Recanalization Therapies in Acute Ischemic Stroke: Pharmacological Agents, Devices, and Combinations by Vijay K. Sharma, Hock Luen Teoh, Lily Y. H. Wong, Jie Su, Benjamin K. C. Ong, Bernard P. L. Chan

“…Mechanical devices and approaches can achieve higher rates of recanalization but their safety and efficacy still need to be established in larger clinical trials. The field of acute revascularization is rapidly evolving, and various combinations of pharmacologic agents, mechanical devices, and novel microbubble/ultrasound technologies are being tested in multiple clinical trials.…”
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Application of Mild Therapeutic Hypothermia on Stroke: A Systematic Review and Meta-Analysis by Shaheen E. Lakhan, Fabricio Pamplona

“…Seven parallel-controlled clinical trials were included in the meta-analysis. Sample sizes ranged from 18 to 62 patients, yielding a total of 288. …”
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Sustainable reduction in sound levels on intensive care units through noise management - an implementation study by Sandra Witek, Claudia Schmoor, Fabian Montigel, Birgit Grotejohann, Sven Ziegler

“…Trial registration German Clinical Trials Register (DRKS): trial registration number: DRKS00025835; Date of registration: 12.08.2021.…”
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Perinatal emotional skills groups for women and birthing people with borderline personality disorder: outcomes from a feasibility randomised controlled trial by Paul Moran, Debra Bick, Lucy Biddle, Belinda Borries, Rebecca Kandiyali, Farah Mgaieth, Vivan Patel, Janice Rigby, Penny Seume, Vaneeta Sadhnani, Nadine Smith, Michaela Swales, Nicholas Turner

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Safety and efficacy of dual versus triple antithrombotic therapy (DAT vs TAT) in patients with atrial fibrillation following a PCI: a systematic review and network meta-analysis by Abdulaali R Almutairi, Renad M Altoukhi, Reema A Alshouimi, Shahad M Al Rammah, Mohammed Y Alzahrani, Abdulmajeed M Alshehri, Osamah M Alfayez, Majed S Al Yami, Omar A Almohammed

“…We aimed to compare the efficacy and safety of DAT regimens using a network meta-analysis (NMA) approach.Design A systematic review and NMA of randomised clinical trials.Methods We conducted a systematic literature review to identify relevant randomised clinical trials and performed a Bayesian NMA for International Society on Thrombosis and Haemostasis (ISTH) major or clinically relevant non-major (CRNM) bleeding, all-cause mortality, stroke, myocardial infarction (MI) and stent thrombosis outcomes. …”
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Current Situation and Consideration about Rehabilitation of Spinal Cord Injury by Anren ZHANG

“…This article reviews the epidemiology, pathophysiology and present situation of treatment for SCI, and points out that conducting epidemiological investigation, establishing unified evaluation criterion of curative effect, arranging randomized controlled clinical trials and searching for safe and effective methods are important. …”
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Immunotherapeutic Approaches in Triple-Negative Breast Cancer: State of the Art and Future Perspectives by Karima Oualla, Loay Kassem, Lamiae Nouiakh, Lamiae Amaadour, Zineb Benbrahim, Samia Arifi, Nawfel Mellas

“…Recently, immunotherapy is being extensively explored in TNBC and clinical trials have shown promising results. In this article, we tried to explain the rationale and mechanisms of targeting the immune system in TNBC, to report the results from recent clinical trials that put immunotherapy as a new standard of care in TNBC in addition to ongoing trials and future directions in the next decade.…”
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mRNA vaccines in the context of cancer treatment: from concept to application by Qiang Fu, Xiaoming Zhao, Jinxia Hu, Yang Jiao, Yunfei Yan, Xuchen Pan, Xin Wang, Fei Jiao

“…Additionally, we summarize preclinical studies and clinical trials to provide valuable insights into the current status of mRNA vaccines in cancer treatment. …”
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The recent landscape of RSV vaccine research by Karen Kelleher, Nadisha Subramaniam, Simon B. Drysdale

“…Recent advancements include nirsevimab, a long-acting mAb that has shown substantial efficacy in reducing medically attended RSV-related disease in infants, in phase III clinical trials, early regional and national real-world data. …”
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The methods of treatment of atrial fibrillation in patients with valvular heart disease by O.M. Grytsay, Y.V. Skybchyk, I.Y. Mokryk, E.V. Zhytyns’kiy, V.О. Kuts, О.J. Zharinov, B.M. Todurov

“…The article also presents the results of clinical trials in valvular atrial fibrillation, after surgical and complex treatment. …”
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Prediction of Survival Outcomes in Patients with Glioma Using Magnetic Resonance Imaging (MRI): A Systematic Review and Meta-Analysis by Mingfang Hu, Jinge Li, Zhangyu Li, Jian Shen

“…Methods: Review of the literature included the following databases: WHO International Clinical Trials Registry Platform; Google Scholar; Web of Science; PubMed; SIGLE; NYAM; Scopus; Randomized controlled trial (RCT); Virtual Health Library (VHL); Cochrane Collaboration; EMBASE; and Clinical Trials. …”
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Prostate-Specific Membrane Antigen-Based Therapeutics by Naveed H. Akhtar, Orrin Pail, Ankeeta Saran, Lauren Tyrell, Scott T. Tagawa

“…Anti-PSMA monoclonal antibody-drug conjugates have also been developed with completed and ongoing early-phase clinical trials. As PSMA is a selective antigen that is highly overexpressed in prostate cancer, anti-PSMA-based immunotherapy has also been studied and utilized in clinical trials.…”
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Neuroprotection as a Therapeutic Target for Diabetic Retinopathy by Cristina Hernández, Massimo Dal Monte, Rafael Simó, Giovanni Casini

“…Of central importance for clinical trials is the detection of retinal neurodegeneration in the clinical setting, and spectral domain optical coherence tomography seems the most indicated technique. …”
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OFFICIAL MEDICATIONS FOR ANTI-TUMOR GENE THERAPY by E. R. Nemtsova, O. A. Bezborodova, R. I. Yakubovskaya, A. D. Kaprin

“…This is a review of modern literature data of official medications for anti-tumor gene therapy as well as of medications that finished clinical trials.The article discusses the concept of gene therapy, the statistical analysis results of initiated clinical trials of gene products, the most actively developing directions of anticancer gene therapy, and the characteristics of anti-tumor gene medications.Various delivery systems for gene material are being examined, including viruses that are defective in  replication (Gendicine™ and Advexin) and oncolytic (tumor specific conditionally replicating) viruses (Oncorine™, ONYX-015, Imlygic®).By now three preparations for intra-tumor injection have been introduced into oncology clinical practice: two of them – Gendicine™ and Oncorine™ have been registered in China, and one of them – Imlygic® has been registered in the USA. …”
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Novel Approaches for Concurrent Irradiation in Locally Advanced Cervical Cancer: Platinum Combinations, Non-Platinum-Containing Regimens, and Molecular Targeted Agents by Giannis Mountzios, Aspasia Soultati, Dimitrios Pectasides, Meletios A. Dimopoulos, Christos A. Papadimitriou

“…More recently, molecular agents targeting critical pathways in cervical malignant transformation are being assessed in early clinical trials in combination with external-beam irradiation. …”
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Clinical Significance of ErbB Receptor Family in Urothelial Carcinoma of the Bladder: A Systematic Review and Meta-Analysis by Yuh-Shyan Tsai, Hong-Lin Cheng, Tzong-Shin Tzai, Nan-Haw Chow

“…Using published evidence, we examined the clinical value and the updated results of clinical trials targeting ErbB receptor family members. …”
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Automatic tool for the reconciliation of serious adverse events for pharmacovigilance: design and implementation of Reconciliaid by Sara Contu, Renaud Schiappa, Yann Chateau, Emmanuel Chamorey

“…Background: Reporting serious adverse events (SAEs) is crucial to reduce or avoid toxicities that can lead to major consequences for patient’s health due to treatments tested in clinical trials. Its exhaustiveness is often inadequate, and we observe discrepancies between data published by pharmacovigilance organizations and clinical databases. …”
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Screening for Atrial Fibrillation by Digital Health Technology in Older People in Homecare Settings: A Feasibility Trial by Edvard Liljedahl Sandberg, Sigrun Halvorsen, Trygve Berge, Jostein Grimsmo, Dan Atar, Bjørnar Leangen Grenne, Jarle Jortveit

“…Users of homecare services are often excluded from clinical trials due to advanced age, multimorbidity, and frailty. …”
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A Reduction in ADAM17 Expression Is Involved in the Protective Effect of the PPAR-α Activator Fenofibrate on Pressure Overload-Induced Cardiac Hypertrophy by Si-Yu Zeng, Hui-Qin Lu, Qiu-Jiang Yan, Jian Zou

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PD-1 Blockade in Advanced Melanoma in Patients with Hepatitis C and/or HIV by Diwakar Davar, Melissa Wilson, Chelsea Pruckner, John M. Kirkwood

“…We argue for the further investigation of checkpoint inhibition in cancer patients with underlying chronic viral infections in the context of carefully designed clinical trials.…”
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