Statistical Inference of the Class of Nonparametric Tests for the Panel Count and Current Status Data from the Perspective of the Saddlepoint Approximation by Abd El-Raheem M. Abd El-Raheem, Mona Hosny, Ehab F. Abd-Elfattah

“…Equal allocation of both treatments is a largely prevalent approach in clinical trials to eliminate experimental bias and increase power. …”
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Therapeutic applicability of helminths in autoimmune diseases – literature overview by Jacek Zwiernik, Tomasz Arłukowicz, Beata Zwiernik, Tomasz Matyskieła, Marta Gimeła-Dargiewicz, Agnieszka Rakowska, Beata Januszko-Giergielewicz, Ewa Rotkiewicz

“…The outcomes of clinical trials conducted both on animals and humans give reasons to assume that the modification of the human intestinal microflora may be the key to fighting against these diseases.…”
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Medicinal products used for the treatment and prophylaxis of COVID-19 by A. Vaitkevičius

“…Data on newly initiated clinical trials on medicinal products for the treatment and prevention of COVID-19 are also provided. …”
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Progress in Managing Heart Failure: an in-depth Review of Sacubitril/Valsartan Combination Therapy by Neeraj Hiremath, Jayasheela S. Hiremath, Sanatkumar B. Nyamagoud, Agadi Hiremath Viswanatha Swamy

“…Numerous significant clinical trials have investigated the drug’s safety and efficacy in treating individuals with heart failure and a failing systemic right ventricle. …”
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Resurgence of blackwater fever among children in sub-Saharan Africa: a scoping review protocol by Julian Abeso, Francis Okello, Peter Olupot-Olupot, George Paasi, Carolyne Ndila, Florence Alaroker, Glorias Asiimwe

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Defining Optimal Aerobic Exercise Parameters to Affect Complex Motor and Cognitive Outcomes after Stroke: A Systematic Review and Synthesis by S. M. Mahmudul Hasan, Samantha N. Rancourt, Mark W. Austin, Michelle Ploughman

“…Using predefined criteria, we included clinical trials of stroke of any type or duration and animal studies employing any established models of stroke. …”
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Omeprazole: Inhibiting the Final Common Pathway to Acid Secretion - The Acid Pump by A.B.R. Thomson

“…Omeprnzole has been shown in clinical trials to be the first consistently effective treatment of erosive/ulcerative reflux esophagitis. …”
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An expert perspective on diversity-oriented standards for assessing sex and gender in clinical research by Hannah R. Hambruch, Nora M. Laskowski, Robert-Paul Juster, Georg Halbeisen, Georgios Paslakis

“…Experts rated the importance and practicality of assessing these concepts in clinical trials and evaluated terms for suitability and comprehension. …”
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A Systematic Literature Review and Indirect Treatment Comparison of Efficacy of Repository Corticotropin Injection versus Synthetic Adrenocorticotropic Hormone for Infantile Spasms by Michael S. Duchowny, Ishveen Chopra, John Niewoehner, George J. Wan, Beth Devine

“…**Objective:** A systematic review and indirect treatment comparison of clinical trials was conducted to assess the comparative efficacy of RCI and synthetic ACTH treatments in infantile spasms. …”
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The Rise of SARS-CoV-2 Variants and the Role of Convalescent Plasma Therapy for Management of Infections by Keneth Iceland, Kasozi

“…This review examines the limited number of clinical trials published, to date that have deployed this therapy and explores clinical trials in progress for the treatment of COVID-19.…”
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Benefits from Long-Term Treatment in Irritable Bowel Syndrome by Stefano Evangelista

“…Long-term treatment should be reserved to diagnosed IBS patients with recurrent symptoms. Clinical trials with stabilized therapies and new active treatments showed an improvement of the symptoms over placebo that is often time-dependent but with high relapse rates (around 40%–50% when stopping treatment). …”
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Retroperitoneal Lymph Node Dissection as Primary Treatment for Metastatic Seminoma by Brian Hu, Siamak Daneshmand

“…To better determine if RPLND can be recommended as a primary treatment option, two prospective clinical trials (SEMS and PRIMETEST) are underway. This review will examine the literature, discuss the benefits/limitations of RPLND, and compare the methodologies of the two ongoing clinical trials.…”
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Optimizing non-invasive vagus nerve stimulation for treatment in stroke by Sheharyar S. Baig, Samantha Dorney, Mudasar Aziz, Simon M. Bell, Ali N. Ali, Li Su, Jessica N. Redgrave, Arshad Majid

“…In this review, we detail the ongoing studies of transcutaneous vagus nerve stimulation in stroke through systematic searches of registered clinical trials. We summarize the upcoming clinical trials of transcutaneous vagus nerve stimulation in stroke, highlighting their indications, parameter settings, scope, and limitations. …”
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How Are n-3 LCPUFAs Antiarrhythmic? A Reassessment of n-3 LCPUFAs in Cardiac Disease by Andrew Ramadeen, Paul Dorian

“…Experimental studies and clinical trials published in the 1980s and 1990s suggested that n-3 LCPUFAs may be antiarrhythmic drugs, but more recent trials have not confirmed this. …”
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A Photothermal Modelling Approach for Micro-LED Arrays in Wireless Optogenetics by Yanping Ji, Chuanzhen Liu, Jiawei Li, Wensi Wang, Mengyi Zheng

“…However, as optogenetics moves towards clinical trials, combinatorial photostimulation based on arrays of LED light sources has emerged. …”
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Inflammation in Heart Failure: Mechanisms and Therapeutic Strategies by Jiang Yu, Guoxiang Zhou, Yongzheng Guo, Yang Long

“…However, almost all clinical trials on the anti-inflammatory treatment of HF have not indicated improved clinical outcomes, and some have reported deterioration of the condition, possibly because of limited understanding of the specific role of inflammation in HF. …”
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Current Perspectives regarding Stem Cell-Based Therapy for Alzheimer’s Disease by Kyeong-Ah Kwak, Seung-Pyo Lee, Jin-Young Yang, Young-Seok Park

“…We also briefly summarize related clinical trials. Finally, future perspectives are discussed with regard to their clinical applications.…”
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Hyponatremia and Congestive Heart Failure: A Marker of Increased Mortality and a Target for Therapy by Adam Romanovsky, Sean Bagshaw, Mitchell H. Rosner

“…Continued clinical trials with these agents are needed to determine their specific role in the treatment of both chronic and decompensated heart failure.…”
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Peroxisome proliferator–activated receptor delta and liver diseases by Tomoo Yamazaki, Edward E. Cable, Bernd Schnabl

“…This review provides an overview of PPAR-delta’s function and biology in the liver, examines its kinetics and therapeutic potential across different liver diseases, and discusses the current status of clinical trials involving its agonists.…”
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Atezolizumab neutralizing assay development: a novel way of evaluating assay cutpoint after sample pretreatment by Rachel Melendez, Jane Ruppel, Cecilia Leddy, Jenny Yang, Ann Brady, Yenny Webb-Vargas, Jochen Brumm, Lynn Kamen, Yuan Song

“…The resulting assay was successfully validated and applied to sample analysis from multiple clinical trials.…”
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