A case of de novo neuroendocrine prostate cancer presented with elevated level of serum CEA carrying BRCA2 mutation: case report and literature review by Weizhe Han, Nihati Rexiati, Fang Yu, Yongzhi Wang, Yueli Tian, Jianyuan Wu, Gang Wang, Tao Liu, Zhonghua Yang

Get full text

The effect of dual-task training in older adults with total hip arthroplasty: a randomized controlled trial by İsmail Uysal, Fatih Özden, Mustafa Yalçın, Emir İbrahim Işık, Zübeyir Sarı

“…Trial Registration The study protocol was registered to “clinicaltrials.gov” (Registration Date: 19/08/2023, Clinical Trial Number: NCT06009419|| https://clinicaltrials.gov/study/NCT06009419 ).…”
Get full text

Perspectives on which health settings geriatricians should staff: a qualitative study of patients, care providers and health administrators by Eric Kai-Chung Wong, Andrea C. Tricco, Wanrudee Isaranuwatchai, David M. J. Naimark, Sharon E. Straus, Joanna E. M. Sale

“…The main barriers to implementing the geriatrician-led CGA related to lack of resources. Clinical trial number Not applicable.…”
Get full text

Median effective dose of remimazolam combined with sufentanil for inhibiting laryngeal mask airway insertion responses in children of different ages by Hongyun Li, Jinxia Wang, Rong Wei, Yan Jiang

“…Conversely, the time from remimazolam administration to the disappearance of the eyelash reflex; LMA insertion success rate; or incidence of coughing, movement, swallowing, and hiccups did not differ significantly between the two groups.ConclusionRemimazolam can be safely used for laryngeal mask anesthesia induction in pediatric patients.Clinical Trial Registrationhttps://www.chictr.org.cn/, identifier ChiCTR2400087333.…”
Get full text

Psychosocial well-being index and sick leave in the workplace: a structural equation modeling of Wittyfit data by Rémi Colin-Chevalier, Bruno Pereira, Samuel Dewavrin, Thomas Cornet, Julien Steven Baker, Frédéric Dutheil

“…This new indicator could be used to analyze the association between psychosocial well-being and other health outcomes.Clinical trial registrationClinicaltrials.gov, identifier NCT02596737.…”
Get full text

An empowerment programme to improve diet quality during pregnancy – the Power 4 a Healthy Pregnancy cluster randomised controlled trial by Renske M. van Lonkhuijzen, Jeanne H. M. de Vries, Elske Brouwer-Brolsma, Susanne Cremers, Janine P. M. Faessen, Edith J. M. Feskens, Annemarie Wagemakers

“…Trial registration International Clinical Trial Registry Platform NL-OMON23191, date of registration: 19/05/2021.…”
Get full text

Assessing caregiver stress and resource needs in pediatric cancer care by Shaimaa Mohamed Amin, Mahmoud Abdelwahab Khedr, Azza Medhat Aziz Mansy, Ahmed Hashem El-Monshed, Mohamed Gamal Noaman Malek, Ayman Mohamed El-Ashry

“…Future research should explore sustainable strategies to further reduce caregiver burden. Clinical trial number Not applicable.…”
Get full text

Real-world effectiveness of hemodialysis modalities: a retrospective cohort study by Yan Zhang, Anke Winter, Belén Alejos Ferreras, Paola Carioni, Otto Arkossy, Michael Anger, Robert Kossmann, Len A. Usvyat, Stefano Stuard, Franklin W. Maddux

“…Abstract Background Results from the CONVINCE clinical trial suggest a 23% mortality risk reduction among patients receiving high-volume (> 23 L) hemodiafiltration. …”
Get full text

Discrimination of Radiologists' Experience Level Using Eye-Tracking Technology and Machine Learning: Case Study by Stanford Martinez, Carolina Ramirez-Tamayo, Syed Hasib Akhter Faruqui, Kal Clark, Adel Alaeddini, Nicholas Czarnek, Aarushi Aggarwal, Sahra Emamzadeh, Jeffrey R Mock, Edward J Golob

“…The encoded features of the eye-fixation data are used by machine learning classifiers to discriminate between faculty and trainee radiologists. A clinical trial case study was conducted using metrics such as the area under the curve, accuracy, F1-score, sensitivity, and specificity to evaluate the discriminability between the 2 groups regarding their level of experience. …”
Get full text

Feasibility, reliability, usability, and satisfaction of a digital medical device (ZEMY) for symptom management in patients treated for breast cancer: a single-arm interventional s... by Luis Teixeira, Christelle Levy, David Coeffic, Rim Ghorbal, Julien Dupin, Nazario Esposito, Olfa Derbel

“…In this open-label, interventional, multicentre, single-arm clinical trial (NCT03558490), patients at all stages of breast cancer initiating oral and/or parenteral treatment were recruited at initiation of therapy and followed for 3 months. …”
Get full text

Development of a Novel Co-Amorphous Curcumin and L-Arginine (1:2): Structural Characterization, Biological Activity and Pharmacokinetics by Jose Antonio Mancillas-Quiroz, Miriam del Carmen Carrasco-Portugal, Karina Mondragón-Vásquez, Juan Carlos Huerta-Cruz, Juan Rodríguez-Silverio, Leyanis Rodríguez-Vera, Juan Gerardo Reyes-García, Francisco Javier Flores-Murrieta, Jorge Guillermo Domínguez-Chávez, Héctor Isaac Rocha-González

Get full text

Treatment options for Achilles tendinopathy: a scoping review of preclinical studies by Nathanael Opoku Agyeman-Prempeh, Huub Maas, George L. Burchell, Neal L. Millar, Maarten H. Moen, Theodoor Henri Smit

“…Preclinical treatments that improved the biomechanical, histological, and biochemical tendon properties may be interesting for clinical trial investigation. Future efforts should focus on developing standardized preclinical Achilles tendinopathy models, improving reporting standards to minimize risk of bias, and facilitating translation to clinical practice.…”
Get full text

Development and validation of a novel risk-predicted model for early sepsis-associated acute kidney injury in critically ill patients: a retrospective cohort study by Bo Li, Kun Zhang, Cong-Cong Zhao, Zi-Han Nan, Yan-Ling Yin, Li-Xia Liu, Zhen-Jie Hu

“…It is not linked to a clinical trial. Data for patients with sepsis included in the development cohort were extracted from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. …”
Get full text

Development of a machine learning model related to explore the association between heavy metal exposure and alveolar bone loss among US adults utilizing SHAP: a study based on NHAN... by Jiayi Chen

“…In the future, more advanced algorithms should be developed to validate these results and related parameters can be tuned to improve the accuracy of the model. Clinical trial number not applicable.…”
Get full text

Superior persistence of ustekinumab compared to anti-TNF in vedolizumab-experienced inflammatory bowel diseases patients: a real-world cohort study by Horng-Yih Chiu, Chia-Jung Kuo, Ming-Wei Lai, Ren-Chin Wu, Chien-Ming Chen, Cheng-Tang Chiu, Yu-Bin Pan, Cheng-Hsun Chiu, Puo-Hsien Le

Get full text

Investigating resting-state functional connectivity changes within procedural memory network across neuropsychiatric disorders using fMRI by Mahdi Mohammadkhanloo, Mohammad Pooyan, Hamid Sharini, Mitra Yousefpour

“…These findings suggest that disrupted rs-FC within this network may related to cognitive networks impairments observed in these disorders. Clinical trial number Not applicable.…”
Get full text

Clinical Profile and Prescription Patterns in Culture-proven Enteric Fever in Children by Divya Priyadharshini, Mobill Clinton, Nandini Sethuraman, Mathrubootham Sridhar, Vidya Krishna

“…Future areas of research interest will include an effective vaccine for paratyphoid fever and a randomized clinical trial on single vs combination therapy in enteric fever.…”
Get full text

Abdominal fat distribution and its relationship to brain changes: the differential effects of age on cerebellar structure and function: a cross-sectional, exploratory study by Yvonne Böttcher, Michael Stumvoll, Kees Straatman, Matthias Raschpichler, Matthias Leopold Schroeter, Katrin Arelin, Haiko Schlögl, Dominik Fritzsch, Meinhard Mende, André Pampel, Arno Villringer, Karsten Mueller

Get full text

Development and Validation of a Predictive Model Based on Serum Silent Information Regulator 6 Levels in Chinese Older Adult Patients: Cross-Sectional Descriptive Study by Yuzi You, Wei Liang, Yajie Zhao

“…The nomogram for CAD outcome prediction in older adult patients with angina pectoris may aid in clinical trial design and personalized clinical decision-making, particularly in institutions where SIRT6 is being explored as a biomarker for aging or cardiovascular health.…”
Get full text

Prediction of pulmonary function decline in fibrous interstitial lung abnormalities based on quantitative chest CT parameters by Dechun Li, Yingli Sun, Zongjing Ma, Bin Chen, Liang Jin, Ming Li

“…The combined model has good predictive value. Clinical trial number 2024K249.…”
Get full text