The Role of Targeted Therapy in Metastatic Renal Cell Carcinoma by Jaya Unnithan, Brian I. Rini

“…This article briefly describes the biological pathways involved in the development of RCC and the results of clinical trials using targeted therapy in metastatic RCC.…”
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Sugar Alcohols, Caries Incidence, and Remineralization of Caries Lesions: A Literature Review by Kauko K. Mäkinen

“…The possible difference between erythritol and xylitol must be confirmed in future clinical trials.…”
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Gene Therapy for HIV Infections: Intracellular Immunization by Alain Piché

“…In this context, a number of intracellular immunization-based strategies have been evaluated, and some of them have reached the stage of phase I/II human clinical trials. These strategies include the use of single-chain antibodies, capsid-targeted viral inactivation, transdominant negative mutants, ribozymes, antisense oligonucleotides and RNA decoys. …”
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The Impact of Sulforaphane on Sex-Specific Conditions and Hormone Balance: A Comprehensive Review by Jed W. Fahey, Mirran Raphaely

“…SF has been the subject of thousands of studies and over 125 clinical trials. The many mechanisms of action of SF in mammalian systems have been extensively documented. …”
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Recent Advances: The Imbalance of Cytokines in the Pathogenesis of Inflammatory Bowel Disease by Qingdong Guan, Jiguo Zhang

“…In this review, we will discuss the recent advances of novel biologics in clinics and clinical trials, and novel proinflammatory and anti-inflammatory cytokines found in IBD with focusing on IL-12 family and IL-1 family members as well as their relevance to the potential therapy of IBD.…”
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Application of bone turnover markers in skeletal and extra-skeletal conditions in children and adults by Agnieszka Postępska, Przemysław Sikora

“…Therefore, there is a need for standardized clinical trials on currently available and new BTMs.…”
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Mesenchymal Stem Cells Improve Healing of Diabetic Foot Ulcer by Yue Cao, Xiaokun Gang, Chenglin Sun, Guixia Wang

“…In this review, we clarify the mechanism of preclinical studies, as well as safety and efficacy of clinical trials in the treatment of DFU. Bone marrow-derived mesenchymal stem cells (BM-MSCs), compared with MSCs derived from other tissues, may be a suitable cell type that can provide easy, effective, and cost-efficient transplantation to treat DFU and protect patients from amputation.…”
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Progress of Clinical Research on Trop2 in Solid Tumors by Ying ZHANG, Yueping LIU

“…Various targeted therapeutics against Trop2, such as anti-Trop2 antibodies and antibody-drug conjugate drugs targeting Trop2, have been developed, and some therapeutics have been approved or are in clinical trials for cancer treatment. In this review, we comprehensively discuss the gene structure, mechanism of action, clinical research, drug development, and other aspects of Trop2 to provide references for the clinical development of effective and safe Trop2-targeting drugs.…”
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Molecular Basis of Triple Negative Breast Cancer and Implications for Therapy by Parvin F. Peddi, Matthew J. Ellis, Cynthia Ma

“…These findings have implications for therapeutic target identification and the design of future clinical trials for this aggressive group of breast cancer.…”
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Understanding cancer predisposition in Singapore: what’s next by Jianbang Chiang, Tarryn Shaw, Joanne Ngeow

“…These include the potential for finding unexpected germline variants through somatic tumour testing, optimal risk management of patients with hereditary conditions involving moderate-penetrance genes, role of polygenic risk score in an under-represented Asian population, management of variants of uncertain significance, clinical trials in patients with germline pathogenic variants and technology in genetic counselling. …”
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PEEP or No PEEP: That Is Not the Question by Jesús Villar, Arthur S Slutsky

“…In the absence of controlled clinical trials, the use of PEEP in acute respiratory distress syndrome needs to be guided by physiological principles that balance the beneficial effects of an increase in functional residual capacity, prevention of alveolar closure, redistribution of lung water and improved ventilation of low ventilation-perfusion areas against the potential harm of alveolar rupture (barotrauma and "volutrauma") and reduction in cardiac output.…”
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Medical Devices Made of Substances: The Need for a Change in Approach in Paediatrics by Stefano Stagi

“…Ethical concerns often prevent clinical trials in children, meaning that specific data for the paediatric population can be lacking. …”
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Pharmacological class effects of anticancer drugs: opportunities for decreasing healthcare spending by Gregory R Pond, Ian F Tannock, Daniel A Goldstein, Leonard B Saltz

“…Here, we review evidence from clinical trials that supports the existence of class effects for several types of anticancer drugs. …”
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Systematic scoping review of the concept of 'genetic identity' and its relevance for germline modification. by Floor M Goekoop, Carla G van El, Guy A M Widdershoven, Nadza Dzinalija, Martina C Cornel, Natalie Evans

“…EU legislation prohibits clinical trials that modify germ line 'genetic identity'. …”
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Harnessing the Effect of Adoptively Transferred Tumor-Reactive T Cells on Endogenous (Host-Derived) Antitumor Immunity by Yolanda Nesbeth, Jose R. Conejo-Garcia

“…However, recent evidence in animal models and clinical trials suggests that host conditioning interventions tailored for some of the most aggressive and frequent epithelial cancers will be needed to maximize the benefit of this approach. …”
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“Lost in translation?” Animal research in the era of precision medicine by Hamideh Frühwein, Norbert W. Paul

“…Abstract Preclinical animal research has long been a cornerstone in evaluating the efficacy, toxicity, and safety of potential drug treatments before they proceed to human clinical trials. However, given the intricate nature of human physiology and the complexities of diseases such as cancer, this paper critically examines the role of animal experimentation in translational research, both from epistemological and ethical viewpoints. …”
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Penile Rehabilitation Therapy with PDE-V Inhibitors Following Radical Prostatectomy: Proceed with Caution by M. Eric Brewer, Edward D. Kim

“…Despite the current enthusiasm of penile rehabilitation therapy, current scientific evidence with clinical trials is still limited.…”
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Exploring oncogenic roles and clinical significance of EZH2: focus on non-canonical activities by Michal Wozniak, Malgorzata Czyz

“…This review also presents the clinical trials in various phases that evaluate the use of EZH2 inhibitors, both as monotherapy and in combination with other agents for the treatment of patients with diverse types of cancers.…”
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Dendritic Cell-Based Approaches for Therapeutic Immune Regulation in Solid-Organ Transplantation by Giuseppe Vassalli

“…Genetically engineered DCs have also been tested. Two clinical trials in type-1 diabetes and rheumatoid arthritis have been carried out, and other trials, including one trial in kidney transplantation, are in progress or are imminent.…”
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CAR-T cell therapy: developments, challenges and expanded applications from cancer to autoimmunity by Yaojie Kong, Jingyao Li, Xueyao Zhao, Yanwei Wu, Liang Chen

“…We reviewed preclinical experiments and clinical trials involving CAR-T, Car-Treg and CAAR-T cell therapies in various autoimmune diseases. …”
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