Safety and effectiveness of dual therapy for Helicobacter pylori infection and the effect on the glycated hemoglobin level in type 2 diabetes by Jie Zhang, Xin Cao, Kai Ma, Yizhou Jiang, Xiangrong Qin, Xiaoyong Wang

“…The present prospective, single-center, single-arm, clinical trial enrolled 75 T2DM patients diagnosed with H. pylori infection. …”
Get full text

Lidocaine Versus Ketamine Pretreatment on Propofol Injection Pain by Amir Murad Khudadad Boujan, Nashmeel fazeel Kareem, Amanj A. Marouf, Saman Abdullah Ahmed Fahmi, Salah Qadir Mahmood

“…This study is randomized controlled clinical trial lasting from June 2015 to November 2015 during which 107 consenting (ASA1 and ASA2) patients were prepared for elective operation with general anesthesia. …”
Get full text

Quantitative Analysis of Postural Instability in Patients with Parkinson’s Disease by Yang Yu, Siquan Liang, Yue Wang, Yanan Zhao, Jiaojiao Zhao, Haitao Li, Jingchao Wu, Yuanyuan Cheng, Fan Wu, Jialing Wu

“…This study trial was registered with the Chinese Clinical Trial Registry (no. ChiCTR1900022715). Results. …”
Get full text

Did selective kinase inhibitors change the management of patients with radioiodine-refractory thyroid cancer? by Tommaso Porcelli, Cristina Luongo, Anna Cerbone, Carmine Di Luccio, Mariantonia Nacchio, Maria Angela De Stefano, Martin Schlumberger, Domenico Salvatore

“…Patients and methods: We extracted data from 69 consecutive patients referred to Federico II University Hospital from September 2016 to September 2024, among whom 44 patients were treated with TKIs as first-line treatment and outside any clinical trial, and form the basis of this report. Results: Thirty-one (71%) patients were treated with the antiangiogenesis inhibitor lenvatinib and 13 (29%) were treated with selective tyrosine kinase inhibitors (s-TKIs). …”
Get full text

Implementation of a value-based approach for older people who have suffered an acute myocardial infarction: study protocol by Denis Juraga, Tomislav Rukavina, Tomislav Rukavina, Mihaela Marinović Glavić, Lovorka Bilajac, Lovorka Bilajac, Lovorka Bilajac, Aleksandar Racz, Esmee L. S. Bally, Oscar Zanutto, Tamara Alhambra-Borrás, Maite Ferrando, Alen Subotić, Hein Raat, Vanja Vasiljev

“…Using this approach, it could be possible to reduce overall healthcare expenses through the active involvement of both older people and their informal caregivers through a shared decision-making process with healthcare professionals.Clinical trial registrationThe ISRCTN registry number is 25089186. …”
Get full text

Impact of variables on recovery time in patients undergoing hemodialysis: an international survey by Nurten Ozen, Tayfun Eyileten, Paulo Teles, Baris Seloglu, Ayse Gurel, Aysegul Ocuk, Volkan Ozen, Filipa Fernandes, Luís Campos, Sara Coutinho, Joana Teixeira, Sandra Cristina Mendo Moura, Olga Ribeiro, Clemente Neves Sousa

“…Further research with larger sample sizes is needed to deepen understanding of these factors and their implications. Clinical trial number NCT04667741.…”
Get full text

Effects of balanced opioid-free anesthesia on post-operative nausea and vomiting in patients undergoing video-assisted thoracic surgery: a randomized trial by Xiang Yan, Chen Liang, Jia Jiang, Ying Ji, An-Shi Wu, Chang-Wei Wei

“…This anesthetic regimen has shown good feasibility without significantly increasing the patient’s pain score and complications. Clinical trial registration number Clinicaltrials.gov, Identifier: NCT05411159. …”
Get full text

Association of systemic immune-inflammation index with all-cause and cardiovascular mortality among adults with depression: evidence from NHANES 2005–2018 by Xinping Yu, Heqing Zheng, Mingxu Liu, Lanxiang Wu, Sheng Tian, Wei Wu

“…Conclusions Higher SII levels were associated with increased risk of all-cause and cardiovascular mortality in adults with depression. Clinical trial number Not applicable.…”
Get full text

Examining anti-inflammatory therapies in the prevention of cardiovascular events: protocol for a systematic review and network meta-analysis of randomised controlled trials by George A Wells, Kevin Emery Boczar, Sheojung Shin, Kathryn A Bezzina, Aishwarya Geejo, Alexander Liam Pearson, Saba Shahab, Christophe A Fehlmann, Sarah Visintini, Rob Beanlands

“…Studies will be retrieved from Medline, Embase, the Cochrane Central Register of Controlled Trials, as well as clinical trial registry websites, Europe PMC and conference abstract handsearching. …”
Get full text

Development of a clinical prediction model for benign and malignant pulmonary nodules with a CTR ≥ 50% utilizing artificial intelligence-driven radiomics analysis by Wensong Shi, Yuzhui Hu, Guotao Chang, He Qian, Yulun Yang, Yinsen Song, Zhengpan Wei, Liang Gao, Hang Yi, Sikai Wu, Kun Wang, Huandong Huo, Shuaibo Wang, Yousheng Mao, Siyuan Ai, Liang Zhao, Xiangnan Li, Huiyu Zheng

“…Future efforts could explore more to improve its precision and value. Clinical trial number Not applicable.…”
Get full text

Association between vascular endothelial growth factor and atrial fibrillation: a systematic review by Nikhil Sharma, Mahalaqua Nazli Khatib, R. Roopashree, Mandeep Kaur, Manish Srivastava, Amit Barwal, G. V. Siva Prasad, Pranchal Rajput, Rukshar Syed, Kamal Kundra, Vinamra Mittal, Muhammed Shabil, Amit Kumar, Pancham Cajla, Ganesh Bushi, Rachana Mehta, Zaid Khan, Prakasini Satapathy, Shilpa Gaidhane, Afukonyo Shidoiku Daniel, Renu Sah

“…Future research should focus on longitudinal studies to better understand the causal relationships and the potential of VEGF as a therapeutic target and biomarker in AF management. Clinical trial number Not applicable.…”
Get full text

Abnormal Glucose Tolerance Is Associated with a Reduced Myocardial Metabolic Flexibility in Patients with Dilated Cardiomyopathy by Domenico Tricò, Simona Baldi, Silvia Frascerra, Elena Venturi, Paolo Marraccini, Danilo Neglia, Andrea Natali

“…This trial is registered with ClinicalTrial.gov NCT02440217.…”
Get full text

Effect of icatibant on sweating-induced dermal pain by Shunsuke Takahagi, Shunsuke Takahagi, Daiki Matsubara, Emi Murakami, Yumi Aoyama, Shinya Imamura, Atsushi Fukunaga, Atsushi Fukunaga, Yoshiko Oda, Hiroyuki Murota, Michihiro Hide, Michihiro Hide

“…The role of bradykinin in the dermal pain varies among patients.Clinical trial registrationhttps://jrct.niph.go.jp/, identifier jRCTs061210021.…”
Get full text

Acute beneficial effects of a functional energy shot on cognitive performance and mood states during cognitively demanding task performance: a randomized, double-blind, placebo-con... by Olivia K. O’Shea, Olivia K. O’Shea, Nathan Lawley, Anna Azzopardi, Allison Gutkowski, Michelle Murphy Niedziela, Rachel Horn, David O. Kennedy, Jason Adamson

“…Working memory tasks showed faster performance post-consumption, and mood assessments revealed positive effects on vigor, fatigue and overall mood disturbance.DiscussionThese results indicate wide cognitive and mood effects of this functional energy shot, potentially attributable to synergistic combination of active ingredients.Clinical trial registrationclinicaltrials.gov, identifier NCT06384586.…”
Get full text

Exploring the Variability in Acute Glycemic Responses to Exercise in Type 2 Diabetes by Tasuku Terada, Alanna Friesen, Baljot S. Chahal, Gordon J. Bell, Linda J. McCargar, Normand G. Boulé

“…This trial is registered with ClinicalTrial.gov NCT01144078.…”
Get full text

Effects of photobiomodulation therapy in patients with chronic non-specific low back pain: protocol for a randomised placebo-controlled trial by Lucíola da Cunha Menezes Costa, Shaiane Silva Tomazoni, Leonardo Oliveira Pena Costa, Layana de Souza Guimarães, Amanda Costa Araujo, Dafne Port Nascimento, Flávia Cordeiro de Medeiros, Marina Athayde Avanzi

“…Therefore, the objective of this clinical trial is to evaluate the effects of PBMT in patients with chronic non-specific LBP in the short, medium and long term.Methods and analyses This is a prospectively registered, two-arm randomised placebo-controlled trial with blinded patients, assessors and treatment providers. …”
Get full text

Targeting Cytokine-Mediated Inflammation in Brain Disorders: Developing New Treatment Strategies by Rahul Mallick, Sanjay Basak, Premanjali Chowdhury, Prasenjit Bhowmik, Ranjit K. Das, Antara Banerjee, Sujay Paul, Surajit Pathak, Asim K. Duttaroy

“…Furthermore, developments in biomarker discoveries and neuroimaging techniques are improving our ability to monitor inflammatory responses, allowing for more accurate and personalized treatment regimens. Preclinical and clinical trial data demonstrate the therapeutic potential of these tailored techniques. …”
Get full text

High peripheral T cell diversity is associated with lower risk of toxicity and superior response to dual immune checkpoint inhibitor therapy in patients with metastatic NSCLC by Alexandre Reuben, Mehmet Altan, Latasha Little, Jianjun Zhang, Ajay Sheshadri, Hai T Tran, Mara B Antonoff, Stephen G Swisher, John V Heymach, Saumil Gandhi, Natalie Vokes, Ziyi Li, Ruoxing Li, Runzhe Chen, Joshua Baguley, Jefferson Sinson, Greg Lizee

“…We used T-cell receptor (TCR) sequencing to systematically analyze prospectively collected patient blood samples from a randomized clinical trial of dual immune checkpoint inhibitor therapy to evaluate changes in the T-cell repertoire and their association with response and irAEs.Methods Patients with immunotherapy-naïve metastatic non-small cell lung cancer (NSCLC) were treated with ipilimumab and nivolumab according to trial protocol (LONESTAR, NCT03391869). …”
Get full text

Cultural competence, professional values, and spiritual well-being in nursing interns: a descriptive cross-sectional study by Amir Mohamad Nazari, Seyedeh Narjes Mousavizadeh, Zahra Khorrami Khoramabadi, Vahid Yousofvand, Seyed Mohammad-Javad Ghazavi Dozein

“…By implementing suitable educational strategies and providing support, educational managers can enhance the cultural competence of nursing interns. Clinical trial number Not applicable.…”
Get full text

Remediating cognitive inflexibility in obsessive compulsive disorder and anorexia nervosa neither moderates nor mediates treatment effects: an exploratory study by Boris van Passel, Boris van Passel, Unna N. Danner, Unna N. Danner, Alexandra E. Dingemans, Theo G. Broekman, Lot C. Sternheim, Lot C. Sternheim, Eni S. Becker, Annemarie A. van Elburg, Annemarie A. van Elburg, Eric F. van Furth, Eric F. van Furth, Gert-Jan Hendriks, Gert-Jan Hendriks, Gert-Jan Hendriks, Daniëlle C. Cath, Daniëlle C. Cath

“…This study explores whether baseline measures of cognitive flexibility predict outcomes in OCD and AN, evaluates whether changes in these measures contribute to treatment outcome, and evaluates the effectiveness of adjunctive cognitive remediation therapy (CRT) in improving cognitive flexibility.MethodsThis secondary analysis utilized linear mixed model analysis on data from a randomized controlled multicenter clinical trial involving adult participants with OCD (n=71) AND AN (n=61). …”
Get full text