Crosstalk between Gut Microbiota and Cancer Immunotherapy: Present Investigations and Future Perspective by Yuhui Tang, Qiaoting Cai, Zhi Tian, Wenkuan Chen, Hailin Tang

“…To better grasp the underlying crosstalk between gut microbiota and immunotherapy, more experimental and clinical trials are indispensable for the customized gut microbiota-based treatments in cancer patients undergoing immunotherapy.…”
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Active Surveillance for Localized Prostate Cancer – Current Practices and Recommendations by Jennifer N. Wu, Marc A. Dall'Era

“…Data from these reports provide information for selecting men for this approach, as well as for following them over time and determining triggers for further intervention. Ongoing clinical trials with watchful waiting and active surveillance for prostate cancer will ultimately provide improved evidence for managing early, localized disease.…”
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Myelodysplastic Syndrome with Transfusion Dependence Treated with Venetoclax by Waqas Jehangir, Alexander Karabachev, Taimoor Jahangir, Elvira Umyarova

“…Venetoclax, an inhibitor of the antiapoptotic protein BCL-2 used to treat chronic lymphocytic leukemia, is currently being evaluated in clinical trials as a monotherapy in high-risk myelodysplastic syndromes/acute myeloid leukemia. …”
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Repository Corticotropin Injection for Treatment of Idiopathic Inflammatory Myopathies by Aarat Patel, Georgia Seely, Rohit Aggarwal

“…Overall, these results are encouraging and suggest that randomized, controlled clinical trials applying RCI to dermatomyositis and polymyositis are warranted.…”
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Hypoxia-inducible factor in cancer: from pathway regulation to therapeutic opportunity by Brian M Ortmann

“…This review will discuss the challenges and opportunities associated with translating HIF inhibition into clinical practice, including ongoing clinical trials and future directions in the development of HIF-based cancer treatments.…”
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Association of age, race, and ethnicity with access, response, and toxicities from CAR-T therapy in children and adults with B-cell malignancies: a review by Marco Ruella, Guido Ghilardi, Zainul S. Hasanali, Sandra P. Susanibar-Adaniya, Lena E. Winestone, Alfred L. Garfall

“…We also review the representation of age, racial, and ethnic groups in key CAR-T clinical trials. We focus on B-cell acute lymphoblastic leukemia, B-cell non-Hodgkin’s lymphoma, and multiple myeloma.…”
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A review on the potential of Bruton’s tyrosine kinase (Btk) inhibitor – Ibrutinib for treatment of Multiple Myeloma (MM) by Sze-Ting Bong, Lydia Ngiik-Shiew Law, Jodi Woan-Fei Law

“…This review provides information on the association of MM and Btk in conjunction with the treatment using ibrutinib. To date, clinical trials of ibrutinib as therapeutic alternative for MM have produced promising results, particularly as combination therapy with other agents such as dexamethasone and carfilzomib. …”
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Repurposing radiosensitising medicines for radiotherapy: an overview by Geoff S Higgins, Jie Man Low, Gonzalo Rodriguez-Berriguete

“…Using a literature-based approach, we identified 42 radiosensitising drugs with varied non-cancer indications and mechanisms of action, that have entered or completed clinical trials in combination with RT or with chemoradiotherapy. …”
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TNF-α as a Therapeutic Target in Acute Pancreatitis — Lessons from Experimental Models by Giuseppe Malleo, Emanuela Mazzon, Ajith K. Siriwardena, Salvatore Cuzzocrea

“…Different specific and nonspecific inhibitors have been developed with promising results in animal models, but, on the other hand, no clinical trials have been designed so far. Difficulties in clinical applications may be multifactorial; experimental models are not fully reliable and reproduce at least some aspects of human disease, timing of intervention should be related to changes in TNF-α serum levels, and inclusion criteria should be accurately selected to better define the population most likely to benefit.…”
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Uncommon BRAF Mutations Associated with Durable Response to Immunotherapy in Patients with Metastatic Melanoma by Brenen P. Swofford, Jade Homsi

“…Further research and clinical trials are needed to study patients with uncommon BRAF mutations and the potential therapeutic benefit of immunotherapy.…”
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Cellular therapy for the peripheral arterial disease treatment: Protocol for a systematic review and meta-analysis. by Mónica Rodríguez-Valiente, Cristina Fuente-Mora, Javier Sánchez-Gálvez, Micaela Ortín-Pérez, Manuel Pardo-Ríos, José Manuel Sánchez-Sáez, Isac Davidson Santiago Fernandes Pimenta, Grasiela Piuvezam, Laura Ramos-Petersen

“…Studies will be selected independently by two reviewers and will include all published randomized and non-randomized clinical trials. The data extraction will include studies population characteristics, type of treatment and main outcomes. …”
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Onychomycosis: Potential of Nail Lacquers in Transungual Delivery of Antifungals by Nida Akhtar, Hemlata Sharma, Kamla Pathak

“…Penetration efficiency was assessed by several researchers across the human nail plate to investigate the potentiality of nail lacquer based formulations. Various clinical trials have also been conducted in order to evaluate the safety and efficacy of nail lacquers in delivering antifungal agents. …”
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Leadless Pacing: Current Status and Ongoing Developments by Richard G. Trohman

“…In order to clarify the role(s) of leadless pacing, this narrative review was undertaken by searching MEDLINE to identify peer-reviewed clinical trials, randomized controlled trials, meta-analyses, and review articles, as well as other clinically relevant reports and studies. …”
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The Physiology, Pharmacology and Therapeutic Manipulation of the Internal Anal Sphincter by Oliver M Jones, Alison F Brading, Neil J McC Mortensen

“…The initial results with this medical approach to anorectal disease have often been disappointing, failing to match the results achievable with surgery, and many of these drugs have a high rate of side effects in the short term. However, clinical trials have yet to establish the optimum doses, dose intervals and routes of administration for many of these therapies. …”
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Structural insights into antibody-based immunotherapy for hepatocellular carcinoma by Masaud Shah, Muhammad Hussain, Hyun Goo Woo

“…Several therapeutic antibodies that counter the immunosuppressive tumor microenvironment have demonstrated efficacy in clinical trials, leading to FDA approvals for advanced HCC treatment. …”
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Cardiovascular Screening for the Asymptomatic Patient with Diabetes: More Cons Than Pros by Konstantinos Makrilakis, Stavros Liatis

“…In nearly all asymptomatic PWD, however, the results of screening will generally not change medical therapy, since aggressive preventive measures, such as control of blood pressure and lipids, would have been already indicated, and above all, invasive revascularization procedures (either with percutaneous coronary intervention or coronary artery bypass grafting) have not been shown in randomized clinical trials to confer any benefit on morbidity and mortality. …”
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In Vitro Activity of Geldanamycin Derivatives against Schistosoma japonicum and Brugia malayi by David Wenkert, Bernadette Ramirez, Yuehai Shen, Michael A. Kron

“…Two of the derivatives, 17-N-allyl-17-demethoxygeldanamycin (17-AAG) and 17-N-(2-dimethylaminoethylamino)-17-demethoxygeldanamycin (DMAG), are currently in human clinical trials as anticancer drugs. Using concentrations considered safe peak plasma concentrations for these two derivatives, all four derivatives were active against both parasites. …”
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Multiple Culprit Coronary Artery Thrombosis in a Patient with Coronary Ectasia by Bruno da Silva Matte, Gustavo Neves de Araujo, Felipe Homem Valle, Ana Maria Rocha Krepsky

“…Although routine aspiration thrombectomy in STEMI was not proven to be beneficial in randomized clinical trials, it was of great value in this case. We also discuss the relation between coronary ectasia, chronic inflammatory status, and increased platelet activity which may have caused plaque disruption in another already vulnerable vessel.…”
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The role and therapeutic effectiveness of Plantago ovata seed husk (psyllium husk) in the prevention and non-pharmacological treatment of gastrointestinal diseases. Part 1. Clinica... by Justyna Przybyszewska, Andrzej Kuźmiński, Michał Przybyszewski, Cezary Popławski

“…The outer seed coat of P. ovata, obtained by cleaning the seeds, contains soluble and insoluble fibre in a ratio of 7:3, making products containing P. ovata husk an ideal source of health-beneficial fibre. The results of clinical trials demonstrate the therapeutic efficacy of psyllium husk for various gastrointestinal disorders. …”
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Targeting capabilities of engineered extracellular vesicles for the treatment of neurological diseases by Xinyu Yang, Xiangyu Gao, Xiaofan Jiang, Kangyi Yue, Peng Luo

“…Additionally, we summarized recent clinical trials involving extracellular vesicles and discussed the challenges and future prospects of using targeting-engineered extracellular vesicles for drug delivery in treating neurological diseases. …”
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