Antitumor Responses of Invariant Natural Killer T Cells by Jennie B. Altman, Adriana D. Benavides, Rupali Das, Hamid Bassiri

“…Finally, we review the successes and failures of clinical trials employing iNKT cell-based immunotherapies and explore the future prospects for the use of such strategies.…”
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Systematic Review of the Relationship between Acute and Late Gastrointestinal Toxicity after Radiotherapy for Prostate Cancer by Matthew Sean Peach, Timothy N. Showalter, Nitin Ohri

“…While numerous strategies to prevent gastrointestinal injury have been studied, clinical trials concentrating on late toxicity have been difficult to carry out. …”
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Metformin Ameliorates D-Galactose-Induced Senescent Human Bone Marrow-Derived Mesenchymal Stem Cells by Enhancing Autophagy by Pingting Ye, Lei Feng, Dan Zhang, Ruihao Li, Yixuan Wen, Xiaohan Tong, Shuo Shi, Chunyan Dong

“…Human bone marrow-derived mesenchymal stem cells (hBMSCs) are promising candidates for stem cell therapy in clinical trials. Applications of hBMSCs in clinical therapy are limited by cellular senescence due to long-term ex vivo expansion. …”
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Advanced In Vitro Models for Preclinical Drug Safety: Recent Progress and Prospects by Dileep G. Nair, Ralf Weiskirchen

“…Differences in physiology between humans and animals or cell lines contribute to the failure of many drug programs during clinical trials. The use of advanced in vitro systems that closely mimic human physiology, such as organ-on-a-chip models like gut–liver-on-a-chip, can be crucial in improving drug efficacy while minimizing toxicity. …”
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The Role of Organelle Stresses in Diabetes Mellitus and Obesity: Implication for Treatment by Yi-Cheng Chang, Siow-Wey Hee, Meng-Lun Hsieh, Yung-Ming Jeng, Lee-Ming Chuang

“…Further results from clinical trials are eagerly awaited.…”
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Verteporfin Photodynamic Therapy Combined with Intravitreal Ranibizumab for Polypoidal Choroidal Vasculopathy Controversy Concerning Long-Term Followup by Maribel Fernández, María Gil, Francisco Gomez-Ulla, Pablo Charlón

“…These data need to be confirmed in large, prospective, and controlled clinical trials which are randomized and carried out over a long period.…”
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Submacular Injection of Ranibizumab as a New Surgical Treatment for Refractory Diabetic Macular Edema by Samir M. El-Baha, Ahmed M. Abdel Hadi, Mahmoud A. Abouhussein

“…The study has been registered in Contact ClinicalTrials.gov PRS Identifier: NCT03975088.…”
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The Effects of Uncomplicated Cataract Surgery on Retinal Layer Thickness by Ali Kurt, Raşit Kılıç

“…This study was registered with Australian New Zealand Clinical Trials Registry (ANZCTR): ACTRN12618000763246.…”
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A Comprehensive Review of the Development and Therapeutic Use of Antivirals in Flavivirus Infection by Aarti Tripathi, Shailendra Chauhan, Renu Khasa

“…Various approaches have been extensively utilized in clinical trials for antiviral development, targeting virus entry, replication, polyprotein synthesis and processing, and egress pathways exploiting virus as well as host proteins. …”
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Multimodal MRI Neuroimaging Biomarkers for Cognitive Normal Adults, Amnestic Mild Cognitive Impairment, and Alzheimer's Disease by Ai-Ling Lin, Angela R. Laird, Peter T. Fox, Jia-Hong Gao

“…Further developments of these techniques and the establishment of promising neuroimaging biomarkers will enhance our ability to diagnose aMCI and AD in their early stages and improve the assessment of therapeutic efficacy in these diseases in future clinical trials.…”
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Extended Peritoneal Dialysis and Renal Recovery in HIV-Infected Patients with Prolonged AKI: A Report of 2 Cases by Donlawat Saengpanit, Pongpratch Puapatanakul, Piyaporn Towannang, Talerngsak Kanjanabuch

“…Its efficacy in providing fluid and small solute removal has also been demonstrated in clinical trials and is equivalent to hemodialysis (HD). …”
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Brain-Derived Neurotrophic Factor and Nerve Growth Factor Therapeutics for Brain Injury: The Current Translational Challenges in Preclinical and Clinical Research by Serena-Kaye Sims, Brynna Wilken-Resman, Crystal J. Smith, Ashley Mitchell, Lilly McGonegal, Catrina Sims-Robinson

“…However, the translation of these studies into clinical trials has been limited. Preclinical experiments have largely failed to result in significant impacts in clinical research. …”
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Comparative Analysis of the Efficiency of Medicinal Plants for the Treatment and Prevention of COVID-19 by Viktor Kamkin, Aidana Kamarova, Baurzhan Shalabayev, Assyltas Kussainov, Marat Anuarbekov, Serik Abeuov

“…It is advisable to conduct further clinical trials for the treatment and rehabilitation of COVID-19 using preparations from this plant.…”
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Possible factors responsible for increased risk of tendon injuries during strength training in adult patients: systematic review by Zbigniew Wroński, Burim Gjinovci, Mario Klasic

“…Material and methods: A search was conducted in June and July 2023 in PubMed/Medline, EMBASE, Science Direct, PEDro, and Cochrane databases. Clinical trials, meta-analyses, randomized controlled trials, reviews, and systematic reviews published within the last ten years were included if they considered strength and resistance training as risk factors for tendon injuries. …”
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Update on Nonsurgical Lung Volume Reduction Procedures by J. Alberto Neder, Denis E. O’Donnell

“…ELVR procedures are currently available in selected Canadian research centers as part of ethically approved clinical trials. If a decision is made to offer an ELVR procedure, one-way valves are the first option in the presence of complete lobar exclusion and no significant collateral ventilation. …”
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Effects of using wearable devices to monitoring physical activity in pulmonary rehabilitation programs for chronic respiratory diseases: A systematic review protocol. by Thaianne Rangel Agra Oliveira, Ana Tereza do Nascimento Sales Figueiredo Fernandes, Thayla Amorim Santino, Fernanda Elizabeth Pereira da Silva Menescal, Patrícia Angélica de Miranda Silva Nogueira

“…We will include baseline data from randomized clinical trials reporting the use of wearable devices for monitoring physical activity in protocols for pulmonary rehabilitation programs for chronic respiratory diseases. …”
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(Mesenchymal) Stem Cell-Based Therapy in Cisplatin-Induced Acute Kidney Injury Animal Model: Risk of Immunogenicity and Tumorigenicity by Ž. Večerić-Haler, A. Cerar, M. Perše

“…Since the risk of tumorigenicity of particular therapy as well as the immune response to solid or cell grafts is a major issue in clinical trials, the aim of the present paper is to critically summarize the results of MSC transplantation on animal models of AKI, particularly cisplatin-induced animal models, and to expose results and main concerns about immunogenicity and tumorigenicity of transplanted MSCs, two important issues that need to be addressed in future studies.…”
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Pre-trained convolutional neural network with transfer learning by artificial illustrated images classify power Doppler ultrasound images of rheumatoid arthritis joints by Jun Fukae, Yoshiharu Amasaki, Yuichiro Fujieda, Yuki Sone, Ken Katagishi, Tatsunori Horie, Tamotsu Kamishima, Tatsuya Atsumi

“…The study was registered in UMIN Clinical Trials Registry (UMIN000054321). Results A total of 156 clinical joint ultrasound images from 74 patients with RA were included. …”
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Pharmacotherapy of Peptic Ulcer Disease by F Molina, MM Vohra, CN Williams

“…Combination therapy has not yet proved to be better than single drug therapy; however, the number of studies is still small, and more clinical trials are necessary. Resistant ulcers have demonstrated that acid is one of several etiological factors and that more research is needed to elucidate the reason(s) for refractoriness. …”
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The Natural History of Pancreatic Cancer in Manitoba: A Population Based Study by Jack Martin, Brian H Weinerman

“…The poor prognosis of all individuals confirms the rationale of trying to develop better treatments for all stages of disease, and stage and pathological differentiation should be taken into account when designing clinical trials.…”
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