Updated treatment guidelines for drug-resistant TB: how safe are clofazimine-based regimens? by E. Pontali, M. Raviglione

“…In June 2024, WHO released ‘Key updates to the treatment of drug-resistant tuberculosis: rapid communication’, after the preliminary publication of results from two clinical trials: ‘BEAT-Tuberculosis’ and ‘endTB’. All proposed regimens include clofazimine (Cfz). …”
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New Strategies in the Treatment of Ta-T1 Transitional Cell Carcinoma (TCC) of the Bladder by Maurizio A. Brausi

“…Furthermore, new chemotherapeutic drugs for intravesical use are being investigated in various clinical trials, with gemcitabine showing particularly promising results. …”
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Contemporary Antiviral Drug Regimens for the Prevention and Treatment of Orolabial and Anogenital Herpes Simplex Virus Infection in the Normal Host: Four Approved Indications and 1... by Fred Y Aoki

“…Although these drugs are only approved for four orolabial and anogenital infections in healthy persons, their efficacy and safety for 13 other related uses in this population have been demonstrated in controlled clinical trials, so called off-label uses. In this review, the evidence supporting these 17 uses, the drugs and regimens evaluated, and their current costs, are described.…”
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The need for evidence-based, outcome-focused medical imaging research for cancer management by Jiazheng Wang, Richard L. Hesketh, John C. Gore, Kevin M. Brindle

“…We argue there remain compelling needs for better designs of clinical trials, imaging protocol standards, quantification methods, efficient translation pathways and patient engagement.…”
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Understanding Complete Pathologic Response in Oesophageal Cancer: Implications for Management and Survival by K. E. O’Sullivan, E. T. Hurley, J. P. Hurley

“…We undertook to perform a review of the current status of morbidity and mortality associated with oesophagectomy, grading systems determining pathologic response, and data from clinical trials managing patients with definitive chemoradiotherapy to inform a discussion on the topic.…”
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Hypertension in the Elderly by Blas Gil-Extremera, Pedro Cía-Gómez

“…Methods. we analysed some significant clinical trials in order to present the relevant findings on those hypertensive population. …”
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The Effects of Hypoxia on the Immune-Modulatory Properties of Bone Marrow-Derived Mesenchymal Stromal Cells by Zsolt Fábián

“…Despite the encouraging in vivo data, however, clinical trials delivered ambiguous results. Since one of the typical features of inflamed tissues is decreased oxygenation, the success of cellular therapy in inflammatory pathologies seems to be affected by the impact of oxygen depletion on transplanted cells. …”
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CANDLE syndrome – a narrative review by Aleksandra Snopkowska, Joanna Gołda, Julia Mężyk, Piotr Gacka, Marcin Dołęga

“…Further research and clinical trials are imperative to enhance understanding and optimise treatment strategies for this rare and debilitating condition.…”
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Efficacy and Safety Concerns with Sn-Mesoporphyrin as an Adjunct Therapy in Neonatal Hyperbilirubinemia: A Literature Review by Prakar Poudel, Sudhir Adhikari

“…This review evaluates in-vitro studies, animal studies, and clinical trials for the efficacy and safety of tin analogues of metalloporphyrin. …”
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The Photobiology of Lutein and Zeaxanthin in the Eye by Joan E. Roberts, Jessica Dennison

“…Lutein and zeaxanthin are antioxidants found in the human retina and macula. Recent clinical trials have determined that age- and diet-related loss of lutein and zeaxanthin enhances phototoxic damage to the human eye and that supplementation of these carotenoids has a protective effect against photoinduced damage to the lens and the retina. …”
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Oxidative Stress and Inflammation in Heart Disease: Do Antioxidants Have a Role in Treatment and/or Prevention? by Fredric J. Pashkow

“…The recognition of the critical importance of oxidative stress has led to the enthusiastic use of antioxidants in the treatment and prevention of heart disease, but the results of prospective, randomized clinical trials have been overall disappointing. Can this contradiction be explained and what are its implications for the discovery/development of future antioxidant therapeutics?…”
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Age-Related White Matter Changes by Yun Yun Xiong, Vincent Mok

“…Although the clinical relevance of WMC has been extensively studied, to date, only very few clinical trials have evaluated potential symptomatic or preventive treatments for WMC. …”
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New specific migraine prevention: monoclonal antibodies against calcitonin gene-related peptide and its receptor by K. Ryliškienė, D. Jatužis, A. Vaitkus

“…During the last decade, blocking calcitonin gene-related peptide (CGRP) has emerged as a possible mechanism for preventing migraine attacks, and monoclonal antibodies against CGRP and its receptor for the specific migraine prophylaxis have been developed. Results of clinical trials, safety and tolerability of the new class of drugs as well as guidelines for their use for the prevention of migraine are presented in this review article. …”
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The use of oral topically acting glucocorticosteroids in the treatment of inflammatory bowel disease by P. Rutgeerts

“…The first results of clinical trials are promising and budesonide has been shown to have an improved safety with almost comparable efficacy in comparison with prednisolone. …”
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A Comprehensive Review on the Effects of Laser Photobiomodulation on Skeletal Muscle Fatigue in Spastic Patients by Sadi F. Stamborowski, Fernanda Púpio Silva Lima, Patrícia Sardinha Leonardo, Mário Oliveira Lima

“…Only a much reduced number of clinical trials have been performed with a small number of participants. …”
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Protocol for the systematic review of age and sex in preclinical models of age-correlated diseases [version 2; peer review: 2 approved] by Céline Heinl, Ines Schadock, Maximilian Wurm, Paul Lucas Wildner, Daniel Butzke, Bettina Bert, Alexandra Bannach-Brown, Matthias Steinfath, Kai Diederich

“…We compare the results with the age and sex of patients in clinical trials focusing on Alzheimer's disease, stroke, type 2 diabetes mellitus, ischemic heart disease, and chronic obstructive pulmonary disease. …”
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Randomised controlled trial comparing intraoperative cell salvage and autotransfusion with standard care in the treatment of hip fractures: a protocol for the WHITE 9 study by Mike Murphy, Nicholas Parsons, James Mason, Juul Achten, Duncan Appelbe, Edward Dickenson, Damian Griffin, Katy Mironov, Matthew Wyse, Amrita Athwal, Xavier Luke Griffin, Heather O'Connor

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The short-, medium-, and long-term prevalence of physical health comorbidities in first-episode psychosis: a systematic review and meta-analysis protocol [version 2; peer review: 3... by Michael Norton, Brian O'Donoghue, Mary Clarke, Karen O'Connor, Jennifer Murphy, Anna Zierotin

“…Methods Using the PRISMA and MOOSE guidelines, Medline, Embase, PsycINFO, and CINAHL+, as well as Clinical Trials gov.uk, OpenGrey, WHO International Clinical Trials Registry Platform, Current Controlled Trials, United States National Institute of Health Trials Registry, and the Irish Health Repository, will be searched from inception. …”
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It’s safe to move! A protocol for a randomised controlled trial investigating the effect of a video designed to increase people’s confidence becoming more active despite back pain... by Ian A Harris, Adrian C Traeger, James H McAuley, Siobhan M Schabrun, Benedict Martin Wand, Aidan Cashin, Christopher Michael Williams, Edel O'Hagan, Sean O'Neill

“…We will publish the results in a peer-reviewed medical journal and on institution websites.Trial registration number Australian New Zealand Clinical Trials Registry (ACTRN12622000466741).…”
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Non-pharmacological interventions for the reduction and maintenance of blood pressure in people with prehypertension: a systematic review protocol by Paul Rutter, Andrew Clegg, Valerio Benedetto, Caroline Watkins, Nefyn Williams, Joseph Spencer, Lucy Hives, Emma P Bray, Cath Harris, Rachel F Georgiou, Nafisa Iqbal

“…The databases/trial registries that will be searched to identify relevant randomised controlled trials (RCTs) and economic evaluations include Medline, EMBASE, CINAHL, PsycINFO, CENTRAL, the WHO International Clinical Trials Registry Platform, ClinicalTrials.gov, Cochrane Library, Scopus and the International HTA Database. …”
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