Misuse of Statistical Methods in 10 Leading Chinese Medical Journals in 1998 and 2008 by Shunquan Wu, Zhichao Jin, Xin Wei, Qingbin Gao, Jian Lu, Xiuqiang Ma, Cheng Wu, Qian He, Meijing Wu, Rui Wang, Jinfang Xu, Jia He

“…Many mistakes were found in the randomised controlled trial (56.3% in 1998; 67.9% in 2008), non- randomised clinical trial (57.3%; 58.6%), basic science study (72.9%; 65.5%), case study or case series study (48.4%; 47.2%), and cross-sectional study (57.1%; 44.2%). …”
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The Neuroprotective Disease-Modifying Potential of Psychotropics in Parkinson's Disease by Edward C. Lauterbach, Leonardo F. Fontenelle, Antonio L. Teixeira

“…Additionally, PD-related gene transcription, animal model, and human neuroprotective clinical trial data were reviewed. Results indicate that, from a PD pathobiology perspective, the safest drugs (i.e., drugs least likely to promote cellular neurodegenerative mechanisms balanced against their likelihood of promoting neuroprotective mechanisms) include pramipexole, valproate, lithium, desipramine, escitalopram, and dextromethorphan. …”
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Safety and efficacy of long-term nicotinamide mononucleotide supplementation on metabolism, sleep, and nicotinamide adenine dinucleotide biosynthesis in healthy, middle-aged Japane... by Shintaro Yamaguchi, Junichiro Irie, Masanori Mitsuishi, Yuichi Uchino, Hideaki Nakaya, Ryo Takemura, Emi Inagaki, Shotaro Kosugi, Hideyuki Okano, Masato Yasui, Kazuo Tsubota, Kaori Hayashi, Jun Yoshino, Hiroshi Itoh

“…An 8-week, single-center, single-arm, open-label clinical trial was conducted. Eleven healthy, middle-aged Japanese men received two 125-mg NMN capsules once daily before breakfast. …”
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Physical literacy among chinese elementary school students: the mediating role of physical knowledge and physical competency by Li Mengyu, Wang Yuxing, Zan Ziqing, Liu Lizhu, You Lili

“…Physical competency explained 56.40% of the association between physical motivation and physical participation. Clinical trial number Not applicable…”
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Understanding Types of Stigma Experienced in Black Women Living With HIV in Baltimore, Maryland: A Mixed Methods Study by Tanya Mikhael, Kyra Jennifer Waligora Mendez, Chun‐An Sun, Joy Chepkorir, Hae‐Ra Han

“…Design Secondary analysis of quantitative and qualitative data from a recent clinical trial in Baltimore, Maryland. Methods Quantitative data were collected in the baseline survey, and qualitative data were gathered during 6‐month follow‐up focus group and individual interviews. …”
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Effectiveness of a holistic neuropsychological rehabilitation program using virtual reality by Liliana Mendes, Luís Paulo Reis, Fernando Barbosa

“…A total of 27 participants of both sexes with moderate or severe ABI participated in an investigation in a clinical trial-type design with pre-test and post-test. …”
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Preclinical evaluation of DC-CIK cells as potentially effective immunotherapy model for the treatment of glioblastoma by Annika Simone Lück, Jingjing Pu, Ahmad Melhem, Matthias Schneider, Amit Sharma, Ingo G. H. Schmidt-Wolf, Jarek Maciaczyk

“…Recently, a successful clinical trial of cytokine-induced killer (CIK) cell immunotherapy in patients with glioblastoma (GBM) has opened a new avenue for adoptive cellular immunotherapies in CNS malignancies. …”
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Evaluation of Urinary Tract Infection following Corticosteroid Therapy in Patients with Multiple Sclerosis Exacerbation by Aliyeh Bazi, Seyed Mohammad Baghbanian, Monireh Ghazaeian, Sahar Fallah, Narjes Hendoiee

“…This double-blind randomized clinical trial was conducted on 56 people with multiple sclerosis relapse who had undergone methylprednisolone for 5 days. …”
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Bacterial wilt disease alters the structure and function of fungal communities around plant roots by Jiemeng Tao, Jingjing Jin, Peng Lu, Shizhou Yu, Mengli Gu, Jinbang Wang, Jianfeng Zhang, Peijian Cao

“…Conclusion This work provides a deep insight into the effects of bacterial wilt disease on fungal communities along the soil-root continuum, and is helpful to identify plant-associated beneficial fungi to resist plant disease. Clinical trial number Not applicable.…”
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Gene Therapy with Endogenous Inhibitors of Angiogenesis for Neovascular Age-Related Macular Degeneration: Beyond Anti-VEGF Therapy by Selwyn M. Prea, Elsa C. Chan, Gregory J. Dusting, Algis J. Vingrys, Bang V. Bui, Guei-Sheung Liu

“…Preclinical studies of gene transfer in a large animal model have provided impressive preliminary results with a number of transgenes. In addition, a clinical trial in patients suffering from advanced neovascular AMD has provided proof-of-concept for successful gene transfer. …”
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The Bipolar Depression Electrical Treatment Trial (BETTER): Design, Rationale, and Objectives of a Randomized, Sham-Controlled Trial and Data from the Pilot Study Phase by Bernardo de Sampaio Pereira Junior, Gabriel Tortella, Beny Lafer, Paula Nunes, Isabela Martins Benseñor, Paulo Andrade Lotufo, Rodrigo Machado-Vieira, André R. Brunoni

“…Conclusion. This upcoming clinical trial will address the efficacy of tDCS for BD on different degrees of refractoriness. …”
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Safety and Efficacy of Combined Yttrium 90 Resin Radioembolization with Aflibercept and FOLFIRI in a Patient with Metastatic Colorectal Cancer by Andre De Souza, Kevin Pelham Daly, James Yoo, Muhammad Wasif Saif

“…An ongoing randomized clinical trial aims to define the role of combined targeted therapy and chemotherapy with radioembolization with Y90.…”
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New therapies in pulmonary arterial hypertension: Recent insights by Giulia Guglielmi, Konstantinos Dimopoulos, S. John Wort

“…Finally, strategies that target the serotonin pathway, and other metabolic and hormonal pathways are described.This review includes both preclinical and clinical trial data that support efficacy, safety and the future potential of such therapies. …”
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Effectiveness of physiological flexion swaddling and oromotor interventions in improving preterm infants' oral feeding ability in the NICU: a randomized controlled trial by Luh K. Wahyuni, Irawan Mangunatmadja, Risma K. Kaban, Elvie Zulka K. Rachmawati, Rizky K. Wardhani, Budiati Laksmitasari, Boya Nugraha

“…Methods: A randomized clinical trial in five Neonatal intensive care units (NICU) was performed involving 70 preterm infants born at 28–34 weeks gestational age. …”
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The Effect of Synbiotic Supplementation on Self-Reported Aggression in Healthy Adult Men: A Randomized, Double-Blind, Placebo-Controlled Trial by Rahele Sadat Montazeri, Farzad Shidfar, Fatemeh Sadat Hosseini-Baharanchi, Golraste Kholasezadeh

“…Methods: This double-blind randomized controlled clinical trial was conducted on 100 healthy adult men working at Iran University of Medical Sciences. …”
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Mesenchymal Stem Cell-Educated Macrophages Ameliorate LPS-Induced Systemic Response by Yaoqin Hu, Chaojin Qin, Guoping Zheng, Dengming Lai, Huikang Tao, Yan Zhang, Guanguan Qiu, Menghua Ge, Lanfang Huang, Lina Chen, Baoli Cheng, Qiang Shu, Jianguo Xu

“…When macrophages were cultured with serum from ARDS patients who were treated with ASCs or placebo in our previous clinical trial, there was no difference in M2 macrophage levels before and after ASCs treatment indicating a suboptimal response to the treatment protocol. …”
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Timing of Acupuncture during LTP-Like Plasticity Induced by Paired-Associative Stimulation by Xiao-kuo He, Qian-qian Sun, Hui-hua Liu, Xin-yi Guo, Cheng Chen, Li-dian Chen

“…This trial was registered in the Chinese Clinical Trial Registry (registration no. ChiCTR-IPR-1900020515).…”
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The Effects of Local Administration of Aminophylline on Transureteral Lithotripsy by Ayyoub Barzegarnezhad, Abolfazl Firouzian, Seyed Abdollah Emadi, Nadali Mousanejad, Roksana Bakhshali

“…In this double-blind randomized clinical trial, 120 patients with ureteral stones were enrolled and randomized into two groups. …”
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Comparison of Dexmedetomidine with Acetaminophen and Its Combination (Apodex) on Pain Control, Emergence Agitation and Delirium in Pediatric Patients Undergoing Adenotonsillectomy... by farzad sarshivi, negin ghadami, karim naseri, soraya sarshivi

“…Materials and Methods: In this randomized double-blind clinical trial, 132 patients, between 2 and 12 years, candidates for adenotonsillectomy were examined in four groups (n=33). …”
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Inhibition of P38 MAPK Downregulates the Expression of IL-1β to Protect Lung from Acute Injury in Intestinal Ischemia Reperfusion Rats by De-Yi Zheng, Min Zhou, Jiao Jin, Mu He, Yi Wang, Jiao Du, Xiang-Yang Xiao, Ping-Yang Li, Ai-Zhu Ye, Jia Liu, Ting-Hua Wang

“…Our findings indicate that the inhibition of P38 α and β may downregulate the expression of IL-1β to protect lung from acute injury in II/R, which could be used as a potential target for reducing ALI induced by II/R in the future clinical trial.…”
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