Comparative Evaluation of Plaque Inhibitory and Antimicrobial Efficacy of Probiotic and Chlorhexidine Oral Rinses in Orthodontic Patients: A Randomized Clinical Trial by Shreya Shruthi Shah, Supriya Nambiar, Deepa Kamath, Ethel Suman, Bhaskaran Unnikrishnan, Asavari Desai, Sanchit Mahajan, Kushan Kishore Dhawan

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Extracorporeal Shockwave Therapy Reduces Pain and Improves Internal Rotation after Arthroscopic Capsular Release: A Randomized Clinical Trial by Zifan Lin, Hong Shao, Jun Chen, Wei Yao, Chang Liu, Zhengbiao Jin, Yunxia Li

“…Methods. A randomized clinical trial including 49 patients who under ACR was included. …”
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Drug-Coated Balloon-Only Strategy for De Novo Coronary Artery Disease: A Meta-analysis of Randomized Clinical Trials by Wenyi Zhang, Mingduo Zhang, Jinfan Tian, Min Zhang, Yuan Zhou, Xiantao Song

“…Backgrounds. Many clinical trials have demonstrated the value of drug-coated balloons (DCB) for in-stent restenosis. …”
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Comparison of Effectiveness of Supervised Exercise Program and Cyriax Physiotherapy in Patients with Tennis Elbow (Lateral Epicondylitis): A Randomized Clinical Trial by Rajadurai Viswas, Rejeeshkumar Ramachandran, Payal Korde Anantkumar

“…Design. Randomized clinical trial. Setting. Physiotherapy and rehabilitation centre. …”
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Antimicrobial efficacy of superoxide water as an intracanal irrigant in primary anterior teeth against facultative anaerobes: A randomized clinical trial by Deepika Narasimha Chari, Bhavna Haresh Dave

“…Materials and Methods: A triple-blinded randomized clinical trial was carried out among children between the age groups of 3 and 7 years. …”
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Effects of Semaglutide Treatment on Psoriatic Lesions in Obese Patients with Type 2 Diabetes Mellitus: An Open-Label, Randomized Clinical Trial by Jelena Petković-Dabić, Ivana Binić, Bojana Carić, Ljiljana Božić, Sanja Umičević-Šipka, Nataša Bednarčuk, Saša Dabić, Mirna Šitum, Snježana Popović-Pejičić, Miloš P. Stojiljković, Ranko Škrbić

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Results of a Randomized, Open-Label, Clinical Trial Investigating the Effects of Supplementation with Heracleum persicum Extract as an Adjunctive Therapy for Dyslipidemia by Yunes Panahi, Bahram Pishgoo, Fatemeh Beiraghdar, Zahra Mohammadi Araghi, Amirhossein Sahebkar, Ehsan Abolhasani

“…In a randomized, open-label, clinical trial, 100 dyslipidemic subjects were randomly assigned to: (1) H. persicum group (n = 50, completers = 18), receiving H. persicum extract (500 mg/day) + atorvastatin (10 mg/day) for 8 weeks, or (2) atorvastatin group (n =50, completers= 34), receiving only atorvastatin (20 mg/day) for 8 weeks. …”
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Efficacy and Tolerability of a Combined Moxifloxacin/Dexamethasone Formulation for Topical Prophylaxis in Phacoemulsification: An Open-Label Single-Arm Clinical Trial by Cesar Ramon G. Espiritu, Mary Ellen A. Sy, Tommee Lynne G. Tayengco

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Barriers and enablers to recruiting participants within paediatric perioperative and anaesthetic settings: lessons learned from a trial of melatonin versus midazolam in the premedi... by Marie C. Hyslop, Diana E. Papaioannou, Robert Bolt, Matthew J. Wilson, Michael Bradburn, Janet Clarkson, Esther Herbert, Nicholas Ireland, Jennifer Kettle, Amanda Loban, Amy C. Norrington, Christopher Vernazza, Christopher Deery

Subjects: “…early termination of clinical trials…”
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Fermented Ophiocordyceps sinensis mycelium products for preventing contrast-associated acute kidney injury: a systematic review of randomized controlled trials by Fenglan Pu, Tianli Li, Chen Shen, Yingqiao Wang, Chunmei Tang, Xiaowen Zhang, Lijiao Yan, Qihe Xu, Jianping Liu

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Evaluating the effects of chlorhexidine and vitamin c mouthwash on oral health in non-surgical periodontal therapy: a randomized controlled clinical trial by Nurdan Ozmeric, Ayaz Enver, Sila Cagri Isler, Ceren Gökmenoğlu, Merve Topaloğlu, Hilal Selamet, Gökçen Altun, Selin Aykol Sayar

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A phase 1 clinical trial of SP16, a first-in-class anti-inflammatory LRP1 agonist, in healthy volunteers. by George F Wohlford, Leo F Buckley, Dinesh Kadariya, Taeshik Park, Juan Guido Chiabrando, Salvatore Carbone, Virginia Mihalick, Matthew S Halquist, Adam Pearcy, Dana Austin, Cohava Gelber, Antonio Abbate, Benjamin Van Tassell

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Peri-implant soft tissue conditioning of immediate posterior implants by CAD-CAM socket sealing abutments: a randomized clinical trial by Mai Mohamed Elgendi, Iman Salah Eldin Hamdy, Hanaa Ibraheem Sallam

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A consort‐guided randomized, blinded, controlled clinical trial on the effects of 6 weeks training on heart rate variability in thoroughbred horses by Emma Santosuosso, Renaud Léguillette, Sierra Shoemaker, Ryan Baumwart, Sierra Temple, Kaneesha Hemmerling, Tessa Kell, Warwick Bayly

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Effectiveness of Frequent Point-of-Care Molecular COVID-19 Surveillance in a Rural Workplace: Nonrandomized Controlled Clinical Trial Among Miners by Akshay Sood, William “Cotton” Jarrell, Xin W Shore, Nestor Sosa, Alisha Parada, Nicholas Edwardson, Alexandra V Yingling, Teah Amirkabirian, Qiuying Cheng, Ivy Hurwitz, Linda S Cook, Shuguang Leng, Orrin B Myers, Douglas J Perkins

“…MethodsIn this nonrandomized controlled clinical trial conducted from February 2021, to March 2022, 169 miners in New Mexico (intervention cohort) and 61 miners in Wyoming (control cohort) were enrolled. …”
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SPIRIT-DEFINE explanation and elaboration: recommendations for enhancing quality and impact of early phase dose-finding clinical trials protocolsResearch in context by Moreno Ursino, Guillermo Villacampa, Jan Rekowski, Munyaradzi Dimairo, Olga Solovyeva, Deborah Ashby, Jordan Berlin, Oliver Boix, Melanie Calvert, An-Wen Chan, Courtney H. Coschi, Thomas R. Jeffry Evans, Elizabeth Garrett-Mayer, Robert M. Golub, Christina Guo, Kathryn S. Hayward, Sally Hopewell, John D. Isaacs, S. Percy Ivy, Thomas Jaki, Olga Kholmanskikh, Andrew Kightley, Shing Lee, Rong Liu, Adrian Mander, Lynley V. Marshall, James Matcham, Dhrusti Patel, Richard Peck, Khadija Rerhou Rantell, Dawn P. Richards, Mahtab Rouhifard, Lesley Seymour, Yoshiya Tanaka, Christopher J. Weir, Johann de Bono, Christina Yap

“…Summary: Transparent and accurate reporting in early phase dose-finding (EPDF) clinical trials is crucial for informing subsequent larger trials. …”
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Regenerative potential of concentrated growth factor compared to platelet-rich fibrin in treatment of necrotic mature teeth: a randomized clinical trial by Taghreed Salah, Wael Hussein, Heba Abdelkafy

“…The study was registered in the Clinical Trials Registry ( ClinicalTrials.gov ) with identifier number NCT06227533. …”
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The Effect of Free Weight Resistance Training on Cognitive Function Explored Through Eye Tracking: A Randomized Double-Blind Clinical Trial by Cristián Mateluna-Núñez, Romualdo Ibáñez-Orellana, César Campos-Rojas, Andrea Santana-Covarrubias, Rodrigo Fuentes Figueroa, Ricardo Martínez-Flores

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The Effect of Eighteen-Month Metformin Treatment in Obese Adolescents: Comparison of Results Obtained in Daily Practice with Results from a Clinical Trial by Marloes P. van der Aa, Vera Hoving, Ewoudt M. W. van de Garde, Antonius de Boer, Catherijne A. J. Knibbe, Marja M. J. van der Vorst

“…This trial is registered with ClinicalTrials.gov number: NCT01487993.…”
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Study protocol: multi-centre, randomised controlled clinical trial exploring stromal targeting in locally advanced pancreatic cancer; STARPAC2 by Hemant M. Kocher, BCI-STARPAC2 team, BPTB team, Precision-Panc team, Peter Sasieni, Pippa Corrie, Mairéad G. McNamara, Debashis Sarker, Fieke E. M. Froeling, Alan Christie, Roopinder Gillmore, Khurum Khan, David Propper

“…We propose a phase II clinical trial to test whether a combination of standard chemotherapy (gemcitabine & nab-Paclitaxel: GEM-NABP) and repurposing All Trans Retinoic Acid (ATRA) to target the stroma may extend progression-free survival and enable successful surgical resection for patients with laPDAC, since data from phase IB clinical trial demonstrate safety of GEM-NABP-ATRA combination to patients with advanced PDAC with potential therapeutic benefit. …”
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