Pharmacological action of Angelica sinensis polysaccharides: a review by Chunzhen Ren, Chunzhen Ren, Chunzhen Ren, Yali Luo, Xiaojuan Li, Like Ma, Chunling Wang, Chunling Wang, Chunling Wang, Xiaodong Zhi, Xiaodong Zhi, Xinke Zhao, Xinke Zhao, Xinke Zhao, Yingdong Li, Yingdong Li, Yingdong Li

“…However, further research should be undertaken to clarify the unconfirmed regulatory mechanisms, conduct standard clinical trials, and evaluate the possible side effects. …”
Get full text

Shed antigen-induced blocking effect on CAR-T cells targeting Glypican-3 in Hepatocellular Carcinoma by Wei Gao, Tong Ding, Beicheng Sun, Nan Li, Fang Gao, Meng Jia, Mitchell Ho, Na Li, Luan Sun, Zhanhui Gao, Lei Ao, Sujuan Ma, Peihua Lu, Shaochang Jia

“…Therefore, sGPC3 acted as dominant negative regulators when competed with cell surface GPC3 to bind anti-GPC3 CAR-T cells, leading to an inhibitory effect on CAR-T cells in HCC.Conclusions We provide a proof-of-concept study demonstrating that GPC3 shedding might cause worse response to CAR-T cell treatment by competing with cell surface GPC3 for CAR-T cell binding, which revealed a new mechanism of tumor immune escape in HCC, providing a novel biomarker for patient enrolment in future clinical trials and/or treatments with GPC3-targeted CAR-T cells.…”
Get full text

Emerging burden of post-cancer therapy complications on unplanned hospitalisation and costs among Australian cancer patients: a retrospective cohort study over 14 years by Rashidul Alam Mahumud, Md. Shahjalal, Padam Kanta Dahal, Md. Parvez Mosharaf, Sabuj Kanti Mistry, Kamrun Nahar Koly, Sujana Haque Chowdhury, Andre M. N. Renzaho, Jeff Gow, Khorshed Alam, Olivia Wawryk

Get full text

Process evaluation of Project Daire: a food environment intervention that impacted food knowledge, wellbeing and dietary habits of primary school children by Naomi Anderson, Sarah F. Brennan, Fiona Lavelle, Sarah E. Moore, Dilara Olgacher, Amy Junkin, Moira Dean, Michelle C. McKinley, Patrick McCole, Ruth F. Hunter, Laura Dunne, Niamh E. O’Connell, Chris T. Elliott, Danielle McCarthy, Jayne V. Woodside

“…National Library of Medicine Clinical Trials.gov (ID: NCT04277312; retrospectively registered 11th February 2020).…”
Get full text

Effectiveness of a Web-Based Self-Guided Intervention (MINDxYOU) for Reducing Stress and Promoting Mental Health Among Health Professionals: Results From a Stepped-Wedge Cluster Ra... by Yolanda López-del-Hoyo, Selene Fernández-Martínez, Adrian Perez-Aranda, Alicia Monreal-Bartolomé, Alberto Barceló-Soler, Loreto Camarero-Grados, Carilene Armas-Landaeta, José Guzmán-Parra, Vera Carbonell, Daniel Campos, Xinyuan Chen, Javier García-Campayo

“…Trial RegistrationClinicalTrials.gov NCT05436717; https://clinicaltrials.gov/study/NCT05436717 International Registered Report Identifier (IRRID)RR2-10.1186/s12912-022-01089-5…”
Get full text

Protocol for the DisCoVeRy trial: multicentre, adaptive, randomised trial of the safety and efficacy of treatments for COVID-19 in hospitalised adults by Florence Ader, Jean-François Timsit, Yazdan Yazdanpanah, François-Xavier Lescure, Laetitia Moinot, Christelle Delmas, Hélène Espérou, Laurent Abel, Benjamin Leveau, Vinca Icard, Toni Alfaiate, Linda Wittkop, Charles Burdet, France Mentré, Marion Schneider, Nathan Peiffer-Smadja, Julien Poissy, Lila Bouadma, Bruno Lina, Florence Morfin-Sherpa, Maude Bouscambert, Alexandre Gaymard, Gilles Peytavin, Jeremie Guedj, Claire Andrejak, Cedric Laouenan, Drifa Belhadi, Axelle Dupont, Basma Basli, Anissa Chair, Samira Laribi, Julie Level, Marie-Capucine Tellier, Aline Dechanet, Dominique Costagliola, Sandrine Couffin-Cadiergues, Juliette Saillard, Claire Fougerou, Carole Cagnot, Soizic Le Mestre, Delphine Lebrasseur-Longuet, Ventzislava Petrov-Sanchez, Alpha Diallo, NoéMie Mercier, Sarah Tubiana, Benjamin Hamze, Ambre Gelley, Marion Noret, Eric D’Ortenzio, Oriane Puechal, Caroline Semaille

“…Introduction To find effective and safe treatments for COVID-19, the WHO recommended to systemically evaluate experimental therapeutics in collaborative randomised clinical trials. As COVID-19 was spreading in Europe, the French national institute for Health and Medical Research (Inserm) established a transdisciplinary team to develop a multi-arm randomised controlled trial named DisCoVeRy. …”
Get full text

Rationale and design of a multicentre randomised controlled trial on circulating tumour DNA-guided neoadjuvant treatment strategy for locally advanced rectal cancer (CINTS-R) by Bin Wu, Yi Xiao, Xiao Zhang, Tao Xu, Qian Liu, Wei Fu, Yang An, Yongheng Li, Guole Lin, Huadan Xue, Guoju Wu, Jiaolin Zhou, Hongwei Yao, Zhenjun Wang, Weijie Chen, Junyang Lu, Guannan Zhang, Xiaoyuan Qiu

“…The results of our trial will be disseminated through peer-reviewed publications and presented at national and international academic conferences.Trial registration number This trial is registered on ClinicalTrials.gov and the registration ID is NCT05601505.…”
Get full text

Real-world outcomes of the CROSS regimen in patients with resectable esophageal or gastro-esophageal junction adenocarcinoma: a nationwide cohort study in the NetherlandsResearch i... by Hanneke van Laarhoven, Rob Verhoeven, Mark van Berge Henegouwen, Nadia Haj Mohammad, Richard van Hillegersberg, Marije Slingerland, Christina T. Muijs, Bas Wijnhoven, Bianca Mostert, Laurens Beerepoot, Grard Nieuwenhuijzen, Sarah Derks, Peter S.N. van Rossum

“…Interpretation: Although survival rates in real-world settings are often lower compared to clinical trials, in our real-world cohort the 3-year OS was only 2.6% lower compared to that reported for the group that underwent nCRT in ESOPEC. …”
Get full text

Effects of high-intensity interval and moderate-intensity continuous training on ambulatory blood pressure and cardiovascular outcomes in older adults with hypertension (HEXA Study... by Francisco Dalton-Alves, Maria Beatriz F Araújo, Bruno Erick B Lucena, Gabriel C Souto, Daniele Samara D Lopes, Maria Isabel S Lucena, Raíssa de Melo Silva, Ludmila L P Cabral, Yuri A Freire, Fabíola L Golveia, Telma Maria Araújo Lemos, Rodrigo A V Browne, Eduardo Caldas Costa

“…Additionally, the procedures adhered to Resolution 466/2012 issued by the Brazilian National Health Council for research involving human subjects.Trial registration number Brazilian Registry of Clinical Trials (ID: RBR-4ntszb).…”
Get full text

Recruitment of Young Gay, Bisexual, and Other Men Who Have Sex With Men for a Web-Based Human Papillomavirus Vaccination Intervention: Differences in Participant Characteristics an... by Daniel J Marshall, Amy L Gower, Mira L Katz, José A Bauermeister, Abigail B Shoben, Paul L Reiter

“…Trial RegistrationClinicalTrials.gov NCT04032106; https://clinicaltrials.gov/study/NCT04032106 International Registered Report Identifier (IRRID)RR2-10.2196/16294…”
Get full text

Acceptability, feasibility, and effectiveness of internet-based cognitive behavior therapy for obsessive–compulsive disorder (OCD-NET): a naturalistic pilot trial during the COVID-... by Elisabeth Kohls, Sabrina Baldofski, Julia Scholl, Oskar Flygare, Lina Lundström, Ursula Beyrich-Kolbus, Marc Steinbrecher, Christian Rück, Christine Rummel-Kluge

“…Trial registration German Clinical Trials register (DRKS): DRKS00021706, registration date: 15.05.2020.…”
Get full text

Study protocol of a pilot randomised controlled trial assessing the feasibility and acceptability of RecoverEsupport: a digital health intervention to enhance recovery in women und... by Christopher Oldmeadow, Mitch J Duncan, Penny Reeves, Priscilla Viana da Silva, Rebecca Wyse, Helen Moore, Alison Zucca, Sancha Robinson, Stephen Ridley Smith, Emma Sansalone, Owen Morris, Rebecca Chenery, Lara Riley, Anna Palazzi-Parsons

“…Trial outcomes will be disseminated via peer-reviewed publications and conference presentations.Trial registration number Australian New Zealand Clinical Trials Registry (ANZCTR) ACTRN12624000417583.…”
Get full text

Clozapine for Treatment-Resistant Disruptive Behaviors in Youths With Autism Spectrum Disorder Aged 10-17 Years: Protocol for an Open-Label Trial by André Luiz Schuh Teixeira da Rosa, Marina Ribeiro Barreto da Costa, Gabriela Bezerra Sorato, Felipe de Moura Manjabosco, Érica Bonganhi de Bem, Lucas Dellazari, Arthur Bezerra Falcão, Lucas de Oliveira Cia, Olivia Sorato Bezerra, Rogério Boff Borges, Luis Augusto Rohde, Ana Soledade Graeff-Martins

“…Trial RegistrationBrazilian Clinical Trials Registry RBR-54j3726; https://ensaiosclinicos.gov.br/rg/RBR-54j3726 International Registered Report Identifier (IRRID)DERR1-10.2196/58031…”
Get full text

New avenues of preoperative evaluation before corneal refractive surgery during the COVID-19 pandemic by S.N. Sakhnov, O.A. Klokova, A.V. Piskunov, R.O. Damashauskas, M.S. Geidenrich, E.I. Dyakonova

“…</i> </p> <p> <i><b>Conclusion</b>: clinical trials comparing the readings produced by Visionix VX 130+ and other devices whose reliability was evidenced by long-term clinical experience have demonstrated that Visionix VX 130+ multifunctional diagnostic system is fully in line with the COVID-19 pandemic requirements. …”
Get full text

Incidence of unintended pregnancies and pregnancy experience among adolescents living with perinatally-acquired HIV in West Africa: a mixed-method study by Désiré Lucien Dahourou, Clément Tisseron, Caroline Yonaba, Joël Djaha, Marie-Sylvie N’Gbeche, Corinne Moh, Kouakou Kouadio, Patricia Nindjin, François Eboua, Belinda Bouah, Karen Malateste, Jean-Claude Azani, Eulalie Kangah, Elisabeth Thio, Philippe Msellati, Julie Jesson, Valériane Leroy, for the IeDEA West-African Collaboration

“…Trial registration Registered with the Pan African Clinical Trials Registry on 13 February 2024 (reference no. …”
Get full text

Adapting a Mobile Health App for Smoking Cessation in Black Adults With Anxiety Through an Analysis of the Mobile Anxiety Sensitivity Program Proof-of-Concept Trial: Qualitative St... by Marshall K Cheney, Adam C Alexander, Lorra Garey, Matthew W Gallagher, Emily T Hébert, Anka A Vujanovic, Krista M Kezbers, Cameron T Matoska, Michael J Zvolensky, Michael S Businelle

“…Trial RegistrationClinicalTrials.gov NCT04838236; https://clinicaltrials.gov/ct2/show/NCT04838236…”
Get full text

Investigating the Efficacy of the Web-Based Common Elements Toolbox (COMET) Single-Session Interventions in Improving UK University Student Well-Being: Randomized Controlled Trial by Jeffrey Lambert, Maria Loades, Noah Marshall, Nina Higson-Sweeney, Stella Chan, Arif Mahmud, Victoria Pile, Ananya Maity, Helena Adam, Beatrice Sung, Melanie Luximon, Keren MacLennan, Clio Berry, Paul Chadwick

“…Trial RegistrationClinicalTrials.gov NCT05718141; https://clinicaltrials.gov/ct2/show/NCT05718141…”
Get full text

A cohort-based multi-omics identifies nuclear translocation of eIF5B /PD-L1/CD44 complex as the target to overcome Osimertinib resistance of ARID1A-deficient lung adenocarcinoma by Dantong Sun, Helei Hou, Feiyue Feng, Weizheng Wu, Jingyu Tan, Tongji Xie, Jiayu Liu, Jinsong Wang, Haili Qian, Junling Li, Puyuan Xing

“…Abstract Background Osimertinib has emerged as a critical element in the treatment landscape following recent clinical trials. Further investigation into the mechanisms driving resistance to Osimertinib is necessary to address the restricted treatment options and survival advantages that are compromised by resistance in patients with EGFR-mutated lung adenocarcinoma (LUAD). …”
Get full text

Balneotherapy for the treatment of post-COVID syndrome: a randomized controlled trial by Diana Ovejero, Anna Ribes, Judit Villar-García, Marta Trenchs-Rodriguez, Daniel Lopez, Xavier Nogués, Robert Güerri-Fernandez, Natalia Garcia-Giralt

“…Trial registration ClinicalTrials.gov NCT05765591 (13/03/2023).…”
Get full text

Impact of prior CAR T-cell therapy on mosunetuzumab efficacy in patients with relapsed or refractory B-cell lymphomas by Elise A. Chong, Elicia Penuel, Ellen B. Napier, Rachel K. Lundberg, Lihua E. Budde, Mazyar Shadman, Matthew J. Matasar, Nancy L. Bartlett, Ian W. Flinn, Francesc Bosch, Keith Fay, Andre Goy, Anita Kumar, Loretta J. Nastoupil, Michael C. Wei, Mei Wu, Shen Yin, Joseph A. Fraietta, Emeline R. Chong, Stephen J. Schuster

“…The trial was registered at www.ClinicalTrials.gov as #NCT02500407.…”
Get full text