Diabetic Macular Edema: A Review by Laura N. Distefano, Jose Garcia-Arumi, Vicente Martinez-Castillo, Anna Boixadera

“…Here, we review some of the clinical trials that have assessed the efficacy of macular laser treatment, either as part of the treatment protocol or as rescue therapy.…”
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Phages as potential life-saving therapeutic option in the treatment of multidrug-resistant urinary tract infections by Beata Zalewska-Piątek, Michalina Nagórka

“…PT demonstrates significant potential in treating chronic and recurrent UTIs, also including catheter-associated infection by reducing bacterial biofilms, delaying catheter blockage, and enhancing antibiotic efficacy when used in combination. Clinical trials and case studies have reported high rates of bacterial eradication and symptom improvement with minimal side effects. …”
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Opioid Therapy for Chronic Nonmalignant Pain by Russell K Portenoy

“…The few controlled clinical trials that have been performed support the safety and efficacy of opioid therapy, but have been too limited to ensure generalization to the clinical setting. …”
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Synergistic Effects of SDS and H2O2 Combinations on Tracheal Scaffold Development: An In Vitro Study Using Goat Trachea by Dhihintia Jiwangga, Ferdiansyah Mahyudin, Gondo Mastutik, Estya Nadya Meitavany, null Juliana, Priangga Adi Wiratama

“…In the development of tissue-engineered tracheal scaffolds, in vitro studies play a crucial role in allowing researchers to evaluate the efficacy and safety of scaffold designs and fabrication techniques before progressing to in vivo or clinical trials. This research involved the decellularization of goat trachea using SDS, H2O2, and their combinations. …”
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Harnessing the AI/ML in Drug and Biological Products Discovery and Development: The Regulatory Perspective by Fahimeh Mirakhori, Sarfaraz K. Niazi

“…Artificial Intelligence (AI) has the disruptive potential to transform patients’ lives via innovations in pharmaceutical sciences, drug development, clinical trials, and manufacturing. However, it presents significant challenges, ethical concerns, and risks across sectors and societies. …”
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New Test for the Comparison of Survival Curves to Detect Late Differences by Ildephonse Nizeyimana, Samuel Mwalili, George Orwa

“…It has been widely exploited in clinical trials when comparing different treatments looking at their survival probabilities. …”
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Nanomédicaments pour le traitement de maladies graves et recherches duales by Couvreur, Patrick

“…Depending on the country and therapeutic indications, between 40 to 60 nanomedicines are currently on the market, with over a hundred in clinical trials. This review aims to describe and discuss the characteristics and functionalities of the different generations of nanocarriers, from their inception to the present day, discussing the prospects they offer for the production of therapeutic proteins, for facilitating gene editing (CRISPR/Cas9), and for enabling immune checkpoint blockade in oncology. …”
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Humour Runs through the Multicoloured Mosaic of Neuropsychotherapy: Scoping Review by M. Šeduikienė, V. Matonis

“…The results of the investigations are divided into five sections: the use of humour in the context of different coping strategies (5 investigations); the use of only humour in the treatment (6 investigations); the use of the styles of humour in the treatment (5 investigations); comprehension of humour by patients (6 investigations), and clinical trials which revealed the sense of humour in the brain of patients (4 investigations). …”
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Opportunities for implementing digital applications to monitor the impact of risk-minimization measures within the pharmacovigilance process: Scoping review of published literature by Ilko Getov, Denitsa Panayotova, Stanimir Dobrev, Maria Dimitrova, Valentina Petkova

“…This is crucial for identifying risks not observed during clinical trials. Digital tools offer potential benefits by providing real-time reporting, comprehensive safety data, and increased patient engagement, thus addressing the challenges of underreporting and incomplete data in pharmacovigilance. …”
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Targeting the Heart of Mycobacterium: Advances in Anti-Tubercular Agents Disrupting Cell Wall Biosynthesis by Ahmad Diab, Henry Dickerson, Othman Al Musaimi

“…Beyond these, six promising molecules currently in Phase II clinical trials are designed to target arabinan synthesis pathways, sutezolid, TBA 7371, OPC-167832, SQ109, and both benzothiazinone derivatives BTZ043 and PBTZ169, highlighting advancements in the development of cell wall-targeting therapies.…”
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Targeting heparan sulfate proteoglycans as an effective strategy for inhibiting cancer cell migration and invasiveness compared to heparin by Lorenzo Depau, Jlenia Brunetti, Chiara Falciani, Elisabetta Mandarini, Marta Zanchi, Maria Francesca Paolocci, Marta Garfì, Alessandro Pini, Luisa Bracci

“…Despite a strong conceptual basis and promising preclinical results, clinical trials have failed to demonstrate any significant advantage of administering heparin to oncology patients. …”
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Do Nonsteroidal Anti-Inflammatory Drugs Affect Bone Healing? A Critical Analysis by Ippokratis Pountos, Theodora Georgouli, Giorgio M. Calori, Peter V. Giannoudis

“…Basic science research defining the exact mechanism with which NSAIDs could interfere with bone cells and also the conduction of well-randomized prospective clinical trials are warranted. In the absence of robust clinical or scientific evidence, clinicians should treat NSAIDs as a risk factor for bone healing impairment, and their administration should be avoided in high-risk patients.…”
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Proteolysis targeting chimera (PROTAC)-driven antibody internalization of oncogenic cell surface receptors by Ezequiel J. Tolosa, Lin Yang, Jennifer Ayers-Ringler, Shinichiro Suzuki, Jayapal Reddy Mallareddy, Janet Schaefer-Klein, Mitesh Borad, Farhad Kosari, Amarnath Natarajan, Aaron S. Mansfield

“…This application of PROTACs may impact the use of ADCs and provides a rationale to combine these agents in clinical trials.…”
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A Review of Herbal Treatment for Functional Gastrointestinal Disorders and Infection by Krupavaram B, A Kishore Babu, Santhiya Manickam Pillay, Tan Ching Siang, Bama V. V. Menon, Ganesh Sritheran Paneerselvam, Long Chiau Ming, Yaser Mohammed Al-Worafi, Wen Han Chooi

“…In this article, we conducted PubMed searches using specific keywords to review clinical trials focusing on conventional and herbal treatments for dyspepsia as well as the adverse effects of non-herbal treatments. …”
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A Revision on the Effectiveness of Omega-3 Polyunsaturated Fatty Acids as Monotherapy in the Treatment of Major Depressive Disorder by Tommaso Accinni, Matteo Panfili, Lorenzo Tarsitani, Massimo Biondi, Massimo Pasquini, Annalisa Maraone

“…Two well-trained reviewers independently looked at the most significant randomized clinical trials (RCTs) from the PubMed database regarding PUFAs’ employment in MDD compared to placebo; “major depressive disorder” and “omega-3 fatty acids,” or “omega-6 fatty acids,” or “polyunsaturated fatty acids (PUFA),” or “n − 3 polyunsaturated fatty acids,” or “eicosapentaenoic acid (EPA),” or “docosahexaenoic acid (DHA)” were used as the medical subject keywords. …”
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Anticonvulsant valproic acid and other short-chain fatty acids as novel anticancer therapeutics: Possibilities and challenges by Lipska Katarzyna, Gumieniczek Anna, Filip Agata A.

“…As a consequence, some pre-clinical and clinical trials were carried out to estimate anticancer effectiveness of VPA, in monotherapy and in new drug combinations, while other SCFAs were tested in pre-clinical studies. …”
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Current Trends in Targeted Therapies for Glioblastoma Multiforme by Fumiharu Ohka, Atsushi Natsume, Toshihiko Wakabayashi

“…In this paper, we review up-to-date clinical trials of GBM treatments in order to overcome these 4 hurdles and to aim at more therapeutical effect than conventional therapies that are ongoing or are about to launch in clinical settings and discuss future perspectives.…”
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HIV-Related Immune Activation and Inflammation: Current Understanding and Strategies by Tingxia Lv, Wei Cao, Taisheng Li

“…To date, several clinical interventions or treatment candidates undergoing clinical trials have been proposed to combat this systemic immune activation/inflammation. …”
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Assessment of safety and patency of 7-mm covered metal stents for preoperative biliary drainage in pancreatic cancer: Prospective multicenter study by Hirotoshi Ishiwatari, Yousuke Kobayashi, Shinya Kawaguchi, Takuji Iwashita, Junichi Kaneko, Jun Ito, Kazuma Ishikawa, Junya Sato, Fumitaka Niiya, Shinya Endo, Tatsunori Satoh, Shinya Uemura, Keita Mori

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