Penile Rehabilitation and Neuromodulation by Fernando Facio, Arthur L. Burnett

“…The purpose of this essay is to describe the mechanisms related to post-RP ED, assess the need for penile rehabilitation and neuromodulation following surgery, and analyze the basic science and clinical trial evidence associated with these applications for preserving EF following prostate cancer treatment.…”
Get full text

Long-Term Stability of Hydromorphone in Human Plasma Frozen at −20°C for Three Years Quantified by LC-MS/MS by Andreas Wehrfritz, Stefanie Schmidt, Harald Ihmsen, Jürgen Schüttler, Christian Jeleazcov

“…To evaluate the stability of the analgesic opioid hydromorphone, 44 human frozen plasma samples of a former clinical trial were reanalyzed after at least three years. …”
Get full text

Hepatoprotection by L-Ornithine L-Aspartate in Non-Alcoholic Fatty Liver Disease by Roger F. Butterworth, Ali Canbay

“…L-ornithine L-aspartate (LOLA) has hepatoprotective properties in patients with fatty liver of diverse etiology and results of a multicenter randomized clinical trial reveal that 12 weeks treatment with oral LOLA (6–9 g/d) results in a dose-related reduction in activities of liver enzymes and triglycerides together with significant improvements of liver/spleen CT ratios. …”
Get full text

The Effectiveness Of Spiritual Emotional Freedom Technique (SEFT) On The Decrease of Psychological Issues In Cancer Patients: A Systematic Review by Meliawati Putri Salsabila, Enie Novieastari

“…The literature search strategy involved keywords related to the topic and title of the study, namely: "Massage" OR "foot massage" OR "reflexiology" AND "Fatigue" AND "Haemodialysis" OR "Chronic kidney disease" AND "Randomised Control" OR "Clinical Trial". 6 articles showing effective results of SEFT application in various populations. …”
Get full text

First Description of the Clinical Activity of Avapritinib in Sporadic Mesenteric Desmoid Tumor by Rebecca Ganzon, Wei Chen, Gabriel Tinoco

“…This clinical finding may be worth exploring in a dedicated clinical trial.…”
Get full text

Is Oral Omega-3 Effective in Reducing Mucocutaneous Side Effects of Isotretinoin in Patients with Acne Vulgaris? by Mina Mirnezami, Hoda Rahimi

“…In this randomized double-blind clinical trial, a total of 118 patients with moderate or severe acne were randomly divided into two (case and control) groups. …”
Get full text

The effect of transcutaneous auricular vagus nerve stimulation on cardiovascular function in subarachnoid hemorrhage patients: A randomized trial by Gansheng Tan, Anna L Huguenard, Kara M Donovan, Phillip Demarest, Xiaoxuan Liu, Ziwei Li, Markus Adamek, Kory Lavine, Ananthv K Vellimana, Terrance T Kummer, Joshua W Osbun, Gregory J Zipfel, Peter Brunner, Eric C Leuthardt

“…Methods: In this randomized clinical trial, 24 SAH patients were assigned to either a taVNS treatment or a sham treatment group. …”
Get full text

Capsaicin-induced secondary hyperalgesia differences between the trigeminal and spinal innervation by Isabela C. Novaes, Soraya S. Ardestani, Allen Matheus S. Nascimento, Paulo C. R. Conti, Leonardo R. Bonjardim, Peter Svensson, Fernando G. Exposto, Yuri M. Costa

“…Abstract This study compared the degree of secondary hyperalgesia and somatosensory threshold changes induced by topical capsaicin between spinal and trigeminal innervation. This crossover clinical trial included 40 healthy individuals in which 0.25 g of 1% capsaicin cream was randomly applied for 45 minutes to a circular area of 2 cm2 to the skin covering the masseter muscle and forearm in 2 different sessions, separated by at least 24 hours and no more than 72 hours (washout period). …”
Get full text

TCR Gene Transfer: MAGE-C2/HLA-A2 and MAGE-A3/HLA-DP4 Epitopes as Melanoma-Specific Immune Targets by Trudy Straetemans, Mandy van Brakel, Sabine van Steenbergen, Marieke Broertjes, Joost Drexhage, Joost Hegmans, Bart N. Lambrecht, Cor Lamers, Pierre van Der Bruggen, Pierre G. Coulie, Reno Debets

“…We intend to start testing these MAGE-specific TCRs in phase I clinical trial.…”
Get full text

Effects of instructional therapeutic play in the behavior of children during the first attempt at intravenous catheterization by Luciano Marques dos Santos, Erika Ribeiro de Souza, Patrícia Kuerten Rocha, Edmara Bazoni Soares Maia, Karine Emanuelle Oliveira Peixoto da Silva, Raygleise dos Santos Borges, Leonardo Bigolin Jantsch, Bianka Sousa Martins Silva

“…Method: This is a quasi-experimental post hoc analysis with a non-equivalent control group, secondary to a randomized clinical trial. The convenience sample comprised 193 children, allocated for convenience into an intervention group (preparation for catheterization with a therapeutic play; n=101 children) and a control group (preparation with structured conversation supported by the use of a booklet; n=92 children). …”
Get full text

Investigating The Effect of Transcutaneous Electrical Nerve Stimulation on The Severity of Restless Legs Syndrome in Hemodialysis Patients by Abolfazl Kalmishi, Ali Abedi, Katayoun Samadi, HamidReza Shoraka, Mostafa Rad

“…Materials and Methods: This clinical trial study was conducted on 60 patients undergoing hemodialysis treatment in the dialysis department of Vasei Sabzevar and Imam Khomeini Esfrain Hospitals, from December of 2022 to March 2023. …”
Get full text

Oral lactoferrin as a treatment of pediatrics’ anemia resulted from chronic kidney diseases: a randomized controlled trial by Sahar Kamal Hegazy, Mai Salah El-Din Koura, Mohamed Shokry Elharoun

“…This randomized and parallel clinical trial aimed to compare the effectiveness of oral lactoferrin with intravenous (IV) iron dextran in managing anemia resulted from CKD in pediatrics. …”
Get full text

The Potential Role of Matrix Metalloproteinases 8 and 9 and Myeloperoxidase in Predicting Outcomes of Bacterial Meningitis of Childhood by Okko Savonius, Irmeli Roine, Saeed Alassiri, Taina Tervahartiala, Otto Helve, Josefina Fernández, Heikki Peltola, Timo Sorsa, Tuula Pelkonen

“…Clinical data and the diagnostic CSF samples from 245 children (median age eight months) with bacterial meningitis were obtained from a clinical trial in Latin America in 1996–2003. MMP-9 levels in the CSF were assessed by zymography, while MMP-8, MPO, and TIMP-1 concentrations were determined with immunofluorometric and enzyme-linked immunosorbent assays. …”
Get full text

Preoperative uterine artery embolisation before hysterectomy in women with giant uterine fibroid and HIV-associated nephropathy by Filip Szkodziak, Sławomir Woźniak, Łukasz Światłowski, Emilia Maleszyk, Piotr Szkodziak, Krzysztof Pyra, Viktor Berczi, Tomasz Paszkowski, Tomasz Jargiełło

“…Although the benefits of pre-operative UAE before planned myomectomy or hysterectomy in high surgical risk patients with large fibroids has yet to be confirmed in a well-designed clinical trial, this procedure seems to be a promising tool to reduce the risk of perioperative complications in such patients.…”
Get full text

Air Bubble Technique for Fundus Visualization during Vitrectomy in Aphakia by Mahmoud Mohamed Farouk, Takeshi Naito, Mohammed Elagouz, Hatem Ammar, Alahmady Hamad Alsmman, Engy Mohamed Mostafa

“…This trial is registered with Pan African Clinical Trial Registry PACTR201709002466296.…”
Get full text

Diagnosis of Sleep Apnea Hypopnea Syndrome Using Fusion of Micro-motion Signals from Millimeter-wave Radar and Pulse Wave Data by Xiang ZHAO, Wei WANG, Chenyang LI, Jian GUAN, Gang LI

“…Experimental results of a clinical trial dataset at Shanghai Jiaotong University School of Medicine Affiliated Sixth People’s Hospital demonstrated that the AHI estimated by the proposed approach correlates with the gold standard PSG with a coefficient of 0.93, indicating good consistency. …”
Get full text

Diagnostic accuracy of CCTA-derived versus angiography-derived quantitative flow ratio (CAREER) study: a prospective study protocol by Liang Zhang, Yang Chen, Cheng Li, Ming Li, Shaofeng Guan, Xinkai Qu, Tingwen Weng, Qian Gan, Zehang Li, Wenzheng Han, Xinrong Zhai, Lin Qi, Xifeng Chang, Shengxian Tu

“…The objective of this investigator-initiated, prospective, single-centre clinical trial is to evaluate the diagnostic performance of CT-QFR with respect to angiography-derived QFR, using FFR as the reference standard.Methods and analysis A total of 216 patients who have at least one lesion with a diameter stenosis of 30%–90% in an artery with ≥2.0 mm reference diameter will be enrolled in the study. …”
Get full text

Diabetic Retinopathy and BDNF: A Review on Its Molecular Basis and Clinical Applications by Mehrdad Afarid, Ehsan Namvar, Fatemeh Sanie-Jahromi

“…The most relevant in vitro and clinical trial studies were then extracted for final interpretation. …”
Get full text

Hyperleukocytosis in a neuroblastoma patient after treatment with natural killer T cells expressing a GD2-specific chimeric antigen receptor and IL-15 by Xin Xu, Shantan Reddy, Saleh Bhar, Frederic D Bushman, Amy N Courtney, Gabriel A Barragán, Gengwen Tian, Erica J Di Pierro, Leonid S Metelitsa, Antonino Montalbano, Hangjin Yu, Claudia Martinez Amador, Nisha Ghatwai, Michael S Wood, Deborah Schady, Aoife M Roche, David de la Cerda, Donald Williams Parsons, Andras Heczey

“…Here, we describe a case of lethal hyperleukocytosis in a patient with neuroblastoma treated on phase 1 clinical trial (NCT03294954) with autologous natural killer T cells (NKTs) expressing a GD2-specific chimeric antigen receptor and cytokine interleukin 15 (GD2-CAR.15). …”
Get full text

DIFFERENT CERVICAL LAMINOPLASTY TECHNIQUES - UPDATE AND SYSTEMATIC REVIEW by FRANCISCO ALVES DE ARAÚJO JÚNIOR, JURANDIR MARCODES RIBAS FILHO, OSVALDO MALAFAIA, ALUÍZIO AUGUSTO ARANTES JÚNIOR, GUILHERME HENRIQUE WEILER CECCATO, PEDRO HELO DOS SANTOS NETO

“…In this phase, a literature review was carried out using the descriptor “cervical laminoplasty”, employing “clinical trial”, “meta-analysis”, “review,” and “systematic review” as filters. …”
Get full text