The Rise of SARS-CoV-2 Variants and the Role of Convalescent Plasma Therapy for Management of Infections by Mohamed, Moubarak, Keneth Iceland, Kasozi, Helal F., Hetta, Hazem M., Shaheen, Abdur, Rauf, Hayder M., Al-kuraishy, Safaa, Qusti, Eida M., Alshammari, Emmanuel Tiyo, Ayikobua, Fred, Ssempijja, Adam Moyosore, Afodun, Ritah, Kenganzi, Ibe Michael, Usman, Juma John, Ochieng, Lawrence Obado, Osuwat, Kevin, Matama, Ali I., Al-Gareeb, Emmanuel, Kairania, Monica, Musenero, Susan, Christina Welburn, Gaber, El-Saber Batiha

“…This review examines the limited number of clinical trials published, to date that have deployed this therapy and explores clinical trials in progress for the treatment of COVID-19…”
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Should the Food and Drug Administration Limit Placebo-Controlled Trials? by Max Goodman, Connor Pedersen

“…Open Access Journal of Clinical Trials. 2018;Volume 10:19-28. doi:10.2147/oajct.s156054; Mezher M. …”
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Treatment of Heart Failure with Sodium-glucose Cotransporter Type 2 Inhibitors by Riber Fabián Donoso Noroña, Nairovys Gómez Martínez, Adisnay Rodríguez Plasencia

“…Ten clinical trials were identified that met the inclusion criteria. …”
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Curcumin as a Therapeutic Agent in Dementia: A Mini Systematic Review of Human Studies by Natascia Brondino, Simona Re, Annalisa Boldrini, Antonella Cuccomarino, Niccolò Lanati, Francesco Barale, Pierluigi Politi

“…In the present systematic review we aimed to evaluate the state-of-the-art of clinical trials of curcumin in AD. We retrieved three published studies, while there are several ongoing clinical trials. …”
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Motor Imagery and Mental Practice in the Subacute and Chronic Phases in Upper Limb Rehabilitation after Stroke: A Systematic Review by Enrique Villa-Berges, Ana Alejandra Laborda Soriano, Orosia Lucha-López, José Miguel Tricas-Moreno, Mar Hernández-Secorún, Miguel Gómez-Martínez, César Hidalgo-García

“…We analysed a total of 11 randomized clinical trials, with moderate and high methodological quality according to the PEDro scale. …”
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Antitumoral and Anti-inflammatory Roles of Somatostatin and Its Analogs in Hepatocellular Carcinoma by Argyrios Periferakis, Georgios Tsigas, Aristodemos-Theodoros Periferakis, Ioana Anca Badarau, Andreea-Elena Scheau, Mircea Tampa, Simona Roxana Georgescu, Andreea Cristiana Didilescu, Cristian Scheau, Constantin Caruntu

“…While the majority of these clinical trials exhibited minor to moderate success, some other studies were inconclusive or even reported negative outcomes. …”
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Novel Antiplatelet Agent Use for Acute Coronary Syndrome in the Emergency Department: A Review by M. Curial, E. Nath, E. Lang

“…To critically review clinical trials using ticagrelor and prasugrel in the treatment of ACS and inform practitioners of their potential utility in treating ACS in the ED. …”
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Systematic comparison of Mendelian randomisation studies and randomised controlled trials using electronic databases by Jie Zheng, George Davey Smith, Tom R Gaunt, Maria K Sobczyk

“…Objective To scope the potential for (semi)-automated triangulation of Mendelian randomisation (MR) and randomised controlled trials (RCTs) evidence since the two methods have distinct assumptions that make comparisons between their results invaluable.Methods We mined ClinicalTrials.Gov, PubMed and EpigraphDB databases and carried out a series of 26 manual literature comparisons among 54 MR and 77 RCT publications.Results We found that only 13% of completed RCTs identified in ClinicalTrials.Gov submitted their results to the database. …”
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A dataset for evaluating clinical research claims in large language models by Boya Zhang, Alban Bornet, Anthony Yazdani, Philipp Khlebnikov, Marija Milutinovic, Hossein Rouhizadeh, Poorya Amini, Douglas Teodoro

“…These claims were then linked to supporting information describing clinical trial results in scientific publications. CliniFact contains 1,970 instances from 992 unique clinical trials related to 1,540 unique publications. …”
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Review of the Impact and Burden of Urinary Urgency on Adults with Overactive Bladder by Adrian Wagg, A. Lenore Ackerman, H. Henry Lai, Diane K. Newman

“…However, urgency has been understudied in clinical trials, potentially owing to inherent difficulties in its assessment. …”
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Phospholipid derived mediators and glomerulonephritis by E. N. Wardle

“…A case can be made for clinical trials of PAF, leukotriene and thromboxane antagonists. …”
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Vedolizumab for inflammatory bowel diseasesI by Igor L. Khalif, M. V. Shapina

“…The results received in clinical trials were confirmed by clinical data in the different countries. …”
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Lymphatic filariasis in Zambia: A scoping review protocol. by Hugh Shirley, Adrienne Orriols, Dylan Hogan, Kingford Chimfwembe, Alinaswe Balya, Kaala Sibbuku, Janelle Lardizabal, Sophie Tillotson, Philip Espinola Coombs, Richard Wamai

“…In consultation with a research librarian, these guidelines will be applied to a literature search of articles from peer-reviewed journals, or government and international regulatory bodies using PubMed, Embase, Web of Science, Cochrane CENTRAL, WHO ICTRP, Pan African Clinical Trials Registry, and ClinicalTrials.gov. Each record will be screened at the abstract and full-text level by two independent reviewers, and results reported via summary statistics.…”
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Role of phytochemicals in cardiovascular disease management: Insights into mechanisms, efficacy, and clinical application by Esther Ugo Alum

“…The review analyzes findings from clinical trials, epidemiological studies, and preclinical research to explain how these phytochemicals are effective in preventing and treating cardiovascular diseases. …”
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Metformin versus insulin in gestational diabetes mellitus: a systematic review by Giovanna Noronha Berti, Igor Gutschov Oviedo Garcia, João Pedro Ruas Floriano de Toledo, Júlia Rodrigues Tatemoto, Lais Watanabe Marino, Mariana de Medeiros Legori, Sérgio Floriano de Toledo

“…Data sources: This article consists of a systematic review of randomized clinical trials. The searches were carried out on MEDLINE including 7 studies, between 2010 to 2021. …”
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Apremilast generic for the treatment of active psoriatic arthritis: A single-center real-life experience from India by Sanjiv Amin, Aneesa Kapadia, Dhiraj Dhoot, Hanmant Barkate

“…Its efficacy and safety have been established in the landmark clinical trials; however, there is still a dearth of its real-world experience in the management of PsA in India. …”
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Short-Term Relapse Quantitation as a Fully Surrogate Endpoint for Long-Term Sustained Progression of Disability in RRMS Patients Treated with Natalizumab by Y. C. Wang, A. Sandrock, J. R. Richert, L. Meyerson, X. Miao

“…Time to sustained worsening in the expanded disability status scale as the standard for evaluating the accumulation of disability has been used as a measure of clinical efficacy in many relapsing-remitting multiple sclerosis (RRMS) clinical trials. However, this measurement usually requires a large sample and long-term study to demonstrate the treatment effect. …”
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Recanalization Therapies in Acute Ischemic Stroke: Pharmacological Agents, Devices, and Combinations by Vijay K. Sharma, Hock Luen Teoh, Lily Y. H. Wong, Jie Su, Benjamin K. C. Ong, Bernard P. L. Chan

“…Mechanical devices and approaches can achieve higher rates of recanalization but their safety and efficacy still need to be established in larger clinical trials. The field of acute revascularization is rapidly evolving, and various combinations of pharmacologic agents, mechanical devices, and novel microbubble/ultrasound technologies are being tested in multiple clinical trials.…”
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Application of Mild Therapeutic Hypothermia on Stroke: A Systematic Review and Meta-Analysis by Shaheen E. Lakhan, Fabricio Pamplona

“…Seven parallel-controlled clinical trials were included in the meta-analysis. Sample sizes ranged from 18 to 62 patients, yielding a total of 288. …”
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Immunotherapeutic Approaches in Triple-Negative Breast Cancer: State of the Art and Future Perspectives by Karima Oualla, Loay Kassem, Lamiae Nouiakh, Lamiae Amaadour, Zineb Benbrahim, Samia Arifi, Nawfel Mellas

“…Recently, immunotherapy is being extensively explored in TNBC and clinical trials have shown promising results. In this article, we tried to explain the rationale and mechanisms of targeting the immune system in TNBC, to report the results from recent clinical trials that put immunotherapy as a new standard of care in TNBC in addition to ongoing trials and future directions in the next decade.…”
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