Multicentre, 26-week, open-label phase 2 trial of the JAK inhibitor filgotinib in Behçet’s disease, idiopathic inflammatory myopathies and IgG4-related disease: DRIMID study protoc... by Sander W Tas, Joost Raaphorst, Paco M J Welsing, Jacob M van Laar, Rogier M Thurlings, Robbert J Goekoop, César Magro Checa, Jan A M van Laar, Bettina C Geertsema-Hoeve, Nicolle H Rekers, Erik Present

“…Introduction Research into novel therapies for rare, immune-mediated inflammatory diseases (IMIDs) faces significant challenges, including small patient populations, complex clinical trial design and difficulties in patient recruitment. …”
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ABCD3-I and ABCD2 Scores in a TIA Population with Low Stroke Risk by Fredrik Ildstad, Hanne Ellekjær, Torgeir Wethal, Stian Lydersen, Hild Fjærtoft, Bent Indredavik

“…Since there is a generally lower stroke risk after TIA during the last years, the benefit of these clinical risk scores and their role in TIA management seems limited. Clinical Trial Registration. This trial is registered with NCT02038725 (retrospectively registered, January 16, 2014).…”
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Silent struggles: a qualitative study exploring mental health challenges of undergraduate healthcare students by Shahd Al-Najdi, Abdulla Mansoor, Ola Al Hayk, Najah Al-Hashimi, Kamran Ali, Alaa Daud

“…Addressing academic pressures, enhancing self-coping mechanisms and social support systems, and reducing the stigma around mental health care are essential steps toward improving student well-being. Clinical trial number Not applicable.…”
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Perioperative tislelizumab plus chemotherapy for locally advanced gastroesophageal junction adenocarcinoma (NEOSUMMIT-03): a prospective, nonrandomized, open-label, phase 2 trial by Run-Cong Nie, Shu-Qiang Yuan, Ya Ding, Yong-Ming Chen, Yuan-Fang Li, Cheng-Cai Liang, Mu-Yan Cai, Guo-Ming Chen, Wei Wang, Xiao-Wei Sun, De-Sheng Weng, Dan-Dan Li, Jing-Jing Zhao, Xiao-Jiang Chen, Yuan-Xiang Guan, Zhi-Min Liu, Yao Liang, Ma Luo, Jun Chi, Hai-Bo Qiu, Zhi-Wei Zhou, Xiao-Shi Zhang, Ying-Bo Chen

“…Abstract This prospective, nonrandomized, open-label phase 2 trial (Chinese Clinical Trial Registry, ChiCTR2200061906) aimed to evaluate the effectiveness of adding the PD-1 antibody tislelizumab to perioperative chemotherapy in patients with locally advanced gastroesophageal junction adenocarcinoma (GEJA). …”
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WT1 Peptide Cancer Vaccine for Patients with Hematopoietic Malignancies and Solid Cancers by Yoshihiro Oka, Akihiro Tsuboi, Olga A. Elisseeva, Hiroko Nakajima, Fumihiro Fujiki, Manabu Kawakami, Toshiaki Shirakata, Sumiyuki Nishida, Naoki Hosen, Yusuke Oji, Ichiro Kawase, Haruo Sugiyama

“…On the basis of these findings, we performed a phase I clinical trial of a WT1 peptide cancer vaccine for the patients with malignant neoplasms. …”
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Early T-Cell Precursor Leukemia Has a Higher Risk of Induction-Related Infection among T-Cell Acute Lymphoblastic Leukemia in Adult by Kangyu Huang, Min Dai, Qiuli Li, Nannan Liu, Dainan Lin, Qiang Wang, Xuan Zhou, Zhixiang Wang, Ya Gao, Hua Jin, Xiaoli Liu, Qifa Liu, Hongsheng Zhou

“…We performed a retrospective cohort study for the prevalence and risk predictors of induction-related infection among consecutive T-ALL patients (N=97) enrolled in a PDT-ALL-LBL clinical trial. Of 97 patients with T-ALL enrolled in the trial, 46 were early T-cell precursor (ETP) ALL and 51 were non-ETP ALL. …”
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Protocol for prognosticating PPD using EEG changes during labor pain by uterine contractions: a prospective cohort study in the first stage of labor by Yan Wang, Wan-Ying He, Chang’ an A. Zhan, Shi-Lei Pan, Wen Wu, Feng-Xian Li, Hong-Fei Zhang

“…Trial registration number: NCT05217251; registration date on the ClinicalTrial.gov platform: February, 1/2022.…”
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Neural Correlates of Social Perception Deficit in Schizophrenia: An Event-related Potential Study by Jiang-juan Li, Xin-ping Li, Jia-min Han, Yi-fan Sun, Xiao-hong Liu, Xue-zheng Gao, Li-min Chen, Zhen-he Zhou, Hong-liang Zhou

“…These findings underscore the potential of the EIRT as a biomarker for cognitive and emotional dysregulation in schizophrenia. Clinical Trial Registration: No: ChiCTR2300078149. …”
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Triglyceride lowering in patients with different severities of hypertriglyceridaemia-associated acute pancreatitis: secondary analysis of a multicentre, prospective cohort study by Xiaoling Li, Lin Gao, Xiang Luo, Wenjian Mao, Lu Ke, Xiaoyan Lai, Lingyan Fu, Yaolu Liu

“…Similar findings were seen in the subgroup with more severe HTG-AP (APACHE II ≥8 at enrolment).Conclusion More rapid decline of serum TG levels was associated with decreased presence of organ failure at day 14 in patients with more severe HTG-AP.Trial registration number The Chinese Clinical Trial Registry, number ChiCTR2000039541.…”
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Effect of enhanced recovery after surgery on older patients undergoing transvaginal pelvic floor reconstruction surgery: a randomised controlled trial by Xuezhu Huang, Sisi Deng, Xiaofeng Lei, Shentao Lu, Ling Dai, Chunyan She

“…Trial registration This study was retrospectively registered with the Chinese Clinical Trial Registry (registration number: ChiCTR2400084608). …”
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Detection of differences in physical symptoms between depressed and undepressed patients with breast cancer: a study using K-medoids clustering by Jianyao Tang, Bingqian Guo, Chuhan Zhong, Jing Chi, Jiaqi Fu, Jie Lai, Yujie Zhang, Zihan Guo, Shisi Deng, Yanni Wu

“…The combination of digital tools and traditional clinical tools for symptom management in follow-up has great potential in the future. Clinical trial number Not applicable.…”
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Early Recognition and Intervention in SIBlingS at High Risk for Neurodevelopment Disorders (ERI-SIBS): a controlled trial of an innovative and ecological intervention for siblings... by Silvia Annunziata, Giulia Purpura, Giulia Purpura, Elena Piazza, Paolo Meriggi, Gabriele Fassina, Laura Santos, Emilia Ambrosini, Antonella Marchetti, Antonella Marchetti, Federico Manzi, Federico Manzi, Davide Massaro, Davide Massaro, Andrea Luna Tacci, Andrea Luna Tacci, Elisabetta Bolognesi, Simone Agostini, Francesca La Rosa, Alessandra Paola Giulia Pedrocchi, Paola Molina, Anna Cavallini

“…The study will have the potential to significantly contribute to future research and the scientific and clinical debate on the best way to implement early intervention in at-risk populations. Clinical Trial RegistrationClinicaltrials.gov identifier (NCT06512649).…”
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The relationship between frailty syndrome and quality of life in patients with hypertension: a multidimensional analysis by Bartosz Uchmanowicz, Anna Chudiak, Robbert Gobbens, Grzegorz Kubielas, Piotr Godek, Stanisław Surma, Dorota Bednarska-Chabowska, Izabella Uchmanowicz, Michał Czapla

“…Routine evaluation of frailty and the implementation of targeted interventions aimed at improving physical, psychological, and social well-being could substantially enhance QoL in this vulnerable population. Clinical trial number Not applicable.…”
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Weight loss-independent changes in human growth hormone during water-only fasting: a secondary evaluation of a randomized controlled trial by Benjamin D. Horne, Benjamin D. Horne, Benjamin D. Horne, Jeffrey L. Anderson, Jeffrey L. Anderson, Heidi T. May, Tami L. Bair, Viet T. Le, Viet T. Le, Leslie Iverson, Kirk U. Knowlton, Kirk U. Knowlton, Joseph B. Muhlestein, Joseph B. Muhlestein

“…Basal HGH and fasting-induced HGH changes correlated inversely with cardiometabolic risk factors.Clinical Trial Registration: clinicaltrials.gov, identifier NCT01059760.…”
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“It's a good idea, but…”: a qualitative evaluation of the GoldiCare intervention in Norwegian home care services by Heike Fischer, Fredrik Klæboe Lohne, Fredrik Klæboe Lohne, Marius Steiro Fimland, Skender Elez Redzovic

“…Trial registrationThis clinical trial was registered on 08/05/2022 under NCT05 487027.…”
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Short-Term Observation of Ultrasonic Cyclocoagulation in Chinese Patients with End-Stage Refractory Glaucoma: A Retrospective Study by Dongpeng Hu, Shu Tu, Chengguo Zuo, Jian Ge

“…The study was registered with Chinese Clinical Trial Registry (http://www.chictr.org.cn; Registration number: ChiCTR-OOC-17014028).…”
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Development of an imputation model to recalibrate birth weights measured in the early neonatal period to time at delivery and assessment of its impact on size-for-gestational age a... by Joanne Katz, James M Tielsch, Luke C Mullany, Diwakar Mohan, Subarna K Khatry, Seema Subedi, Scott L Zeger, Elizabeth A Hazel

“…We aimed to develop an imputation model that predicts the ‘true’ birth weight at time of delivery.Design We developed and applied a model that recalibrates weights measured in the early neonatal period to time=0 at delivery and uses those recalibrated birth weights to impute missing birth weights.Setting This is a secondary analysis of pregnancy cohort data from two studies in Sarlahi district, Nepal.Participants The participants are 457 babies with daily weights measured in the first 10 days of life from a subsample of a larger clinical trial on chlorhexidine (CHX) neonatal skin cleansing and 31 116 babies followed through the neonatal period to test the impact of neonatal massage oil type (Nepal Oil Massage Study (NOMS)).Outcome measures We developed an empirical Bayes model of early neonatal weight change using CHX trial longitudinal data and applied it to the NOMS dataset to recalibrate and then impute birth weight at delivery. …”
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Improving Anxiety Related to Chronic Pain Through a Sleep Circadian Intervention Program: A Pilot Study by Sonia López-Monzoni, Gloria Hernando Benito, Sofía Romero-Peralta, Laura Silgado-Martínez, Maria Esther Viejo-Ayuso, Leticia Álvarez-Balado, Enrique Rodríguez Matarranz, Carles Forné Izquierdo, Manuel Sánchez-de-la-Torre, Juan Fernando Masa, Ferrán Barbé, Francisco García-Río, Antonio Martínez-Nicolás, Belén García-Mediano, Esther Solano-Pérez, Olga Mediano

“…This was a randomized clinical trial (NCT03646084), in which 49 CMP patients were assigned to SCIP (<i>n</i> = 15, mean age 51 years and 40% women) or non-SCIP groups (<i>n</i> = 26, 53 years and 61.5% women). …”
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Comparative evaluation of intravenous versus intranasal dexmedetomidine on emergence delirium and hemodynamics in pediatric patients undergoing adenotonsillectomy: a randomized con... by Chenxu Dai, Chenxu Dai, Xuemei Zhao, Xuemei Zhao, Aoxue Li, Xuedong Zhang, Penglei Wang, Ye Zhang, Yun Wu

“…Intranasal administration of dexmedetomidine provided more stable hemodynamics and more prolonged analgesia and sedation than intravenous infusion of dexmedetomidine.Clinical Trial Registrationhttps://www.chictr.org.cn/showproj.html?…”
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Study protocol for Adaptive ChemoTherapy for Ovarian cancer (ACTOv): a multicentre phase II randomised controlled trial to evaluate the efficacy of adaptive therapy (AT) with carbo... by Michelle Lockley, Kathy Robinson, Rowan Miller, Charlie Gourley, Nicholas Counsell, Iain Mcneish, Trevor Graham, Uma Anne Mukherjee, Helen Hockings, Apini Patel, Priya Narayanan, Katie Wilkinson, Harjot Dhanda, Alexander R A Anderson

“…ACTOv is the first clinical trial of AT in this disease setting.Methods and analysis 80 patients will be randomised 1:1 to standard therapy (control) or AT (investigational) arms. …”
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