Adjuvants for peptide-based cancer vaccines by Willem W Overwijk, Hiep Khong

“…One reason for this difference may be the use of potent, effective vaccine adjuvants in animal models, vs. the use of safe, but very weak, vaccine adjuvants in clinical trials. As vaccine adjuvants dictate the type and magnitude of the T cell response after vaccination, it is critical to understand how they work to design safe, but also effective, cancer vaccines for clinical use. …”
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A Brief Review on Medicinal Plants-At-Arms against COVID-19 by Shivani Srivastava, Fangzhou He, Yuanding Huang, Meng Niu, Alok Adholeya, Weng Kung Peng

“…Accordingly, this review highlights the unprecedented opportunities offered by medicinal plants and their compounds, candidates as the therapeutic agent, against COVID-19 by acting as viral protein inhibitors and immunomodulator in (32 clinical trials and hundreds of in silico experiments) conjecture with modern science. …”
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Palmitoylethanolamide: A Natural Body-Own Anti-Inflammatory Agent, Effective and Safe against Influenza and Common Cold by J. M. Keppel Hesselink, Tineke de Boer, Renger F. Witkamp

“…However, it is less known that 6 clinical trials in a total of nearly 4000 people were performed and published last century, specifically studying PEA as a therapy for influenza and the common cold. …”
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Mesenchymal Stem Cells and Cardiovascular Disease: A Bench to Bedside Roadmap by Manuel Mazo, Miriam Araña, Beatriz Pelacho, Felipe Prosper

“…In this review, we will focus on their use in the therapy of myocardial infarction, looking at their characteristics, in vitro and in vivo mechanisms of action, as well as clinical trials.…”
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Selecting the appropriate design in biomedical research: experimental studies. Part II by Raúl Aguilera Eguía, Ángel Roco Videla, Olga Patricia López Soto, Brenda Herrera Serna, Héctor Fuentes Barria, Mariana Melo Lonconao

“…Considerations are issued from the historical evolution and theoretical foundations, to the practical implementation of experimental designs, with a particular focus on randomized clinical trials, for their robustness in demonstrating causal relationships and influence in optimizing clinical decisions. …”
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Experimental and Clinical Use of Therapeutic Hypothermia for Ischemic Stroke: Opportunities and Limitations by Tine Zgavc, An-Gaëlle Ceulemans, Sophie Sarre, Yvette Michotte, Said Hachimi-Idrissi

“…Several studies with TH in experimental models and small clinical trials have shown beneficial effects. Despite this, implementation into the clinical setting is still lacking due to methodological considerations as well as hypothermia-related complications. …”
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New Immunotherapeutic Approaches for Glioblastoma by Gustavo Ignacio Vázquez Cervantes, Dinora F. González Esquivel, Saúl Gómez-Manzo, Benjamín Pineda, Verónica Pérez de la Cruz

“…In this review, we summarize and discuss promising immunotherapies for GBM currently under preclinical investigation as well as in clinical trials.…”
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New Therapeutic Approaches for the Treatment of Rheumatoid Arthritis may Rise from the Cholinergic Anti-Inflammatory Pathway and Antinociceptive Pathway by Xiao Hua Pan, Jianxin Zhang, Xiaowei Yu, Ling Qin, Ligeng Kang, Peng Zhang

“…More preclinical experiments and clinical trials are required to confirm our viewpoint.…”
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Behavioural Assessment of Pediatric Pain by Ronald L Blount, Kristin A Loiselle

“…Two recent scholarly reviews of behavioural assessment methods were conducted by the Society of Pediatric Psychology Evidence-Based Assessment Task Force and the Pediatric Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials, which classified various instruments as well established, approaching well established or promising. …”
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Current Potential of Pantoprazole in Treatment and Prevention of Gastrointestinal Diseases by A. A. Sheptulin, S. S. Kardasheva, A. A. Kurbatova

“…Pantoprazole is considered among optimal PPIs for efficacy, safety and adherence on the basis of clinical trials for treatment and prevention of gastrointestinal diseases, systematic reviews and meta-analyses.…”
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Targeting Histone Deacetylases: A Novel Approach in Parkinson’s Disease by Sorabh Sharma, Rajeev Taliyan

“…In the recent past, studies with HDAC inhibitors result in beneficial effects in both in vivo and in vitro models of PD. Various clinical trials have also been initiated to investigate the possible therapeutic potential of HDAC inhibitors in patients suffering from PD. …”
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Serotonin and Its Receptor as a New Antioxidant Therapeutic Target for Diabetic Kidney Disease by Yu Yang, Hui Huang, Zheng Xu, Jun-kai Duan

“…We conclude that 5-HTR is a potential therapeutic target for treating DKD, as it has been successfully applied in animal models and has currently being investigated in randomized and controlled clinical trials.…”
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Therapeutic implications for the PD-1 axis in cerebrovascular injury by James Feghali, Christopher M. Jackson

“…PD-1 agonism has already demonstrated success in clinical trials for rheumatoid arthritis and is being tested in other chronic inflammatory diseases. …”
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Cell Therapies for Heart Function Recovery: Focus on Myocardial Tissue Engineering and Nanotechnologies by Marie-Noëlle Giraud, Anne Géraldine Guex, Hendrik T. Tevaearai

“…The results of multiple clinical trials have already been reported, almost exclusively involving the direct injection of stem cells. …”
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Integrins and Their Extracellular Matrix Ligands in Lymphangiogenesis and Lymph Node Metastasis by Jie Chen, J. Steven Alexander, A. Wayne Orr

“…Work over the past 40 years, varying from molecular examination to clinical trials, verified this hypothesis and identified a host of therapeutic targets to limit tumor angiogenesis, including the integrin family of extracellular matrix receptors. …”
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My Bad, You Got This: witnessing, therapist attitude and the synergy between psychedelics and inner healing intelligence in the treatment of trauma by Lawrence Fischman

“…The MAPS (Multidisciplinary Association for Psychedelic Studies) sponsored MDMA-assisted therapy protocol has had greater success in treating trauma in preliminary clinical trials than any prior psychotherapeutic, pharmacologic, or combined approach. …”
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Proangiogenic Features of Mesenchymal Stem Cells and Their Therapeutic Applications by Hongyan Tao, Zhibo Han, Zhong Chao Han, Zongjin Li

“…Accordingly, several clinical trials using MSCs have been performed and revealed that MSCs may improve relevant clinical parameters in patients with vascular diseases. …”
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Call for a consensual definition of dyslipidemia in coronary angiography trials by Aurélien Clerc, Mario Togni, Stephane Cook

“…Dyslipidemia is extensively analyzed in clinical trials investigating its role as a risk factor for coronary artery disease (CAD). …”
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Metalloproteinase Inhibitors: Status and Scope from Marine Organisms by Noel Vinay Thomas, Se-Kwon Kim

“…Three decades of endeavor for designing potent matrix metalloproteinase inhibitory substances (MMPIs) with many not making upto final clinical trials seek new resources for devising MMPIs. …”
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MSCs: Delivery Routes and Engraftment, Cell-Targeting Strategies, and Immune Modulation by Thomas J. Kean, Paul Lin, Arnold I. Caplan, James E. Dennis

“…Mesenchymal stem cells (MSCs) are currently being widely investigated both in the lab and in clinical trials for multiple disease states. The differentiation, trophic, and immunomodulatory characteristics of MSCs contribute to their therapeutic effects. …”
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