Longitudinal exploration of cancer-related cognitive impairment in patients with newly diagnosed aggressive lymphoma: protocol for a feasibility study by Vincent Dore, Christopher C Rowe, Meinir Krishnasamy, Haryana Dhillon, Adam K Walker, Karla Gough, Priscilla Gates, Carlene Wilson, Eliza Hawkes, Yuliya Perchyonok, Janette L Vardy, Michiel de Ruiter

“…Peer reviewed publications and conference presentations will report the findings of this novel study.Trial registration number Australian New Zealand Clinical Trials Registry (ACTRN12619001649101).…”
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Supporting primary care clinicians in caring for patients with alcohol use disorder: study protocol for Records for Alcohol Care Enhancement (RACE), a factorial four-arm randomized... by Kara M. Magane, Richard Saitz, Sarah Fielman, Marc R. LaRochelle, Christopher W. Shanahan, Christine A. Pace, Michael LaValley, Kaley Penington, Skylar Karzhevsky, Emily Hurstak

“…Trial registration ClinicalTrials.gov identifier/registration number (NCT number): NCT05492942…”
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Effectiveness of nurse-led volunteer support and technology-driven pain assessment in improving the outcomes of hospitalised older adults: protocol for a cluster randomised control... by Max K Bulsara, Christopher Etherton-Beer, Rosemary Saunders, Kate Crookes, Mustafa Atee, Caroline Bulsara, Beverley Ewens, Olivia Gallagher, Renee M Graham, Karen Gullick, Sue Haydon, Kim-Huong Nguyen, Bev O'Connell, Karla Seaman, Jeff Hughes, Seng Giap Marcus Ang, Debra Scaini

“…Two interventions that have the potential to prevent progression of frailty and improve patient outcomes in hospitalised older adults but have yet to be subject to clinical trials are nurse-led volunteer support and technology-driven assessment of pain.Methods and analysis This single-centre, prospective, non-blinded, cluster randomised controlled trial will compare the efficacy of nurse-led volunteer support, technology-driven pain assessment and the combination of the two interventions to usual care for hospitalised older adults. …”
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Impaired creatinine-based estimated glomerular filtration rate in Thai individuals switching to dolutegravir: illustrating the role of cystatin C testing to aid clinical decision m... by Carlo Sacdalan, Curtis Austin, Aswathy Varma, Suteeraporn Pinyakorn, Eugène Kroon, Donn J. Colby, Phillip Chan, Orlanda Goh, Krittaporn Pornpaisakul, Jintana Intasan, Tassanee Luekasemsuk, Merlin L. Robb, Nitiya Chomchey, Nittaya Phanuphak, Jintanat Ananworanich, Sandhya Vasan, Denise Hsu, the SEARCH 010/RV254 study group

“…Trial registration Clinical Trials Registry Number: ClininicalTrials.gov NCT00796146.…”
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Estudio genético en adultos con glomeruloesclerosis focal y segmentaria by Melissa Pilco-Terán, Amir Shabaka, Mónica Furlano, Ana Tato Ribera, Isabel Galán Carrillo, Eduardo Gutiérrez, Roser Torra, Gema Fernández-Juárez

“…This document proposes clinical recommendations for carrying out genetic studies in adults with FSGS, highlighting the need for a correct classification for adequate therapeutic planning and improvement of results in clinical trials.…”
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Precise Acetabular Prosthesis Positioning Using a Novel Robot‐Assisted Total Hip Arthroplasty System: A Multicenter, Randomized Controlled Trial by Xiao Geng, Ziyang Dong, Yang Li, Minwei Zhao, Yanqing Liu, Zijian Li, Hong Cai, Ming Zhang, Xinfeng Yan, Zhiwen Sun, Xin Lv, Feng Guo, Feng Li, Hua Tian

“…Trial Registration Clinical Trials: NCT05947734…”
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Overview of preclinical and phase II clinical studies on Pegmolesatide’s long-term erythropoiesis stimulating effect via EPOR-mediated signal transduction by Xiaoying Ma, Zhen Li, Lu Zhang, Hui Qian, Qinkai Chen, Ye Tao, Yunfan Li, Dandan Wang, Zhizhen Hu, Weili Luo, Ping Li, Hai Yu, Changlin Mei, Xueqing Yu, Yuanfeng Zhou

“…Furthermore, two Phase II clinical trials in dialysis and non-dialysis chronic kidney disease (CKD) patients with anemia, respectively CTR20140533 and CTR20140539, assessed PK-PD and safety following repeated administration. …”
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Long-term outcome in people who use drugs successfully treated for hepatitis C infection with glecaprevir/pibrentasvir by Shana Yi, David Truong, Brian Conway

“…Background: Several clinical trials, including the recently published the GRAND PLAN study from Vancouver Infectious Diseases Center (VIDC), have demonstrated the efficacy of hepatitis C (HCV) therapy among active drug users, including those facing significant addiction-related and social challenges. …”
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Regular versus as-needed treatments for mild asthma in children, adolescents, and adults: a systematic review and network meta-analysis by Prapaporn Pornsuriyasak, Sunatee Sa-nguansai, Kunlawat Thadanipon, Pawin Numthavaj, Gareth J. McKay, John Attia, Ammarin Thakkinstian

“…PubMed, Scopus, and ClinicalTrials.gov were searched up to 31st March 2024. …”
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Construct validity and responsiveness of ASAS Health Index assessed in two longitudinal studies of tumour necrosis factor alpha inhibitor initiation and dose reduction in patients... by Merete Lund Hetland, Inge Juul Sørensen, Mikkel Østergaard, Mikael Boesen, Susanne Juhl Pedersen, Sara Nysom Christiansen, Ole Rintek Madsen, Mette Klarlund, Marie Wetterslev, Mate Lorincz, Mads Bakkegaard, Anne Duer, Kasper Kjærulf Gosvig

“…ASAS HI had a large responsiveness in MANGO (standardised response mean (SRM)=−1.3, effect size (ES)=−1.7) and moderate responsiveness in DOBIS (SRM=0.7, ES=0.6).Conclusion ASAS HI showed good construct validity, discriminatory ability and responsiveness.Trial registration number ClinicalTrials.gov: NCT02011386.…”
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Synthesis and Anti-Cancer Activity In Vitro of Synephrine Derivatives by Ekaterina M. Zhidkova, Evgeniya S. Oleynik, Ekaterina A. Mikhina, Daria V. Stepanycheva, Diana D. Grigoreva, Lyubov E. Grebenkina, Kirill V. Gordeev, Ekaterina D. Savina, Andrey V. Matveev, Marianna G. Yakubovskaya, Ekaterina A. Lesovaya

“…More than 30 SEGRAs have been described so far, yet none of them reached clinical trials for anti-cancer treatment. In the present work, we propose a novel approach to increase the number of potential SEGRAs by obtaining derivatives of synephrine, a molecule of natural origin. …”
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Gene signatures derived from transcriptomic-causal networks stratify colorectal cancer patients for effective targeted therapy by Akram Yazdani, Heinz-Josef Lenz, Gianluigi Pillonetto, Raul Mendez-Giraldez, Azam Yazdani, Hanna Sanoff, Reza Hadi, Esmat Samiei, Alan P. Venook, Mark J. Ratain, Naim Rashid, Benjamin G. Vincent, Xueping Qu, Yujia Wen, Michael Kosorok, William F. Symmans, John Paul Y. C. Shen, Michael S. Lee, Scott Kopetz, Andrew B. Nixon, Monica M. Bertagnolli, Charles M. Perou, Federico Innocenti

“…The patients were enrolled in a randomized clinical trial receiving either cetuximab or bevacizumab in combination with chemotherapy. …”
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The Role of Intravenous Selexipag in Managing PAH and Bridging Gaps in Oral Treatment: A Narrative Review by Goren S, Kidwai N, Aronow WS, Lanier GM

“…Additionally, selexipag should not be used with medications that block CYP enzymes. A phase III clinical trial reports that common side effects of the IV form of selexipag include headaches and irritation at the injection site. …”
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Efficacy and cost-effectiveness of an ACT and compassion-based intervention for women with breast cancer: study protocol of two randomised controlled trials {1} by Inês A. Trindade, Andreia Soares, David Skvarc, Diogo Carreiras, Joana Pereira, Óscar Lourenço, Filipa Sampaio, Bruno de Sousa, Teresa C. Martins, Paula Boaventura, Joana Marta-Simões, Mind Project Team, Helena Moreira

“…Trials registration {2a, 2b} ClinicalTrials.gov NCT05642897 and NCT06212414. Registered on December 8, 2022, and January 18, 2024.…”
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Modalities for the treatment of primary open-angle glaucoma by Zh.G. Oganezova, S.V. Simonova

“…Among these agents, selective alpha2-adrenoreceptor agonists are the most promising medications. Clinical trials on brimonidine demonstrate its direct neuroprotective effect which is independent of its IOP-lowering effect (i.e., cell survival improves even in ocular hypertension until IOP is well-controlled). …”
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Acquired vulnerability against EGF receptor inhibition in gastric cancer promoted by class I histone deacetylase inhibitor entinostat by Tamara Zenz, Robert Jenke, Denys Oliinyk, Sandra Noske, René Thieme, Tim Kahl, Ines Gockel, Florian Meier-Rosar, Achim Aigner, Thomas RH Büch

“…Introduction: Histone deacetylase inhibitors (HDACi) have shown promising preclinical activity in gastric cancer cells; unfortunately, however, these could not be confirmed in clinical trials. This highlights the need for the identification of underlying reasons, which may also provide the basis for possible combination therapies. …”
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The aptamer BC 007 for treatment of dilated cardiomyopathy: evaluation in Doberman  Pinschers of efficacy and outcomes by Sabine Werner, Gerd Wallukat, Niels‐Peter Becker, Katrin Wenzel, Johannes Müller, Ingolf Schimke, Gerhard Wess

“…Using a natural large animal model of DCM considered superior to small animal models of immunization‐induced cardiomyopathy, combined with a study design comparable with clinical trials, we believe that our results provide the basis for optimism that treatment with BC 007 might also be effective in human patients with DCM.…”
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Sex Differences in Computed Tomography Coronary Stenosis Severity Versus Flow Impairment and Impact on Revascularization, Clinical Events and Health Care Costs: A FORECAST Substudy by Lavinia Gabara, Jonathan Hinton, Mohamed Kira, James Shambrook, Ausami Abbas, Sam Wilding, Jonathon A. Leipsic, Pamela S. Douglas, Nick Curzen

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Impact of the Smarter Safer Homes Solution on Quality of Life and Health Outcomes in Older People Living in Their Own Homes: Randomized Controlled Trial by Wei Lu, David Silvera-Tawil, Hwan-Jin Yoon, Liesel Higgins, Qing Zhang, Mohanraj Karunanithi, Julia Bomke, Joshua Byrnes, Jennifer Hewitt, Vanessa Smallbon, Jill Freyne, Deepa Prabhu, Marlien Varnfield

“…Trial RegistrationAustralian New Zealand Clinical Trials Registry ACTRN12618000829213; https://tinyurl.com/2n6a75em International Registered Report Identifier (IRRID)RR2-10.2196/31970…”
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Mailed smoking cessation support for Aboriginal and Torres Strait Islander people who smoke: protocol for a hybrid type 1 effectiveness – implementation trial by Raglan Maddox, Catherine Chamberlain, Billie Bonevski, Amanual Getnet Mersha, Jamie Bryant, Michelle Kennedy, Nathan Taylor, Cathy Segan, Kayden Roberts-Barker, Zabowie Mills, Kade Booth, Joley Foster

“…Findings will be disseminated through publications, conference presentations and sharing with relevant government bodies.Trial registration number Australian New Zealand Clinical Trials Registry (ACTRN12623001021662).…”
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