Gastric Cytoprotection as Basis of Gastrointestinal Mucosa Protection and Repair in Erosive Ulcerative Lesions of Various Aetiologies by K. V. Ivashkin, E. A. Izatullaev, V. R. Korneeva

“…In experiment, MMSC prevented the ethanol-induced GM damage, stimulated mucin release and its redistribution on the GM surface; in clinical trials, MMSC effectively facilitated remission in duodenal ulcer.Conclusion. …”
Get full text

Survival Analysis of Diabetic Colorectal Cancer Patients on Metformin by Alex Brandon Wong, Ravi Patnaik, Li Ling Chaw, Shir Kiong Lu, Long Chiau Ming, Wen Han Chooi, Ya Chee Lim

“…However, the association between cancer progression and metformin use requires further investigation, and high-powered clinical trials are needed to support these findings. …”
Get full text

Nutraceuticals and Pharmaceuticals by E. A. Poluektova, A. G. Beniashvili, R. V. Maslennikov

“…Some nutraceuticals, such as probiotics, have confirmed their effectiveness in clinical trials, while the beneficial properties of others require further elucidation.Conclusions. …”
Get full text

Therapeutic Strategies for High-Dose Vasopressor-Dependent Shock by Estevão Bassi, Marcelo Park, Luciano Cesar Pontes Azevedo

“…The use of more than 0.5 mcg/kg/min of norepinephrine or epinephrine to maintain target blood pressure is often used in clinical trials as a threshold. Nearly 6% of critically ill patients will develop refractory shock, which accounts for 18% of deaths in intensive care unit. …”
Get full text

Epidural Dexamethasone for Postoperative Analgesia in Patients Undergoing Unilateral Inguinal Herniorrhaphy: A Comparative Study by M. R. Razavizadeh, MR. Fazel, N. Heydarian, F. Atoof

“…Forty-four patients were enrolled in this double-blind, clinical trial study. Patients were randomly allocated into dexamethasone or control group. …”
Get full text

Comprehensive evaluation of pure and hybrid collaborative filtering in drug repurposing by Clémence Réda, Jill-Jênn Vie, Olaf Wolkenhauer

“…The outcomes of past clinical trials can be used to predict novel drug-disease associations by leveraging drug- and disease-related similarities. …”
Get full text

Antimicrobial proteins from oyster hemolymph improve the efficacy of conventional antibiotics. by Kate Summer, Qi Guo, Lei Liu, Bronwyn Barkla, Sarah Giles, Kirsten Benkendorff

“…Effective HPE concentrations are comparable to AMPPs currently approved for use or in clinical trials pipelines. Proteomics analysis of HPE identified a number of proteins including abundant known AMPPs. …”
Get full text

Biomarkers of Joint Damage in Osteoarthritis: Current Status and Future Directions by Rajkamal Kumavat, Vijay Kumar, Rajesh Malhotra, Hemant Pandit, Elena Jones, Frederique Ponchel, Sagarika Biswas

“…The most unmet clinical need is, however, related to the monitoring of disease progression over a short period that can be used in clinical trials. In this review, the value of biomarkers identified over the past decade has been highlighted. …”
Get full text

Aaron Temkin BECK: After Cricitical Thinking to A Creative Psychotherapy Theory by Mehmet DİNÇ

“…Numerous controlled clinical trials have now demonstrated that cognitive therapy is effective in a variety of psychiatric conditions including depression, bulimia nervosa, hypochondriasis, social phobia, obsessive-compulsive disorder, substance abuse, body dysmorphic disorder, and post-traumatic stress disorder. …”
Get full text

A Bayesian Adaptive Design in Cancer Phase I Trials Using Dose Combinations in the Presence of a Baseline Covariate by Márcio Augusto Diniz, Sungjin Kim, Mourad Tighiouart

“…A Bayesian adaptive design for dose finding of a combination of two drugs in cancer phase I clinical trials that takes into account patients heterogeneity thought to be related to treatment susceptibility is described. …”
Get full text

Homeostasis and metabolism of iron and other metal ions in neurodegenerative diseases by Leilei Chen, Qingqing Shen, Yingjuan Liu, Yunqi Zhang, Liping Sun, Xizhen Ma, Ning Song, Junxia Xie

“…Additionally, the promising results and limitations observed in clinical trials of these metal ion chelators will also be addressed. …”
Get full text

The Nrf2/Keap1/ARE Pathway and Oxidative Stress as a Therapeutic Target in Type II Diabetes Mellitus by Joshua A. David, William J. Rifkin, Piul S. Rabbani, Daniel J. Ceradini

“…Animal studies and clinical trials have shown promising results suggesting that activation of this pathway can delay or reverse some of these impairments in TIIDM. …”
Get full text

Review of the clinical status of cardiotoxicity of HER-2 positive breast cancer targeted therapeutic drugs by Xiang Zhang, Yulian Yin, Qiuting Yu, Xinlin Chen, Yiqin Cheng

“…We list the evidence of cardiotoxicity for various drugs based on current clinical trials and summarize their corresponding epidemiological profiles. …”
Get full text

Comparison of Gastric Emptying Time after the Ingestion of Whisky with Isocalorically Adjusted Glucose Solution by Tadashi Okabe, Hideo Terashima, Atsuhiro Sakamoto

“…This study is registered with the University Hospital Medical Information Network (UMIN) Clinical Trials Registry (UMIN000034443).…”
Get full text

Phytocannabinoids: a new frontier in Alzheimer’s disease management by Jagadeesh S. Rao

“…At present, numerous FDA-controlled clinical trials are being conducted to assess the beneficial impacts of THC and CBD in the treatment of cognitive and neuropsychiatric symptoms associated with AD. …”
Get full text

Beneficial Effects of Palmitoylethanolamide on Expressive Language, Cognition, and Behaviors in Autism: A Report of Two Cases by Nicola Antonucci, Alessandra Cirillo, Dario Siniscalco

“…We propose appropriate double-blind clinical trials to further explore palmitoylethanolamide efficacy and safety.…”
Get full text

Environmental Enrichment Therapy for Autism: Outcomes with Increased Access by Eyal Aronoff, Robert Hillyer, Michael Leon

“…We have previously shown in two randomized clinical trials that environmental enrichment is capable of ameliorating symptoms of autism spectrum disorder (ASD), and in the present study, we determined whether this therapy could be effective under real-world circumstances. 1,002 children were given daily Sensory Enrichment Therapy, by their parents, using personalized therapy instructions given over the Internet. …”
Get full text

Bottlenecks in the Efficient Use of Advanced Therapy Medicinal Products Based on Mesenchymal Stromal Cells by Natalia Escacena, Elena Quesada-Hernández, Vivian Capilla-Gonzalez, Bernat Soria, Abdelkrim Hmadcha

“…Additionally, hundreds of clinical trials related to the potential benefits of MSCs are in progress. …”
Get full text

Pathogenesis of Myeloproliferative Neoplasms: Role and Mechanisms of Chronic Inflammation by Sylvie Hermouet, Edith Bigot-Corbel, Betty Gardie

“…Moreover, the JAK inhibitor clinical trials showed that the reduction of symptoms linked to inflammation was beneficial to patients even in the absence of significant decrease in the JAK2-V617F mutant load. …”
Get full text

Evaluating the Effectiveness of Cyclin-Dependent Kinase 4/6 Inhibitors in Early- and Very Early-Onset Metastatic Breast Cancer: A Multicenter Study by Akif Doğan, Nurullah İlhan, Goncagül Akdağ, Sedat Yıldırım, Mustafa Seyyar, Zeynep Yüksel Yaşar, Hande Nur Erölmez, Heves Sürmeli, Buğra Öztosun, Özlem Nuray Sever, Hatice Odabaş, Mahmut Emre Yıldırım, Devrim Çabuk, Nedim Turan, Mahmut Gümüş

“…The findings underscore the urgent need for personalized treatment strategies, routine genetic testing, and dedicated clinical trials designed to address the specific needs of these high-risk subgroups. …”
Get full text