Hybrid versus vaccine immunity of mRNA-1273 among people living with HIV in East and Southern Africa: a prospective cohort analysis from the multicentre CoVPN 3008 (Ubuntu) studyRe... by Nigel Garrett, Asa Tapley, Aaron Hudson, Sufia Dadabhai, Bo Zhang, Nyaradzo M. Mgodi, Jessica Andriesen, Azwidihwi Takalani, Leigh H. Fisher, Jia Jin Kee, Craig A. Magaret, Manuel Villaran, John Hural, Erica Andersen-Nissen, Guido Ferarri, Maurine D. Miner, Bert Le Roux, Eduan Wilkinson, Richard Lessells, Tulio de Oliveira, Jackline Odhiambo, Parth Shah, Laura Polakowski, Margaret Yacovone, Taraz Samandari, Zvavahera Chirenje, Peter James Elyanu, Joseph Makhema, Ethel Kamuti, Harriet Nuwagaba-Biribonwoha, Sharlaa Badal-Faesen, William Brumskine, Soritha Coetzer, Rodney Dawson, Sinead Delany-Moretlwe, Andreas Henri Diacon, Samantha Fry, Katherine Margaret Gill, Zaheer Ahmed Ebrahim Hoosain, Mina C. Hosseinipour, Mubiana Inambao, Craig Innes, Steve Innes, Dishiki Kalonji, Margaret Kasaro, Priya Kassim, Noel Kayange, William Kilembe, Fatima Laher, Moelo Malahleha, Vongane Louisa Maluleke, Grace Mboya, Kirsten McHarry, Essack Mitha, Kathryn Mngadi, Pamela Mda, Tumelo Moloantoa, Cissy Kityo Mutuluuza, Nivashnee Naicker, Vimla Naicker, Anusha Nana, Annet Nanvubya, Maphoshane Nchabeleng, Walter Otieno, Elsje Louise Potgieter, Disebo Potloane, Zelda Punt, Jamil Said, Yashna Singh, Mohammed Siddique Tayob, Yacoob Vahed, Deo Ogema Wabwire, M. Juliana McElrath, James G. Kublin, Linda-Gail Bekker, Peter B. Gilbert, Lawrence Corey, Glenda E. Gray, Yunda Huang, Philip Kotze, Sharlaa Badal-Faesen, Kagisho Baepanye, Veronique Bailey, Katekani Baloyi-Oseh, Mumtaz Booley, Johannes Louis Botha, Yolande Brown, Valerie Brown, Lisa Bunts, Soritha Coetzer, Myron Cohen, Shirley Collie, Rodney Dawson, Pallabi Deb, Hana El Sahly, Jill El-Khorazaty, Andries Engelbrecht, Marianne Gildea, Dhevium Govender, Jen Hanke, Jayla Harris, Simone Hendricks, Nick Hopkinson, Haley Howell, Nzeera Ketter, Kentse Khuto, Faatima Laher Omar, Leolin Katsidzira, Kim Linton, James Ludwig, Bongile Mabilane, Matshidiso Malefo, Ndiitwani Mamushiana, Daciana Margineantu, Jeanine May, Fatima Mayat, Cindy Molitor, Yeshnee Naidoo, Michelle Nebergall, Alan Nguyen, Sarah Nikles, Bianca Noronha, Melissa Peda, Tamara Phiri, Shanthie Pillay, Sureshnee Pillay, Lori Proulx-Burns, Laurie Rinn, Lisa Sanders, Carrie Sopher, Smitha Sripathy, Michael Stirewalt, Houriiyah Tegally, Sara Thiebaud, Alicia Toledano, Stephanie Van Wyk, Shamaya Whitby, Stephany Wilcox, Eduan Wilkinson, Haven Wilvich, Charles Wiysonge, Nelisiwe Xaba, Ntokozo Xulu

“…The ongoing Ubuntu study is registered on ClinicalTrials.gov (NCT05168813) and this work was conducted from December 2021 to March 2023. …”
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First-Line Chemo-Immunotherapy in SCLC: Outcomes of a Binational Real-World Study by Laura Moliner, MD, Núria Zellweger, MSc, Sabine Schmid, MD, Martina Bertschinger, MD, Christine Waibel, MD, Ferdinando Cerciello, MD, PhD, Patrizia Froesch, MD, Michael Mark, MD, Adrienne Bettini, MD, Pirmin Häuptle, MD, Veronika Blum, MD, Lisa Holer, MSc, Stefanie Hayoz, PhD, Martin Früh, MD, Samreen Ahmed, FRCP, MD, MBBS, MSc, Shradha Bhagani, MD, Nicola Steele, MD, Hannah-Leigh Gray, BSc, Stephen D. Robinson, MD, Michael Davidson, MD (Res), Samantha Cox, MD, MSc, MBBCh, Taha Khalid, MD, Tom R. Geldart, MD, Luke Nolan, FRCS, PhD, Deborah C. Scott, MBChB (MRCP), Lindsay Hennah, MD, Tom Newsom-Davis, MD, PhD, Emma Rathbone, MD, PhD, Catherine Handforth, MD, Arshi Denton, MD, Shairoz Merchant, PhD, Fiona Blackhall, MD, PhD, Laetitia A. Mauti, MD, Raffaele Califano, MD, Sacha I. Rothschild, MD, PhD

“…This retrospective study aims to evaluate the real-world effectiveness of chemo-immunotherapy in patients with ES-SCLC, focusing on subpopulations excluded from clinical trials. Methods: A retrospective binational multicenter study was conducted, involving consecutive patients with ES-SCLC from 10 British and 10 Swiss institutions. …”
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Factors Contributing to Retention in Care and Treatment Adherence Among People Living With HIV Returning to Care in South-Eastern Tanzania: A Qualitative Study by Matimbwa H, Lolo SA, Matoy LS, Ndaki R, Ngahyoma S, Mollel HA, Luoga E, Vanobberghen F, Vianney JM, Idindili B, Weisser M

“…Ndege1. 1, Agatha Ngulukila1. 1, Alex John Ntamatungiro1. 16. 67. 7, Vaileth Nyaenza3. 310. 1011. 11, Emmanuel Nyenza1. 1, Amina Nyuri1. 1, James Okuma4. 45. 5, Ally Olotu1. 1, Daniel H Paris4. 45. 5, Martin Rohacek1. 14. 45. 5, Leila Samson1. 1, Elizabeth Senkoro1. 1, George Sigalla1. 1, Joseph Singo1. 1, Jamali B Siru1. 1, Jenifa Tarimo1. 1, Albart R Malabe3. 310. 1011. 11, Juerg Utzinger4. 45. 5, Fiona Vanobberghen4. 45. 5, Maja Weisser1. 14. 45. 510. 10, John Wigay1. 1, Lulu Wilson1. 1 On behalf of the KIULARCO Study Group1Interventions and Clinical Trials Department, Ifakara Health Institute, Morogoro, Tanzania; 2School of Life Science and Bioengineering, The Nelson Mandela African Institute of Science and Technology, Tengeru, Arusha, Tanzania; 3Department of Health Services, Mzumbe University, Mbeya, Tanzania; 4Department of Secondary Education, Singida, Tanzania; 5Chronic Disease of Ifakara, St. …”
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Clinical impact of [18F]FDG-PET/CT in ARI0002h treatment, a CAR-T against BCMA for relapsed/refractory multiple myeloma by Inés Zugasti, Marta Tormo-Ratera, Aina Oliver-Caldés, Juan Carlos Soler-Perromat, Verónica González-Calle, David F. Moreno, Valentín Cabañas, Nieves López-Muñoz, Álvaro Bartolomé-Solanas, Marta Español-Rego, Juan Luis Reguera-Ortega, Laura Rosiñol, Lucía López-Corral, Natalia Tovar, Luis Gerardo Rodríguez-Lobato, Rosa Maria Alvarez Perez, Sara Varea, Eulàlia Olesti, Adolfo Gomez-Grande, Laura Frutos, Pilar Tamayo, Manel Juan, José M. Moraleda, Álvaro Urbano-Ispizua, E. Azucena González-Navarro, Joaquín Martínez-López, Maria-Victoria Mateos, Xavier Tomás, Xavier Setoain, Carlos Fernández de Larrea

“…This trial was registered at www.ClinicalTrials.gov as #NCT04309981; and EudraCT, 2019-001472-11.…”
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Tacedinaline (CI-994), a class I HDAC inhibitor, targets intrinsic tumor growth and leptomeningeal dissemination in MYC-driven medulloblastoma while making them susceptible to anti... by Arndt Borkhardt, Nan Qin, Stephen T Keir, Darell D Bigner, Allison Cole, Matthias Wölfl, Viktoria Marquardt, Johanna Theruvath, David Pauck, Daniel Picard, Lena Blümel, Mara Maue, Jasmin Bartl, Ulvi Ahmadov, Maike Langini, Frauke-Dorothee Meyer, Joselyn Cruz-Cruz, Claus M Graef, Till Milde, Olaf Witt, Anat Erdreich-Epstein, Gabriel Leprivier, Ulf Kahlert, Anja Stefanski, Kai Stühler, Julia Hauer, Thomas Beez, Christiane B Knobbe-Thomsen, Ute Fischer, Jörg Felsberg, Finn K Hansen, Rajeev Vibhakar, Sujatha Venkatraman, Samuel H Cheshier, Guido Reifenberger, Thomas Kurz, Marc Remke, Siddhartha Mitra

“…Therefore, targeting epigenetic modifiers for cancer treatment has gained increasing interest, and inhibitors for various epigenetic modulators have been intensively studied in clinical trials. Here, we report a cross-entity, epigenetic drug screen to evaluate therapeutic vulnerabilities in MYC amplified MB, which sensitizes them to macrophage-mediated phagocytosis by targeting the CD47-signal regulatory protein α (SIRPα) innate checkpoint pathway.Methods We performed a primary screen including 78 epigenetic inhibitors and a secondary screen including 20 histone deacetylase inhibitors (HDACi) to compare response profiles in atypical teratoid/rhabdoid tumor (AT/RT, n=11), MB (n=14), and glioblastoma (n=14). …”
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Therapeutic plasma exchange accelerates immune cell recovery in severe COVID-19 by Aurelie Guironnet-Paquet, Aurelie Guironnet-Paquet, Hind Hamzeh-Cognasse, Frederic Berard, Fabrice Cognasse, Fabrice Cognasse, Jean Christophe Richard, Hodane Yonis, Mehdi Mezidi, Olivier Desebbe, Bertrand Delannoy, Sophie Demeret, Clemence Marois, Clemence Marois, Clemence Marois, Samir Saheb, Quoc Viet Le, Mathieu Schoeffler, Paul Simon Pugliesi, Sophie Debord, Paul Bastard, Paul Bastard, Paul Bastard, Paul Bastard, Aurélie Cobat, Aurélie Cobat, Aurélie Cobat, Jean Laurent Casanova, Jean Laurent Casanova, Jean Laurent Casanova, Jean Laurent Casanova, Jean Laurent Casanova, Rémi Pescarmona, Sébastien Viel, Jean François Nicolas, Jean François Nicolas, Audrey Nosbaum, Audrey Nosbaum, Marc Vocanson, Olivier Hequet, Olivier Hequet

“…BackgroundImmunological disturbances (anti-type I IFN auto-antibody production, cytokine storm, lymphopenia, T-cell hyperactivation and exhaustion) are responsible for disease exacerbation during severe COVID-19 infections.MethodsIn this study, we set up a prospective, randomised clinical trial (ClinicalTrials.gov ID: NCT04751643) and performed therapeutic plasma exchange (TPE) in severe COVID-19 patients in order to decrease excess cytokines and auto-antibodies and to assess whether adding TPE to the standard treatment (ST, including corticosteroids plus high-flow rate oxygen) could help restore immune parameters and limit the progression of acute respiratory distress syndrome (ARDS).ResultsAs expected, performing TPE decreased the amount of anti-type I IFN auto-antibodies and improved the elimination or limited the production of certain inflammatory mediators (IL-18, IL-7, CCL2, CCL3, etc.) circulating in the blood of COVID-19 patients, compared to ST controls. …”
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FERN: is it possible to conduct a randomised controlled trial of intervention or expectant management for early-onset selective fetal growth restriction in monochorionic twin pregn... by Kerry Woolfall, Jamie J Kirkham, Jane Sandall, Mariana Popa, Enrico Lopriore, Mark Turner, Shakila Thangaratinam, Aris T Papageorghiou, Andrew Sharp, Lawrence Impey, Andy Healey, Jessica Mendoza, Asma Khalil, Dharmintra Pasupathy, Brigitte Vollmer, Zarko Alfirevic, Rajeswari Parasuraman, Jan Deprest, Richard Edmund Ashcroft, Kurt Hecher, Smriti Prasad, Baskaran Thilaganathan, Richard J Jackson, Tracy Karen Mitchell, Natasha Fenwick, Monique C Haak, Liesbeth Lewi, Shauna Leven, Fabricio Da Silva Costa, Odai Yaghi, Tracey Ricketts, George Attilakos, Carolyn Bailie, Christine Cornforth, Mark Denbow, Louise Hardman, Jane Harrold, Joel Marsden, Tommy Mousa, Surabhi Nanda, Michelle Watson, Karen Wilding, Dilly Anumba, Edward D Johnstone, Yoav Yinon, Ahmet Baschat

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Antiviral efficacy of fluoxetine in early symptomatic COVID-19: an open-label, randomised, controlled, adaptive platform trial (PLATCOV)Research in context by Podjanee Jittamala, Simon Boyd, William H.K. Schilling, James A. Watson, Thundon Ngamprasertchai, Tanaya Siripoon, Viravarn Luvira, Elizabeth M. Batty, Phrutsamon Wongnak, Lisia M. Esper, Pedro J. Almeida, Cintia Cruz, Fernando R. Ascencao, Renato S. Aguiar, Najia K. Ghanchi, James J. Callery, Shivani Singh, Varaporn Kruabkontho, Thatsanun Ngernseng, Jaruwan Tubprasert, Wanassanan Madmanee, Kanokon Suwannasin, Amornrat Promsongsil, Borimas Hanboonkunupakarn, Kittiyod Poovorawan, Manus Potaporn, Attasit Srisubat, Bootsakorn Loharjun, Walter R.J. Taylor, Farah Qamar, Abdul Momin Kazi, M. Asim Beg, Danoy Chommanam, Sisouphanh Vidhamaly, Kesinee Chotivanich, Mallika Imwong, Sasithon Pukrittayakamee, Arjen M. Dondorp, Nicholas P.J. Day, Mauro M. Teixeira, Watcharapong Piyaphanee, Weerapong Phumratanaprapin, Nicholas J. White

“…Summary: Background: The selective serotonin reuptake inhibitors (SSRIs) fluoxetine and fluvoxamine were repurposed for the treatment of early COVID-19 based on their antiviral activity in vitro, and observational and clinical trial evidence suggesting they prevented progression to severe disease. …”
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Surgical interventions for spontaneous supratentorial intracerebral haemorrhage: a systematic review and network meta-analysisResearch in context by Jiayidaer Huan, Minghong Yao, Yu Ma, Fan Mei, Yanmei Liu, Lu Ma, Xiaochao Luo, Jiali Liu, Jianguo Xu, Chao You, Hunong Xiang, Kang Zou, Xiao Liang, Xin Hu, Ling Li, Xin Sun

“…Methods: In this systematic review and network meta-analysis, we searched PubMed, Cochrane Central Register of Controlled Trials, Embase, and ClinicalTrials.gov from inception to June 16, 2024. Eligible studies were randomised controlled trials (RCTs) comparing surgery (i.e., CC, ES, MIPS, or DC) with CMT or comparing different types of surgeries in patients with spontaneous supratentorial ICH. …”
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Multi-cancer early detection tests for general population screening: a systematic literature review by Ros Wade, Sarah Nevitt, Yiwen Liu, Melissa Harden, Claire Khouja, Gary Raine, Rachel Churchill, Sofia Dias

“…Published and unpublished prospective clinical trials and cohort studies of blood-based MCED tests for screening were sought. …”
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Comparative Lipid-Lowering/Increasing Efficacy of 7 Statins in Patients with Dyslipidemia, Cardiovascular Diseases, or Diabetes Mellitus: Systematic Review and Network Meta-Analyse... by Xiaodan Zhang, Lu Xing, Xiaona Jia, Xiaocong Pang, Qian Xiang, Xia Zhao, Lingyue Ma, Zhiyan Liu, Kun Hu, Zhe Wang, Yimin Cui

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A multicenter, randomized, open label, two formulation, crossover bioequivalence trial of doxorubicin hydrochloride liposomal injection in Chinese patients with metastatic breast c... by Jingshu Wang, Xiuping Lai, Herui Yao, Hui Yang, Xiaolong Cao, Xiaochen Wang, Ying Wang, Weiqi Nian, Xiaodong Zheng, Qingxiu Mai, Anding Liu, Xiaozhi Lv, Xiaoying Bi, Junyi Chen, Junyan Wu, Suiwen Ye

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Combined pyrotinib and fulvestrant for hormone receptor‐positive and HER2‐positive metastatic breast cancer: A multicenter, single‐arm, phase II trial by Jianli Zhao, Yunfang Yu, Wei Ren, Linxiaoxiao Ding, Yongjian Chen, Peng Yuan, Jian Yue, Yaping Yang, Guorong Zou, Tao Chen, Jie Chai, Li Zhang, Wenjing Wu, Yinduo Zeng, Xiujuan Gui, Yangyang Cai, Simin Luo, Zhongyu Yuan, Kang Zhang, Herui Yao, Ying Wang

“…Abstract This multicenter, single‐arm, phase II clinical trial (NCT04034589) evaluated the efficacy and safety of pyrotinib combined with fulvestrant in patients with HR‐positive/HER2‐positive metastatic breast cancer who had experienced trastuzumab treatment failure. …”
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Role of cognitive impairment in predicting the long-term risk of all-cause mortality: a 20-year prospective cohort study in China by Shuang Zhao, Han Yang, Haijuan Zhao, Miao Miao, Qingqing Wang, Yaru Wang, Yuying Yin, Xin Wang

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How to improve the quality of euglycemic glucose clamp tests in long-acting insulin studies by Yi Yang, Fu Kuang, XueYing Zhu, Li Li, Yao Huang, Yang Liu, Xian Yu

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Comparison of models to predict incident chronic liver disease: a systematic review and external validation in Chinese adults by Xue Cong, Shuyao Song, Yingtao Li, Kaiyang Song, Cameron MacLeod, Yujie Cheng, Jun Lv, Canqing Yu, Dianjianyi Sun, Pei Pei, Ling Yang, Yiping Chen, Iona Millwood, Shukuan Wu, Xiaoming Yang, Rebecca Stevens, Junshi Chen, Zhengming Chen, Liming Li, Christiana Kartsonaki, Yuanjie Pang, on behalf of the China Kadoorie Biobank Collaborative Group

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Long-Term Therapeutic Effects of ²²⁵Ac-DOTA-E[c(RGDfK)]₂ Induced by Radiosensitization via G2/M Arrest in Pancreatic Ductal Adenocarcinoma by Mitsuyoshi Yoshimoto, Kohshin Washiyama, Kazunobu Ohnuki, Ayano Doi, Miki Inokuchi, Motohiro Kojima, Brian W. Miller, Yukie Yoshii, Anri Inaki, Hirofumi Fujii

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Phase I Trial of Upamostat Combined With Gemcitabine in Locally Unresectable or Metastatic Pancreatic Cancer: Safety and Preliminary Efficacy Assessment by Xiuping Lai, Di Cheng, Huixin Xu, Jingshu Wang, Xiaozhi Lv, Herui Yao, Liuning Li, Junyan Wu, Suiwen Ye, Zhihua Li

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Bioequivalence study of fluticasone propionate nebuliser suspensions in healthy Chinese subjects by Feng Cheng, Tao Shen, Fucheng Zhang, Chenghao Lei, Ye Zhu, GuoJun Luo, Dawei Xiao

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Therapy of genomic unstable solid tumours (WHO grade 3/4）in clinical stage III/IV using individualised neoantigen tumour peptides-INP trial (individualised neoantigen tumour peptid... by Ling Wang, Xia Chen, Juan Zhao, Jiaxi Tang, Wanyan Tang, Bin Liao, Weiqi Nian

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