Targeted Anticancer Immunotoxins and Cytotoxic Agents with Direct Killing Moieties by Koji Kawakami, Oumi Nakajima, Ryuichi Morishita, Ryozo Nagai

“…Such targetable agents, including RFB4(dsFv)-PE38 (BL22), IL13-PE38QQR, and Tf-CRM107, are being tested in clinical trials. Several agents using unique technology such as a cleavable adapter or immunoliposomes with antibodies are also in the preclinical stage. …”
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Stroke Prevention: Managing Modifiable Risk Factors by Silvia Di Legge, Giacomo Koch, Marina Diomedi, Paolo Stanzione, Fabrizio Sallustio

“…The results of recent clinical trials investigating new anticoagulants (factor Xa inhibitors and direct thrombin inhibitors) clearly indicate alternative strategies in stroke prevention for patients with atrial fibrillation. …”
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Health Status Measurement Instruments in Chronic Obstructive Pulmonary Disease by Yves Lacasse, Eric Wong, Gordon Guyatt, Roger S Goldstein

“…Generic questionnaires should not be used alone in clinical trials as evaluative instruments because of their inability to detect change over time. …”
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Early mobilization post-myocardial infarction: A scoping review. by Haroon Munir, Jake Fromowitz, Michael Goldfarb

“…More robust evidence from randomized clinical trials is required to inform clinicians and influence practice.…”
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Biological Evaluation of Garcinia kola Heckel by Abdulrahman Mahmoud Dogara, Saber W. Hamad, Harmand A. Hama, Sarwan W. Bradosty, Soran Kayfi, Sawsan S. Al-Rawi, Abubakar Abdullahi Lema

“…However, the safety and efficacy of G. kola have not been wholly assessed in humans, and further well-designed clinical trials are needed to corroborate preclinical findings. …”
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Error fields: personalized robotic movement training that augments one’s more likely mistakes by Naveed Reza Aghamohammadi, Moria Fisher Bittmann, Verena Klamroth-Marganska, Robert Riener, Felix C. Huang, James L. Patton

“…This study reports results from a clinical trial registered on ClinicalTrials.gov with ID: NCT02720341.…”
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Potential Use of Euphorbia hirta for Dengue: A Systematic Review of Scientific Evidence by Sashini D. Perera, Uthpala A. Jayawardena, Chanika D. Jayasinghe

“…Hence, well-controlled clinical trials and contemporary pharmacological approaches including activity guided fractionation and elucidation of the mode of action are encouraged to establish the use of E. hirta for dengue.…”
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Crossroad of Tradition and Innovation – The Application of Lactic Acid Fermentation to Increase the Nutritional and Health-Promoting Potential of Plant-Based Food Products – a Revi... by Anna Maria Ogrodowczyk, Natalia Drabińska

“…However, still more clinical trials evaluating the effect of their consumption on the human health are in demand.…”
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Diagnostic and Therapeutic Advances of RNAs in Precision Medicine of Gastrointestinal Tumors by Runhan Liu, Jiaxin Zhou, Xiaochen Chen, Jie Zhang, Qunzhi Chen, Xiaoming Liu, Kunhou Yao

“…Many RNA-based therapeutics, such as small interfering RNA (siRNA) and antisense oligonucleotides (ASO), have entered clinical trials or are available on the market. This review provides a narrative examination of the diagnostic and therapeutic potential of RNA in gastrointestinal cancers, with an emphasis on its application in precision medicine. …”
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Beneficial Effects of Dietary Nitrate on Endothelial Function and Blood Pressure Levels by Jenifer d’El-Rei, Ana Rosa Cunha, Michelle Trindade, Mario Fritsch Neves

“…The increased levels of nitrite by nitrate intake seem to have beneficial effects in many of the physiological and clinical settings. Several clinical trials are being conducted to determine the broad therapeutic potential of increasing the bioavailability of nitrite in human health and disease, including studies related to vascular aging. …”
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Patients with Acromegaly Presenting with Colon Cancer: A Case Series by Murray B. Gordon, Samer Nakhle, William H. Ludlam

“…We performed a retrospective analysis of the incidental diagnoses of colon cancer from the ACCESS trial (ClinicalTrials.gov identifier: NCT01995734). Colon cancer was identified in 2 patients (4.5%). …”
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Designing a Long Acting Erythropoietin by Fusing Three Carboxyl-Terminal Peptides of Human Chorionic Gonadotropin β Subunit to the N-Terminal and C-Terminal Coding Sequence by Fuad Fares, Avri Havron, Eyal Fima

“…The therapeutic efficacy of EPO-CTP analog needs to be established in higher animals and in human clinical trials.…”
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Therapeutic Options for the Management of the Cardiorenal Syndrome by Katerina Koniari, Marinos Nikolaou, Ioannis Paraskevaidis, John Parissis

“…That leads to an increasing concern about novel options, such as the use of vasopressin antagonists, adenosine A1 receptor antagonists, and renal-protective dopamine. Initial clinical trials have shown quite encouraging results in some heart failure subpopulations but have failed to demonstrate a clear beneficial role of these agents. …”
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Prognostic value of circulating Chromogranin A in prostate cancer: a systematic review and meta-analysis by Xiaoying Tang, Zhenyu Liu, Liangdong Song, Huixuan Zhu, Shuai Su, Delin Wang

“…Therefore, we conducted a meta-analysis of the available findings to explore the value of circulating Chromogranin A in the prognosis of prostate cancer.MethodsWe systematically searched the PubMed, Embase, Web of Science, Cochrane Library, and Clinical Trials databases for studies on the relationship between CgA and survival outcomes in prostate cancer from inception until December 2024, and we focused on articles detecting circulating CgA, with the primary endpoints of the studies being overall survival (OS), and progression-free survival (PFS).ResultsOf the 2049 articles retrieved, 10 articles met our inclusion criteria, involving a total of 1445 patients. …”
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Funicular Myelosis in a Butcher: It Was the Cream Cans by Fabian Wolpert, Krisztina Baráth, Janis Brakowski, Roland Renzel, Michael Linnebank, Andreas R. Gantenbein

“…Nevertheless, there are only a few clinical trials assessing its long-term effects and there is no literature about the role of nutritional vitamin B12 supplementation in the context of nitrous oxide abuse. …”
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A 3-Month, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Ability of an Extra-Strength Marine Protein Supplement to Promote Hair Growth and Decrease Shedding in... by Glynis Ablon

“…This trial is registered with ClinicalTrials.gov Identifier: NCT02297360.…”
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Special Problems Associated with Surgical Trials in Inflammatory Bowel Disease by Robin S McLeod

“…However, it also appears that there are certain issues that are unique to, or at least occur more frequently in, clinical trials assessing surgical interventions. The issues of special concern in surgical trials can broadly be categorized as methodological and feasibility issues. …”
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Therapeutic exercise protocol for the prevention of anterior cruciate ligament injuries in female soccer players with dynamic knee valgus (RCT) by Amanda Coves García, Emilio José Poveda Pagán

“…Trial registration ClinicalTrials.gov NCT06083818. Registered on 03 October 2023.…”
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Prevention and treatment of cerebral vasospasm following aneurysmal subarachnoid hemorrhage by Kyle McGrath, Grace Hey, Ghaidaa Ebrahim, Noah Gilberstadt, David Mahan, Brandon Lucke-Wold

“…Numerous preclinical investigations highlight novel targets related to the immune response that could prove effective at improving outcomes in clinical trials. Further investigation of the glymphatic system and its role in PHCV pathogenesis could result in novel pharmacologic targets. …”
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The Impact of Polyunsaturated Fatty Acid Supplementation on Inflammatory Markers in Preterm Infants – A Literature Review by Larysa Bielecka

“…Materials and Methods A review of randomized clinical trials (RCTs) published in 2020-2024 regarding the relationship between the supplementation of polyunsaturated fatty acids and the levels of inflammatory markers in preterm infants. …”
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