Genomic characterization of chronic lymphocytic leukemia in patients of African ancestry by Cecilia Bonolo de Campos, Chantal E. McCabe, Laura A. Bruins, Daniel R. O’Brien, Sochilt Brown, Renee C. Tschumper, Cristine Allmer, Yuan Xiao Zhu, Kari G. Rabe, Sameer A. Parikh, Neil E. Kay, Huihuang Yan, James R. Cerhan, John N. Allan, Richard R. Furman, J. Brice Weinberg, Danielle M. Brander, Diane F. Jelinek, Marta Chesi, Susan L. Slager, Esteban Braggio

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Evaluation of efficacy and safety of coenzyme Q10 in pediatric hemodialysis patients: a randomized controlled trial by Salma A. Rahman Sharaf, Sarah Farid Fahmy, Heba M. Adel Abou Zaghla, Ahmed Hussein Hassan, Sara Mahmoud Zaki

“…Abstract Background There is evidence from clinical trials that coenzyme Q10 significantly improves mitochondrial function and decreases oxidative stress and cardiovascular disease in adult hemodialysis patients. …”
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Damoctocog Alfa Pegol, a PEGylated B-domain Deleted Recombinant Extended Half-life Factor VIII for the Treatment of Hemophilia A: A Product Review by Mark T. Reding, Shadan Lalezari, Gili Kenet, Giovanni Di Minno, Jonathan Ducore, Alexander Solms, Anita Shah, Pål André Holme, Lone H. Poulsen, Karina Meijer, Mindy Simpson, Maria Elisa Mancuso

“…Damoctocog alfa pegol was generally well tolerated and none of the patients in any of the clinical trials, including the PROTECT VIII clinical program, HEM-POWR, or ongoing single-center studies, developed FVIII inhibitors. …”
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Stem Cell Therapy for the Treatment of Amyotrophic Lateral Sclerosis: Comparison of the Efficacy of Mesenchymal Stem Cells, Neural Stem Cells, and Induced Pluripotent Stem Cells by Lauren Frawley, Noam Tomer Taylor, Olivia Sivills, Ella McPhillamy, Timothy Duy To, Yibo Wu, Beek Yoke Chin, Chiew Yen Wong

“…Results: MSCs, derived from various tissues, show neuroprotective and regenerative qualities, with clinical trials suggesting potential benefits but limited by small sample sizes and non-randomised designs. …”
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Analysis of pulmonary sequestration cases, based on the 11-year birth defects surveillance data of Changsha hospitals by Ruobin Xie, Tao-Sha Wang, Yanling Wang, Wei-Dong Wang

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Swiss chiropractic practice-based research network and musculoskeletal pain cohort pilot study: protocol of a nationwide resource to advance musculoskeletal health services researc... by Milo A Puhan, Viktor von Wyl, Alice Kongsted, Cesar A Hincapié, Léonie Hofstetter, Rahim Lalji

“…Findings will be reported to stakeholders after each study phase, presented at local and international conferences, and disseminated through peer-reviewed publications.Study pre-registration Phase I—Swiss chiropractic PBRN (ClinicalTrials.gov identifier: NCT05046249); Phase 2—Swiss chiropractic cohort (Swiss ChiCo) pilot study (ClinicalTrials.gov identifier: NCT05116020).…”
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Endoscopic Dilation with Bougies versus Balloon Dilation in Esophageal Benign Strictures: Systematic Review and Meta-Analysis by Iatagan R. Josino, Antônio C. Madruga-Neto, Igor B. Ribeiro, Hugo G. Guedes, Vitor O. Brunaldi, Diogo T. H. de Moura, Wanderley M. Bernardo, Eduardo G. H. de Moura

“…We included 5 randomized clinical trials (RCTs), totalizing 461 patients. Among them, 151 were treated with bougie dilation and 225 underwent balloon dilation. …”
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Translational Science in Vascular Aging: From Bench to Bedside—Insights from a VascAgeNet Roundtable by Elisabetta Bianchini, Lynn Roth, Pierre Boutouyrie, Smriti Badhwar, Achim Schwarz, Vincenzo Gemignani, Rosa Maria Bruno, Bernhard Hametner, Chloe Park, Giacomo Pucci, Ioana Mozos, Dimitrios Terentes-Printzios, Rachel E. Climie, Andrea Guala, Jordi Alastruey, Christopher C. Mayer

“…Pragmatic and registry-based clinical trials offer viable alternatives to traditional randomized controlled trials, facilitating real-world applicability. …”
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Resting state EEG in young children with Tuberous Sclerosis Complex: associations with medications and seizures by Caitlin C. Clements, Anne-Michelle Engelstad, Carol L. Wilkinson, Carly Hyde, Megan Hartney, Alexandra Simmons, Helen Tager-Flusberg, Shafali Jeste, Charles A. Nelson

“…Such a biomarker could be useful in clinical trials as an endpoint or predictor of treatment response. …”
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IMRAS-Immunization with radiation-attenuated Plasmodium falciparum sporozoites by mosquito bite: Cellular immunity to sporozoites, CSP, AMA1, TRAP and CelTOS. by Martha Sedegah, Michael R Hollingdale, Harini Ganeshan, Maria Belmonte, Jun Huang, Arnel Belmonte, Sandra Inoue, Rachel Velasco, Bradley Hickey, Nimfa Teneza-Mora, Joanne Lumsden, Sharina Reyes, Jo Glenna Banania, Anatalio Reyes, Ivelese Guzman, Thomas L Richie, Judith E Epstein, Eileen Villasante

“…<h4>Trial registration</h4>ClinicalTrials.gov NCT01994525.…”
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Differences in immune-related toxicity between PD-1 and PD-L1 inhibitors: a retrospective cohort study in patients with advanced cancer by Cecilia Olsson Ladjevardi, Marcus Skribek, Anthoula Koliadi, Viktoria Rydén, Ali Inan El-Naggar, Evangelos Digkas, Antonios Valachis, Gustav J. Ullenhag

“…Pooled analyses based on clinical trials show a favorable toxicity profile for treatment with PD-L1 compared to PD-1 inhibitors. …”
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Cadaveric simulation versus standard training for postgraduate trauma and orthopaedic surgical trainees: protocol for the CAD:TRAUMA study multicentre randomised controlled educati... by Damian Griffin, Hannah K James, Giles T R Pattison, Joanne D Fisher

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Impairment of cocaine-mediated behaviours in mice by clinically relevant Ras-ERK inhibitors by Alessandro Papale, Ilaria Maria Morella, Marzia Tina Indrigo, Rick Eugene Bernardi, Livia Marrone, Francesca Marchisella, Andrea Brancale, Rainer Spanagel, Riccardo Brambilla, Stefania Fasano

“…Furthermore, a screening of small therapeutics currently in clinical trials for cancer therapy revealed PD325901 as a brain-penetrating drug that blocks ERK signalling in the nanomolar range. …”
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Title not available by Carlos Sverdloff, Vinícius Marcondes-Rezende, Ligia de Cassia-Val, Ma. Elena Cedano-Limón, Lygia Nerath-Bonanato, Murali Pendela, Mohammad H. Badii, Sreekanth Kakarla, Nelly C. Lemus-Castro

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Pain Reduction in Patellofemoral Knee Patients During 3-Month Intervention with Biomechanical and Sensorimotor Foot Orthoses: A Randomized Controlled Clinical Study by Steven Simon, Andreas Heine, Jonas Dully, Carlo Dindorf, Oliver Ludwig, Michael Fröhlich, Stephan Becker

“…This trial was registered in the WHO International Clinical Trials Registry Platform (ICTRP) and German Clinical Trials Register (DRKS00035082).…”
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Artificial intelligence methods applied to longitudinal data from electronic health records for prediction of cancer: a scoping review by Victoria Moglia, Owen Johnson, Gordon Cook, Marc de Kamps, Lesley Smith

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In Silico Evaluation of Algorithm-Based Clinical Decision Support Systems: Protocol for a Scoping Review by Michael Dorosan, Ya-Lin Chen, Qingyuan Zhuang, Shao Wei Sean Lam

“…Such CDS systems are traditionally assessed via controlled but resource-intensive clinical trials. ObjectiveThis paper presents a review protocol for preimplementation in silico evaluation methods to enable broadened impact analysis under simulated environments before clinical trials. …”
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Experiences of change following a blended intervention for adults with ADHD and emotion dysregulation: a qualitative interview study by Emilie S. Nordby, Viktor Schønning, Alice Barnes, Hayley Denyer, Jonna Kuntsi, Astri J. Lundervold, Frode Guribye

“…Trial registration Registered on 21st November 2022 at ClinicalTrials.gov. ClinicalTrials.gov ID: NCT05644028.…”
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Statistical analysis plan for a pragmatic randomised controlled trial comparing enhanced acceptance and commitment therapy plus ( +) added to usual aftercare versus usual aftercare... by Clare Robinson, Trudie Chalder, Paul McCrone, Olivier Quintin, Evdoxia Gkaintatzi, Imran Khan, Stephanie J. C. Taylor, on behalf of the SURECAN GROUP

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Rasch-Built Overall Amyotrophic Lateral Sclerosis Disability Scale as a Novel Tool to Measure Disease Progression by Can Sun, Yong Chen, Lu Xu, Wenjing Wang, Nan Zhang, Christina N. Fournier, Nan Li, Dongsheng Fan

“…<b>Background:</b> A valuable outcome measure to monitor amyotrophic lateral sclerosis (ALS) disease progression is crucial in clinical trials. Rasch-Built Overall Amyotrophic Lateral Sclerosis Disability Scale (ROADS) is a novel questionnaire assessing ALS disability. …”
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