Perspectives for Clinical Translation of Adipose Stromal/Stem Cells by Mimmi Patrikoski, Bettina Mannerström, Susanna Miettinen

“…Moreover, the current status of clinical trials applying ASCs and the patent landscape in the field of ASC research are presented. …”
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Usefulness of Therapeutic Laser for Pain Management in Orthodontic Treatment by Karen Daniela Villavicencio Córdova, Katherim Anahí Cortez Campaña, Pamela Jeanneth Salinas Villacis

“…Of the total selected, 13 were bibliographic review articles, 20 clinical trials and 1 case report. It was determined that the recommended wavelength for a favorable and relieving result to exist, in the areas of pain where the laser is applied, is 810 nm (nanometers) and that the laser sessions can be applied daily or intermittently. with a maximum irradiation of 10 seconds in each area of pain. …”
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Does Fundus Fluorescein Angiography Procedure Affect Ocular Pulse Amplitude? by Gökhan Pekel, Semra Acer, Ramazan Yagci, Ebru Nevin Cetin, Mehmet Can Hiraali, Hüseyin Kaya

“…Although both mean OPA and IOP values were decreased after FFA procedure, the difference was not statistically significant. This clinical trial is registered with Australian New Zealand Clinical Trials Registry number ACTRN12613000433707.…”
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Exercise Induced Adipokine Changes and the Metabolic Syndrome by Saeid Golbidi, Ismail Laher

“…In this paper we briefly describe the pathophysiologic role of four important adipokines (adiponectin, leptin, TNF-α, and IL-6) in the metabolic syndrome and review some of the clinical trials that monitored these adipokines as a clinical outcome before and after exercise.…”
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Chimeric Antigen Receptor-Modified T Cells for Solid Tumors: Challenges and Prospects by Yelei Guo, Yao Wang, Weidong Han

“…Recent studies have highlighted the successes of chimeric antigen receptor-modified T- (CART-) cell-based therapy for B-cell malignancies, and early phase clinical trials have been launched in recent years. The few published clinical studies of CART cells in solid tumors have addressed safety and feasibility, but the clinical outcome data are limited. …”
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Selection of the appropriate design in biomedical research: foundations and considerations for evidence-based practice. Part I by Raúl Aguilera Eguía, Ángel Roco Videla, Olga Patricia López Soto, Brenda Herrera Serna, Georgiy Polevoy Polevoy, Héctor Fuentes Barria

“…Research designs can be classified as primary, such as randomized clinical trials, or secondary, such as reviews. They are also divided into experimental, which evaluate interventions, and observational, which simply observe without intervening. …”
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Adjuvants for peptide-based cancer vaccines by Willem W Overwijk, Hiep Khong

“…One reason for this difference may be the use of potent, effective vaccine adjuvants in animal models, vs. the use of safe, but very weak, vaccine adjuvants in clinical trials. As vaccine adjuvants dictate the type and magnitude of the T cell response after vaccination, it is critical to understand how they work to design safe, but also effective, cancer vaccines for clinical use. …”
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A Brief Review on Medicinal Plants-At-Arms against COVID-19 by Shivani Srivastava, Fangzhou He, Yuanding Huang, Meng Niu, Alok Adholeya, Weng Kung Peng

“…Accordingly, this review highlights the unprecedented opportunities offered by medicinal plants and their compounds, candidates as the therapeutic agent, against COVID-19 by acting as viral protein inhibitors and immunomodulator in (32 clinical trials and hundreds of in silico experiments) conjecture with modern science. …”
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Palmitoylethanolamide: A Natural Body-Own Anti-Inflammatory Agent, Effective and Safe against Influenza and Common Cold by J. M. Keppel Hesselink, Tineke de Boer, Renger F. Witkamp

“…However, it is less known that 6 clinical trials in a total of nearly 4000 people were performed and published last century, specifically studying PEA as a therapy for influenza and the common cold. …”
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Mesenchymal Stem Cells and Cardiovascular Disease: A Bench to Bedside Roadmap by Manuel Mazo, Miriam Araña, Beatriz Pelacho, Felipe Prosper

“…In this review, we will focus on their use in the therapy of myocardial infarction, looking at their characteristics, in vitro and in vivo mechanisms of action, as well as clinical trials.…”
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Selecting the appropriate design in biomedical research: experimental studies. Part II by Raúl Aguilera Eguía, Ángel Roco Videla, Olga Patricia López Soto, Brenda Herrera Serna, Héctor Fuentes Barria, Mariana Melo Lonconao

“…Considerations are issued from the historical evolution and theoretical foundations, to the practical implementation of experimental designs, with a particular focus on randomized clinical trials, for their robustness in demonstrating causal relationships and influence in optimizing clinical decisions. …”
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Experimental and Clinical Use of Therapeutic Hypothermia for Ischemic Stroke: Opportunities and Limitations by Tine Zgavc, An-Gaëlle Ceulemans, Sophie Sarre, Yvette Michotte, Said Hachimi-Idrissi

“…Several studies with TH in experimental models and small clinical trials have shown beneficial effects. Despite this, implementation into the clinical setting is still lacking due to methodological considerations as well as hypothermia-related complications. …”
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New Immunotherapeutic Approaches for Glioblastoma by Gustavo Ignacio Vázquez Cervantes, Dinora F. González Esquivel, Saúl Gómez-Manzo, Benjamín Pineda, Verónica Pérez de la Cruz

“…In this review, we summarize and discuss promising immunotherapies for GBM currently under preclinical investigation as well as in clinical trials.…”
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New Therapeutic Approaches for the Treatment of Rheumatoid Arthritis may Rise from the Cholinergic Anti-Inflammatory Pathway and Antinociceptive Pathway by Xiao Hua Pan, Jianxin Zhang, Xiaowei Yu, Ling Qin, Ligeng Kang, Peng Zhang

“…More preclinical experiments and clinical trials are required to confirm our viewpoint.…”
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Behavioural Assessment of Pediatric Pain by Ronald L Blount, Kristin A Loiselle

“…Two recent scholarly reviews of behavioural assessment methods were conducted by the Society of Pediatric Psychology Evidence-Based Assessment Task Force and the Pediatric Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials, which classified various instruments as well established, approaching well established or promising. …”
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Current Potential of Pantoprazole in Treatment and Prevention of Gastrointestinal Diseases by A. A. Sheptulin, S. S. Kardasheva, A. A. Kurbatova

“…Pantoprazole is considered among optimal PPIs for efficacy, safety and adherence on the basis of clinical trials for treatment and prevention of gastrointestinal diseases, systematic reviews and meta-analyses.…”
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Targeting Histone Deacetylases: A Novel Approach in Parkinson’s Disease by Sorabh Sharma, Rajeev Taliyan

“…In the recent past, studies with HDAC inhibitors result in beneficial effects in both in vivo and in vitro models of PD. Various clinical trials have also been initiated to investigate the possible therapeutic potential of HDAC inhibitors in patients suffering from PD. …”
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Serotonin and Its Receptor as a New Antioxidant Therapeutic Target for Diabetic Kidney Disease by Yu Yang, Hui Huang, Zheng Xu, Jun-kai Duan

“…We conclude that 5-HTR is a potential therapeutic target for treating DKD, as it has been successfully applied in animal models and has currently being investigated in randomized and controlled clinical trials.…”
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Therapeutic implications for the PD-1 axis in cerebrovascular injury by James Feghali, Christopher M. Jackson

“…PD-1 agonism has already demonstrated success in clinical trials for rheumatoid arthritis and is being tested in other chronic inflammatory diseases. …”
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Cell Therapies for Heart Function Recovery: Focus on Myocardial Tissue Engineering and Nanotechnologies by Marie-Noëlle Giraud, Anne Géraldine Guex, Hendrik T. Tevaearai

“…The results of multiple clinical trials have already been reported, almost exclusively involving the direct injection of stem cells. …”
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