Proposal and Strategy for Nursing-Led Research: Protocol for an Unfunded Clinical Trial by Leticia Carmen Simón-López, Ismael Ortuño-Soriano, Raquel Luengo-González, Paloma Posada-Moreno, Ignacio Zaragoza-García, Rubén Sánchez-Gómez

“… BackgroundClinical trials are known to provide cause-and-effect results and data with low levels of bias. …”
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Insight into the Advances in Clinical Trials of SARS-CoV-2 Vaccines by Syed Mohammed Basheeruddin Asdaq, Shahamah Jomah, Syed Imam Rabbani, Ali Musharraf Alamri, Salman Khalaf Salem Alshammari, Badr Sami Duwaidi, Majed Sadun Alshammari, Abdulhakeem S. Alamri, Walaa F. Alsanie, Majid Alhomrani, Nagaraja Sreeharsha, Mohd. Imran

“…All these vaccines in clinical trials have shown robust production of neutralizing antibodies sufficient to prevent infection. …”
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IUPHAR review: Drug repurposing in Schizophrenia – An updated review of clinical trials by Jihan K. Zaki, Jakub Tomasik, Sabine Bahn

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Correction: Relevance of tumor boards for the inclusion of patients in oncological clinical trials by Hendrik Dapper, Maurice Dantes, Peter Herschbach, Hana Algül, Volker Heinemann

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Enhancing vaccine clinical trials participation among elderly: challenges and strategies by Paul Gillard, Samer Nakhle, Darin Brimhall, Ouzama Henry, Narcisa Mesaros

“…In fact, recent megatrials enrolling more than 30,000 elderly participants demonstrated the feasibility of large-scale clinical trials involving this very specific population. …”
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IDH-mutant gliomas in children and adolescents - from biology to clinical trials by Louise Evans, Sarah Trinder, Sarah Trinder, Andrew Dodgshun, Andrew Dodgshun, David D. Eisenstat, David D. Eisenstat, David D. Eisenstat, James R. Whittle, James R. Whittle, James R. Whittle, Jordan R. Hansford, Jordan R. Hansford, Jordan R. Hansford, Santosh Valvi, Santosh Valvi, Santosh Valvi

“…Here, we describe the biology of mIDH gliomas and review the literature regarding the emergence of mIDH inhibitors, including clinical trials in adults. Given the paucity of clinical trial data from pediatric patients with mIDH glioma, we propose guidelines for the inclusion of pediatric and AYA patients with gliomas onto prospective trials and expanded access programs as well as the potential of combined mIDH inhibition and immunotherapy in the treatment of patients with PMMRDIA at high risk of progression.…”
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An analysis of controlled human infection studies registered on ClinicalTrials.gov by James Wilkinson, Joshua Osowicki, Euzebiusz Jamrozik, Ian J Saldanha, Meta Roestenberg, Danny Toomey, Jupiter Adams-Phipps, John Pietro, Jake Littman, Steffen Kamenicek, Daniel Kaufman

“…We hypothesised that data may be more easily aggregated using a clinical trial registry such as ClinicalTrals.gov, the largest publicly accessible registry of clinical trial data. …”
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Clinical trials to gene therapy development and production in Brazil: a review by Jonas Alex Morales Saute, Virginia Picanço-Castro, Ana Carolina de Freitas Lopes, João Batista da Silva Júnior, Johanna Henriques Nehm, Franciele dos Santos Maciel, Ida Vanessa Doederlein Schwartz, Juliana Maria Ferraz Sallum, Margareth Castro Ozelo, Roberto Giugliani, Martin Bonamino, Hilda Petrs-Silva, Guilherme Baldo

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Lessons to be Learned for Gastroenterology from Recent Issues in Clinical Trial Methodology by C Ohmann, J Albrecht

“…This article reviews actual and conflicting issues of clinical trials with respect to gastroenterology. Major problems in trial design are neglect of previous research, inadequate sample size calculations and irrelevant outcome criteria. …”
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Acupuncture Anxiolytic Effects on Physiological and Psychological Assessments for a Clinical Trial by Monir Shayestehfar, Tohid Seif-Barghi, Sahar Zarei, Amir Mehran

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Phases I–III Clinical Trials Using Adult Stem Cells by Ricardo Sanz-Ruiz, Enrique Gutiérrez Ibañes, Adolfo Villa Arranz, María Eugenia Fernández Santos, Pedro L. Sánchez Fernández, Francisco Fernández-Avilés

“…First randomized clinical trials have demonstrated that stem cell therapy can improve cardiac recovery after the acute phase of myocardial ischemia and in patients with chronic ischemic heart disease. …”
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Efficacy of MI Paste® on Bleaching-Related Sensitivity: Randomized Clinical Trial by Shaista Rashid, Mohamed ElSalhy

“…This randomized controlled split-mouth clinical trial included 45 subjects that were randomly divided into two groups. …”
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Patients’ Perceptions of their Participation in a Clinical Trial for Postoperative Crohn’s Disease by ED Kennedy, JE Blair, R Ready, BG Wolff, AH Steinhart, PW Carryer, RS McLeod

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Critical Aspects of Clinical Trial Design for Novel Cell and Gene Therapies by Zinovia Kefalopoulou, Iciar Aviles-Olmos, Thomas Foltynie

“…Detailed evaluation of these discordant findings has highlighted several crucial issues such as patient selection criteria, details surrounding transplantation or gene therapy methodologies, as well as the study designs themselves that ought to be carefully considered in the planning phases of future clinical trials. Beyond the provision of symptomatic efficacy and safety data, it also remains to be identified whether the possibilities offered by stem cell and gene therapy technological advances might translate to meaningful neuroprotection and/or disease-modifying effects or alleviate the nonmotor aspects of PD and thus offer additional benefits beyond those achieved through conventional pharmacotherapy or deep brain stimulation (DBS).…”
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A descriptive-multivariate analysis of community knowledge, confidence, and trust in COVID-19 clinical trials amongst Ugandans working in healthcare settings. by Keneth Iceland, Kasozi, Lawrence Obado, Osuwat

Subjects: “…COVID-19 clinical trials in resource poor countries; COVID-19 vaccines; Clinical trials in Africa; COVID-19 and medical workers; vaccines, Oxford-AstraZeneca.…”
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Advancements in Managing Anthracycline-Induced Cardiotoxicity: Insights from Interventional Clinical Trials by Zhao M, Zhang X, Zhou D, Song J

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CLINICAL TRIAL ASSESSING THE PREVALENCE OF ORAL COMPLICATION IN A DENTURE WEARERS POPULATION by Cosmin Bida, Doriana Agop-Forna, Dana Gabriela Budala, Norina Forna

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Cuban Public Registry of Clinical Trials: First of the World Health Organization in America by Olga Lidia Cuevas Pérez, Jayce Díaz Díaz, Mileydis López Bacallao

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Demographic clinical trial diversity assessment methods: Use of real-world data by Hua Chen, Nnadozie Emechebe, Sudeep Karve, Leon Raskin, Jailene Leal, Ning Cheng, Wendy Sebby, Kim Ribeiro, Samuel Crawford

Subjects: “…Clinical trial diversity…”
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Hydrophobic and Hydrophilic IOLs in Patients with Uveitis – A Randomised Clinical Trial by Pålsson S, Schuborg C, Sterner B, Andersson Grönlund M, Zetterberg M

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