Efficacy of Lazolex® Gel in the Treatment of Herpes Simplex Mucocutaneous Infections and the Prevention of Recurrences: A Pilot Study by Tina A. Kituashvili, Vakhtang G. Kvirkvelia, George G. Galdava, Nino G. Archvadze

“…A single-center, single-arm, open-label, phase II clinical trial was conducted with 30 patients divided into two groups: 15 patients with herpes simplex virus type 1 (HSV-1) infections and 15 with herpes simplex virus type 2 (HSV-2). …”
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Angiotensin receptor neprilysin inhibition versus individualized RAAS blockade: design and rationale of the PARALLAX trial by Rolf Wachter, Sanjiv J. Shah, Martin R. Cowie, Peter Szecsödy, Victor Shi, Ghionul Ibram, Ziqiang Zhao, Jianjian Gong, Sven Klebs, Burkert Pieske

“…We sought to compare the effect of ARNI to background‐medication‐based individualized comparators (BMICs) on N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP), functional capacity [6 min walk distance (6MWD)], symptoms, and quality of life [Kansas City Cardiomyopathy Questionnaire (KCCQ)] in patients with HF and EF >40% in a randomized clinical trial. Methods PARALLAX is a prospective, randomized, controlled, double‐blind multicentre clinical trial in patients with chronic symptomatic HF with EF >40%, New York Heart Association (NYHA) class II–IV symptoms, elevated natriuretic peptides, and evidence of structural heart disease. …”
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Long-term real-world evidence of CPX-351 of high-risk patients with AML identified high rate of negative MRD and prolonged OS by Thomas Cluzeau, Fabio Guolo, Edmond Chiche, Paola Minetto, Ramy Rahme, Sarah Bertoli, Luana Fianchi, Jean-Baptiste Micol, Michele Gottardi, Pierre Peterlin, Sara Galimberti, Xavier Thomas, Giuliana Rizzuto, Olivier Legrand, Michela Rondoni, Emmanuel Raffoux, Giambattista Bertani, Alexis Caulier, Michelina D’Argenio, Caroline Bonmati, Atto Billio, Caroline Lejeune, Barbara Scappini, Arnaud Pigneux, Patrizia Zappasodi, Christan Recher, Francesco Grimaldi, Lionel Ades, Roberto M. Lemoli

“…These data provide the rationale for the 2 ongoing studies evaluating CPX-351 vs 7+3 in non–MRC-AML and non–t-AML using MRD as the primary end point for ALFA-2101 phase 2 clinical trial and event-free survival for AMLSG 30-18 phase 3 clinical trial.…”
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Antibiotic Prophylaxis in Transarterial Therapy of Hepatocellular Carcinoma: A Meta-Analysis by Jun Wang, Xiao Dong He, You Cheng Zhang

“…Accordingly, this meta-analysis examined clinical trial evidence regarding the effects of prophylactic antibiotic therapy versus no prophylactic treatment with respect to infectious complications in patients undergoing transarterial therapy for HCC.…”
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Therapeutic landscape for inherited ocular diseases: current and emerging therapies by Hwei Wuen Chan, Jaslyn Oh, Bart Leroy

“…This review discusses the fundamentals underlying the mode of inheritance, natural history studies and clinical trial outcomes, as well as current and emerging therapies covering gene therapy strategies, cell-based therapies and bionic vision.…”
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Digestive bleeding in children by Ana Barbarita Navarro Sombert, Graciela Goire Herrera, Ledicel Nilo Gámez Fonts, Luis Antonio García Rodríguez

“…The most serious bleedings are secondary to esophageal varices and Meckel's diverticulum. A good clinical trial, supported by image and endoscopic tests, and standardized therapy, are the key elements for the reduction of mortality in these patients. …”
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EXPAREL® (Long-Acting Liposomal Bupivacaine) Use for Popliteal Nerve Block in Postoperative Pain Control after Ankle Fracture Fixation by Patrick Discepola, Mohamed Bouhara, Minho Kwon, Bilal A. Siddiqui, Trevor A. Whitwell, Swetha Y. Sanghvi, Keith D. Cook, Ross E. Moore, Anna Korban, Jean D. Eloy

“…These inconsistent results and the possibility of bimodal kinetics creating analgesic gaps as seen in two of our patients indicate that more studies with larger sample size are needed to better characterize these phenomena and determine if more consistent results can be obtained in a future clinical trial.…”
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The Efficacy of Implementing Labor Analgesia Education via the WeChat Public Platform—A Randomized Controlled Study by Lijun Ma, Yan Cheng, Hailian Liu, Wenjing Yang, Chen Yang

“…It has significant clinical value and promising prospects for promotion. Clinical Trial Registration: The study was registered with the Chinese Clinical Trial Registry (ChiCTR1900025231).…”
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Efficacy analysis of folic acid in chronic atrophic gastritis with Helicobacter pylori infection: a systematic review and meta-analysis by Hui Li, Jincheng Li, Mingyu Lai

“…Methods Using a systematic review method, consider randomized controlled trials (RCT), including clinical trial reports, unpublished clinical trial data, and conference papers. …”
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Impact of the COVID-19 pandemic on cerebral venous sinus thrombosis in China: a comparative study by Xiaoming Zhang, Kun Fang, Duo Lan, Xiangqian Huang, Xunming Ji, Ran Meng, Da Zhou

“…Trial registration This study protocol was reviewed and approved by the ethics committee of Xuanwu Hospital, Capital Medical University (No. 2022-004, dated on November 20, 2022). The clinical trial was registered at Chinese Clinical Trial Registry (ChiCTR2200057621).…”
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Association of Serum Adiponectin with Intima Media Thickness of Dorsalis Pedis Artery and Macroangiopathy in Type 2 Diabetes by Tao Chen, Mei Tu, Lihua Huang, Youping Zheng

“…Decrease of adiponectin as an independent risk factor for both macroangiopathy and D-IMT among Chinese patients with T2DM suggests that adiponectin might have clinical utility in the prediction of diabetic macroangiopathy. This clinical trial is registered in the “Chinese Clinical Trial Registry.” …”
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Combination therapy versus monotherapy: retrospective analysis of antibiotic treatment of enterococcal endocarditis by Razan Saman, Christopher P. Primus, Robert West, Simon J. Woldman, Jonathan A. T. Sandoe

“…Clinical trial number Not applicable.…”
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The antihypertensive efficacy of a quadruple single-pill combination in patients with resistant hypertension: study protocol for a randomized, open-label, crossover trial by Yuanyuan Yao, Xin Zhang, Runyu Ye, Shanshan Jia, Xiangyu Yang, Xiaoping Chen

“…Trial registration Chinese Clinical Trial Registry ChiCTR2400081878. Registered on March 14, 2024 ( http://www.chictr.org.cn ).…”
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Medical thoracoscopy combined with intrapleural injection of urokinase for treatment of pleural infection-a multicenter, prospective, randomized controlled study: study protocol by Kaige Wang, Linhui Yang, Panwen Tian, Fen Tan, Dan Liu, Weimin Li

“…Methods This study is a prospective, multicenter, randomized controlled clinical trial involving patients with pleural infections. …”
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aDolescent and prEconception health peRspectiVe of Adult Non-communicable diseases (DERVAN): protocol for rural prospective adolescent girls cohort study in Ratnagiri district of K... by Suvarna Patil, Netaji Patil, Charudatta Joglekar, Arvind Yadav, Anup Nilawar, Ulka Banavali, Rohit Bhat, Vijay Dombale, Bhushan Warpe, Rachana Mohite, Kiran Joshi

“…Its registration code is EC/755/INST/MH/2015/RR-18. It is not a clinical trial but as required we have also registered the study on Clinical Trial Registry of India (CTRI). …”
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Effects of transcranial magnetic stimulation combined with extracorporeal shockwave therapy for poststroke spasticity: study protocol for a randomised controlled trial by Man Yang, Lu Liu, Peng-Yu Wang, Yang Zhu, Ling-Yi Liao, Qiu-Yi Peng, Yong Tao, Jin-Jing Liu, Xiang-Qin Fang, Shi-Hao Gao, Chang-Yue Gao

“…The study will be disseminated through peer-reviewed publications and conference presentations.Trial registration number This study was registered in the Chinese Clinical Trial Registry (https://www.chictr.org.cn/; unique identifier: ChiCTR2400080862; data: 9 February 2024; study protocol V. 2.0).…”
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Ultrasound localization microscopy in the diagnosis of breast tumors and prediction of relevant histologic biomarkers associated with prognosis in humans: the protocol for a prospe... by Jia Li, Lei Chen, Ronghui Wang, Jiang Zhu, Ao Li, Jianchun Li, Zhaojun Li, Wen Luo, Wenkun Bai, Tao Ying, Cong Wei, Di Sun, Yuanyi Zheng

“…This study is a part of that clinical trial.…”
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Research Progress on Tumor Treatment Strategies Targeting TGF-β by Jian ZHANG, Binyue LYU, Xiao ZHAO

“…Currently, multiple drugs targeting this pathway are in clinical trial stage, which involve three aspects of TGF-β, namely, production, activation, and signal transduction. …”
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IMPACT-CABG Trial: Implantation of CD133+ Stem Cells in Patients Undergoing Coronary Bypass Surgery—Presentation of the First Treated Patient by Jessica Forcillo, Louis-Mathieu Stevens, Samer Mansour, Ignacio Prieto, Denis-Claude Roy, Nicolas Noiseux

“…The IMPACT-CABG study is the first Canadian randomized-controlled phase II clinical trial aiming to assess the effect of intramyocardial (IM) injections of CD133+-selected stem cells in patients referred for coronary artery bypass graft (CABG) with a “chronic” myocardial infarction and persistent left ventricular dysfunction. …”
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Enhancing collaborative clinical reasoning among multidisciplinary healthcare teams in a neurosurgery ICU: insights from video-reflexive ethnography by Ching-Yi Lee, Ching-Hsin Lee, Sze-Yuen Yau, Hung-Yi Lai, Po-Jui Chen, Mi-Mi Chen

“…By enhancing CCR, healthcare teams can improve patient outcomes and ensure safer healthcare delivery. Clinical trial number Not required, as this is not a clinical trial and does not involve any healthcare interventions with human participants.…”
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