Excess ventilation and chemosensitivity in patients with inefficient ventilation and chronic coronary syndrome or heart failure: a case–control study by Prisca Eser, Dominic Käesermann, Pietro Calamai, Anja Kalberer, Laura Stütz, Sarina Huber, James Duffin, Matthias Wilhelm

“…Low VRTs were related to resting excess ventilation in patients with CCS or HF; however, rapid shallow breathing at peak exercise was present only in patients with HF.Clinical trial registration numberNCT05057884.…”
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Efficacy of yeast beta-glucan 1,3/1,6 supplementation on respiratory infection, fatigue, immune markers and gut health among moderate stress adults in Klang Valley of Malaysia: pro... by Suzana Shahar, Kalavathy Ramasamy, Norhayati Ibrahim, Nur Nadia Mohamad Habibullah, Munirah Ismail, Mohd Zul Amin Kamaruddin, Shirley Gee Hoon Tang, Mohd Faisal Abdul Hamid

“…However, little is known regarding the efficacy of YBG at lower dosages in relation to URTI, fatigue, immune response and uncertainties of how they affect the gut microbiota composition.Methods and analysis This 12-week randomised, double-blinded, placebo control, parallel-group clinical trial aims to evaluate the efficacy of YBG 1,3/1,6 on respiratory tract infection, fatigue, immune markers and gut health among adults with moderate stress. …”
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Multicentre, 26-week, open-label phase 2 trial of the JAK inhibitor filgotinib in Behçet’s disease, idiopathic inflammatory myopathies and IgG4-related disease: DRIMID study protoc... by Sander W Tas, Joost Raaphorst, Paco M J Welsing, Jacob M van Laar, Rogier M Thurlings, Robbert J Goekoop, César Magro Checa, Jan A M van Laar, Bettina C Geertsema-Hoeve, Nicolle H Rekers, Erik Present

“…Introduction Research into novel therapies for rare, immune-mediated inflammatory diseases (IMIDs) faces significant challenges, including small patient populations, complex clinical trial design and difficulties in patient recruitment. …”
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ABCD3-I and ABCD2 Scores in a TIA Population with Low Stroke Risk by Fredrik Ildstad, Hanne Ellekjær, Torgeir Wethal, Stian Lydersen, Hild Fjærtoft, Bent Indredavik

“…Since there is a generally lower stroke risk after TIA during the last years, the benefit of these clinical risk scores and their role in TIA management seems limited. Clinical Trial Registration. This trial is registered with NCT02038725 (retrospectively registered, January 16, 2014).…”
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Perioperative tislelizumab plus chemotherapy for locally advanced gastroesophageal junction adenocarcinoma (NEOSUMMIT-03): a prospective, nonrandomized, open-label, phase 2 trial by Run-Cong Nie, Shu-Qiang Yuan, Ya Ding, Yong-Ming Chen, Yuan-Fang Li, Cheng-Cai Liang, Mu-Yan Cai, Guo-Ming Chen, Wei Wang, Xiao-Wei Sun, De-Sheng Weng, Dan-Dan Li, Jing-Jing Zhao, Xiao-Jiang Chen, Yuan-Xiang Guan, Zhi-Min Liu, Yao Liang, Ma Luo, Jun Chi, Hai-Bo Qiu, Zhi-Wei Zhou, Xiao-Shi Zhang, Ying-Bo Chen

“…Abstract This prospective, nonrandomized, open-label phase 2 trial (Chinese Clinical Trial Registry, ChiCTR2200061906) aimed to evaluate the effectiveness of adding the PD-1 antibody tislelizumab to perioperative chemotherapy in patients with locally advanced gastroesophageal junction adenocarcinoma (GEJA). …”
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WT1 Peptide Cancer Vaccine for Patients with Hematopoietic Malignancies and Solid Cancers by Yoshihiro Oka, Akihiro Tsuboi, Olga A. Elisseeva, Hiroko Nakajima, Fumihiro Fujiki, Manabu Kawakami, Toshiaki Shirakata, Sumiyuki Nishida, Naoki Hosen, Yusuke Oji, Ichiro Kawase, Haruo Sugiyama

“…On the basis of these findings, we performed a phase I clinical trial of a WT1 peptide cancer vaccine for the patients with malignant neoplasms. …”
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Early T-Cell Precursor Leukemia Has a Higher Risk of Induction-Related Infection among T-Cell Acute Lymphoblastic Leukemia in Adult by Kangyu Huang, Min Dai, Qiuli Li, Nannan Liu, Dainan Lin, Qiang Wang, Xuan Zhou, Zhixiang Wang, Ya Gao, Hua Jin, Xiaoli Liu, Qifa Liu, Hongsheng Zhou

“…We performed a retrospective cohort study for the prevalence and risk predictors of induction-related infection among consecutive T-ALL patients (N=97) enrolled in a PDT-ALL-LBL clinical trial. Of 97 patients with T-ALL enrolled in the trial, 46 were early T-cell precursor (ETP) ALL and 51 were non-ETP ALL. …”
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Neural Correlates of Social Perception Deficit in Schizophrenia: An Event-related Potential Study by Jiang-juan Li, Xin-ping Li, Jia-min Han, Yi-fan Sun, Xiao-hong Liu, Xue-zheng Gao, Li-min Chen, Zhen-he Zhou, Hong-liang Zhou

“…These findings underscore the potential of the EIRT as a biomarker for cognitive and emotional dysregulation in schizophrenia. Clinical Trial Registration: No: ChiCTR2300078149. …”
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Triglyceride lowering in patients with different severities of hypertriglyceridaemia-associated acute pancreatitis: secondary analysis of a multicentre, prospective cohort study by Xiaoling Li, Lin Gao, Xiang Luo, Wenjian Mao, Lu Ke, Xiaoyan Lai, Lingyan Fu, Yaolu Liu

“…Similar findings were seen in the subgroup with more severe HTG-AP (APACHE II ≥8 at enrolment).Conclusion More rapid decline of serum TG levels was associated with decreased presence of organ failure at day 14 in patients with more severe HTG-AP.Trial registration number The Chinese Clinical Trial Registry, number ChiCTR2000039541.…”
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Effect of enhanced recovery after surgery on older patients undergoing transvaginal pelvic floor reconstruction surgery: a randomised controlled trial by Xuezhu Huang, Sisi Deng, Xiaofeng Lei, Shentao Lu, Ling Dai, Chunyan She

“…Trial registration This study was retrospectively registered with the Chinese Clinical Trial Registry (registration number: ChiCTR2400084608). …”
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Weight loss-independent changes in human growth hormone during water-only fasting: a secondary evaluation of a randomized controlled trial by Benjamin D. Horne, Benjamin D. Horne, Benjamin D. Horne, Jeffrey L. Anderson, Jeffrey L. Anderson, Heidi T. May, Tami L. Bair, Viet T. Le, Viet T. Le, Leslie Iverson, Kirk U. Knowlton, Kirk U. Knowlton, Joseph B. Muhlestein, Joseph B. Muhlestein

“…Basal HGH and fasting-induced HGH changes correlated inversely with cardiometabolic risk factors.Clinical Trial Registration: clinicaltrials.gov, identifier NCT01059760.…”
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Development of an imputation model to recalibrate birth weights measured in the early neonatal period to time at delivery and assessment of its impact on size-for-gestational age a... by Joanne Katz, James M Tielsch, Luke C Mullany, Diwakar Mohan, Subarna K Khatry, Seema Subedi, Scott L Zeger, Elizabeth A Hazel

“…We aimed to develop an imputation model that predicts the ‘true’ birth weight at time of delivery.Design We developed and applied a model that recalibrates weights measured in the early neonatal period to time=0 at delivery and uses those recalibrated birth weights to impute missing birth weights.Setting This is a secondary analysis of pregnancy cohort data from two studies in Sarlahi district, Nepal.Participants The participants are 457 babies with daily weights measured in the first 10 days of life from a subsample of a larger clinical trial on chlorhexidine (CHX) neonatal skin cleansing and 31 116 babies followed through the neonatal period to test the impact of neonatal massage oil type (Nepal Oil Massage Study (NOMS)).Outcome measures We developed an empirical Bayes model of early neonatal weight change using CHX trial longitudinal data and applied it to the NOMS dataset to recalibrate and then impute birth weight at delivery. …”
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Improving Anxiety Related to Chronic Pain Through a Sleep Circadian Intervention Program: A Pilot Study by Sonia López-Monzoni, Gloria Hernando Benito, Sofía Romero-Peralta, Laura Silgado-Martínez, Maria Esther Viejo-Ayuso, Leticia Álvarez-Balado, Enrique Rodríguez Matarranz, Carles Forné Izquierdo, Manuel Sánchez-de-la-Torre, Juan Fernando Masa, Ferrán Barbé, Francisco García-Río, Antonio Martínez-Nicolás, Belén García-Mediano, Esther Solano-Pérez, Olga Mediano

“…This was a randomized clinical trial (NCT03646084), in which 49 CMP patients were assigned to SCIP (<i>n</i> = 15, mean age 51 years and 40% women) or non-SCIP groups (<i>n</i> = 26, 53 years and 61.5% women). …”
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Comparative evaluation of intravenous versus intranasal dexmedetomidine on emergence delirium and hemodynamics in pediatric patients undergoing adenotonsillectomy: a randomized con... by Chenxu Dai, Chenxu Dai, Xuemei Zhao, Xuemei Zhao, Aoxue Li, Xuedong Zhang, Penglei Wang, Ye Zhang, Yun Wu

“…Intranasal administration of dexmedetomidine provided more stable hemodynamics and more prolonged analgesia and sedation than intravenous infusion of dexmedetomidine.Clinical Trial Registrationhttps://www.chictr.org.cn/showproj.html?…”
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Rapid Verbal Persuasion to increase influenza vaccine uptake: protocol for a randomized hybrid type 2 effectiveness -implementation trial by Siyuan Liu, Lan Gao, Yingying Jin, Jiangyun Chen, Dadong Wu, Yiyuan Cai, Tao Wang, Sanhao Huang, Ciling Yan, Run Wang, Dong Roman Xu

“…Trial registration Chinese Clinical Trial Registry. Trial identifier: ChiCTR2400091302 (Registration Date: October 25, 2024); ChiCTR2400091324 (Registration Date: October 25, 2024).…”
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Machine learning reveals sex differences in distinguishing between conduct-disordered and neurotypical youth based on emotion processing dysfunction by Gregor Kohls, Erik M. Elster, Peter Tino, Graeme Fairchild, Christina Stadler, Arne Popma, Christine M. Freitag, Stephane A. De Brito, Kerstin Konrad, Ruth Pauli

“…However, the data also underscore the heterogeneity of CD, namely that only a subset of those affected are likely to have emotion dysfunction and that other neurocognitive domains (not tested here) probably also contribute to CD etiology. Clinical trial number Not applicable.…”
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Robotic versus laparoscopic surgery for severe deep endometriosis: protocol for a randomised controlled trial (ROBEndo trial) by Tero Rautio, Pasi Ohtonen, Outi Uimari, Anna Maria Terho, Johanna Mäkelä-Kaikkonen, Terhi Puhto, Sari Koivurova

“…Advanced endometriosis surgery offers an excellent platform to study the feasibility and long-term outcomes of robotic surgery compared with conventional laparoscopy.Methods and analysis ROBEndo is a prospective, randomised, controlled clinical trial in a single-centre setting. Patients with deep endometriosis verified by MRI needing surgery at Oulu University Hospital (Oulu, Finland) will be considered eligible. 70 patients will be allocated 1:1 to receive either robotic-assisted or conventional laparoscopic surgery in two strata: radical surgery (with the removal of the uterus and adnexae) and gynaecological organ-sparing surgery. …”
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Effects of intranasal oxytocin on neural reward processing in children and adolescents with reactive attachment disorder: A randomized controlled trial by Shinichiro Takiguchi, Shinichiro Takiguchi, Kai Makita, Takashi X. Fujisawa, Takashi X. Fujisawa, Shota Nishitani, Shota Nishitani, Akemi Tomoda, Akemi Tomoda, Akemi Tomoda

“…Further investigation is needed to fully understand the neural mechanisms of intranasal OT and identify novel targets for pediatric cases with RAD.Clinical trial registration: UMIN-CTR; UMIN000013215. …”
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Language function improvement and cortical activity alteration using scalp acupuncture coupled with speech-language training in post-stroke aphasia: A randomised controlled study by Bingbing Lin, Jinglei Ni, Xiao Xiong, Lanlan Zhang, Jian Song, Mengxue Wang, Linsong Chai, Yunshi Huang, Jia Huang

“…Methods: This assessor-blinded, parallel-arm design, single-center, randomized clinical trial recruited 64 patients with post-stroke aphasia. …”
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Effect of arm-ergometry versus treadmill supervised exercise on health-related quality of life and mental health in patients with peripheral artery disease: secondary outcomes from... by Sandra Magalhães, Mário Santos, Sofia Viamonte, Fernando Ribeiro, Joana Martins, Cristine Schmidt, Henrique Cyrne-Carvalho

“…Methods This was an ancillary study of the ARMEX trial, a single-center, single-blinded, parallel group, randomized clinical trial, enrolling symptomatic PAD patients referred to a cardiovascular rehabilitation program (CRP). …”
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