Recent advances in the prevention of secondary ischemic stroke: A narrative review by Yue Qiao, Aminah I. Fayyaz, Yuchuan Ding, Xunming Ji, Wenbo Zhao

“…This review summarizes the latest advancements in the secondary prevention of ischemic stroke over the past 5 years, highlighting the key clinical trials and novel interventions. The optimization of traditional risk factor management and the emergence of novel therapeutic methods have provided more options for clinical practice. …”
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Is There a Role of Targeted Agents in the Management of Adrenocortical Cancers? by M. W. Saif, B. Fallon, K. N. Syrigos

“…Recent developments in the understanding of the pathogenesis of ACC have led to multiple clinical trials involving targeted agents in the management of ACC. …”
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Linezolid and serotonin syndrome by Haytham A. Wali

“…Assessments of the pharmacological mechanisms, large-scale clinical trials, and cohort studies are essential to elucidate risk factors and outcomes. …”
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Selective Decontamination of the Digestive Tract Reduces Pneumonia and Mortality by Lenneke E. M. Haas, Marcus J. Schultz

“…Selective decontamination of the digestive tract (SDD) has been subject of numerous randomized controlled trials in critically ill patients. Almost all clinical trials showed SDD to prevent pneumonia. Nevertheless, SDD has remained a controversial strategy. …”
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Extensive Longitudinal Transverse Myelitis Temporally Related to the Use of AZD1222, AstraZeneca COVID-19 Vaccine: Cerebrospinal Fluid Analysis and Recent Data Review by Paulo Diniz da Gama, Tiago Gomes de Alcantara, Rafaela Ramos Smaniotto, Penélope de Lima Petuco, Wammer Alves de Almeida, Rodrigo Assad Diiniz da Gama, Yara Dadalti Fragoso

“…Neurological complications such as transverse myelitis raise concerns as cases were observed in clinical trials. Cerebrospinal fluid analysis is routine in these cases and the characteristics of the abnormalities found are of great help not only in establishing the diagnosis but also in understanding this rare condition. …”
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Belzutifan for the treatment of renal cell carcinoma by Xiancheng Wu, David Lazris, Risa Wong, Scott S. Tykodi

“…Belzutifan has demonstrated activity in clinical trials as a front- and later-line therapy, and in combination with tyrosine kinase inhibitors. …”
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Gut Microbiome in Obsessive Compulsive Disorder: Potential of Probiotics as an Adjuvant Therapy by Grace Yong-En Kong, Vengadesh Letchumanan, Loh Teng-Hern Tan, Jodi Woan-Fei Law

“…In vivo animal studies showed that probiotics can potentially improve OCD symptoms. Nevertheless, clinical trials are required to determine the efficacy of probiotics as an adjuvant therapy to alleviate OCD symptoms. …”
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Detoxification of Implant Surfaces Affected by Peri-Implant Disease: An Overview of Surgical Methods by Pilar Valderrama, Thomas G. Wilson Jr

“…The aim of this review was to summarize in vitro and in vivo studies as well as clinical trials that have evaluated surgical approaches for detoxification of the implant body surfaces. …”
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The Discovery of Novel Experimental Therapies for Inflammatory Arthritis by Charles J. Malemud

“…A few of them have even entered the first phase of human clinical trials.…”
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Update on Edoxaban for the Prevention and Treatment of Thromboembolism: Clinical Applications Based on Current Evidence by Ali Zalpour, Thein Hlaing Oo

“…Emerging evidence from the clinical trials has shown that DOACs are noninferior to VKA or low-molecular-weight heparins in the prevention and treatment of thromboembolism. …”
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The Informed Consent in Allergology from a Scientific, Technological and Social Perspective by Marisela Luisa Pérez Pacaréu, Yanet Morejón del Rosario, Gloria Arlenys Suárez Rodríguez, Aleima Rodríguez Carbajal

“…This paper reviews the application of the informed consent within the specialty of allergology in procedures (skin tests), therapeutic interventions (immunotherapy) and research (clinical trials) from a scientific, technological and social perspective, based on the advances achieved in Cuba in recent years to obtain better allergenic extracts for testing, high-quality vaccines and new drugs to benefit the allergic patient. …”
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Intestinal microbiome as effective regulator of enteral and central nervous system activity by V. T. Ivashkin, K. V. Ivashkin

“…Accumulated data change the current concept on human microbiome and its potential, however further clinical trials required.…”
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Adaptive Treatment of Metastatic Prostate Cancer Using Generative Artificial Intelligence by Youcef Derbal

“…As such, the study is expected to help facilitate the design of clinical trials of GenAI-supported cancer treatments.…”
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Revolutionizing acute myeloid leukemia treatment: a systematic review of immune-based therapies by Ugochi Ebinama, Binsah George

“…This comprehensive review article specifically examines classical unconjugated and toxin-conjugated monoclonal antibodies, which are currently in the preclinical phase or undergoing evaluation in clinical trials. The review delves into the proposed mechanisms through which these monoclonal antibodies elicit anti-tumor activity and identifies the challenges associated with designing targeted immunotherapy. …”
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Iron Chelation Therapy in Myelodysplastic Syndromes by Emanuela Messa, Daniela Cilloni, Giuseppe Saglio

“…The usefulness of iron chelation in MDS patients is still under debate, mainly because of the lack of solid prospective clinical trials that should take place in the future. …”
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Recent Advances in Antiviral Therapy for Chronic Hepatitis C by Akihiro Tamori, Masaru Enomoto, Norifumi Kawada

“…This review introduces the characteristics and results of recent clinical trials of several DAAs: NS3/4A protease inhibitors, NS5A inhibitors, and NS5B inhibitors. …”
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L-Ornithine L-Aspartate for the Treatment of Sarcopenia in Chronic Liver Disease: The Taming of a Vicious Cycle by Roger F. Butterworth

“…Thus, a vicious cycle occurs whereby hyperammonemia causes severe muscle damage and sarcopenia that, in turn, limits the capacity of muscle to remove excess blood-borne ammonia and the cycle continues. Randomized clinical trials and meta-analyses confirm that L-ornithine L-aspartate (LOLA) is an effective ammonia-lowering agent currently employed for the treatment of hepatic encephalopathy (HE) that stimulates both urea synthesis by residual hepatocytes and muscle glutamine synthesis together with putative hepatoprotective actions. …”
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The Dynamicity of the Oxytocin Receptor in the Brain May Trigger Sensory Deficits in Autism Spectrum Disorder by Claudia Camerino

“…The neurohormone oxytocin (Oxt) is involved in the etiology of ASD, and there are several ongoing clinical trials regarding Oxt administration in ASD patients. …”
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The hypoglycemic potential of phenolics from functional foods and their mechanisms by Oksana Golovinskaia, Chin-Kun Wang

“…Nevertheless, further clinical trials are required to confirm the bioavailability, safety, and efficacy of phenolics, especially the dosage and duration of treatment, to avoid adverse effects and give better dietary recommendations.…”
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Long-Term Use of Ruxolitinib in an AML Patient with Posttransplant Steroid Refractory GVHD by Philip T. Sobash, Achuta K. Guddati, Vamsi Kota

“…The long-term use of ruxolitinib has not been explicitly studied outside the context in the treatment of multiple myeloma. With current clinical trials underway for the use of ruxolitinib in srGVHD, there are still no current guidelines or protocols for long-term clinical use. …”
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