Eligibility for sacubitril–valsartan in patients with acute decompensated heart failure by David Carballo, Jérôme Stirnemann, Nicolas Garin, Chistophe Marti, Jacques Serratrice, Sebastian Carballo

“…Abstract Aims Large‐scale clinical trials have demonstrated clinical benefits of sacubitril–valsartan in symptomatic heart failure with reduced ejection fraction patients (PARADIGM‐HF), with potential benefits in patients hospitalized for acute decompensated heart failure (ADHF) (PIONEER‐HF) and fewer benefits in patients with heart failure with preserved ejection fraction (PARAGON‐HF). …”
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Saudi urologists’ treatment pattern for high-risk Bacillus Calmette–Guérin naïve and Bacillus Calmette–Guérin unresponsive nonmuscle invasive bladder cancer by Mohammad Alghafees, Mohamad Abou Chakra, Abdullah Alkhayal, Mohamad Moussa, Mohammad Alkhamees, Bader Alsaikhan, Ahmed Alasker, Abdulrahman Alsayyari, Abdullah Alsaghyir, Ali Alkahtani, Michael A. O'Donnell

“…To properly select treatment for this condition, there is an urgent need to implement initiatives to open clinical trials and provide guideline-based protocols to Saudi Arabia and throughout the Arab world.…”
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Physical activity for children and adolescents with attention deficit hyperactivity disorder: a protocol of a systematic review and meta-analysis by Ole Jakob Storebø, Marie-Louise Jensen, Merete Bender Bjerrum, Marianne Vamosi

“…These reviews, for example, included both randomised and non-randomised clinical trials or had restrictions regarding the frequency and intensity of the physical activity interventions they included. …”
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Vitamins and Mineral Supplements for Retinitis Pigmentosa by Ying Zhao, Kai Feng, Ruibao Liu, Jinhua Pan, Lailin Zhang, Xuejing Lu

“…Therefore, this study aimed to systematically review data from randomized clinical trials (RCTs) evaluating the safety and efficacy of vitamins and mineral supplements for the treatment of RP. …”
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Exploring the development, evaluation and implementation of complex health interventions to prevent early childhood caries in preschool children: A scoping review protocol. by Peggy C J M van Spreuwel, Milou L C Munk-Overkamp, Linda C Smit, Kirsten A Ziesemer, Cor van Loveren, Geert J M G van der Heijden, Josef J M Bruers, Katarina Jerković-Ćosić

“…<h4>Inclusion criteria</h4>This scoping review will consider clinical trials reporting CHI's to prevent ECC that starts during pregnancy or in the first year of life. …”
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Omega-3 Fatty Acids and Vitamin D in Cardiology by Norbert Güttler, Kirila Zheleva, Mariana Parahuleva, Ridvan Chasan, Mehmet Bilgin, Christiane Neuhof, Mehmet Burgazli, Bernd Niemann, Ali Erdogan, Andreas Böning

“…Current interest has focused on n-3 polyunsaturated fatty acids (PUFA) and vitamin D. Clinical trial results on this subject are contradictory in many aspects. …”
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Determining prognostic factors in the treatment of primary hemifacial spasm: Clinical outcomes and complications. A literature review by Juan Carlos Acevedo-González, Alex Taub-Krivoy, Julian Alfonso Sierra-Peña, Julian Geronimo Lizarazo

“…Each author reviewed abstracts, applying inclusion criteria like systematic reviews, clinical trials, observational studies, and case series, while excluding theoretical or non-English articles. …”
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Human-based complex in vitro models: their promise and potential for rare disease therapeutics by Surat Parvatam, Francesca Pistollato, Lindsay J. Marshall, Fabia Furtmann, Devashree Jahagirdar, Mohua Chakraborty Choudhury, Sujata Mohanty, Harshita Mittal, Saveetha Meganathan, Rakesh Mishra

“…We also discuss how these systems are being used in clinical trials to develop efficacy models for rare diseases. …”
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Hyperthermia and targeting heat shock proteins: innovative approaches for neurodegenerative disorders and Long COVID by David M. Smadja, David M. Smadja, M. Marc Abreu, M. Marc Abreu

“…Despite the absence of robust clinical trials, the therapeutic implications of WBH extend to immune modulation and the restoration of disrupted physiological pathways. …”
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Rescue Therapy with a Proton Pump Inhibitor Plus Amoxicillin and Rifabutin for Helicobacter pylori Infection: A Systematic Review and Meta-Analysis by Xiaoqun Liu, Hui Wang, Zhifa Lv, Youhua Wang, Ben Wang, Yong Xie, Xiaojiang Zhou, Nonghua Lv

“…To conduct a systematic review and meta-analysis of clinical trials for eradication of Helicobacter pylori (H. pylori) that included a treatment arm with a proton pump inhibitor, rifabutin, and amoxicillin. …”
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A comprehensive review of remimazolam for sedation by Nazir Noor, Rhorer Legendre, Alexandra Cloutet, Ahish Chitneni, Giustino Varrassi, Alan D. Kaye

“…However, further large clinical trials will provide us with a better understanding of the advantages and disadvantages of remimazolam.…”
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How is cognitive behavioural therapy for insomnia delivered to adults with comorbid persistent musculoskeletal pain and disordered sleep? A scoping review. by Abigail Browne, Roisin Cahalan, Kieran O' Sullivan

“…Electronic searches of ten database and three clinical trials registries were performed up to 25 October 2023. …”
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DPP-4 Inhibitors as Treatments for Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis by Qixian Wang, Min Long, Hua Qu, Rufei Shen, Rui Zhang, Jing Xu, Xin Xiong, Hui Wang, Hongting Zheng

“…Further optimized clinical trials are needed.…”
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Validation of a multiplexed immunoassay for immunological analysis of pre erythrocytic malaria vaccines by L. K. Stockdale, S. Provstgaard-Morys, D. Bellamy, D. Woods, K. Rapi, A. Bajer, B. Hollingdale, O. Muñoz, S. Malik, A. V. S. Hill, K. J. Ewer

“…Abstract The primary immunological readout for clinical trials of R21/MatrixM™ malaria vaccine, is total IgG antibody specific to the central four amino acid NANP repeat region of the circumsporozoite protein. …”
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Current Status of Treatment of Spinal and Bulbar Muscular Atrophy by Fumiaki Tanaka, Masahisa Katsuno, Haruhiko Banno, Keisuke Suzuki, Hiroaki Adachi, Gen Sobue

“…Since ligand-induced nuclear translocation of mutant AR has been shown to be a critical step in motor neuron degeneration in SBMA, androgen deprivation therapies using leuprorelin and dutasteride have been developed and translated into clinical trials. Although the results of these trials are inconclusive, renewed clinical trials with more sophisticated design might prove the effectiveness of hormonal intervention in the near future. …”
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Clinical Outcomes from Unselected “Real-World” Patients with Long Coronary Lesion Receiving 40 mm Biodegradable Polymer Coated Sirolimus-Eluting Stent by Anurag Polavarapu, Raghava Sarma Polavarapu, Jayesh Prajapati, Kamlesh Thakkar, Asif Raheem, Tamanpreet Mayall, Ashok Thakkar

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Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer’s disease: the need for rigor by Joshua D. Grill, Daniel Gillen

“…Abstract We consider the recent publication by Ornish and colleagues and the rigor expected for interventional clinical trials. We contend that lifestyle intervention trials should strive for the same rigor as drug trials and highlight opportunities to improve rigor in this example, particularly in design, data analysis, and publication of results for this and other lifestyle intervention studies.…”
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Warm and humid environment induces gut microbiota dysbiosis and bacterial translocation leading to inflammatory state and promotes proliferation and biofilm formation of certain ba... by Yinrui Guo, Jianlang He, Shaojie Li, Shiqi Zou, Haiting Zhang, Xin Yang, Jian Wang

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Prevention and Treatment of Cytomegalovirus Infection in Transplant Recipients by Jutta K Preiksatis

“…Strategies for preventing CMV infection, including donorrecipient matching, the use of CMV 'safe' cellular blood products, passive and active immunization, and prophylactic antiviral drugs are discussed. Clinical trials of antiviral drugs alone. or in combination with immunoglobulin for the treatment of CMV disease are reviewed.…”
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Transfusion Thresholds, Quality of Life, and Current Approaches in Myelodysplastic Syndromes by Ioannis Koutsavlis

“…Fatigue is the main reported symptom in this group of patients and current clinical trials are looking for a more liberal approach of red cell transfusion and the effect on quality of life as opposed to the restrictive strategy used in the critical care setting. …”
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