Promising role of voxelotor in managing sickle cell disease in children: a narrative review by Amit Agrawal, Gaurav Jadon, Japna Singh, Dalwinder Janjua

“…The group that received voxelotor also showed a greater decrease in hemolytic markers but a comparable incidence of side effects. Six ongoing clinical trials also sought to ascertain the effectiveness and safety of high-dose voxelotor when administered to children younger than 12 years. …”
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Angiotensin-Converting Enzyme 2: The First Decade by Nicola E. Clarke, Anthony J. Turner

“…In light of the entrance of human recombinant ACE2 into clinical trials, we discuss the potential use of ACE2 as a therapeutic and highlight some pertinent questions that still remain unanswered about ACE2.…”
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Biologics and Small Molecules for Inflammatory Nail Disorders: A Narrative Review by Carrie A. Forman, Shari R. Lipner

“…Conclusion: Many biologics and small molecules are effective in treating nail psoriasis and alopecia areata, with each requiring precautions for adverse events. Clinical trials for use of biologics and small molecules for nail lichen planus and atopic dermatitis have not been published to date.…”
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Sulforaphane as a preventive agent in Oral Cancer- A Systematic Review by M. Parasakthi, Kavitha Sanjeev

“…Conclusion: Based on the analysis of studies included in this systematic review, sulforaphane is found to be effective in prevention of oral cancer. But further clinical trials are necessary to assess the effects of sulforaphane on oral cancer patients.…”
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Behavioral Intervention versus Pharmacotherapy or Their Combinations in the Management of Overactive Bladder Dysfunction by Khanh Tran, Robert M. Levin, Shaker A. Mousa

“…We carried out a comprehensive systematic review of the available literature on the effectiveness of behavioral intervention, anticholinergic drugs, and their combination in the management of adults with overactive bladder, with emphasis on results from clinical trials and primary literature. Each treatment intervention is efficacious, and the choice should be based on the patient's severity of symptoms, tolerability, compliance and satisfaction with the treatment. …”
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Novel Immunotherapeutic Approaches for Neuroblastoma and Malignant Melanoma by Fabio Morandi, Francesco Frassoni, Mirco Ponzoni, Chiara Brignole

“…Indeed, several immunotherapeutic clinical trials have been performed and some of them also resulted beneficial. …”
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EGFR inhibitors in the treatment of colorectal cancer by M. В. Zabelin, A. D. Kaprin, A. A. Kostin, E. V. Gameeva, S. E. Varlamova

“…A review of current literature data on the use of both approved for clinical use (cetuximab, panitumumab) and an -EGFR an bodies at the stage of clinical trials is presented. EGFR inhibitors are one of the main groups of targeted drugs used to treat pa ents with colorectal cancer. …”
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THE ROLE OF ANTIBIOTICS IN TREATING SALIVARY GLAND INFECTIONS by Irina Adriana Beuran, Simona Claudia Stefan, Elisabeta Maria Vasca, Robert Marius Grosu, Marius Petrea, Gabriel-Valeriu Popa, Bogdan Oprisan

“…The effectiveness of antibiotic treatment is well documented in the medical literature, with clinical trials indicating a significant reduction in symptoms and prevention of severe complications when treatment is administered correctly. …”
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Probiotics for Alleviating Alcoholic Liver Injury by Zelin Gu, Yanlong Liu, Shumeng Hu, Ying You, Jiaqi Wen, Wancong Li, Yuhua Wang

“…Many animal experiments and clinical trials showed that probiotics are effective for the treatment of alcoholic liver disease. …”
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Lipopeptide adjuvants for antibiotics and vaccines: the future step in the fight against multidrug-resistant and extensively drug-resistant pathogens by Chloé O. Sebilleau, Steven J. Sucheck

“…Findings discussed in this review could be applied to the development of safer, more effective adjuvants, that could expand the use or repurpose current antibiotics or improve vaccination results in future clinical trials.…”
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The Key to Unlocking the Chemotherapeutic Potential of PPARγ Ligands: Having the Right Combination by Graham Skelhorne-Gross, Christopher J. B. Nicol

“…Despite extensive preclinical evidence that peroxisome proliferator-activated receptor (PPAR)γ activation protects against tumourigenesis, results from a few clinical trials using PPARγ ligands as monotherapy show modest success. …”
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Nanocurcumin in myocardial infarction therapy: emerging trends and future directions by Mei Lv, Qing Sun, Yilin Yu, Jinwei Bao

“…Micelles composed of polymers have demonstrated high biocompatibility and targeting capabilities with increased cardio-protective effects. Research and clinical trials are essential for comprehensive analysis and efficacy of curcumin-based nano-therapeutics in cardiovascular condition and lowering risk of MI.…”
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A Case of Rituximab Use as an Induction and Maintenance of Remission in ANCA-Associated Vasculitis by Neveen Awad, Shahd Hafiz, Abdurahman Albeity, Hani Almoallim

“…There are no randomized clinical trials addressing rituximab effect in induction and remission at the same time. …”
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Advances in Selenium and Related Compounds Inhibiting Multi-Organ Fibrosis by Xiao X, Huang G, Yu X, Tan Y

“…Additionally, the article summa-rizes some of the anti-fibrotic drugs currently in clinical trials for the aforementioned organ fibroses.Keywords: selenium, fibrosis, organ, clinical…”
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Advances in sodium-glucose transporter protein 2 inhibitors and tumors by Jiaqi Wang, Wenyong Yang

“…The aim of this article is to provide a comprehensive understanding of the research progress of SGLT2i in different tumors by integrating the latest studies and to encourage further exploration of SGLT2i therapies in clinical trials. This could pave the way for more effective management strategies and improved outcomes for tumor patients.…”
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Meditation as an Adjunct to the Management of Multiple Sclerosis by Adam B. Levin, Emily J. Hadgkiss, Tracey J. Weiland, George A. Jelinek

“…Additional rigorous clinical trials are required to validate the existing findings and determine if meditation has an impact on disease course over time.…”
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The Potential Role of Liver Transplantation as a Treatment Option in Colorectal Liver Metastases by Pål-Dag Line, Morten Hagness, Svein Dueland

“…There is an increasing interest in liver transplantation in these patients in the transplant community, and currently 4 clinical trials are active and are recruiting.…”
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Recent advances of antibody-drug conjugates in treating breast cancer with different HER2 status by Yue Qiu, Yaqin Shi, Zhujun Chao, Xinyu Zhu, Yan Chen, Linlin Lu

“…Numerous ongoing clinical trials seek to optimize dosing strategies and identify patient populations that would benefit most from ADCs. …”
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Choosing the Right Angiotensin Converting Enzyme Inhibitors; Gender –Specific Approach by Neena Elsa Varghese, K. Jegaveerapandi, Goutham Yerrakula

“…This review highlights the historical underrepresentation of women in clinical trials for cardiovascular medications, leading to a knowledge gap regarding the effectiveness and safety of these drugs in female patients. …”
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Effect of Cordyceps militaris extract containing cordycepin on the adipogenesis and lipolysis of adipocytes by Kazuya Kusama, Kodai Oka, Yumi Yashiro, Kanoko Yoshida, Hiroaki Miyaoka, Kazuhiro Tamura

“…Further studies, including clinical trials, are required to validate the clinical potential of cordycepin.…”
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