Tumor metabolic regulators: key drivers of metabolic reprogramming and the promising targets in cancer therapy by Kun Huang, Ying Han, Yihong Chen, Hong Shen, Shan Zeng, Changjing Cai

“…We also summarize recent clinical trials involving metabolic regulators and the challenges of metabolism-based tumor therapies in clinical translation. …”
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Assessing Health-Related Quality of Life in Asthma by Elizabeth F Juniper

“…The questionnaires chosen for review have good measurement properties and validity and can be used in both clinical trials and clinical practice to assess the impact of asthma on a patient’s life. …”
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Role of Interleukin- (IL-) 17 in the Pathogenesis and Targeted Therapies in Spondyloarthropathies by I-Tsu Chyuan, Ji-Yih Chen

“…Recently, several clinical trials targeting IL-17 pathways demonstrated the positive response of IL-17 blockade in treating AS, indicating a great potential of IL-17-targeting therapy in SpA. …”
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Analysis of the Modified Rankin Scale in Randomised Controlled Trials of Acute Ischaemic Stroke: A Systematic Review by Aimie Nunn, Philip M. Bath, Laura J. Gray

“…Historically, most acute stroke clinical trials were neutral statistically, with trials typically dichotomising ordinal scales, such as the modified Rankin Scale. …”
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Multilevel Constrained Bandits: A Hierarchical Upper Confidence Bound Approach with Safety Guarantees by Ali Baheri

“…While MAB has proven valuable in applications such as clinical trials and online advertising, traditional formulations have limitations; specifically, they struggle to handle three key real-world scenarios: (1) when decisions must follow a hierarchical structure (as in autonomous systems where high-level strategy guides low-level actions); (2) when there are constraints at multiple levels of decision-making (such as both system-wide and component-level resource limits); and (3) when available actions depend on previous choices or context. …”
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Minimising harms of tight glycaemic control in older patients with type 2 diabetes by Wade Thompson

“…It assesses the evidence from clinical trials and guidelines, with a focus on preventing hypoglycaemia and improving patient-centred care through relaxed HbA1c targets. …”
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Phosphate Frustration: Treatment Options to Complement Current Therapies by Pablo E. Pergola

“…We present treatment options to complement current therapies including tenapanor, a novel sodium/hydrogen exchanger isoform 3 inhibitor that blocks the dominant paracellular phosphate absorption pathway and has been shown to reduce phosphate levels in several clinical trials.…”
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Interdental papilla recession and reconstruction of the lost triangle: a review of the current literature by Sanabel O. Barakat

“…Further, systematic reviews evaluating the efficacy of surgical reconstruction of deficient IDP are still lacking due to the scarcity of large-scale clinical trials and the absence of long-term clinical outcomes. …”
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Outcome differences in acute vs. acute on chronic heart failure and cardiogenic shock by Tara L. Jones, Michael C. Tan, Vidang Nguyen, Kathleen E. Kearney, Charles C. Maynard, Emily Anderson, Claudius Mahr, James M. McCabe

“…Abstract Aims Despite advances in coronary reperfusion and percutaneous mechanical circulatory support, mortality among patients presenting with cardiogenic shock (CS) remains unacceptably high. Clinical trials and risk stratification tools have largely focused on acute CS, particularly secondary to acute coronary syndrome. …”
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Efficacy of tranilast in preventing exacerbating cardiac function and death from heart failure in muscular dystrophy patients with advanced-stage heart failure: a single-arm, open-... by Tsuyoshi Matsumura, Takayasu Fukudome, Yasufumi Motoyoshi, Akinori Nakamura, Satoshi Kuru, Kazuhiko Segawa, Ruriko Kitao, Chigusa Watanabe, Takuhisa Tamura, Toshiaki Takahashi, Hiroya Hashimoto, Masahiro Sekimizu, Akiko M. Saito, Masanori Asakura, Koichi Kimura, Yuko Iwata

“…Conclusions The findings suggest that tranilast can inhibit TRPV2 expression for an extended period and is effective in preventing the worsening of cardiac function and subsequent death from heart failure. Clinical trial registration details The study was registered in the UMIN Clinical Trials Registry (UMIN-CTR: UMIN000031965, URL: http://www.umin.ac.jp/ctr/ ) [March 30, 2018] and the Japan Registry of Clinical Trials (jRCT, registration number: jRCTs031180038, URL: https://jrct.niph.go.jp/ ) [November 12, 2021]. …”
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The AEDUCATE Collaboration. Comprehensive antenatal education birth preparation programmes to reduce the rates of caesarean section in nulliparous women. Protocol for an individual... by Soo Downe, Lisa Askie, Sarah J Lord, Hannah G Dahlen, Kenneth William Finlayson, Anna Lene Seidler, Federico Girosi, Kylie Elizabeth Hunter, Kate M Levett, Mary-Ann Davey, Caroline A Smith, Julie Fleet, Mary Steen, Elizabeth Newnham, Anette Werner, Leslie Arnott, Kerry Sutcliffe

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Impact of alternative diagnostic labels for melanoma in situ on management choices and psychological outcomes: protocol for an online randomised study by Brooke Nickel, Lisa Parker, Jon Emery, Richard A Scolyer, Raymond Barnhill, David Elder, Katy JL Bell, Elspeth Davies, Blake O'Brien, Adewole S Adamson, Alexander C J van Akkooi, Farzaneh Boroumand, Zhuohan Wu, Peter M Ferguson, Donald Low, Cynthia Low, Sherrie Liu, Stacey Lewis, Bella Spongberg-Ross

“…The results of the study will be published in a peer-reviewed medical journal, and a plain language summary of the findings will be shared on the Wiser Healthcare publication page (https://www.wiserhealthcare.org.au/category/publications/).Trial registration number Australian New Zealand Clinical Trials Registry (ID 386943).…”
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Hormonal Contraception and Bone Metabolism: Emerging Evidence from a Systematic Review and Meta-Analysis of Studies on Post-Pubertal and Reproductive-Age Women by Alice Tassi, Ambrogio P Londero, Anjeza Xholli, Giulia Lanzolla, Serena Bertozzi, Luca Savelli, Federico Prefumo, Angelo Cagnacci

“…., those listed in PubMed/Medline, Embase, Scopus, the Cochrane Database, International Clinical Trials Registry, and ClinicalTrials.gov). We examined published randomized controlled trials (RCTs) and prospective studies. …”
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Pembrolizumab and Pemetrexed for Older Patients With Nonsquamous NSCLC and Programmed Cell Death-Ligand 1 Tumor Proportion Scores of Less Than 50% by Yoshihito Kogure, MD, PhD, Hiroya Hashimoto, PhD, Haruko Daga, MD, PhD, Yasushi Fukuda, MD, Akihiro Bessho, MD, PhD, Tadaaki Yamada, MD, PhD, Yukihiro Toi, MD, Tomoki Kimura, MD, PhD, Hiroshige Yoshioka, MD, PhD, Koichi Azuma, MD, PhD, Naoki Furuya, MD, PhD, Yasutaka Fukui, MD, PhD, Akiko M. Saito, MD, PhD, Nobuyuki Yamamoto, MD, PhD, Hideo Saka, MD, Masashi Kondo, MD, PhD

“…This trial was registered at ClinicalTrials.gov (NCT04396457) and the Japan Registry of Clinical Trials (jRCTs041200012).…”
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Preimplantation genetic testing for aneuploidy in severe male factor infertility: protocol for a multicenter randomised controlled trial by Li Wang, Li Jin, Yao Lu, Chen Zhang, He-Feng Huang, Yun Sun, Xian-hua Lin, Meng-xi Guo, Dan-dan Wu, Jian-lin Zhang, Cheng-liang Zhou, Chen-ming Xu, Song-chang Chen, Song-ying Zhang, Xiao-xi Sun, Yan-ting Wu

“…The findings will be disseminated to the public through conference presentations and publication in peer-reviewed scientific journals.Trial registration number ClinicalTrials.gov, NCT02941965.…”
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Assessment of Bowel Preparation Using Low-Volume Sulphate-Based Preparations in Comparison with Macrogols: A Multicenter, Randomized, Comparative Clinical Study of the 3rd Phase by Evgeny D. Fedorov, Viktor V. Veselov, Sergey V. Kashin, Ekaterina V. Tikhomirova, Alexey V. Veselov, Dmitry V. Zavyalov, Anne Kornowski, Tatyana Gorskaya, Magali Volteau, Thierry Ponchon

“…Despite the higher incidence of nausea in the OSS group, the patients showed significantly higher compliance with the OSS mode as compared to that of Macrogol.This study is registered with the ClinicalTrials.gov Registry of Clinical Trials, No. NCT02321462.…”
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Initial treatment of steroid-sensitive idiopathic nephrotic syndrome in children with mycophenolate mofetil versus prednisone: protocol for a randomised, controlled, multicentre tr... by Burkhard Toenshoff, Martin Konrad, Steffen Luntz, Anja Sander, Peter F Hoyer, Rasmus Ehren, Marcus R Benz, Jorg Doetsch, Alexander Fichtner, Jutta Gellermann, Dieter Haffner, Britta Höcker, Bärbel Kästner, Markus J Kemper, Uwe Querfeld, Lutz T Weber

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Unraveling the protein kinase C/NDRG1 signaling network in breast cancer by C. Saponaro, M. Damato, E. Stanca, S. Aboulouard, F. A. Zito, S. De Summa, D. Traversa, L. Schirosi, S. Bravaccini, F. Pirini, E. Fonzi, M. Tebaldi, M. Puccetti, A. Gaballo, L. Pantalone, M. Ronci, L. Magnani, D. Sergi, A. Tinelli, S. Tacconi, L. Siculella, A. M. Giudetti, I. Fournier, M. Salzet, M. Trerotola, D. Vergara

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Effectiveness of the Modified WHO Labour Care Guide to Detect Prolonged and Obstructed Labour Among Women Admitted at Eight Publicly Funded, Midwife-Led Community Health Facilities... by Mugyenyi GR, Tumuhimbise W, Atukunda EC, Tibaijuka L, Ngonzi J, Kayondo M, Kanyesigye M, Musimenta A, Yarine FT, Byamugisha JK

“…More controlled and powered studies should evaluate the two tools in different facilities and sub-populations.Trial Registration: This trial registration was registered with clinical trials.gov number NCT05979194 on 2023-08-07, and the protocol was published by BMJ open, as 10.1136/bmjopen-2023-079216 on 15 April 2024.21 Trial registration number NCT05979194 clinical trials.gov.Keywords: modified WHO LCG, partograph, effectiveness, labour monitoring, ambispective cohort study, Uganda…”
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Study protocol for a pragmatic randomised controlled trial of comparing enhanced acceptance and commitment therapy plus (+) added to usual aftercare versus usual aftercare only, in... by Imran Khan, Stephanie J. C. Taylor, Clare Robinson, Elisavet Moschopoulou, Paul McCrone, Liam Bourke, Mohamed Thaha, Kamaldeep Bhui, Derek Rosario, Damien Ridge, Sheila Donovan, Ania Korszun, Paul Little, Adrienne Morgan, Olivier Quentin, Rebecca Roylance, Peter White, Trudie Chalder

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