Motor Imagery and Mental Practice in the Subacute and Chronic Phases in Upper Limb Rehabilitation after Stroke: A Systematic Review by Enrique Villa-Berges, Ana Alejandra Laborda Soriano, Orosia Lucha-López, José Miguel Tricas-Moreno, Mar Hernández-Secorún, Miguel Gómez-Martínez, César Hidalgo-García

“…We analysed a total of 11 randomized clinical trials, with moderate and high methodological quality according to the PEDro scale. …”
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A Review of the Progress in the Development of Leishmaniasis Vaccines by Narges Khaghanzadeh, Fatemeh Javadi, Afshin Samiei

“…Additionally, the mutant gene-centered LmCen-/- vaccine has completed Phase 1 clinical trials in humans. Given the importance of developing a leishmaniasis vaccine, research in this area continues. …”
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Antitumoral and Anti-inflammatory Roles of Somatostatin and Its Analogs in Hepatocellular Carcinoma by Argyrios Periferakis, Georgios Tsigas, Aristodemos-Theodoros Periferakis, Ioana Anca Badarau, Andreea-Elena Scheau, Mircea Tampa, Simona Roxana Georgescu, Andreea Cristiana Didilescu, Cristian Scheau, Constantin Caruntu

“…While the majority of these clinical trials exhibited minor to moderate success, some other studies were inconclusive or even reported negative outcomes. …”
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Novel Antiplatelet Agent Use for Acute Coronary Syndrome in the Emergency Department: A Review by M. Curial, E. Nath, E. Lang

“…To critically review clinical trials using ticagrelor and prasugrel in the treatment of ACS and inform practitioners of their potential utility in treating ACS in the ED. …”
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Systematic comparison of Mendelian randomisation studies and randomised controlled trials using electronic databases by Jie Zheng, George Davey Smith, Tom R Gaunt, Maria K Sobczyk

“…Objective To scope the potential for (semi)-automated triangulation of Mendelian randomisation (MR) and randomised controlled trials (RCTs) evidence since the two methods have distinct assumptions that make comparisons between their results invaluable.Methods We mined ClinicalTrials.Gov, PubMed and EpigraphDB databases and carried out a series of 26 manual literature comparisons among 54 MR and 77 RCT publications.Results We found that only 13% of completed RCTs identified in ClinicalTrials.Gov submitted their results to the database. …”
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A dataset for evaluating clinical research claims in large language models by Boya Zhang, Alban Bornet, Anthony Yazdani, Philipp Khlebnikov, Marija Milutinovic, Hossein Rouhizadeh, Poorya Amini, Douglas Teodoro

“…These claims were then linked to supporting information describing clinical trial results in scientific publications. CliniFact contains 1,970 instances from 992 unique clinical trials related to 1,540 unique publications. …”
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Responsive afatinib treatment in high-grade salivary gland ductal carcinoma and NSCLC with uncommon EGFR mutations: Treatment outcomes by Sivakamavalli Jeyachandran

“…Preclinical studies demonstrate its effectiveness in inhibiting tumor growth and inducing apoptosis in EGFR-amplified cell lines. Clinical trials confirm significant tumor responses and improved progression-free survival with afatinib treatment. …”
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Review of the Impact and Burden of Urinary Urgency on Adults with Overactive Bladder by Adrian Wagg, A. Lenore Ackerman, H. Henry Lai, Diane K. Newman

“…However, urgency has been understudied in clinical trials, potentially owing to inherent difficulties in its assessment. …”
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Should the Food and Drug Administration Limit Placebo-Controlled Trials? by Max Goodman, Connor Pedersen

“…Open Access Journal of Clinical Trials. 2018;Volume 10:19-28. doi:10.2147/oajct.s156054; Mezher M. …”
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Phospholipid derived mediators and glomerulonephritis by E. N. Wardle

“…A case can be made for clinical trials of PAF, leukotriene and thromboxane antagonists. …”
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Vedolizumab for inflammatory bowel diseasesI by Igor L. Khalif, M. V. Shapina

“…The results received in clinical trials were confirmed by clinical data in the different countries. …”
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Novel approaches in myelofibrosis by Steffen Koschmieder

“…Together, the new generations of clinical trials promise to offer substantial improvements in the management of MF patients and long‐term disease control.…”
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Lymphatic filariasis in Zambia: A scoping review protocol. by Hugh Shirley, Adrienne Orriols, Dylan Hogan, Kingford Chimfwembe, Alinaswe Balya, Kaala Sibbuku, Janelle Lardizabal, Sophie Tillotson, Philip Espinola Coombs, Richard Wamai

“…In consultation with a research librarian, these guidelines will be applied to a literature search of articles from peer-reviewed journals, or government and international regulatory bodies using PubMed, Embase, Web of Science, Cochrane CENTRAL, WHO ICTRP, Pan African Clinical Trials Registry, and ClinicalTrials.gov. Each record will be screened at the abstract and full-text level by two independent reviewers, and results reported via summary statistics.…”
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Physical activity and erectile dysfunction: a systematic review by Camila Araujo, Melissa Souza, Aline Fernandes, Andreia Pelegrini, Alexandro Andrade, Adriana Guimarães

“…Concerning physical activity, 17 studies identified a significant association with a lower incidence of ED, including cross-sectional and quasi-experimental studies and randomized clinical trials. ED appeared to be associated with different factors related to men’s lifestyle, particularly their level of education, non-communicable chronic diseases, body mass index and age. …”
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Role of phytochemicals in cardiovascular disease management: Insights into mechanisms, efficacy, and clinical application by Esther Ugo Alum

“…The review analyzes findings from clinical trials, epidemiological studies, and preclinical research to explain how these phytochemicals are effective in preventing and treating cardiovascular diseases. …”
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Diagnostic and therapeutic recommendations for chronic pancreatitis. Recommendations of the Working Group of the Polish Society of Gastroenterology and the Polish Pancreas Club by Roland Kadaj-Lipka, Michał Lipiński, Krystian Adrych, Marek Durlik, Anita Gąsiorowska, Mirosław Jarosz, Grażyna Jurkowska, Ewa Małecka-Panas, Grzegorz Oracz, Mariusz Rosołowski, Barbara Skrzydło-Radomańska, Renata Talar-Wojnarowska, Grażyna Rydzewska

“…In addition, the expert group assessed the value of clinical studies on which the statements are based, on a scale where A means high (based on meta‑analyses and randomised clinical trials), B means medium (based on clinical trials and observational studies), and C means low (based mainly on expert opinion).…”
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Metformin versus insulin in gestational diabetes mellitus: a systematic review by Giovanna Noronha Berti, Igor Gutschov Oviedo Garcia, João Pedro Ruas Floriano de Toledo, Júlia Rodrigues Tatemoto, Lais Watanabe Marino, Mariana de Medeiros Legori, Sérgio Floriano de Toledo

“…Data sources: This article consists of a systematic review of randomized clinical trials. The searches were carried out on MEDLINE including 7 studies, between 2010 to 2021. …”
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Apremilast generic for the treatment of active psoriatic arthritis: A single-center real-life experience from India by Sanjiv Amin, Aneesa Kapadia, Dhiraj Dhoot, Hanmant Barkate

“…Its efficacy and safety have been established in the landmark clinical trials; however, there is still a dearth of its real-world experience in the management of PsA in India. …”
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Personalized Organoid-Based Treatments in Older Patients with Cancer: A Registry Study in Progress by Pirmin Häuptle, Kirsten Mertz, Michèle Voegeli, Robert Rosenberg, Emanuel Burri, Svetozar Subotic, Anna Romanens, Anne Leuppi-Taegtmeyer, Christian Regenbrecht, Lena Wedeken, Marcus Vetter

“…The treatment of older patients with cancer is challenging owing to frailty and the presence of comorbidities, which complicate treatment decisions by impacting tolerance to therapeutic interventions, as well as poor representation of this patient population in clinical trials, leading to a lack of evidence-based data, especially in later lines of therapy. …”
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Short-Term Relapse Quantitation as a Fully Surrogate Endpoint for Long-Term Sustained Progression of Disability in RRMS Patients Treated with Natalizumab by Y. C. Wang, A. Sandrock, J. R. Richert, L. Meyerson, X. Miao

“…Time to sustained worsening in the expanded disability status scale as the standard for evaluating the accumulation of disability has been used as a measure of clinical efficacy in many relapsing-remitting multiple sclerosis (RRMS) clinical trials. However, this measurement usually requires a large sample and long-term study to demonstrate the treatment effect. …”
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