Participant experiences in HIV cure-directed trial with an extended analytical treatment interruption in Philadelphia, United States by Andrea Bilger, Eion Plenn, Frances K. Barg, Katharine A. Rendle, William B. Carter, Andrea Lamour-Harrington, Nora Jones, Beth Peterson, John A. Sauceda, Pablo Tebas, Karam Mounzer, David Metzger, Luis J. Montaner, Karine Dubé

“…Continued efforts to understand how people with HIV experience ATIs will improve future designs of HIV cure clinical trials.…”
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Targeting the activated allosteric conformation of the endothelin receptor B in melanoma with an antibody-drug conjugate: mechanisms and therapeutic efficacy by Amaury Herbet, Marie Hautière, Frédéric Jean-Alphonse, Delphine Vivier, Christophe Leboeuf, Narciso Costa, Aloïse Mabondzo, Guilhem Bousquet, Franck Denat, Eric Reiter, Didier Boquet

“…Conclusions xiRB49-MMAE is a promising drug candidate for clinical trials in ETB + tumors. RB49 could be used as a diagnostic tool for patient stratification.…”
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Experiences, perceptions and ethical considerations of the malaria infection study in Thailand by Bhensri Naemiratch, Natinee Kulpijit, Supanat Ruangkajorn, Nicholas P. J. Day, Jetsumon Prachumsri, Phaik Yeong Cheah

“…Trial registration This manuscript is part of the clinical trials registered under ClinicalTrials.gov IDs NCT04083508 (MIST1) registered on 5 Sep 2019 and NCT05071079 (MIST2) registered on 28 July 2021. …”
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East Midlands knee pain multiple randomised controlled trial cohort study: cohort establishment and feasibility study protocol by Michael Doherty, Roshan das Nair, Ana Valdes, Reuben Ogollah, Paul Greenhaff, Bonnie Millar, Michelle Hall, Amy Fuller, Polykarpos Angelos Nomikos, David A Walsh, A Abhishek

“…Qualitative interviews will be conducted with a sample of participants from each of the two active intervention arms.Ethics and dissemination This protocol was approved by the East Midlands-Derby Research Ethics Committee (18/EM/0288) and registered at ClinicalTrials.gov (protocol v4.0, 10/02/2020). The study will be reported in accordance with the Consolidated Standards of Reporting Trials guidance and standards. …”
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European ILD registry algorithm for self-assessment in interstitial lung diseases (eurILDreg ASA-ILD). by Ekaterina Krauss, Laurenz H Claas, Silke Tello, Jennifer Naumann, Sandra Wobisch, Stefan Kuhn, Raphael W Majeed, Karen Moor, Maria Molina-Molina, Oisin Byrne, Rebecca Borton, Marlies S Wijsenbeek, Nik Hirani, Carlo Vancheri, Bruno Crestani, Andreas Guenther, eurILDreg investigators

“…The eurIPFreg and eurIPFbank are listed in ClinicalTrials.gov (NCT02951416). EurILDreg is registered in German Clinical Trials Register, DRKS 00028968.…”
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Efficacy and Safety of Antimalarial as Repurposing Drug for COVID-19 Following Retraction of Chloroquine and Hydroxychloroquine by Latarissa IR, Khairinisa MA, Iftinan GN, Meiliana A, Sormin IP, Barliana MI, Lestari K

“…This study provides a descriptive synthesis of clinical trials evaluating antimalarial drugs for COVID-19 treatment conducted after the withdrawal of CQ and HCQ. …”
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Hepatocellular carcinoma: signaling pathways and therapeutic advances by Jiaojiao Zheng, Siying Wang, Lei Xia, Zhen Sun, Kui Ming Chan, René Bernards, Wenxin Qin, Jinhong Chen, Qiang Xia, Haojie Jin

“…Here, we provide here a comprehensive review of cellular signaling pathways, their therapeutic potential, evidence derived from late-stage clinical trials in HCC and discuss the concepts underlying earlier clinical trials, biomarker identification, and the development of more effective therapeutics for HCC.…”
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Outcomes in stage IIA versus stage IIB/III in the PALLAS trial [ABCSG-42/AFT-05/PrE0109/BIG-14-13]) by A. DeMichele, A. C. Dueck, D. Hlauschek, M. Martin, H. Burstein, G. Pfeiler, N. Zdenkowski, A. Wolff, M. Bellet-Ezquerra, E. Winer, M. Balic, K. Miller, M. Colleoni, D. Lake, G. Rubovsky, D. Cameron, J. Balko, C. F. Singer, Z. Nowecki, H. Iwata, N. Wolmark, K. A. Parraga, H. Rugo, G. G. Steger, T. Traina, G. Werutsky, D. Czajkowska, O. Metzger, S. El-Abed, K. P. Theall, R. D. Lu, P. O’Brien, C. Fesl, E. Mayer, M. Gnant

“…Trial Registration ClinicalTrials.gov number NCT02513394 Registered 30 Jul 2015.…”
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Recruiting Young People for Digital Mental Health Research: Lessons From an AI-Driven Adaptive Trial by Wu Yi Zheng, Artur Shvetcov, Aimy Slade, Zoe Jenkins, Leonard Hoon, Alexis Whitton, Rena Logothetis, Smrithi Ravindra, Stefanus Kurniawan, Sunil Gupta, Kit Huckvale, Eileen Stech, Akash Agarwal, Joost Funke Kupper, Stuart Cameron, Jodie Rosenberg, Nicholas Manoglou, Manisha Senadeera, Svetha Venkatesh, Kon Mouzakis, Rajesh Vasa, Helen Christensen, Jill M Newby

“… BackgroundWith increasing adoption of remote clinical trials in digital mental health, identifying cost-effective and time-efficient recruitment methodologies is crucial for the success of such trials. …”
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Evaluation of long‐acting cabotegravir safety and pharmacokinetics in pregnant women in eastern and southern Africa: a secondary analysis of HPTN 084 by Sinead Delany‐Moretlwe, Brett Hanscom, Xu Guo, Clemensia Nkabiito, Patricia Mandima, Patricia Ntege Nahirya, Juliet Mpendo, Muchaneta Bhondai‐Mhuri, Nyaradzo Mgodi, Rebecca Berhanu, Jennifer Farrior, Estelle Piwowar‐Manning, Susan L. Ford, Craig W. Hendrix, Alex R. Rinehart, James F. Rooney, Adeola Adeyeye, Raphael J. Landovitz, Myron S. Cohen, Mina C. Hosseinipour, Mark A. Marzinke, the HPTN 084 Study Team

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The Canadian Multicentre MAC Treatment Study by Stephen D Shafran, The Canadian HIV Trials Network

“…Collaborative, Canadian, multicentre clinical trials in HIV disease can be successfully implemented.…”
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To Live or to Die: Prosurvival Activity of PPARγ in Cancers by Y. Lynn Wang, Qi Miao

“…We discuss the following five aspects of the nuclear hormone receptor and its agonists: (1) relative expression of PPARγ in human tumor versus normal tissues; (2) receptor-dependent proneoplastic effects; (3) impact of PPARγ and its agonists on tumors in animal models; (4) clinical trials of thiazolidinediones (TZDs) in human malignancies; (5) TZDs as chemopreventive agents in epidemiology studies. …”
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Therapeutics in paediatric genetic diseases: current and future landscape by Ai Ling Koh, Saumya Shekhar Jamuar

“…Specifically, gene therapy has been shown to be effective in various clinical trials, and indeed, these trials have led to regulatory approvals, paving the way for gene therapies for other types of PGDs. …”
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Radioimmunotherapy: A Specific Treatment Protocol for Cancer by Cytotoxic Radioisotopes Conjugated to Antibodies by Hidekazu Kawashima

“…This review outlines the fundamentals of RIT and current knowledge of the preclinical/clinical trials for cancer treatment.…”
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Efficacy of the herbal preparation STW 5 in multi-target therapy of functional dyspepsia by A. A. Sheptulin, V. O. Kaybysheva

“…Mechanism of action includes effect on motility of the stomach and intestine, visceral sensitivity along with anti-inflammatory and cytoprotective effects. Controlled clinical trials have confirmed high efficacy of Iberogast® at treatment of FD (including pediatric practice) as well as good tolerability of the drug.Conclusion. …”
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Number of Patients per Cohort and Sample Size Considerations Using Dose Escalation with Overdose Control by Mourad Tighiouart, André Rogatko

“…The main objective of cancer phase I clinical trials is to determine a maximum tolerated dose (MTD) of a new experimental treatment. …”
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Exact Group Sequential Methods for Estimating a Binomial Proportion by Zhengjia Chen, Xinjia Chen

“…Illustrative examples are given for applications in clinical trials.…”
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Sporadic inclusion body myositis in the rheumatology clinic by Fernando Henrique Carlos de Souza, Gustavo Luiz Behrens Pinto, Jean Marcos de Souza, Pablo Arturo Olivo Pallo, Leonardo Santos Hoff, Samuel Katsuyuki Shinjo

“…Although there have been no robust clinical trials, training exercise/physiotherapy should be prescribed regularly in sIBM patients.…”
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Eosinophilic gastroenteritis – a manifestation of an allergic disease in the gastrointestinal tract? Part 2. Treatment by Andrzej Kuźmiński, Tomasz Rosada, Justyna Przybyszewska, Natalia Ukleja-Sokołowska, Zbigniew Bartuzi

“…Unfortunately, there is still a lack of well-designed, prospective. and randomized clinical trials involving large groups of patients with EGE and assessing the effectiveness of individual treatments. …”
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Glucocorticoids and Preterm Hypoxic-Ischemic Brain Injury: The Good and the Bad by Laura Bennet, Joanne O. Davidson, Miriam Koome, Alistair Jan Gunn

“…Fetuses at risk of premature delivery are now routinely exposed to maternal treatment with synthetic glucocorticoids. In randomized clinical trials, these substantially reduce acute neonatal systemic morbidity, and mortality, after premature birth and reduce intraventricular hemorrhage. …”
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