Biomarker-Based Targeting of the Androgen-Androgen Receptor Axis in Advanced Prostate Cancer by Manish Kohli, Rui Qin, Rafael Jimenez, Scott M. Dehm

“…Specific examples of rational clinical trial designs incorporating potential predictive biomarkers from these pathways will illustrate several aspects of pharmacogenetic and pharmacogenomic predictive biomarker development in advanced prostate cancer therapeutics.…”
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Comparative Numerical Analysis between Two Types of Orthodontic Wire for the Lingual Technique, Using the Finite Element Method by Rosa Alicia Hernández-Vázquez, Rodrigo Arturo Marquet-Rivera, Octavio Alejandro Mastache-Miranda, Angel Javier Vázquez-López, Salvador Cruz-López, Juan Alejandro Vázquez-Feijoo

“…The present study establishes the bases so that it is possible to find the indications for each type of wire. A clinical trial of a lingual orthodontic patient was used. …”
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Sex differences in the association between repetitive negative thinking and neurofilament light by Yolanda Lau, Amit Bansal, Cassandre Palix, Harriet Demnitz-King, Miranka Wirth, Olga Klimecki, Gael Chetelat, Géraldine Poisnel, Natalie L. Marchant, The Medit-Ageing Research Group

“…Baseline data from 134 cognitively healthy older adults in the Age-Well clinical trial were utilised. Worry and brooding were assessed using questionnaires. …”
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Prediction of individual patient outcomes to psychotherapy vs medication for major depression by Devon LoParo, Boadie W. Dunlop, Charles B. Nemeroff, Helen S. Mayberg, W. Edward Craighead

“…We used machine learning to develop predictor variables that combined demographic and clinical items from a randomized clinical trial. The variables predicted a meaningful proportion of variance in end-of-treatment depression severity for cognitive behavioral therapy (39.7%), escitalopram (32.1%), and duloxetine (67.7%), leading to a high accuracy in predicting remission (71%). …”
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A 15-Item modification of the PSP rating scale to improve clinical meaningfulness and statistical performance by Tien Dam, Lili Yang, Colin Gillis, Yumeng Li, John O’Gorman, Barbara Kolb, Adam L. Boxer, Lawrence Golbe, Samantha Budd Haeberlein, On behalf of the AL-108-231, PROSPERA, and 4RTNI investigators

“…The approach to develop the 15-item PSPRS provides an example of how to modify an existing clinical outcome assessment for use as a primary endpoint in a clinical trial of a progressive neurological disorder.…”
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Impact of rapid antibiotic susceptibility testing for Gram-negative bacteremia varies by pathogen type and resistance: a secondary analysis of the RAPIDS GN trial by Ritu Banerjee, Abhigya Giri, Lauren Komarow, Maria Souli, Sarah B. Doernberg, Robin Patel

“…This analysis of patients with sepsis previously enrolled in a randomized controlled clinical trial demonstrates that rapid susceptibility testing of bacteria from blood cultures had the greatest impact for patients with antibiotic-resistant infections. …”
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Early screening of lung function by electrical impedance tomography in people with normal spirometry reveals unrecognized pathological features by Shuoyao Qu, Enzhi Feng, Daihan Dong, Lin Yang, Meng Dai, Inéz Frerichs, Shaojie Liu, Yi Gao, Jinping Zheng, Liqiang Song, Zhanqi Zhao

“…The regional time constant based on electrical impedance tomography can be a promising tool for early screening of lung function impairment. Clinical trial registration: ChiCTR2300076673, www.chictr.org.cn .…”
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A Novel Curcumin-Based Drug Powder Inhalation Medicine for Chronic Obstructive Pulmonary Disease by Qin Shen, Yongjie Jiang, Jing Chen, Xueling Wang, Jiao Zheng

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Evaluation of anterior fixed appliances on maxillary arch growth in preschool children by Mohamed Ghaly, Nahed Abo Hamila

“…The study was conducted as a clinical trial and it was carried out at Pediatric Dentistry Department, Faculty of Dentistry, Tanta University. …”
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Vascular Endothelial Growth Factor (VEGF) Family and the Immune System: Activators or Inhibitors? by Cristina Maria Failla, Maria Luigia Carbone, Carmela Ramondino, Emanuele Bruni, Angela Orecchia

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Fecal DNA Screening in Colorectal Cancer by Suzanne Richter

“…Current challenges include cost reduction and demonstration of mortality benefit in a rigorous clinical trial. Despite current challenges, fecal DNA testing is worth pursuing. …”
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CYP2A6 Polymorphisms May Strengthen Individualized Treatment for Nicotine Dependence by Yawo Mawuli Akrodou

“…., CYP2A6*1H, CYP2A6*4A, CYP2A6*9, and CYP2A6*12A) are associated with underrated nicotine metabolizing activity (50%–75%), linking them to low scores for nicotine dependence (0–4) on the FTND scale. In a clinical trial involving the use of bupropion, people who were carriers of slow nicotine metabolizers were found to have a tendency to maintain abstinence 1.7 times longer than people with normal nicotine metabolizers. …”
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Understanding tinnitus symptom dynamics and clinical improvement through intensive longitudinal data by Milena Engelke, Jorge Piano Simões, Laura Basso, Nina Wunder, Berthold Langguth, Thomas Probst, Rüdiger Pryss, Winfried Schlee

“…App data from a multi-center randomized clinical trial were analysed using time-series feature extraction and nested cross-validated ordinal regression with elastic net regulation to predict clinical improvement based on the Clinical Global Impression—Improvement scale (CGI-I). …”
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Proliferative Vitreoretinopathy after Eye Injuries: An Overexpression of Growth Factors and Cytokines Leading to a Retinal Keloid by Francesco Morescalchi, Sarah Duse, Elena Gambicorti, Mario R. Romano, Ciro Costagliola, Francesco Semeraro

“…This paper reviews the current literature and clinical trial data on the pathogenesis of PVR and its correlation with ocular trauma and describes the biochemical/molecular events that will be fundamental for the development of novel treatment strategies. …”
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Noni Juice Improves Serum Lipid Profiles and Other Risk Markers in Cigarette Smokers by Mian-Ying Wang, Lin Peng, Vicki Weidenbacher-Hoper, Shixin Deng, Gary Anderson, Brett J. West

“…One hundred thirty-two adult heavy smokers completed a randomized, double blind, placebo-controlled clinical trial designed to investigate the effect of noni juice on serum cholesterol, triglyceride, low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol (HDL), high-sensitivity C-reactive protein (hs-CRP), and homocysteine. …”
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TNG908 is a brain-penetrant, MTA-cooperative PRMT5 inhibitor developed for the treatment of MTAP-deleted cancers by Kimberly J. Briggs, Kevin M. Cottrell, Matthew R. Tonini, Alice Tsai, Minjie Zhang, Douglas A. Whittington, Wenhai Zhang, Steven A. Lombardo, Satoshi Yoda, Erik W. Wilker, Samuel R. Meier, Yi Yu, Teng Teng, Alan Huang, John P. Maxwell

“…TNG908 is being tested clinically in patients with MTAP-deleted tumors, including glioblastoma, in a Phase I/II clinical trial (NCT05275478).…”
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Aerobic Exercise Improves Signs of Restless Leg Syndrome in End Stage Renal Disease Patients Suffering Chronic Hemodialysis by Mojgan Mortazavi, Babak Vahdatpour, Aida Ghasempour, Diana Taheri, Shahrzad Shahidi, Firouzeh Moeinzadeh, Bahareh Dolatkhah, Shahaboddin Dolatkhah

“…In this randomized clinical trial we aimed to find a nonpharmacological way to improve signs of restless leg syndrome and patients’ quality of life. …”
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Testosterone exacerbates neutrophilia and cardiac injury in myocardial infarction via actions in bone marrow by Elin Svedlund Eriksson, Marta Lantero Rodriguez, Bente Halvorsen, Inger Johansson, Anna K. F. Mårtensson, Anna S. Wilhelmson, Camilla Huse, Thor Ueland, Pål Aukrust, Kaspar Broch, Lars Gullestad, Brage Høyem Amundsen, Geir Øystein Andersen, Mikael C. I. Karlsson, Malin Hagberg Thulin, Alessandro Camponeschi, Dana Trompet, Ola Hammarsten, Björn Redfors, Jan Borén, Elmir Omerovic, Malin C. Levin, Andrei S. Chagin, Tuva B. Dahl, Åsa Tivesten

“…Post-hoc analysis of clinical trial data showed that neutrophilia was greater in men than women after reperfusion of first-time ST-elevation MI, and tocilizumab, an interleukin-6 receptor inhibitor, reduced blood neutrophil counts and infarct size to a greater extent in men than women. …”
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Malaria Vaccine Development: Are Bacterial Flagellin Fusion Proteins the Bridge between Mouse and Humans? by Daniel Y. Bargieri, Irene S. Soares, Fabio T. M. Costa, Catarina J. Braga, Luis C. S. Ferreira, Mauricio M. Rodrigues

“…The recent report of the first Phase I clinical trial of a vaccine containing a Salmonella flagellin as carrier/adjuvant may fuel the use of these proteins in vaccine formulations. …”
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Focusing on Sodium Glucose Cotransporter-2 and the Sympathetic Nervous System: Potential Impact in Diabetic Retinopathy by Lakshini Y. Herat, Vance B. Matthews, P. Elizabeth Rakoczy, Revathy Carnagarin, Markus Schlaich

“…Excitingly, the EMPA-REG clinical trial, which focuses on the clinically used SGLT2 inhibitor empagliflozin, has been extremely fruitful and has highlighted beneficial cardiovascular and renal outcomes. …”
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