A Bayesian phase 2 model based adaptive design to optimise antivenom dosing: Application to a dose-finding trial for a novel Russell's viper antivenom in Myanmar. by James A Watson, Thomas Lamb, Jane Holmes, David A Warrell, Khin Thida Thwin, Zaw Lynn Aung, Min Zaw Oo, Myat Thet Nwe, Frank Smithuis, Elizabeth A Ashley

“…We propose a model based, Bayesian phase 2 type, adaptive clinical trial design for the characterisation of optimal initial antivenom doses in contexts where both efficacy and toxicity are measured as binary endpoints. …”
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Efficacy and safety of perioperative analgesia in PENG block for children undergoing hip surgery with developmental dysplasia: study protocol for a randomized, double-blinded, non-... by Mingzhe Xu, Yi He, Zhi Li, Bin Du

“…Trial registration Chinese Clinical Trial Registry ChiCTR2100053128. Registered on November 12, 2021.…”
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Femtosecond Laser Implantation of a 355-Degree Intrastromal Corneal Ring Segment in Keratoconus: A Three-Year Follow-Up by Marwa Mahmoud Abdellah, Hatem Gamal Ammar

“…The study has been registered for the Pan African Clinical Trial Registry (http://www.pactr.org) database within No: PACTR201810796878908 on 29 October 2018.…”
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Clinical Efficacy Between Intravenous Paracetamol and Intravenous Fentanyl for Propofol Deep Sedation in Colonoscopy: A Randomized Controlled Trial by Thiparporn T, Supan W, Amornyotin S

“…Sedation-related complications were relatively lower in the propofol deep sedation with iv paracetamol group compared to the propofol deep sedation with iv fentanyl group.Registration: This trial was registered with the Thai Clinical Trial Registry (TCTR 20190321002).Keywords: colonoscopy, propofol, deep sedation, intravenous paracetamol, fentanyl…”
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Biomimic Nanodrugs Overcome Tumor Immunosuppressive Microenvironment to Enhance Cuproptosis/Chemodynamic‐Induced Cancer Immunotherapy by Hangyi Wu, Xiaoyu Lu, Yuhan Hu, J. Baatarbolat, Zhihao Zhang, Yiping Liang, Youwen Zhang, Ye Liu, Huixia Lv, Xin Jin

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Efficacy of continuous intravenous infusion of lidocaine on postoperative sore throat after laryngeal mask insertion: a randomized controlled trial by Jianxin Jiang, Jimin Wu, Shuqi Shi, Xiaoli Dong, Jiaxiang Yin, Yini Wu

“…Trial Registration Chinese Clinical Trial Registry (ChiCTR2300070339,04/10/2023).…”
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Combination therapy of intravitreal ranibizumab and sub-tenon triamcinolone for treatment of resistant diabetic macular edema: a clinical study in Egypt by Hossam Eldin M. A. Khalil, Hazem E. Haroun, Alaa A. I. Shalan, Waleed M. Mahran

“…Methods This is a two-arm, randomized, prospective clinical trial that included 100 eyes of patients with refractory DME divided into 2 equal groups: group 1 received posterior subtenon triamcinolone (STTA) and anti-VEGF injections (0.5 mg ranibizumab), and group 2 received anti-VEGF injections (0.5 mg ranibizumab) only, in the same session. …”
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A randomized controlled trial to assess the efficacy of standardized tai chi in prefrail older adults with immunosenescence: design and protocol by Wen Zhong, Wei Huang, Hua Deng, Shuang Qiu, Qiyue Yang, Huanan Jia

“…Trial registration Chinese Clinical Trial Registry; registration number: ChiCTR2200065815; prospectively registered on November 16th, 2022.…”
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Impact of leadless pacemaker implantation site on cardiac synchronization and tricuspid regurgitation by Xiao-fei Gao, Hong Zhu, Jia-sheng Zhang, Ning-Zhang, Xiao-hong Pan, Yi-Zhou Xu

“…Abstract Background To investigate the optimization of leadless pacemaker placement and to assess its impact on heart synchronization and tricuspid regurgitation. Results A clinical trial was conducted involving 53 patients who underwent leadless pacemaker implantation at the Second Affiliated Hospital of Zhejiang University School of Medicine and Hangzhou First People’s Hospital between March 2022 and February 2023. …”
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Urban versus rural older adults: occupational balance and quality of life comparison by Emel Pekçetin, Serkan Pekçetin, Emine Sağlamoğlu, Gamze Ekici

“…Trial registration The clinical trial number is not applicable.…”
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The efficacy of acupuncture in relieving postoperative pain in patients with low simple anal fistula: Protocol of a prospective, randomised, controlled trial. by Min Yang, De Zheng, Xingtao Jin, Huili Tang, Weiwei Cao, Qianqian Ye, Yin Qu, Zubing Mei

“…<h4>Trial registration</h4>This study was registered in the China Clinical Trial Registry on June 1, 2024, with registration number: ChiCTR2400085178.…”
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Reliability of nociceptive monitors vs. standard practice during general anesthesia: a prospective observational study by Daniel Widarsson Norbeck, Sophie Lindgren, Axel Wolf, Pether Jildenstål

“…Trial registration Clinical trial - NCT05218551.…”
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Molecular assessment of NMDAR subunits and neuronal apoptosis in the trigeminal ganglion in a model of male migraine-induced rats following Moringa oleifera alcoholic extract admin... by Ahmad Vafaeian, Ali Vafaei, Mohammad Reza Parvizi, Mohsen Chamanara, Mojgan Mehriardestani, Yasaman Hosseini

“…Conclusions Moringa oleifera extract appears to mitigate symptoms of migraine by inhibiting apoptosis, suggesting potential efficacy in migraine treatment; however, additional research investigating a wider range of pathways is necessary. Clinical trial number Not applicable.…”
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Insulin autoimmune syndrome in a 3-year-old boy: the youngest to date in China and a narrow review by Ming Cheng, Yuan Ding, Dongmei Wang, Chunxiu Gong

“…Elevated levels of IAAs and an inappropriate insulin to C-peptide molar ratio during an extended OGTT are critical indicators. Clinical Trial Number Not applicable.…”
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An Investigation of the Anticancer Mechanism of <i>Caesalpinia sappan</i> L. Extract Against Colorectal Cancer by Integrating a Network Pharmacological Analysis and Experimental Va... by Mibae Jeong, Jaemoo Chun, Sang-Min Park, Heerim Yeo, Se Won Na, In Jin Ha, Bonglee Kim, Mi-Kyung Jeong

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The effects and durability of an 8-week dynamic neuromuscular stabilization program on balance and coordination in adult males with intellectual disabilities: a randomized controll... by Hamed Babagoltabar-Samakoush, Behnoosh Aminikhah, Saeid Bahiraei

“…Trial registration RTC, Registered prospectively at the registry of the clinical trial (UMIN000053560), Registered on 07/02/2024.…”
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Impact of electrical muscle stimulation-induced muscle contractions on endogenous pain modulatory system: a quantitative sensory testing evaluation by Satoshi Ohga, Takafumi Hattori, Kazuhiro Shimo, Hajime Maeda, Takako Matsubara

“…Trial registration This study was enrolled in the UMIN-CTR Clinical Trial Registry (registration number: UMIN000051951; date of approval: August 19, 2023).…”
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Bibliometrics of the current state of application of teletechnology in the rehabilitation of patients with heart and large blood vessel disease by Sican Wang, Ping Yu, Xuemei Zhou, Yuan Yuan, Jian Chen, Dongmei Chen, Jingyan Liang, Jingyan Liang, Li Xu

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Dynamic Augmented Reality Cues for Telementoring in Minimally Invasive Surgeries: Scoping Review by Hawa Hamza, Omar M Aboumarzouk, Abdulla Al-Ansari, Nikhil V Navkar

“…This review describes the MIS (including surgery type, specialty, procedure, and clinical trial), the telementoring system, the dynamic AR cues generated by these systems, and evaluation of the technology in terms of technical aspects, user perceptions, skills gained, and patient outcomes. …”
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The value of multiparametric MRI radiomics and machine learning in predicting preoperative Ki-67 expression level in breast cancer by Yan Lu, Long Jin, Ning Ding, Mengjuan Li, Shengnan Yin, Yiding Ji

“…This model could facilitate personalized clinical treatment strategies for individuals diagnosed with breast cancer (BC). Clinical trial number Not applicable.…”
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