Pulmonary Delivery of Antibiotics to the Lungs: Current State and Future Prospects by Yahya H. Dallal Bashi, Rachel Mairs, Rand Murtadha, Vicky Kett

“…This paper presents a comprehensive review of the current literature, clinical trials, and products approved for the delivery of antibiotics to the lungs. …”
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Gene Therapy for Parkinson's Disease by Rachel Denyer, Michael R. Douglas

“…This paper summarises the theoretical approaches to gene therapy for Parkinson's disease and the findings of clinical trials in this rapidly changing field.…”
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Artificial intelligence-based video monitoring of movement disorders in the elderly: a review on current and future landscapes by Kye Won Park, Maryam S Mirian, Martin J McKeown

“…The AI-based video monitoring systems offer improved efficiency and objectivity in remote patient monitoring, enabling real-time analysis of data, more uniform outcomes and augmented support for clinical trials. However, challenges, such as video quality, privacy compliance and noisy training labels, during development need to be addressed. …”
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Corneal Stem Cells as a Source of Regenerative Cell-Based Therapy by Jasmin S. Nurković, Radiša Vojinović, Zana Dolićanin

“…Until now, various approaches and methods for isolation of LESCs and CSSCs and their successful transplantation have been described and tested in several preclinical studies and clinical trials. This review describes in detail phenotypic characteristics of LESCs and CSSCs and discusses their therapeutic potential in corneal regeneration. …”
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Weighted Wilcoxon-Type Rank Test for Interval Censored Data by Ching-fu Shen, Jin-long Huang, Chin-san Lee

“…Interval censored (IC) failure time data are often observed in medical follow-up studies and clinical trials where subjects can only be followed periodically, and the failure time can only be known to lie in an interval. …”
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Targeted Therapy in Hepatocellular Carcinoma by Clarinda W. L. Chua, Su Pin Choo

“…There have been many targeted drugs that have shown potential in the treatment of HCC. Many clinical trials have been carried out with many more in progress. …”
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Comprehensive review of myocardial injury after noncardiac surgery: prevention, intervention, and long-term management strategies by Moiud Mohyeldin, Sarah J. Norman, Ayzia Carney, Courtney Odza

“…We discuss the role of aspirin, statins, anticoagulation, and Dual Antiplatelet Therapy (DAPT) within the context of MINS, drawing on evidence from notable clinical trials as well as observational studies. Despite advancements in understanding and managing MINS, the condition continues to be associated with high mortality and major adverse cardiovascular events (MACE), underscoring the need for ongoing research and development of more effective management protocols.…”
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Umbilical Cord as Prospective Source for Mesenchymal Stem Cell-Based Therapy by Irina Arutyunyan, Andrey Elchaninov, Andrey Makarov, Timur Fatkhudinov

“…A review of preclinical studies and clinical trials using this cell type is performed. Prospects for the use of mesenchymal stem cells, derived from the umbilical cord, in cell transplantation are associated with the need for specialized biobanking and transplant standardization criteria.…”
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Systematic review and meta-analysis of the effect of zinc on wound healing by Nazanin Zand, Elena Arribas Lopez, Omorogieva Ojo, Tony Kochhar

“…The review followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and included data from four electronic data bases. Five clinical trials met the inclusion criteria. The meta-analysis suggested that zinc treatment may be associated with improvements in ulcers healing at the final endpoint MD: 1.41 (95% CI 1.04, 1.92, p = 0.03). …”
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Peroxisome Proliferator-Activated Receptors and the Heart: Lessons from the Past and Future Directions by Wang-Soo Lee, Jaetaek Kim

“…We also describe the results and lessons learned from important clinical trials on PPAR agonists and discuss the potential future directions for this class of drugs.…”
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The effectiveness of dexamethasone as a combination therapy for COVID-19 by Namazi Nader

“…Still, there is no effective pharmaceutical agent for the treatment of COVID-19 though several drugs are undergoing clinical trials. Recent studies have shown that dexamethasone, a corticosteroid, can reduce the rate of COVID-19-related mortality in the intensive care unit by 35 % for patients who are on mechanical ventilation. …”
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PPARγ and Its Role in Cardiovascular Diseases by Mini Chandra, Sumitra Miriyala, Manikandan Panchatcharam

“…This review aims to discuss the role of PPARγ in the various cardiovascular diseases and summarize the current knowledge on PPARγ agonists from multiple clinical trials. Finally, we also review the new PPARγ agonists under development as potential therapeutics with reduced or no adverse effects.…”
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Immunotherapy with CAR-Modified T Cells: Toxicities and Overcoming Strategies by Shangjun Sun, He Hao, Ge Yang, Yi Zhang, Yang Fu

“…The adverse events observed in the clinical trials are described in this review, after which, some innovative strategies developed to overcome these unwanted toxicities are outlined, including suicide genes, targeted activation, and other novel strategies.…”
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Dietary Recommendations for the Prevention of Type 2 diabetes: What Are They Based on? by Patrice Carter, Kamlesh Khunti, Melanie J. Davies

“…In addition we aim to explore the available evidence from both observation studies and clinical trials to determine whether these recommendations are appropriate.…”
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Receptor Tyrosine Kinases and Inhibitors in Lung Cancer by Evan Pisick, Simha Jagadeesh, Ravi Salgia

“…The inhibitors against the specific RTKs are in various preclinical and clinical trials, and this will be detailed.…”
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Current and future therapeutic options for chronic hepatitis D virus infection by Mariantonietta Pisaturo, Antonio Russo, Pierantonio Grimaldi, Salvatore Martini, Nicola Coppola

“…PegIFNα, for which there are more data, appears to be an excellent combination regimen, if not contraindicated, both for Bulevirtide (BLV), data supported by important clinical trials and real-world studies, and probably for lonarfanib, although in the latter case the results are not yet definitive as the studies are fewer. …”
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Testosterone Deficiency, Cardiac Health, and Older Men by G. Hackett, M. Kirby, A. J. Sinclair

“…There are recent data to suggest that testosterone replacement therapy may reduce cardiovascular mortality as well as improving multiple surrogate markers for cardiovascular events. Specific clinical trials of testosterone replacement therapy are needed in selected populations but in the meantime we must treat patients based on the best current evidence.…”
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Motion – All Patients with GERD Should Be Offered Once in a Lifetime Endoscopy: Arguments against the Motion by James W Freston

“…The evidence for the recommendation that patients with gastroesophageal reflux disease (GERD) be offered once in a lifetime endoscopy is weak and is not supported by any clinical trials. GERD is a very prevalent condition, yet only 10% of patients with GERD have Barrett’s esophagus (BE). …”
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Pilot Study of Ofloxacin and Interferon-Alpha Combination Therapy for Chronic Hepatitis C without Sustained Response to Initial Interferon Therapy by Masafumi Komatsu, Tohru Ishii, Tsuyoshi Ono, Takao Hoshino, Tomoyuki Kuramitsu, Takashi Goto, Tomoo Fujii, Itaru Toyoshima, Mitsuro Chiba, Osamu Masamune

“…The fraction of subjects whose levels of serum ALT normalized was also higher in the IFN plus OFLX group. Larger clinical trials should be undertaken.…”
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Prostaglandin-Induced Cystoid Macular Edema Following Routine Cataract Extraction by Negin Agange, Sameh Mosaed

“…Definitive conclusions about causal relationships cannot be made without well-designed, prospective clinical trials addressing this issue.…”
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