A Review on the Application of PD-1 Blockade in EBV-Associated Nasopharyngeal Carcinoma Immunotherapy by Jin Bian, Yan Niu, Yanli Ma, Fuhua Chen, Ning Ma

“…Immune checkpoint blockade therapy targeting the programmed cell death-1 (PD-1) and programmed cell death ligand-1 (PD-L 1) receptors have shown efficacy in early phase I clinical trials, with ongoing phase III clinical trials. …”
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Cytokine Reduction in the Treatment of Joint Conditions by J. D. Sipe, J. Martel-Pelletier, I. G. Otterness, J.-P. Pelletier

“…Pharmacologic regulation of IL-1 and TNFα remain primary targets for treatment of arthritis, and results of early clinical trials are promising. However, the results of long-term clinical trials will be required to support the value of anti-cytokine therapy in treatment of arthritis.…”
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Methodological insights into intervention and outcomes in randomised controlled trials of herbal medicine for obesity: a scoping review by Janice Sue Wen Chan, Mei Siu Lau, Siti Hajar Muhamad Rosli, Siti Khadijah Mustapha Kamal, Wan Nurul Nadia Wan Seman, Nurul Hidayah Ali, Terence Yew Chin Tan, Ida Farah Ahmad, Puspawathy Krishnan, Marisa Khatijah Borhan, Ami Fazlin Syed Mohamed, Xin Yi Lim

“…Background: With rising obesity rates worldwide, clinical trials focused on identifying effective treatments are increasing. …”
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Tecovirimat in the management of poxviruses: a narrative review of available evidence by Olalekan John Okesanya, Jerico Bautista Ogaya, Ikponmwosa Jude Ogieuhi, Mohamed Mustaf Ahmed, Bonaventure Michael Ukoaka, Ojoisimi Franca Jamgbadi, Deborah Oluwaseun Shomuyiwa, Don Lucero-Prisno Eliseo, Blessing Olawunmi Amisu, Olakulehin Adebusuyi, William K. Chung, Emery Manirambona, Nimat Bola Idris, Janet Alexis A. De los Santos

“…Methodology A literature search was conducted using keywords from Scopus and ClinicalTrials.gov. English studies from 2018 to 2024 were included. …”
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The Potential Use of Mesenchymal Stem Cells and Their Derived Exosomes as Immunomodulatory Agents for COVID-19 Patients by Faisal A. Alzahrani, Islam M. Saadeldin, Abrar Ahmad, Dipak Kumar, Esam I. Azhar, Arif Jamal Siddiqui, Bassem Kurdi, Abdulrahim Sajini, Abdulmajeed F. Alrefaei, Sadaf Jahan

“…This review highlights the available clinical trials that support the therapeutic potential of MSCs or MSCs-Exo in severely affected COVID-19 patients.…”
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Human Brain Organoid: A Versatile Tool for Modeling Neurodegeneration Diseases and for Drug Screening by Cuili Ma, Hwanwook Seong, Xiaowei Li, Xiao Yu, Shunliang Xu, Yujing Li

“…Clinical trials serve as the fundamental prerequisite for clinical therapy of human disease, which is primarily based on biomedical studies in animal models. …”
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Effectiveness of Single-Tablet Combination Therapy in Improving Adherence and Persistence and the Relation to Clinical and Economic Outcomes by Carly J. Paoli, Jörg Linder, Khushboo Gurjar, Deepika Thakur, Julie Wyckmans, Stacy Grieve

“…This may be due to clinical trial procedures aimed at maximizing adherence and HRQoL measures that are not designed to evaluate drug administration. …”
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DEPEND study protocol: early detection of patients with pancreatic cancer – a pilot study to evaluate the utility of faecal elastase-1 and 13C-mixed triglyceride breath test as scr... by Christopher D Byrne, Sam Wilding, Paul Remi Afolabi, Declan McDonnell, Victoria Goss, Jocelyn Walters, Zaed Z Hamady

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Evaluation of the Content Validity of the COVID-19 Symptoms Daily Diary by Dine J, Guan Y, Milien M, Ervin C, Byrne DD, Brown ML, De Anda C, Norquist JM

“…This rigorous evaluation (aligned with regulatory guidance) indicates that the CSDD is fit for the purpose of supporting efficacy endpoints in planned clinical trials evaluating medications for COVID-19 treatment.Keywords: patient-reported outcome measures, COVID-19, qualitative, symptom burden…”
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The effects of ultra-selective beta1-antagonism on the metabolic and cytokine profile in septic shock patients receiving noradrenaline: a sub-investigation from the STRESS-L Random... by Jarrod L. Thomas, Kirsty C. McGee, Anower Hossain, Gavin D. Perkins, Anthony C. Gordon, Duncan Young, Danny McAuley, Mervyn Singer, Ranjit Lall, Tina Kramaric, Janet M. Lord, Tony Whitehouse, Luis A. J. Mur, for the STRESS-L. collaborators

“…Trial Registration: EU Clinical Trials Register Eudra CT: 2017-001785-14 ( https://www.clinicaltrialsregister.eu/ctr-search/trial/2017-001785-14/GB ); ISRCTN registry Identifier: ISRCTN12600919 ( https://www.isrctn.com/ISRCTN12600919 ).…”
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The COVID-19 impact: Insights into the pharmaceutical sector through 10-K reports by Shan Wang, Fan Yang, Xinyue Fang, Fang Wang

“…A topic modeling analysis reveals four impact areas, including new product development processes, sales and operations, COVID-19 treatment and prevention drug early development, and COVID-19 drug clinical trials. Companies reporting COVID-19 drug clinical trials are the most optimistic in the sample, while companies reporting sales and operations are the most pessimistic. …”
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Mesenchymal Stem Cells: A Potential Therapeutic Approach for Amyotrophic Lateral Sclerosis? by Agnese Gugliandolo, Placido Bramanti, Emanuela Mazzon

“…In this review, we focused on the studies involving ALS rodent models and clinical trials in order to understand the potential beneficial effects of MSC transplantation. …”
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Precision medicine using molecular-target drugs in psoriatic arthritis by Ippei Miyagawa, Yoshiya Tanaka

“…However, to make precision medicine in PsA feasible, shifting from conventional clinical trials to clinical trials based on biomarker profiles and accumulating further data are necessary.…”
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Research Progress on the GIP/GLP-1 Receptor Coagonist Tirzepatide, a Rising Star in Type 2 Diabetes by Zijun Ma, Kaiqin Jin, Mengmeng Yue, Xin Chen, Jun Chen

“…Its hypoglycaemic and weight loss effects have been demonstrated in several large clinical trials, and there is also evidence that it has great potential for cardiovascular protection. …”
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An individual community member’s perspective on HIV cure-related research by Thomas J. Villa

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Poly-ADP ribose polymerase (PARP) inhibitor regimens for platinum-sensitive ovarian cancer in randomized, double-blind, phase III controlled trials: protocol for a systematic revie... by Xiaolian Peng, Jie Liu

“…IntroductionClinical trials have shown that PARP inhibitors are effective in treating patients with platinum-sensitive ovarian cancer. …”
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Safety profile of EZH2 inhibitors for cancer: a systematic review and meta-analysis by Zhou Zhao, Xiufeng Chen, Huayang Pang, Yan Shi, Hao Sun

“…Objective To evaluate the safety profiles of EZH2-targeted inhibitors in cancer treatment, focusing on treatment-related adverse events (TRAEs) across various clinical trials. Methods We conducted a systematic review and meta-analysis using data from clinical trials involving EZH2 inhibitors reported up to May 31, 2024. …”
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PD-1/PD-L1 inhibitors related adverse events: A bibliometric analysis from 2014 to 2024 by Qingya Song, Zongliang Yu, Wenping Lu, Zhili Zhuo, Lei Chang, Heting Mei, Yongjia Cui, Dongni Zhang

“…Biomarker research and multi-phase clinical trials are likely to be key areas of focus in future studies.…”
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Can fecal calprotectin be used as a biomarker of non-alcoholic fatty liver disease in obese adolescents? by Büşra Tetik Dinçer, Ayşe Merve Usta, Alev Kural, Nazlı Helvacı, Ahmet Uçar, Nafiye Urgancı

“…Trial registration This trial is registered in ClinicalTrials.gov (Trial registration number [ClinicalTrials.gov ID] NCT06229184).…”
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Inhaled Corticosteroid Therapy Does Not Control Asthma by Robert L Cowie, Margot F Underwood, Stephen K Field

“…BACKGROUND: Randomized clinical trials demonstrate efficacy and show that inhaled corticosteroid therapy can control asthma, but details concerning their effectiveness in achieving this goal in the community are lacking.…”
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