Thrombomodulin: A Bifunctional Modulator of Inflammation and Coagulation in Sepsis by Takayuki Okamoto, Hironobu Tanigami, Koji Suzuki, Motomu Shimaoka

“…A recombinant soluble form of thrombomodulin has been approved to treat patients suffering from disseminated intravascular coagulation (DIC) and has thus far shown greater therapeutic potential than heparin. A phase II clinical trial is currently underway in the USA to study the efficacy of thrombomodulin for the treatment of sepsis with DIC complications. …”
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Exogenous Surfactant Therapy for Pediatric Patients with Acute Respiratory Distress Syndrome by James F Lewis, Jasvinder S Dhillon, Ram N Singh, Craig C Johnson, Timothy C Frewen

“…Based on the results of this pilot study, a more appropriate multicentre clinical trial should be designed to evaluate this treatment strategy.…”
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Progression from Sustained BK Viruria to Sustained BK Viremia with Immunosuppression Reduction Is Not Associated with Changes in the Noncoding Control Region of the BK Virus Genome by Imran A. Memon, Bijal A. Parikh, Monique Gaudreault-Keener, Rebecca Skelton, Gregory A. Storch, Daniel C. Brennan

“…We performed PCR amplification and sequencing of (1) stored urine and (2) plasma samples from the time of peak viremia from 11 patients with sustained viremia who participated in a 200-patient clinical trial. The antimetabolite was withdrawn for BK viremia and reduction of the calcineurin inhibitor for sustained BK viremia. …”
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Human Cardiospheres as a Source of Multipotent Stem and Progenitor Cells by Lucio Barile, Mihaela Gherghiceanu, Laurenţiu M. Popescu, Tiziano Moccetti, Giuseppe Vassalli

“…CDCs have been tested safely in an initial phase-1 clinical trial in patients after myocardial infarction. …”
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Genetic Correction of Sickle Cell Anemia and β-Thalassemia: Progress and New Perspective by Ajay Perumbeti, Punam Malik

“…Correction of the β-globinopathies using lentivirus vectors carrying the β- or γ-globin genes and elements of the locus control region has now been well established in murine models, and an understanding of "what is required to cure these diseases" has been developed in the first decade of the 21st century. A clinical trial using one such vector has been initiated in France with intriguing results, while other trials are under development. …”
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Expert insights on Hodgkin’s lymphoma development in an activated PI3K delta syndrome patient undergoing leniolisib treatment by Francesca Conti, Francesca Conti, Mattia Moratti, Mattia Moratti, Elena Sabattini, Pier Luigi Zinzani, Pier Luigi Zinzani

“…Here, we provide expert perspective on the suspected causality of a case of lymphoma observed in a 20-year-old female patient who was included in a clinical trial of leniolisib, a PI3K inhibitor.…”
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Fractional-Order PI Control of First Order Plants with Guaranteed Time Specifications by F. J. Castillo-Garcia, A. San Millan-Rodriguez, V. Feliu-Batlle, L. Sanchez-Rodriguez

“…CDCs have been tested safely in an initial phase-1 clinical trial in patients after myocardial infarction. …”
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Machine Learning Techniques for Quantification of Knee Segmentation from MRI by Sujeet More, Jimmy Singla, Ahed Abugabah, Ahmad Ali AlZubi

“…The review paper also focuses on automatic approaches and semiautomatic approaches which are extensively used with performance metrics and sufficient achievement for clinical trial assistance. Furthermore, the results of different approaches related to MR sequences used to image the knee tissues and future aspects of the segmentation are discussed.…”
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Adult acute megakaryoblastic leukemia with persistent diarrhea and extreme thrombocytosis: A very unusual case by Nevin Alayvaz Aslan, Gülsün Gülten

“…Patients with megakaryoblastic leukemia respond poorly to standard induction regimens and they should be advised to participate in a clinical trial.…”
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START—the Swiss tele-assisted rehabilitation and training program to support transition from inpatient to outpatient care in the subacute phase after a stroke: feasibility, safety... by Szabina Gäumann, Carina Ziller, Carina Ziller, Nele Paulissen, Nele Paulissen, Frank Behrendt, Frank Behrendt, Zorica Suica, Zorica Suica, Björn Crüts, Luana Gammerschlag, Katrin Parmar, Katrin Parmar, Hans Ulrich Gerth, Hans Ulrich Gerth, Leo H. Bonati, Leo H. Bonati, Leo H. Bonati, Corina Schuster-Amft, Corina Schuster-Amft, Corina Schuster-Amft

“…Despite these challenges, the study's findings will provide insights into the feasibility of mobile-based telerehabilitation and guide the design of a future randomized controlled trial. Clinical Trial RegistrationThe study is registered with the Swiss National Clinical Trial Portal (SNCTP000005943), EUDAMED (CIV-CH-24-05-046954), and clinicaltrils.gov (NCT06449612).…”
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Remimazolam for the prevention of emergence agitation in adults following nasal surgery under general anesthesia: a prospective randomized clinical controlled trial by Yanfei Lu, Qiaomin Xu, Hong Dai, Jimin Wu, Mengting Ai, Haiyan Lan, Xiaoli Dong, Gongchen Duan

“…Trial registration The trial was registered, before patient enrollment, in the Chinese Clinical Trial Registry ( www.chictr.org.cn ) (clinical trial number: ChiCTR2300075300; Principal Investigator: Gongchen Duan; date of registration: 31 August 2023; https://www.chictr.org.cn/bin/project/edit?…”
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Assessments of prostate cancer cell functions highlight differences between a pan‐PI3K/mTOR inhibitor, gedatolisib, and single‐node inhibitors of the PI3K/AKT/mTOR pathway by Adrish Sen, Salmaan Khan, Stefano Rossetti, Aaron Broege, Ian MacNeil, Ann DeLaForest, Jhomary Molden, Laura Davis, Charles Iversrud, Megan Seibel, Ross Kopher, Stephen Schulz, Lance Laing

“…Gedatolisib is currently being evaluated in a Phase 1/2 clinical trial in combination with darolutamide in patients with mCRPC previously treated with an AR inhibitor, and in a Phase 3 clinical trial in combination with palbociclib and fulvestrant in patients with HR+/HER2− advanced breast cancer.…”
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Azithromycin to prevent acute lower respiratory infections among Australian and New Zealand First Nations and Timorese children (PETAL trial): study protocol for a multicentre, int... by Anne B Chang, Keith Grimwood, Yuejen Zhao, Gabrielle B McCallum, Catherine A Byrnes, Heidi Smith-Vaughan, Peter S Morris, Christine Connors, Adrian Trenholme, Shirley Lawrence, Joshua Francis, Kobi L Schutz, Mark D Chatfield, Nevio Sarmento, Robyn L. Marsh, Emily R Bowden, Nicholas Fancourt, Adriano Vieira, Kim M Hare, Dennis Bonney, Felicity Marwick, Bronwyn Karvonen, Carolyn Maclennan, Milena Santos Lay, Endang Soares da Silva

“…The study outcomes will be disseminated to academic and medical communities via international peer-reviewed journals and conference presentations, and findings reported to health departments and consumer-based health organisations.Clinical trial registration Australia New Zealand Clinical Trial Registry ACTRN12619000456156.…”
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Bladder cancer. A retrospective analysis of the use of vinfluvin in real clinical practice by A. S. Zhabina, A. I. Novikov, F. V. Moiseenko, N. M. Volkov, E. O. Stepanova, E. V. Artemeva, N. H. Abduloeva, V. M. Moiseenko

“…In our analysis vinflunine was more effective than in randomized clinical trial and other studies from real practice in Europe. …”
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N-of-1 medicine by Peter Wang, Qiao Ying Leong, Ni Yin Lau, Wei Ying Ng, Siong Peng Kwek, Lester Tan, Shang-Wei Song, Kui You, Li Ming Chong, Isaiah Zhuang, Yoong Hun Ong, Nigel Foo, Xavier Tadeo, Kirthika Senthil Kumar, Smrithi Vijayakumar, Yoann Sapanel, Marlena Natalia Raczkowska, Alexandria Remus, Agata Blasiak, Dean Ho

“…Therefore, it is important to define each domain and delineate their commonalities and differences in an effort to develop novel clinical trial designs, streamline workflow development, rethink regulatory considerations, create value in healthcare and economics assessments, and other factors. …”
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The Impact of Sira Vedha (Phlebotomy) at the Right Elbow Joint in the Treatment of Non-Alcoholic Fatty Liver Disease - A Research Report by Gaurav Sawarkar, Punam Sawarkar

“…Sushruta recommended Sira Vedha at the right elbow joint for liver diseases, but clinical evidence for its efficacy in NAFLD is lacking. This clinical trial aimed to generate evidence for Sira Vedha in NAFLD patients. …”
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Immunological responses in patients with tuberculosis and in vivo effects of acetyl-L-carnitine oral administration by Emilio Jirillo, Maria Altamura, Carlo Marcuccio, Cosimo Tortorella, Claudio De Simone, Salvatore Antonaci

“…In view of the presence of nonspecific and specific immune deficits in TBC patients, a clinical trial was carried out in a group of 20 individuals with active pulmonary TBC by oral administration of acetyl-L-carnitine (ALC). …”
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Stem Cells in the Treatment of Neuropathic Pain: Research Progress of Mechanism by Meichen Liu, Kai Li, Yunyun Wang, Guoqing Zhao, Jinlan Jiang

“…In this review, we briefly introduce the neuropathic pain, the current treatment strategy, and the development of stem cell therapy, and we collected the experimental and clinical trial articles of many kinds of stem cells in the treatment of neuropathic pain from the past ten years. …”
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Comprehensive analysis of targetable mutations and tumor microenvironment in urachal cancer by David J. Benjamin, Tolulope T. Adeyelu, Andrew Elliott, Sourat Darabi, Thomas Lee, Rana R. McKay, Matthew J. Oberley, Arash Rezazadeh Kalebasty

“…This study provides new insights into the molecular profiles of urachal tumor samples and possibility of association with colorectal cancer that might guide future clinical trial design.…”
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Key tips to shift student perspectives through transformative learning in medical education by Efraim J. Hart, Merel H. de Heer-Koster, Maria van der Harst, Joyce L. Browne, Fedde Scheele

“…The potential impact of these tips on medical education is substantial, as they provide a pathway toward a more responsive, ethical, and sustainable future of healthcare. Clinical trial number: Not applicable.…”
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