Relevance of superoxide dismutase type 1 to lipoid pneumonia: the first retrospective case-control study by Yinan Hu, Yanhong Ren, Yinzhen Han, Zhen Li, Weiqing Meng, Yuhui Qiang, Mengyuan Liu, Huaping Dai

“…Methods The clinical data of 22 patients with proven LP from January 2008 to June 2024 and their prognostic information up to June 2024 were retrospectively gathered (ClinicalTrials.gov, NCT06430008). Additionally, information on patients with URTI, bacterial and fungal pneumonia, COP, PAP, lung mucinous adenocarcinoma and pulmonary edema, was collected totaling 140 patients as control subjects. …”
Get full text

Neoadjuvant immunotherapy for DNA mismatch repair proficient/microsatellite stable non-metastatic rectal cancer: a systematic review and meta-analysis by Huan Zhang, Jing Huang, Huanji Xu, Nanhao Yin, Nanhao Yin, Liyan Zhou, Liyan Zhou, Jianxin Xue, Jianxin Xue, Jianxin Xue, Min Ren

“…Therefore, a meta-analysis was carried out to assess the efficacy and safety of NIT in patients with non-metastatic pMMR/MSS RC.MethodsPubMed, Embase, Web of Science, the Cochrane Library, ClinicalTrials.gov, ASCO and ESMO were searched to obtain related studies up to July 2024. …”
Get full text

First-in-human phase 1 dose-escalation results with livmoniplimab, an antibody targeting the GARP:TGF-ß1 complex, as monotherapy and in combination with the anti–PD-1 antibody budi... by Toshio Shimizu, Toshio Shimizu, John Powderly, Albiruni Abdul Razak, Patricia LoRusso, Kathy D. Miller, Steven Kao, Sarah Kongpachith, Catherine Tribouley, Michelle Graham, Brian Stoll, Maulik Patel, Mohammad Sahtout, Martha Blaney, Rachel Leibman, Talia Golan, Talia Golan, Anthony Tolcher

“…The first-in-human, phase 1, dose-escalation results are presented herein (ClinicalTrials.gov: NCT03821935).MethodsThe dose-escalation phase enrolled adult patients with advanced solid tumors. …”
Get full text

Definition of sinonasal and otological exacerbation in patients with primary ciliary dyskinesia: an expert consensus by Myrofora Goutaki, Yin Ting Lam, Andreas Anagiotos, Miguel Armengot, Andrea Burgess, Raewyn Campbell, Mathilde Carlier, Nathalie Caversaccio, Neil K. Chadha, Berat Demir, Sinan Ahmed D. Dheyauldeen, Onder Gunaydin, Amanda Harris, Isolde Hayn, Deniz Inal-Ince, Eric Levi, Trini Lopez Fernandez, Jane S. Lucas, Bernard Maitre, Anne-Lise M.L. Poirrier, Lynne Schofield, Kazuhiko Takeuchi, Christine van Gogh, Nikolaus E. Wolter, Jean-François Papon

“…While pulmonary exacerbations in primary ciliary dyskinesia are defined, there is no definition for ear-nose-throat exacerbations, a potential outcome for research and clinical trials. Methods We set up an expert panel of 24 ear-nose-throat specialists, respiratory physicians, other healthcare professionals and patients to develop consensus definitions of sinonasal and otological exacerbations in children and adults with primary ciliary dyskinesia for research settings. …”
Get full text

A systematic scoping review of clinical indications for induction of labour. by Dominiek Coates, Angela Makris, Christine Catling, Amanda Henry, Vanessa Scarf, Nicole Watts, Deborah Fox, Purshaiyna Thirukumar, Vincent Wong, Hamish Russell, Caroline Homer

“…Studies were identified via the databases PubMed, Maternity and Infant Care, CINAHL, EMBASE, and ClinicalTrials.gov from between April 2008 and November 2019, and also from reference lists of included studies. …”
Get full text

Study protocol for a randomized controlled trial of Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation: the PROMIZING study by Karen J. Bosma, Claudio M. Martin, Karen E. A. Burns, Jordi Mancebo Cortes, Juan Carlos Suárez Montero, Yoanna Skrobik, Kevin E. Thorpe, Andre Carlos Kajdacsy-Balla Amaral, Yaseen Arabi, John Basmaji, Gaëtan Beduneau, Francois Beloncle, Guillaume Carteaux, Emmanuel Charbonney, Alexandre Demoule, Martin Dres, Vito Fanelli, Anna Geagea, Ewan Goligher, François Lellouche, Tommaso Maraffi, Alain Mercat, Pablo O. Rodriguez, Jason Shahin, Stephanie Sibley, Savino Spadaro, Katerina Vaporidi, M. Elizabeth Wilcox, Laurent Brochard, On behalf of the Canadian Critical Care Trials Group and, the REVA Network

“…This multi-centre open-label clinical trial plans to involve approximately 20 sites in several continents. …”
Get full text

Screening and characterization of the scFv for chimeric antigen receptor T cells targeting CEA-positive carcinoma by Chengcheng Zhang, Linling Wang, Qianzhen Zhang, Junjie Shen, Xia Huang, Meiling Wang, Yi Huang, Jun Chen, Yanmin Xu, Wenxu Zhao, Yanan Qi, Yunyan Li, Yanjiao Ou, Zhi Yang, Cheng Qian

“…The identified optimal scFv, M5A, could be potentially applied in future clinical trials of CAR-T cell therapy targeting CEA-positive carcinoma.…”
Get full text

Early treatment discontinuation in patients with deficient mismatch repair or microsatellite instability high metastatic colorectal cancer receiving immune checkpoint inhibitors by Chiara Cremolini, Sara Lonardi, Filippo Pietrantonio, Julien Taieb, David Tougeron, Margherita Ambrosini, Michael J Overman, Alice Boilève, Lisa Salvatore, Rosine Guimbaud, Priya Jayachandran, Frank A Sinicrope, Thibault Mazard, Javier Ros, Vincenzo Nasca, Simon Pernot, Emily Alouani, Marie Decraecker, Emilie Hafliger, Pauline Parent

“…In the ETD group, 28 (20%) patients had a PFS event and 9 restarted ICIs with a disease control rate of 66%.Conclusions In our international series of dMMR/MSI-H mCRC, ETD of ICIs in the absence of PD did not seem detrimental in terms of PFS and OS compared with continuing treatment beyond 1 year. Randomized clinical trials to compare short and long treatment duration are now warranted.…”
Get full text

High‐risk cytogenetic abnormalities in multiple myeloma: PETHEMA‐GEM experience by Veronica González‐Calle, Paula Rodriguez‐Otero, Maria J. Calasanz, Manuela Guijarro, Joaquin Martínez‐López, Laura Rosiñol, Miguel T. Hernández, Ana I. Teruel, Mercedes Gironella, Albert Oriol, Javier de laRubia, Ana P. González‐Rodríguez, Joan Bargay, Felipe deArriba, Luis Palomera, Marta‐Sonia González‐Pérez, Anna Sureda, Enrique Ocio, Juan J. Lahuerta, Joan Bladé, Jesus F. San Miguel, Maria V. Mateos, Norma C. Gutiérrez

“…The analysis included 1304 patients from four different GEM‐PETHEMA clinical trials. Genetic alterations, such as t(4;14), t(14;16), del(17p), +1q, and del(1p), were investigated using FISH on CD38 purified plasma cells. …”
Get full text

Real-time mechanism-based interventions for daily alcohol challenges: Protocol for ecological momentary assessment and intervention by Shuyan Liu, Matthias Haucke, Rika Groß, Kay Schneider, Jaekyung Shin, Fabian Arntz, Patrick Bach, Tobias Banaschewski, Christian Beste, Lorenz Deserno, Ulrich Ebner-Priemer, Tanja Endrass, Marvin Ganz, Ali Ghadami, Marco Giurgiu, Andreas Heinz, Falk Kiefer, Reinhold Kliegl, Bernd Lenz, Marta Anna Marciniak, Andreas Meyer-Lindenberg, Andreas B. Neubauer, Michael Rapp, Michael N. Smolka, Jens Strehle, Rainer Spanagel, Gianna Spitta, Heike Tost, Henrik Walter, Hilmar Zech, Dominic Reichert, Markus Reichert

“…Trial registration German Clinical Trials Register DRKS00033133.…”
Get full text

Differences in the response to TNF inhibitors at distinct joint locations in patients with psoriatic arthritis: results from nine European registries by Adrian Ciurea, Seraphina Kissling, Andrea Götschi, Lykke Midtbøll Ørnbjerg, Simon Horskjær Rasmussen, Bálint Tamási, Burkhard Möller, Michael J. Nissen, Bente Glintborg, Anne Gitte Loft, Almut Scherer, René Bräm, Karel Pavelka, Jakub Závada, Joao Madruga Dias, Paula Valente, Bjorn Gudbjornsson, Olafur Palsson, Vappu Rantalaiho, Ritva Peltomaa, Catalin Codreanu, Corina Mogosan, Florenzo Iannone, Marco Sebastiani, Gareth T. Jones, Gary J. Macfarlane, Isabel Castrejon, Ziga Rotar, Brigitte Michelsen, Johan K. Wallman, Irene van der Horst-Bruinsma, Oliver Distler, Mikkel Østergaard, Merete Lund Hetland, Raphael Micheroli, Caroline Ospelt

“…Abstract Background Efficacy of tumour necrosis factor inhibitors (TNFi) for peripheral arthritis in patients with psoriatic arthritis (PsA) has been established in randomized clinical trials that have used improvement in summated joint counts as an outcome. …”
Get full text

Effects of different-valent vaccines against human papillomavirus (HPV) to prevent persistent HPV16/18 infections and CIN2+ in women: a systematic review and network meta-analysis by Haiyue Wu, Lucia Li, Kun Fu, YuFei Shen, Yingnan Lu, Zexi Liao, Yingzhen Liu, Wenting Zha, Lisha Wu, Yu Zhang

“…Methods: PubMed, Web of Science, Cochrane, Embase and ClinicalTrials.gov were searched from their inception to March 2024. …”
Get full text

The anti-circumsporozoite antibody response to repeated, seasonal booster doses of the malaria vaccine RTS,S/AS01E by M. Sanni Ali, Lisa Stockdale, Issaka Sagara, Issaka Zongo, Rakiswendé Serge Yerbanga, Almahamoudou Mahamar, Frédéric Nikièma, Amadou Tapily, Frédéric Sompougdou, Modibo Diarra, Duncan Bellamy, Samuel Provstgaard-Morys, Charles Zoungrana, Djibrilla Issiaka, Alassane Haro, Koualy Sanogo, Abdoul Aziz Sienou, Mahamadou Kaya, Seydou Traore, Oumar M. Dicko, Youssouf Kone, Hama Yalcouye, Ismaila Thera, Kalifa Diarra, Paul Snell, Opokua Ofori-Anyinam, Chris Ockenhouse, Cynthia Lee, Katie Ewer, Halidou Tinto, Abdoulaye Djimde, Jean-Bosco Ouedraogo, Alassane Dicko, Daniel Chandramohan, Brian Greenwood

“…Although anti-CSP antibody titres declined after repeated booster doses of RTS,S/AS01E a high, although declining, level of efficacy was sustained suggesting that there may have been changes in the characteristics of the anti-CSP antibody following repeated booster doses. Clinical Trials Registration. NCT03143218.…”
Get full text

Recomendaciones para el diagnóstico y tratamiento de las vasculitis asociadas a anticuerpos anticitoplasma de neutrófilo by Enrique Morales, Iñigo Rúa-Figueroa, José Luis Callejas Rubio, Ana Ávila Bernabéu, Ricardo Blanco Alonso, Maria C. Cid Xutgla, Gema Fernández Juárez, Natalia Mena-Vázquez, Juan José Ríos Blanco, Joaquín Manrique Escola, F. Javier Narváez García, Bernardo Sopeña, Luis F. Quintana Porras, Susana Romero-Yuste, Roser Solans Laqué

“…The use of glucocorticoids, cyclophosphamide and other immunosupressants (such as azathioprine, mychophenolate and methotrexate) was optimised in a series of clinical trials that established the treatment of reference. …”
Get full text

Investigation and analysis of the demand for smart home automation in patients with ischemic stroke and functional impairment (脑梗死伴功能障碍患者对智慧居家模块需求的调查分析)... by FEI Cailian (费才莲), XIE Juan (谢娟), ZHANG Jingyi (张静怡), WANG Yu (王瑜), GAO Liandi (高连娣)

“…In order to ensure that the implementation of this automation system provides tangible benefits to patients, it is crucial to enhance its functionality, actively promote awareness among the target population, and establish an effective foundation for subsequent clinical trials of the intelligent home management system software. …”
Get full text

Current AAV-mediated gene therapy in sensorineural hearing loss by Jieyu Qi, Xiaolong Fu, Liyan Zhang, Fangzhi Tan, Nianci Li, Qiuhan Sun, Xiaojie Hu, Zuhong He, Ming Xia, Renjie Chai

“…It is currently possible to regenerate hair cells to treat sensorineural hearing loss by FX-322, a small molecule drug in clinical trials. With the development of genetic engineering technology, gene therapy has brought a promising treatment strategy for many previously intractable diseases. …”
Get full text

Risk Factors for Hospital Readmission Following Noncardiac Surgery: International Cohort Study by Michael H. McGillion, RN, PhD, Flavia K. Borges, MD, PhD, David Conen, MD, MPH, Daniel I. Sessler, MD, Brenda L. Coleman, RN, PhD, Maura Marcucci, MD, MSc, Carley Ouellette, RN, MSc, Marissa Bird, RN, PhD, Carly Whitmore, RN, PhD, Shaunattonie Henry, RN, PhD, Sandra Ofori, MD, MSc, Shirley M. Pettit, RN, Deborah M. Bedini, RN, MHS, Leslie P. Gauthier, MScT, Jennifer Lounsbury, RN(EC), MN, Nancy M. Carter, RN, PhD, Vikas Tandon, MD, Ameen Patel, MD, Teresa Cafaro, MD, MSc, Marko R. Simunovic, MD, John A. Harlock, MD, Diane Heels-Ansdell, MSc, Fadi Elias, MD, MS, Theodore Rapanos, MD, Shawn Forbes, MD, Elizabeth Peter, RN, PhD, Judy Watt-Watson, RN, PhD, Kelly Metcalfe, RN, PhD, Sandra L. Carroll, RN, PhD, Philip J. Devereaux, MD, PhD

“…Risk factors for readmission were assessed using Cox regression (ClinicalTrials.gov, NCT00512109). Results:. Of 36,657 eligible participants, 2744 (7.5%; 95% confidence interval [CI], 7.2–7.8) were readmitted within 30 days of discharge. …”
Get full text

Sacubitril/Valsartan for Blood Pressure Lowering in Non‐Dialysis‐Dependent Chronic Kidney Disease Stage 3–5 Patients With Hypertension: A Multicenter Clinical Study by Yu Yan, Xiaomin Li, Juan Cao, Jingyuan Cao, Yao Wang, Liang Wang, Jirong Yu, Lianhua Chen, Min Yang, Xinzhong Huang, Lei Shen, Hong Ding, Manzhi Li, Di Yin, Linglin Jiang, Liang Tang, Yujia Jiang, Ling Hu, Jiyi Si, Hui Zhang, Liqin Cui, Xiameng Gu, Kun Hu, Dongxing Mu, Bicheng Liu, Xiaoliang Zhang, Dong Sun, Xin Wan, Bin Wang

“…Trial Registration: ClinicalTrials.gov identifier: ChiCTR2400086079…”
Get full text

Pilot of a team-based quality improvement strategy to improve cardiovascular risk factors care in community mental health centers by Karly A. Murphy, Karly A. Murphy, Joseph Gennusa, Arlene T. Dalcin, Arlene T. Dalcin, Courtney Cook, Courtney Cook, Stacy Goldsholl, Tyler Fink, Gail L. Daumit, Gail L. Daumit, Gail L. Daumit, Gail L. Daumit, Gail L. Daumit, Gail L. Daumit, Nae-Yuh Wang, Nae-Yuh Wang, Nae-Yuh Wang, Nae-Yuh Wang, Nae-Yuh Wang, David Thompson, David Thompson, Emma E. McGinty

“…Long term investments are needed to support organizational quality improvement work and providers’ efficacy to delivery - evidence-based CVD risk factor care delivery.Clinical Trial Registrationhttp://www.ClinicalTrials.gov, identifier NCT04696653.…”
Get full text

Phase II, single-arm trial of preoperative short-course radiotherapy followed by chemotherapy and camrelizumab in locally advanced rectal cancer by Jun Fan, Jing Wang, Tao Zhang, Xin Li, Lan Zhang, Zheng Wang, Tao Liu, Gang Li, Peng Zhang, Chi Ma, Ming Cai, Gang Wu, Zhenyu Lin, Kailin Cai, Xiu Nie, Junli Liu, Hongli Liu, Weikang Zhang, Jingbo Gao, Chuanqing Wu, Linfang Wang, Zhiguo Hou, Kunyu Yang, Kaixiong Tao

“…A randomized controlled trial is ongoing to confirm these results.Trial registration number ClinicalTrials.gov identifier: NCT04231552.…”
Get full text