A randomized controlled, trial on effects of mobile phone text messaging in combination with motivational interviewing versus standard infant feeding counselling on breastfeeding a... by Moleen Zunza, Lehana Thabane, Louise Kuhn, Christine Els, Carl Lombard, Mark F. Cotton, Taryn Young

“…Trial registration The trial was registered on ClinicalTrials.gov (NCT05063240) and Pan African Clinical Trial Registries (PACTR202110870407786) before recruitment of the first subject.…”
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Vagal Blocking Improves Glycemic Control and Elevated Blood Pressure in Obese Subjects with Type 2 Diabetes Mellitus by S. Shikora, J. Toouli, M. F. Herrera, B. Kulseng, H. Zulewski, R. Brancatisano, L. Kow, J. P. Pantoja, G. Johnsen, A. Brancatisano, K. S. Tweden, M. B. Knudson, C. J. Billington

“…This trial is registered with ClinicalTrials.gov NCT00555958.…”
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AI-assisted detection for chest X-rays (AID-CXR): a multi-reader multi-case study protocol by Fergus Gleeson, Alex Novak, Indrajeet Das, Ruchir Shah, Edwin van Beek, Sarim Ather, Howell Fu, Nabeeha Salik, Alan Campbell, Farhaan Khan, Abdala Trinidad Espinosa Morgado, Marusa Kotnik, Louise Wing, John Murchison, Jong Seok Ahn, Sang Hyup Lee, Ambika Seth

“…The results will be presented at relevant conferences and published in a peer-reviewed journal.Trial registration number Protocol ID 310995-B (awaiting approval), ClinicalTrials.gov…”
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Analysis of the correlation between the dose exposure intensity and apatinib in advanced gastric cancer: a retrospective cohort study by Xiao Ma, Xiao Ma, Lan Gao, Siying Che, Chaofeng Tao

“…BackgroundApatinib is a small molecule anti-angiogenesis targeted drug that has demonstrated significant efficacy as a late-line treatment in advanced gastric cancer in phase 3 clinical trials. This study amid to evaluate the correlation between dose exposure intensity and efficacy and safety of apatinib in the treatment of advanced gastric cancer.MethodsWe conducted an observational, retrospective cohort study of patients with advanced gastric cancer who received apatinib targeted therapy in Beijing Friendship Hospital affiliated to Capital Medical University between June 1, 2018, and June 30, 2021. …”
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A systematic review and meta-analysis of the effectiveness of perineural dextrose injection in peripheral compression neuropathies of the upper limbs by Fatemeh Azizi, Faezeh Saber Gharesoo, Fereshteh Eidy, Sama Heidari, Nastaran Maghbouli, Shirin Djalalinia, Amir Kasaeian

“…The quality of the clinical trials was assessed using Cochrane tools. Random-effect model was employed for meta-analysis. …”
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Homoharringtonine: mechanisms, clinical applications and research progress by Wen Wang, Lan He, Lan He, Ting Lin, Ting Lin, Ting Lin, Fulan Xiang, Yibin Wu, Fangliang Zhou, Fangliang Zhou, Fangliang Zhou, Yingchun He, Yingchun He, Yingchun He

“…Additionally, HHT exhibits multiple biological activities, including immunomodulation, antiviral effects, and anti-fibrotic properties, with recent studies also revealing its potential neuroprotective functions. In clinical trials, Homoharringtonine has demonstrated promising efficacy in the treatment of hematological malignancies, particularly in various types such as acute myeloid leukemia and chronic myeloid leukemia. …”
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The Canadian Registry for Pulmonary Fibrosis: Design and Rationale of a National Pulmonary Fibrosis Registry by Christopher J. Ryerson, Benjamin Tan, Charlene D. Fell, Hélène Manganas, Shane Shapera, Shikha Mittoo, Mohsen Sadatsafavi, Teresa To, Andrea Gershon, Jolene H. Fisher, Kerri A. Johannson, Nathan Hambly, Nasreen Khalil, Theodore K. Marras, Julie Morisset, Pearce G. Wilcox, Andrew J. Halayko, Mohammad Adil Khan, Martin Kolb

“…As the largest and most comprehensive cohort of Canadian ILD patients, CARE-PF establishes a network for future clinical research and early phase clinical trials and provides a platform for translational and basic science research.…”
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Machine learning models for dementia screening to classify brain amyloid positivity on positron emission tomography using blood markers and demographic characteristics: a retrospec... by Noriyuki Kimura, Kotaro Sasaki, Teruaki Masuda, Takuya Ataka, Mariko Matsumoto, Mika Kitamura, Yosuke Nakamura, Etsuro Matsubara

“…Trial registration UMIN Clinical Trials Registry (UMIN000051776, registered on 31/08/2023).…”
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Feasibility of a Mobile App–Based Cognitive-Behavioral Perinatal Skills Program: Protocol for Nonrandomized Pilot Trial by Andrea B Temkin-Yu, Aliza Ayaz, Ella Blicker, Michael X Liu, Ace Oh, Isabelle E Siegel, Meredith J Seewald, Alison D Hermann, Soudebah Givrad, Lara M Baez, Lauren M Osborne, Cori M Green, Maddy M Schier, Alexandra M Davis, Shasha Zhu, Avital Falk, Shannon M Bennett

“…Trial RegistrationClinicalTrials.gov NCT05897619; https://classic.clinicaltrials.gov/ct2/show/NCT05897619 International Registered Report Identifier (IRRID)PRR1-10.2196/59461…”
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Promotional tone in reviews of menopausal hormone therapy after the Women's Health Initiative: an analysis of published articles. by Adriane Fugh-Berman, Christina Pike McDonald, Alicia M Bell, Emily Catherine Bethards, Anthony R Scialli

“…Themes that were common in articles considered promotional included attacks on the methodology of the WHI, arguments that clinical trial results should not guide treatment for individuals, and arguments that observational studies are as good as or better than randomized clinical trials for guiding clinical decisions. …”
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Oridonin: A natural terpenoid having the potential to modulate apoptosis and survival signaling in cancer by Abhishek Chauhan, Hemant Joshi, Divya Kandari, Diwakar Aggarwal, Ritu Chauhan, Hardeep Singh Tuli, Arpit Mehrotra, Abhilasha Sood, Ujjawal Sharma, Darin Mansor Mathkor, Shafiul Haque, Naveen Chandra Joshi, Laurent Dufossé

“…Further research, including clinical trials, is necessary to fully harness its potential as a cancer treatment alternative.…”
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Almond snacking modestly improves diet quality and waist circumference but not psychosocial assessments and other cardiometabolic markers in overweight, middle-aged adults: A rando... by Vernon Uganiza Rayo, Lauren Okamoto, Maricarmen Cervantes, Mee Young Hong, Nathaniel Jason, Mark Kern, Changqi Liu, Elise North, Svitlana Storm, Oliver C. Witard, Shirin Hooshmand

“…Future mechanistic studies are warranted to understand the effect of almond supplementation on cardiometabolic health in various populations. ClinicalTrials.gov Identifier: NCT04787718.…”
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Fetal cardiac function in pregnancy affected by congenital heart disease: protocol for a multicentre prospective cohort study by Anna Erenbourg, Tracie Barber, Vera Cecotti, Stefano Faiola, Ilaria Fantasia, Tamara Stampaljia, Hagai Avnet, Beata Radzymińska-Chruściel, Neama Meriki, Alec Welsh

“…Trial registration The study protocol has been registered in the ClinicalTrials.gov Protocol Registration System, identification number NCT05698277.…”
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Pharmacogenomic screening identifies and repurposes leucovorin and dyclonine as pro-oligodendrogenic compounds in brain repair by Jean-Baptiste Huré, Louis Foucault, Litsa Maria Ghayad, Corentine Marie, Nicolas Vachoud, Lucas Baudouin, Rihab Azmani, Natalija Ivljanin, Alvaro Arevalo-Nuevo, Morgane Pigache, Lamia Bouslama-Oueghlani, Julie-Anne Chemelle, Marie-Aimée Dronne, Raphaël Terreux, Bassem Hassan, François Gueyffier, Olivier Raineteau, Carlos Parras

“…These findings support the repurposing of leucovorin and dyclonine for clinical trials targeting myelin disorders, offering potential therapeutic avenues for PBI and MS.…”
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Diagnosing and managing patients with heart failure with preserved ejection fraction: a consensus survey by Christi Deaton, Robin Fox, Ian Wellwood, Carolyn Chew-Graham, Katherine Brown, Sharon Dixon, Thomas Blakeman, Alistair Brown, Julie Smith, Nick Thomas, Adam Jones, Basilio Hernandez-Diaz, Christopher Keast, Heather Rutter, Kyle Knox, Matthew Gaw, Nick Wooding, Christine A'Court, Hannah Swayze, Helen Ashdown, Victoria Glover, Rosalynn Austin, Eva Khair, Muhammad Zakir Hossain, Emma Sowden, Faye Forsyth, Mollika Chakravorty, Sophie Maclachlan, Edward Kane, Jessica Odone, Natasha Thorley, Susana Borja-Boluda, Muhammed Hossain, John Sharpley, Brain Gordon, Joanna Taffe, Aaron Long, Affan Aziz, Chris Schramm, Sine MacDonald, Helena Papworth, Craig Needs, David Cronk, Chris Newark, Duncan Blake, Amman Basuita, Emma Gayton, Jonathan Crawshaw, Rachael Ayerst, Shamila Wanninayake, Elisabetta Angeleri-Rand

“…Creation of collaborative care pathways is needed to support the increasing number of older patients with HFpEF.Trial registration number ClinicalTrials. gov (reference number: NCT03617848).…”
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Successful Regulatory T Cell-Based Therapy Relies on Inhibition of T Cell Effector Function and Enrichment of FOXP3+ Cells in a Humanized Mouse Model of Skin Inflammation by S. Landman, V. L. de Oliveira, M. Peppelman, E. Fasse, E. van Rijssen, S. C. Bauland, P. van Erp, I. Joosten, H. J. P. M. Koenen

“…Background. Recent clinical trials using regulatory T cells (Treg) support the therapeutic potential of Treg-based therapy in transplantation and autoinflammatory diseases. …”
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Efficacy and Safety of Aprocitentan in the Treatment of Hypertension: A Meta-Analysis of Evidence from Randomized Controlled Trials by Li Zheng, Ming Liu, Xiaotong Gu, Yatong Zhang, Yan Wang

“…Methods: We searched PubMed, Embase, ClinicalTrials.gov, and the Cochrane Library databases from inception to June 3, 2024, for randomized controlled trials (RCTs) that compared the efficacy and safety between aprocitentan and placebo in treating hypertension. …”
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Myofascial trigger points therapy increases neck mobility and reduces headache pain in migraine patients – pilot study by Maciej Olesiejuk, Małgorzata Chalimoniuk, Tomasz Sacewicz

“…Clinical trial number: not applicable.…”
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Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation (the PROMIZING study): update to the statistical analysis plan for a randomized controlled tri... by Karen J. Bosma, Myriam Lafreniere-Roula, Arlene Jiang, Anna Heath, Yongdong Ouyang, Kaitlyn Wade, Pingzhao Hu, Karen E. A. Burns, Claudio M. Martin, Yoanna Skrobik, Sorcha Mulligan, Kevin E. Thorpe, Laurent Brochard, members of the Canadian Critical Care Trials Group and the REVA Network

“…Trial registration ClinicalTrials.gov Identifier: NCT02447692 prospectively registered May 19, 2015.…”
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Accuracy of algorithms to identify patients with a diagnosis of major cancers and cancer-related adverse events in an administrative database: a validation study in an acute care h... by Takashi Fujiwara, Yasuyuki Okumura, Hironobu Tokumasu, Takashi Kanemitsu, Kosei Tajima, Akinori Yuri, Masahiro Iwasaku

“…Overall, PPV tended to be low, with the definition based on International Classification of Diseases, 10th revision alone for AEs.Conclusion Diagnostic accuracy was not so high, and therefore needs to be further investigated.Trial registration number University Hospital Medical Information Network (UMIN) Clinical Trials Registry (UMIN000039345).…”
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