Thymus and activation-regulated chemokine (CCL17) as a clinical biomarker in atopic dermatitis: significance and limitations in the new treatment era by Yoko Kataoka

“…In this new era, TARC remains a useful biomarker for more accurate drug selection and the determination of therapeutic efficacy; Currently, in clinical trials of AD, all outcome measurements depend on the clinical score; however the use of a biomarker, such as TARC, as a secondary outcome measure will clarify the characteristics of each drug and the pathophysiological conditions for which it is expected to be effective.…”
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Rimegepant for the treatment of migraine by Amnon A. Berger, Ariel Winnick, Austin H. Carroll, Alexandra Welschmeyer, Nathan Li, Marc Colon, Antonella Paladini, Giovanni F. Ramírez, Jamal Hasoon, Elyse M. Cornett, Jaehong Song, Giustino Varrassi, Adam M. Kaye, Alan D. Kaye, Latha Ganti

“…Rimegepant, a second-generation gepant, has shown efficacy in several clinical trials in treating acute migraine. Ongoing trials are also evaluating its role in migraine prophylaxis, and results are promising. …”
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FDA’s approval of resmetirom (Rezdiffra): a breakthrough in MASH management by Muhammad Mazhar Azam, Sameen Mukhtar, Muhammad Haris, Fatima Laique, Suhaina Amir, Mubashir Mohiuddin, Bibek Giri

“…This mechanism effectively reduces fibrosis markers, improves liver enzyme levels, and minimizes liver fat buildup. Clinical trials have shown that resmetirom has a favorable safety profile, with manageable side effects like diarrhea and nausea. …”
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Promising New Treatments for Psoriasis by Sarah Dubois Declercq, Roxane Pouliot

“…This review describes new psoriasis treatments, which are on the market or currently in clinical trials that are being used to treat moderate-to-severe plaque psoriasis. …”
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Update in the Early Management and Reperfusion Strategies of Patients with Acute Ischemic Stroke by Aldo A. Mendez, Edgar A. Samaniego, Sunil A. Sheth, Sudeepta Dandapat, David M. Hasan, Kaustubh S. Limaye, Bradley J. Hindman, Colin P. Derdeyn, Santiago Ortega-Gutierrez

“…After the publication of pivotal clinical trials, endovascular thrombectomy has become part of the standard of care in selected cases of AIS since 2015. …”
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The Effects of Vitamin D Supplement on Prevention of Recurrence of Preeclampsia in Pregnant Women with a History of Preeclampsia by Sanam Behjat Sasan, Farnaz Zandvakili, Nasrin Soufizadeh, Elaheh Baybordi

“…This study has been registered in Iranian Registry of Clinical Trials (IRCT) site with ID number IRCT2017010131695N1.…”
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Human Mesenchymal Stem Cells: The Present Alternative for High-Incidence Diseases, Even SARS-Cov-2 by Karen J. Juárez-Navarro, Eduardo Padilla-Camberos, Néstor Fabián Díaz, Ariel Miranda-Altamirano, N. Emmanuel Díaz-Martínez

“…Here, we summarize a general overview of MSCs and their therapeutic mechanisms; also, we discuss some of the novel clinical trial protocols and their results as well as a comparison between the number of registries, countries, and search portals.…”
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Single-Cell Transcriptome Analysis of Human Adipose-Derived Stromal Cells Identifies a Contractile Cell Subpopulation by Elize Wolmarans, Juanita Mellet, Chrisna Durandt, Fourie Joubert, Michael S. Pepper

“…The potential for human adipose-derived stromal cells (hASCs) to be used as a therapeutic product is being assessed in multiple clinical trials. However, much is still to be learned about these cells before they can be used with confidence in the clinical setting. …”
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Therapies for Mitochondrial Disorders by Kayli Sousa Smyth, Anne Mulvihill

“…Obstacles towards discovering effective therapies include the rarity of MTDS, its pathogenic complexity and lack of clinical trials. Despite the lack of current curative therapies for MTDS, emerging therapies promise exciting and clinically meaningful therapies in the future.…”
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Is Thymoglobulin or Rituximab the Cause of This Serum Sickness? A Case Report of Serum Sickness Dilemma and Literature Review by Amarpreet Sandhu, Antonia Harford, Pooja Singh, Eduardo Alas

“…There are not any evidence-based guidelines or published clinical trials to help guide therapy for antibody-induced serum sickness; however, we successfully treated our case with three doses of Methylprednisone 500 mg intravenously. …”
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Disease-Specific Target Gene Expression Profiling of Molecular Imaging Probes: Database Development and Clinical Validation by Lawrence Wing-Chi Chan, Connie Hiu-Ching Ngo, Fengfeng Wang, Moss Y. Zhao, Mengying Zhao, Helen Ka-Wai Law, Sze Chuen Cesar Wong, Benjamin Yat-Ming Yung

“…Validated with the in vitro study, the expression profiles of disease-associated targets can indicate the eligibility of patients for clinical trials of the treatment probe. A Web search tool of the DIPP database is available at http://www.polyu.edu.hk/bmi/dipp/ .…”
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Efficacy of Nivolumab in a Patient with Metastatic Renal Cell Carcinoma and End-Stage Renal Disease on Dialysis: Case Report and Literature Review by Jawaher Ansari, Muhammad Ali, Ashraf Farrag, Arwa M. Ali, Abdulaziz Alhamad

“…Treatment of patients with metastatic renal cell carcinoma (mRCC) and end-stage renal disease (ESRD) on dialysis poses a therapeutic challenge, particularly as this patient group was excluded from the pivotal clinical trials. In addition, there is uncertainty regarding drug dosing/pharmacokinetics, lack of safety and efficacy data, and potential for increased toxicity when using targeted therapy or immunotherapy for the management of patients with mRCC on dialysis. …”
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Therapeutic Effects of Milk Thistle (Silybum marianum L.) and Artichoke (Cynara scolymus L.) on Nonalcoholic Fatty Liver Disease in Type 2 Diabetic Rats by Aida Doostkam, Mohammad Fathalipour, Mohammad Hossein Anbardar, Azar Purkhosrow, Hossein Mirkhani

“…Nonetheless, long-term randomized clinical trials are necessary to confirm the observed results.…”
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Mesenchymal Stem Cells as New Therapeutic Agents for the Treatment of Primary Biliary Cholangitis by Aleksandar Arsenijevic, C. Randall Harrell, Crissy Fellabaum, Vladislav Volarevic

“…In this review, we have summarized the therapeutic potential of MSCs for the treatment of these diseases, emphasizing molecular and cellular mechanisms responsible for MSC-based effects in an animal model of PBC and therapeutic potential observed in recently conducted clinical trials. We have also presented several outstanding problems including safety issues regarding unwanted differentiation of transplanted MSCs which limit their therapeutic use. …”
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A scoping review protocol on diagnostic strategies to detect occult malignancies in individuals with ischemic stroke. by Jenneke Leentjens, Nicholas L J Chornenki, Janneke Spiegelenberg, Valentina Ly, Dariush Dowlatshahi, Deborah M Siegal

“…Addressing this knowledge gap will help guide the development of future clinical trials on occult cancer screening patients with ischemic stroke.…”
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Dry Swab-Based Nucleic Acid Extraction vs. Spin Column-Based Nucleic Acid Extraction for COVID-19 RT-PCR Testing: A Comparative Study by Mohammed Faraaz Khan, C. Roopa

“…The trial was registered with the Clinical Trials Registry of India (CTRI) with a CTRI registration number of CTRI/2021/12/038792.…”
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Acute Toxicity and Neuroprotective Effect of “RJ6601”, a Newly Formulated Instant Soup, in Geriatric Rats by Rujikarn Chaisanam, Jintanaporn Wattanathorn

“…Subchronic toxicity studies and clinical trials are essential to confirm the safety of RJ6601 consumption and its health benefits.…”
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Current State of Type 1 Diabetes Immunotherapy: Incremental Advances, Huge Leaps, or More of the Same? by Brett Phillips, Massimo Trucco, Nick Giannoukakis

“…This paper will highlight the preclinical successes and the excitement generated by phase II trials while offering alternative possibilities and new translational avenues that can be explored given the very recent disappointment in leading agents in more advanced clinical trials.…”
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The Clinical Application and Progress of Mirogabalin on Neuropathic Pain as a Novel Selective Gabapentinoids by Hui Tang, Jing Lu, Yazhuo Duan, Dejun Li

“…Our review was aimed at encompassing the bulk of clinical research on mirogabalin, which included clinical trials, special considerations, coadministration studies, case reports, and cost-effectiveness studies. …”
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Musculoskeletal Adverse Events Associated with PCSK9 Inhibitors: Disproportionality Analysis of the FDA Adverse Event Reporting System by Lingqing Ding, Congqin Chen, Yongkuan Yang, Jie Fang, Longxing Cao, Yige Liu

“…Some studies suggest that potential safety issues about PCSK9 inhibitors have not been sufficiently explored in clinical trials, including musculoskeletal adverse events (MAEs). …”
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