A Randomized Trial of Ionic Silver Dressing to Reduce Surgical Site Infection After Gastrointestinal Surgery by Chihiro Kosugi, MD, Keiji Koda, MD, Hiroaki Shimizu, MD, Masato Yamazaki, MD, Kiyohiko Shuto, MD, Mikito Mori, MD, Akihiro Usui, MD, Hiroyuki Nojima, MD, Satoshi Endo, MD, Hiroo Yanagibashi, MD, Hidehito Arimitsu, MD, Toru Tochigi, MD, Tetsutaro Sazuka, MD, Mihono Hirota, MD, Hideyuki Kuboki, MD

“…The primary end point was superficial SSI within 30 days after surgery (UMIN Clinical Trials Registry ID: 000043081). Results:. A total of 865 patients (427 study group, 438 control group) were qualified for primary end-point analysis. …”
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Feasibility, acceptability and preliminary effects of a social network-based, peer-led HIV self-testing intervention among men in two Ugandan fishing communities, 2022 by Joseph KB Matovu, Aisha Twahiri Namwama, Linda Kemigisha, Geoffrey Taasi, Jennipher Nakabugo, Julius Wandabwa, Laura M. Bogart, Nuraan Fakier, Rhoda K. Wanyenze, Peter Olupot-Olupot, Joshua Musinguzi, David Serwadda

“…Trial registration ClinicalTrials.Gov: NCT05685498 (retrospectively registered on January 17, 2023).…”
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Artemether/Lumefantrine for the Treatment of P. malariae in a Patient on Hemodialysis by Rita Patrocínio-Jesus, João Cunha, Diva Trigo, Bárbara Flor-de-Lima, Patrícia Pacheco

“…There have been no clinical trials to assess the efficacy of this medication in patients with renal impairment. …”
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Tau-Reactive Endogenous Antibodies: Origin, Functionality, and Implications for the Pathophysiology of Alzheimer’s Disease by Lenka Hromadkova, Saak Victor Ovsepian

“…Multiple anti-tau antibodies inhibiting the formation and propagation of cytotoxic tau or promoting its clearance and degradation have been tested in clinical trials, albeit with the inconclusive outcome. …”
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Digital Twins of Biological Systems: A Narrative Review by Ghufran A. Alsalloum, Nour M. Al Sawaftah, Kelly M. Percival, Ghaleb A. Husseini

“…The influence of DTs extends beyond healthcare and can revolutionize healthcare management, drug development, clinical trials, and various biomedical research fields…”
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Role of Inflammatory Cell Subtypes in Heart Failure by Derek Strassheim, Edward C. Dempsey, Evgenia Gerasimovskaya, Kurt Stenmark, Vijaya Karoor

“…Various types of immune cells are implicated in myocardial inflammation and include neutrophils, macrophages, eosinophils, mast cells, natural killer cells, T cells, and B cells. Recent clinical trials have targeted inflammatory cascades as therapy for heart failure with limited success. …”
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Long Term Safety of Infliximab by Thomas F Schaible

“…In several placebo controlled, randomized clinical trials and open trials, 771 patients have been given infliximab (a further 192 received placebo). …”
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The mitochondria as an emerging target of self-renewal in T-cell acute lymphoblastic leukemia by Majd A. Al-Hamaly, Evelyn Winter, Jessica S. Blackburn

“…Mitocans have shown promise in T-ALL both in vitro and in vivo, with some currently in early-phase clinical trials. However, due to challenges in studying LSCs in T-ALL, our understanding of how mitochondrial function influences self-renewal remains limited. …”
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The Renoprotective Actions of Peroxisome Proliferator-Activated Receptors Agonists in Diabetes by M. C. Thomas, K. A. Jandeleit-Dahm, C. Tikellis

“…This review will examine these direct and indirect actions of PPAR agonists in the diabetic kidney and explore recent findings of clinical trials of PPAR agonists in patients with diabetes.…”
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Electromyographic parameters for treatment of pelvic floor disorders in pregnant and postpartum women: A review protocol. by Alethéa Cury Rabelo Leitão, Silvia Oliveira Ribeiro Lira, Elizabel de Souza Ramalho Viana

“…A systematic review of randomized controlled experimental studies (clinical trials) and quasi-experimental studies in English, Portuguese or Spanish, which used electromyography as an intervention for treatment of pelvic floor disorders in pregnant or postpartum women up to 12 months after delivery will be performed in online databases (Scopus, Medline, Pedro, Scielo and Pubmed),. …”
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Toxicological Review of Anticancer Plants Used in Traditional Medicine in Morocco by Soufiane Drioua, Abha Cherkani-Hassani, Otman El-Guourrami, Mouna Ameggouz, Ahmed Zahidi, Abdelhakim Bouyahaya, Sayyed Ibrahim Shah, Yaser Mohammed Al-Worafi, Long Chiau Ming, Hanane Benzaied, Anass Doukkali

“…Further research, including preclinical and clinical trials, should be conducted to investigate the potential therapeutic benefits of these plants. …”
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Clinical Outcomes of Specific Immunotherapy in Advanced Pancreatic Cancer: A Systematic Review and Meta-Analysis by Jiang Chen, Guo Xiao-Zhong, Xing-Shun Qi

“…To evaluate the clinical outcomes of PC-specific immunotherapy, we performed a systematic review and meta-analysis of the relevant published clinical trials. The effects of specific immunotherapy were compared with those of nonspecific immunotherapy and the meta-analysis was executed with results regarding the overall survival (OS), immune responses data, and serum cancer markers data. …”
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Convergence of evolving artificial intelligence and machine learning techniques in precision oncology by Elena Fountzilas, Tillman Pearce, Mehmet A. Baysal, Abhijit Chakraborty, Apostolia M. Tsimberidou

“…., digital twins, in order to provide the necessary information to design or expedite the conduct of clinical trials. Currently, many operational and technical challenges exist related to data technology, engineering, and storage; algorithm development and structures; quality and quantity of the data and the analytical pipeline; data sharing and generalizability; and the incorporation of these technologies into the current clinical workflow and reimbursement models.…”
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Rare epithelial gastric cancers: a review of the current treatment knowledge by Angelica Petrillo, Margaret Ottaviano, Luca Pompella, Emilio Francesco Giunta, Pasquale Pisapia, Gianpaolo Marte, Andrea Tufo, Sara Di Lorenzo, Jessica Orefice, Chiara Miceli, Umberto Malapelle, Bruno Daniele, Ferdinando De Vita

“…Our main aim is to translate the scarce evidence from the literature into daily clinical practice, never forgetting that all the clinicians dedicated to rare GCs should encourage such patients’ enrolment in clinical trials and promote international collaborations. …”
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Clinical Biology and Potential Use of Thrombopoietin by Russell Basser

“…However, one of these agents, interleukin-11, was successfully shown to reduce the incidence of severe thrombocytopenia in patients receiving dose-intensive chemotherapy, and has now received approval from the United States Food and Drug Administration for this purpose. Initial clinical trials of thrombopoietin, the central regulator of megakaryocytopoiesis and thrombopoiesis, and its analogues showed these agents to be the most potent stimulators of thrombopoiesis and to be associated with few adverse effects. …”
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Is There a Role of Targeted Agents in the Management of Adrenocortical Cancers? by M. W. Saif, B. Fallon, K. N. Syrigos

“…Recent developments in the understanding of the pathogenesis of ACC have led to multiple clinical trials involving targeted agents in the management of ACC. …”
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Linezolid and serotonin syndrome by Haytham A. Wali

“…Assessments of the pharmacological mechanisms, large-scale clinical trials, and cohort studies are essential to elucidate risk factors and outcomes. …”
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Selective Decontamination of the Digestive Tract Reduces Pneumonia and Mortality by Lenneke E. M. Haas, Marcus J. Schultz

“…Selective decontamination of the digestive tract (SDD) has been subject of numerous randomized controlled trials in critically ill patients. Almost all clinical trials showed SDD to prevent pneumonia. Nevertheless, SDD has remained a controversial strategy. …”
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Extensive Longitudinal Transverse Myelitis Temporally Related to the Use of AZD1222, AstraZeneca COVID-19 Vaccine: Cerebrospinal Fluid Analysis and Recent Data Review by Paulo Diniz da Gama, Tiago Gomes de Alcantara, Rafaela Ramos Smaniotto, Penélope de Lima Petuco, Wammer Alves de Almeida, Rodrigo Assad Diiniz da Gama, Yara Dadalti Fragoso

“…Neurological complications such as transverse myelitis raise concerns as cases were observed in clinical trials. Cerebrospinal fluid analysis is routine in these cases and the characteristics of the abnormalities found are of great help not only in establishing the diagnosis but also in understanding this rare condition. …”
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Belzutifan for the treatment of renal cell carcinoma by Xiancheng Wu, David Lazris, Risa Wong, Scott S. Tykodi

“…Belzutifan has demonstrated activity in clinical trials as a front- and later-line therapy, and in combination with tyrosine kinase inhibitors. …”
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