Effects of Neural Load on Hamstring Stretching upon Flexibility, Maximum Isometric Strength, and Tibial Nerve Pressure Pain Threshold in Healthy Subjects: A Randomized Clinical Trial by Carlos Fernández-del Rivero, Pablo García-Gil, Juan Mínguez-Cruz, Daniel Pecos-Martín, Samuel Fernández-Carnero, Alexander Achalandabaso-Ochoa, Daniel Rodríguez-Almagro

Get full text

Effect of Locally Delivered Melatonin as an Adjunct to Nonsurgical Therapy on GCF Antioxidant Capacity and MMP-9 in Stage II Periodontitis Patients: A Randomized Controlled Clinical Trial by Enji Ahmed, Olfat G. Shaker, Nermin Yussif, Dalia M. Ghalwash

“…This split-mouth randomized controlled clinical trial was performed on 24 patients with grade II periodontitis. …”
Get full text

Which clinical trial designs and statistical approaches have been used in assessments of orphan maintenance by the European Medicines Agency between 2012 and 2022?... by Fabian Windfuhr, Kristina Larsson, Theodor Framke, Florian Lasch

“…To demonstrate a significant benefit, comparisons between the new product and the already approved medicinal products—either directly by a head-to-head comparison within a clinical trial or indirectly as a cross-trial comparison—are necessary. …”
Get full text

Single postoperative infusion of zoledronic acid to improve patient-reported outcome after hip or knee replacement: study protocol for a randomised, controlled, double-blinded clinical trial by Jonas Ranstam, Jörg Schilcher, Ewa Roos, Jonathan Brandt, Håkan Ledin, Per Aspenberg

“…Bisphosphonates are drugs that inhibit osteoclast function. Several clinical trials suggest that bisphosphonates lead to improved implant fixation and one small study even indicates better functional outcome. …”
Get full text

The effect of probiotic-fortified kefir on depression, appetite, oxidative stress, and inflammatory parameters in Iranian overweight and obese elderly: a randomized, double-blind, placebo-controlled clinical trial by Mehran Noori, Zainab Shateri, Siavash Babajafari, Mohammad Hadi Eskandari, Karim Parastouei, Mohammad Ghasemi, Hoseein Afshari, Mohammad Samadi

“…Methods This study was a double-blind, randomized, and placebo-controlled clinical trial conducted on 67 elderly men aged over 65, who were randomly divided into two groups. …”
Get full text

Feasibility and acceptability for LION, a fully remote, randomized clinical trial within the VA for light therapy to improve sleep in Veterans with and without TBI: An MTBI2 sponsored protocol by Jonathan E. Elliott, Jessica S. Brewer, Allison T. Keil, Brittany R. Ligman, Mohini D. Bryant-Ekstrand, Alisha A. McBride, Katherine Powers, Savanah J. Sicard, Elizabeth W. Twamley, Maya E. O’Neil, Andrea D. Hildebrand, Thuan Nguyen, Benjamin J. Morasco, Jessica M. Gill, Bradley A. Dengler, Miranda M. Lim

Get full text

Longer-term safety and efficacy of baricitinib for atopic dermatitis in pediatric patients 2 to <18 years old: a randomized clinical trial of extended treatment to 3.6 years by Andreas Wollenberg, Masanori Ikeda, Chia-Yu Chu, Lawrence F. Eichenfield, Marieke M. B. Seyger, Apurva Prakash, Robinette Angle, Danting Zhu, Marco Pontes, Amy S. Paller

“…No new safety signals were identified.Trial Registration ClinicalTrials.gov Identifier: NCT03952559…”
Get full text

Comparative Evaluation of Ketoprofen Gel Alone and in Combination with Doxycycline Gel as Local Drug Delivery in the Treatment of Chronic Periodontitis among Smokers and Non-Smokers: A Randomized Clinical Trial by Krupali J. Gandhi, Priyadarshini P. Nadig, Shivlal Vishnoi, Bhumika S. Sheth, Jinal Desai, Kandarp Raj

Get full text

Comment on &ldquo;Effect of Acupuncture Intervention on Chronic Musculoskeletal Pain in Hemodialysis-Dependent Kidney Failure Patients: Study Protocol for a Randomized Controlled Clinical Trial&rdquo; [Letter] by He L, Lv S

Get full text

β-hydroxy-β-methylbutyrate-enriched nutritional supplements for obese adults during weight loss: study protocol of a randomised, double-blind, placebo-controlled clinical trial by Ming Yang, Xiaofan Jing, Yuxiang Liang, Renjie Wang, Hongbo Fu, Jiaojiao Jiang

Get full text

Feasibility and acceptability for LION, a fully remote, randomized clinical trial within the VA for light therapy to improve sleep in Veterans with and without TBI: An MTBI2 sponsored protocol. by Jonathan E Elliott, Jessica S Brewer, Allison T Keil, Brittany R Ligman, Mohini D Bryant-Ekstrand, Alisha A McBride, Katherine Powers, Savanah J Sicard, Elizabeth W Twamley, Maya E O'Neil, Andrea D Hildebrand, Thuan Nguyen, Benjamin J Morasco, Jessica M Gill, Bradley A Dengler, Miranda M Lim

Get full text

Effectiveness of direct patient outreach with a narrative naloxone and overdose prevention video to patients prescribed long-term opioid therapy in the USA: the Naloxone Navigator randomised clinical trial by Jason M Glanz, Ingrid A Binswanger, Shane R Mueller, Komal J Narwaney, Nicole M Wagner, Stanley Xu, Courtney R Kraus, Kris Wain, Sheila Botts

“…The objective of this study was to determine if a targeted, digital health intervention changed patient risk behaviour, increased naloxone uptake and increased knowledge about opioid overdose prevention and naloxone.Methods We conducted a pragmatic randomised clinical trial among patients prescribed LTOT in a healthcare delivery system in Colorado. …”
Get full text

Health-Related Quality of Life, Treatment Satisfaction, Adherence and Persistence in β-Thalassemia and Myelodysplastic Syndrome Patients with Iron Overload Receiving Deferasirox: Results from the EPIC Clinical Trial by John Porter, Donald K. Bowden, Marina Economou, Jacques Troncy, Arnold Ganser, Dany Habr, Nicolas Martin, Adam Gater, Diana Rofail, Linda Abetz-Webb, Helen Lau, Maria Domenica Cappellini

Get full text

Combination Therapy with 1% Nanocurcumin Gel and 0.1% Triamcinolone Acetonide Mouth Rinse for Oral Lichen Planus: A Randomized Double-Blind Placebo Controlled Clinical Trial by Mahin Bakhshi, Shahzad Gholami, Arash Mahboubi, Mahmoud Reza Jaafari, Mahshid Namdari

“…This double-blind randomized clinical trial was conducted on 31 patients with erosive or ulcerative OLP. …”
Get full text

A randomized double-blind clinical trial investigating the effects of ellagic acid on glycemic status, liver enzymes, and oxidative stress in patients with non-alcoholic fatty liver disease by Sara Mighani, Rasoul Samimi, Mohamadreza Rashidi Nooshabadi, Seyed Amir Farzam, Hossein Khadem Haghighian, Maryam Javadi

“…Trial registration This study was prospectively registered at the Iranian Registry of Clinical Trials on the 23th of January 2022 (ID: IRCT20141025019669N21).…”
Get full text

Response to: Comment on “Effects of a Pragmatic Home-Based Exercise Program Concurrent With Neoadjuvant Therapy on Physical Function of Patients With Pancreatic Cancer: The PancFit Randomized Clinical Trial” by An T. Ngo-Huang, DO, Nathan H. Parker, PhD, Keri L. Schadler, PhD, Matthew H. G. Katz, MD

Get full text

Hybrid natural language processing tool for semantic annotation of medical texts in Spanish by Leonardo Campillos-Llanos, Ana Valverde-Mateos, Adrián Capllonch-Carrión

Subjects: Get full text

Development, opportunities, and challenges of siRNA nucleic acid drugs by Bowen Xiao, Shaopeng Wang, Yu Pan, Wenjun Zhi, Chensheng Gu, Tao Guo, Jiaqi Zhai, Chenxu Li, Yong Q. Chen, Rong Wang

Subjects: Get full text

Real-world clinical evidence of oral semaglutide on metabolic abnormalities in subjects with type 2 diabetes: a multicenter retrospective observational study (the Sapporo-Oral SEMA... by Sho Furusawa, Hiroshi Nomoto, Chiho Oba-Yamamoto, Jun Takeuchi, Miki Ito, Hiroyoshi Kurihara, Shin Aoki, Aika Miya, Hiraku Kameda, Akinobu Nakamura, Tatsuya Atsumi

Subjects: “…clinical trial…”
Get full text

From awareness to action: Effects of a schoolbased intervention on TV viewing behavior stages and screen time guidelines knowledge in Brazilian adolescents by Priscila Cristina dos Santos, Alexsandra da Silva Bandeira, Bruno Gonçalves Galdino da Costa, Ana Caroline Ferreira Campos de Sousa, Kelly Samara da Silva

Subjects: Get full text