Integrins and Their Extracellular Matrix Ligands in Lymphangiogenesis and Lymph Node Metastasis by Jie Chen, J. Steven Alexander, A. Wayne Orr

“…Work over the past 40 years, varying from molecular examination to clinical trials, verified this hypothesis and identified a host of therapeutic targets to limit tumor angiogenesis, including the integrin family of extracellular matrix receptors. …”
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Proangiogenic Features of Mesenchymal Stem Cells and Their Therapeutic Applications by Hongyan Tao, Zhibo Han, Zhong Chao Han, Zongjin Li

“…Accordingly, several clinical trials using MSCs have been performed and revealed that MSCs may improve relevant clinical parameters in patients with vascular diseases. …”
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Call for a consensual definition of dyslipidemia in coronary angiography trials by Aurélien Clerc, Mario Togni, Stephane Cook

“…Dyslipidemia is extensively analyzed in clinical trials investigating its role as a risk factor for coronary artery disease (CAD). …”
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MSCs: Delivery Routes and Engraftment, Cell-Targeting Strategies, and Immune Modulation by Thomas J. Kean, Paul Lin, Arnold I. Caplan, James E. Dennis

“…Mesenchymal stem cells (MSCs) are currently being widely investigated both in the lab and in clinical trials for multiple disease states. The differentiation, trophic, and immunomodulatory characteristics of MSCs contribute to their therapeutic effects. …”
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Promising role of voxelotor in managing sickle cell disease in children: a narrative review by Amit Agrawal, Gaurav Jadon, Japna Singh, Dalwinder Janjua

“…The group that received voxelotor also showed a greater decrease in hemolytic markers but a comparable incidence of side effects. Six ongoing clinical trials also sought to ascertain the effectiveness and safety of high-dose voxelotor when administered to children younger than 12 years. …”
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Angiotensin-Converting Enzyme 2: The First Decade by Nicola E. Clarke, Anthony J. Turner

“…In light of the entrance of human recombinant ACE2 into clinical trials, we discuss the potential use of ACE2 as a therapeutic and highlight some pertinent questions that still remain unanswered about ACE2.…”
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Behavioral Intervention versus Pharmacotherapy or Their Combinations in the Management of Overactive Bladder Dysfunction by Khanh Tran, Robert M. Levin, Shaker A. Mousa

“…We carried out a comprehensive systematic review of the available literature on the effectiveness of behavioral intervention, anticholinergic drugs, and their combination in the management of adults with overactive bladder, with emphasis on results from clinical trials and primary literature. Each treatment intervention is efficacious, and the choice should be based on the patient's severity of symptoms, tolerability, compliance and satisfaction with the treatment. …”
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Novel Immunotherapeutic Approaches for Neuroblastoma and Malignant Melanoma by Fabio Morandi, Francesco Frassoni, Mirco Ponzoni, Chiara Brignole

“…Indeed, several immunotherapeutic clinical trials have been performed and some of them also resulted beneficial. …”
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THE ROLE OF ANTIBIOTICS IN TREATING SALIVARY GLAND INFECTIONS by Irina Adriana Beuran, Simona Claudia Stefan, Elisabeta Maria Vasca, Robert Marius Grosu, Marius Petrea, Gabriel-Valeriu Popa, Bogdan Oprisan

“…The effectiveness of antibiotic treatment is well documented in the medical literature, with clinical trials indicating a significant reduction in symptoms and prevention of severe complications when treatment is administered correctly. …”
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Probiotics for Alleviating Alcoholic Liver Injury by Zelin Gu, Yanlong Liu, Shumeng Hu, Ying You, Jiaqi Wen, Wancong Li, Yuhua Wang

“…Many animal experiments and clinical trials showed that probiotics are effective for the treatment of alcoholic liver disease. …”
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Lipopeptide adjuvants for antibiotics and vaccines: the future step in the fight against multidrug-resistant and extensively drug-resistant pathogens by Chloé O. Sebilleau, Steven J. Sucheck

“…Findings discussed in this review could be applied to the development of safer, more effective adjuvants, that could expand the use or repurpose current antibiotics or improve vaccination results in future clinical trials.…”
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The Key to Unlocking the Chemotherapeutic Potential of PPARγ Ligands: Having the Right Combination by Graham Skelhorne-Gross, Christopher J. B. Nicol

“…Despite extensive preclinical evidence that peroxisome proliferator-activated receptor (PPAR)γ activation protects against tumourigenesis, results from a few clinical trials using PPARγ ligands as monotherapy show modest success. …”
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A Case of Rituximab Use as an Induction and Maintenance of Remission in ANCA-Associated Vasculitis by Neveen Awad, Shahd Hafiz, Abdurahman Albeity, Hani Almoallim

“…There are no randomized clinical trials addressing rituximab effect in induction and remission at the same time. …”
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Advances in sodium-glucose transporter protein 2 inhibitors and tumors by Jiaqi Wang, Wenyong Yang

“…The aim of this article is to provide a comprehensive understanding of the research progress of SGLT2i in different tumors by integrating the latest studies and to encourage further exploration of SGLT2i therapies in clinical trials. This could pave the way for more effective management strategies and improved outcomes for tumor patients.…”
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The Potential Role of Liver Transplantation as a Treatment Option in Colorectal Liver Metastases by Pål-Dag Line, Morten Hagness, Svein Dueland

“…There is an increasing interest in liver transplantation in these patients in the transplant community, and currently 4 clinical trials are active and are recruiting.…”
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Effect of Cordyceps militaris extract containing cordycepin on the adipogenesis and lipolysis of adipocytes by Kazuya Kusama, Kodai Oka, Yumi Yashiro, Kanoko Yoshida, Hiroaki Miyaoka, Kazuhiro Tamura

“…Further studies, including clinical trials, are required to validate the clinical potential of cordycepin.…”
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Crosstalk between Gut Microbiota and Cancer Immunotherapy: Present Investigations and Future Perspective by Yuhui Tang, Qiaoting Cai, Zhi Tian, Wenkuan Chen, Hailin Tang

“…To better grasp the underlying crosstalk between gut microbiota and immunotherapy, more experimental and clinical trials are indispensable for the customized gut microbiota-based treatments in cancer patients undergoing immunotherapy.…”
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Active Surveillance for Localized Prostate Cancer – Current Practices and Recommendations by Jennifer N. Wu, Marc A. Dall'Era

“…Data from these reports provide information for selecting men for this approach, as well as for following them over time and determining triggers for further intervention. Ongoing clinical trials with watchful waiting and active surveillance for prostate cancer will ultimately provide improved evidence for managing early, localized disease.…”
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Myelodysplastic Syndrome with Transfusion Dependence Treated with Venetoclax by Waqas Jehangir, Alexander Karabachev, Taimoor Jahangir, Elvira Umyarova

“…Venetoclax, an inhibitor of the antiapoptotic protein BCL-2 used to treat chronic lymphocytic leukemia, is currently being evaluated in clinical trials as a monotherapy in high-risk myelodysplastic syndromes/acute myeloid leukemia. …”
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Repository Corticotropin Injection for Treatment of Idiopathic Inflammatory Myopathies by Aarat Patel, Georgia Seely, Rohit Aggarwal

“…Overall, these results are encouraging and suggest that randomized, controlled clinical trials applying RCI to dermatomyositis and polymyositis are warranted.…”
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