Plasmablastic Lymphoma: A Review of Current Knowledge and Future Directions by Ghaleb Elyamany, Eman Al Mussaed, Ali Matar Alzahrani

“…The introduction of genes encoding artificial receptors called chimeric antigen receptors (CARs) and CAR-modified T cells targeted to the B cell-specific CD19 antigen have demonstrated promising results in multiple early clinical trials. The aim of this paper is to review the recent advances in epidemiology; pathophysiology; clinical, pathologic, and molecular characteristics; therapy; and outcome in patients with PBL.…”
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Infrapatellar Fat Pad Stem Cells: From Developmental Biology to Cell Therapy by Ronaldo J. F. C. do Amaral, Henrique V. Almeida, Daniel J. Kelly, Fergal J. O’Brien, Cathal J. Kearney

“…We conclude with a perspective for future clinical trials using IFP stem cells.…”
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Advancing Multiple Myeloma Immunotherapy: A Review of Chimeric Antigen Receptor T-Cell and Bispecific T-Cell Engagers Cell Therapies in Revolutionizing Treatment by Rahul Navab, Pragyat Futela, Verkha Kumari, Jayesh Valecha, Ramansh Bandhu Gupta, Rohit Jain

“…These therapies exhibit impressive efficacy in clinical trials, leading to FDA approvals for specific MM patient populations. …”
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Ethnopharmacology, Biological Evaluation, and Chemical Composition of Ziziphus spina-christi (L.) Desf.: A Review by Mahmoud Dogara Abdulrahman, Ali Muhammad Zakariya, Harmand A. Hama, Saber W. Hamad, Sawsan S. Al-Rawi, Sarwan W. Bradosty, Ahmad H. Ibrahim

“…However, the safety and efficacy of Z. spina have not been wholly assessed in humans, and further well-designed clinical trials are needed to corroborate preclinical findings. …”
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Challenges in Assessing Outcomes among Infants of Pregnant HIV-Positive Women Receiving ART in Uganda by Barbara Castelnuovo, Frank Mubiru, Ivan Kalule, Shadia Nakalema, Agnes Kiragga

“…We report very low documented HIV transmission comparable with those reported in clinical trials settings; however, demonstrating the efficacy of Option B-plus in terms of averted transmission in routine settings is challenging since high proportion of infants do not have documented HIV tests.…”
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Efficacy of Abiraterone and Enzalutamide in Pre- and Postdocetaxel Castration-Resistant Prostate Cancer: A Trial-Level Meta-Analysis by Mike Fang, Mary Nakazawa, Emmanuel S. Antonarakis, Chun Li

“…The results from this comprehensive meta-analysis suggest a survival advantage with the use of first-line enzalutamide over abiraterone in CRPC and highlight the need for prospective clinical trials.…”
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Association between dietary intake of live microbes and chronic obstructive pulmonary disease: a cross-sectional study of NHANES 2007–2012 by Yifeng Xu, Zhaoqi Yan, Liangji Liu

“…Trial registration ClinicalTrials.gov Identifier NCT00005154 First Posted date 26/05/2000(retrospectively registered).…”
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Mechanisms Underlying the Osteo- and Adipo-Differentiation of Human Mesenchymal Stem Cells by Yu Zhang, Dilaware Khan, Julia Delling, Edda Tobiasch

“…In this review, the current findings for adipo- and osteo-differentiation are summarized together with a brief statement on first clinical trials.…”
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Exploring the associations between the biomechanical and psychological mechanistic pathways of lower back pain development amongst persons with lower-limb amputation: A study proto... by Alexandra Withey, Dario Cazzola, Abby Tabor, Elena Seminati

“…<h4>Trial reference number</h4>The study is registered at IRAS ID: 321729 and at ClinicalTrials.gov: NCT06243549.…”
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The Organotypic Longitudinal Spinal Cord Slice Culture for Stem Cell Study by Joanna Sypecka, Sylwia Koniusz, Maria Kawalec, Anna Sarnowska

“…The urgent need for an appropriate in vitro model for spinal cord regeneration results from a greater number of clinical trials concerning regenerative medicine in the spinal cord injury and from still insufficient knowledge of the molecular mechanisms involved in the neuroreparative processes. …”
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Targeting gut microbiota in osteoporosis: impact of the microbial-based functional food ingredients by Pauline Duffuler, Khushwant S. Bhullar, Jianping Wu

“…Moreover, additional animal studies and clinical trials are needed to understand the interactions between gut microbiota and bone metabolism before further applications.…”
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PET in neurotherapeutic discovery and development by Melissa Chassé, Neil Vasdev

“…Examples highlight the preclinical and clinical uses of PET for studying biomarker function, drug candidate PK/PD, target occupancy/engagement, dosing regimen determination, clinical trial patient selection, and quantifying biomarker changes in response to treatments.…”
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Natural products as anticancer agents and enhancing their efficacy by a mechanism-based precision approach by Stephen Safe

“…Many of the compounds perform poorly in clinical trials due to pharmacokinetic consideration and limited uptake (e.g., curcumin) and these are issues that can be addressed. …”
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Gamma delta T cells in acute myeloid leukemia: biology and emerging therapeutic strategies by Venkata Lokesh Battula, Abhishek Maiti, Adishwar Rao, Akriti Agrawal, Gautam Borthakur

“…Insights from murine models and clinical data in humans show improved overall survival, leukemia-free survival, reduced risk of relapse, enhanced graft-versus-leukemia effect, and decreased graft-versus-host disease in patients with AML who have higher reconstitution of γδ T cells following allogeneic hematopoietic stem cell transplantation. Clinical trials leveraging γδ T cell biology have used unmodified and modified allogeneic cells as well as bispecific engagers and monoclonal antibodies. …”
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A modern approach to the treatment of acute low back pain: a proposal of a new treatment algorithm by Robert Rupiński, Urszula Grata-Borkowska, Jarosław Drobnik

“…Several randomized clinical trials have demonstrated the efficacy of this method in reducing pain and disability to a degree comparable to high-dose NSAID therapy. …”
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Exploring TNFR1: from discovery to targeted therapy development by Yingying Li, Ruiwei Ye, Haorui Dai, Jiayi Lin, Yue Cheng, Yonghong Zhou, Yiming Lu

“…This review emphasizes the emerging field of targeted therapies aimed at selectively modulating TNFR1 activity, identifying promising therapeutic strategies that exploit TNFR1 as a drug target through an evaluation of current clinical trials and preclinical studies. In conclusion, this study contributes novel insights into the biological functions of TNFR1 and presents potential therapeutic strategies for clinical application, thereby having substantial scientific and clinical significance.…”
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Control of atropoisomerism: an access to valuable compounds by Choppin, Sabine, Wencel-Delord, Joanna, Colobert, Françoise

“…Atropoisomerism is well-known in biaryls, however this phenomenon is encountered in many pharmaceutically relevant compounds such as heterobiaryl, diarylamines, benzamides and anilides.Currently four FDA-approved drugs are atropostable and many others are in clinical trials. It is also important to note that almost 30% of recent FDA-approved small molecules are “proatropisomeric” and interact with a target in a specific chiral conformation.Given this vivid interest in C–C but also C–N atropisomerically stable compounds, this account will detail the new atropoisomeric strategies we developed and their applications in the synthesis of relevant molecules and ligands.…”
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Efficacy and safety of laquinimod versus placebo in relapsing-remitting multiple sclerosis: a systematic review and meta-analysis of randomized controlled trials by Malik Waleed Zeb Khan, Aizaz Ali, Amna Hussain, Safeena Khan, Ammara Tahir, Muhammad Haris Khan, Touba Azeem, Abdul Moeez, Arysha Monis, Aban Masaud Mian, Fazia Khattak, Moosa Ali, Jibran Ikram

“…Methods An extensive electronic search was conducted across PubMed, Embase, Cochrane Database of Systematic Reviews, and ClinicalTrials.gov to identify suitable studies. Risk of bias was assessed using Cochrane’s Risk of Bias tool. …”
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Comprehensive review of preclinical evaluation strategies for COVID-19 vaccine candidates: assessing immunogenicity, toxicology, and safety profiles by Delaram Doroud, Mojtaba Daneshi, Fatemeh Kazemi-Lomedash, Zohre Eftekhari

“…This guidance is essential for researchers and manufacturers to design effective vaccines that can progress to clinical trials safely. …”
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Ferric Carboxymaltose as Treatment in Women with Iron-Deficiency Anemia by Melvin H. Seid, Angelia D. Butcher, Ashwin Chatwani

“…This trial is registered with ClinicalTrials.gov, NCT00548860.…”
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