Etoposide targets 2A protease to inhibit enterovirus 71 replication by Qinqin Liang, Sai Shi, Qingjie Zhang, Yaxin Wang, Sheng Ye, Binghong Xu

“…The findings indicate that Etoposide serves as a promising inhibitor of the EV71 2Apro, demonstrating strong antiviral properties and positioning itself as a formidable candidate for clinical trials against EV71.IMPORTANCEWe first used a drug screening approach focused on monomeric compounds and their derivatives from traditional Chinese medicine to identify an EV71 2Apro inhibitor—Etoposide. …”
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A Novel Telehealth Exercise Program Designed for Rural Survivors of Cancer With Cancer-Related Fatigue: Single-Arm Feasibility Trial by Ryan J Marker, Andrew J Kittelson, Jared J Scorsone, Ian A Moran, John C Quindry, Heather J Leach

“…MethodsA single-arm clinical trial of the BfitBwell Telehealth Program was performed. …”
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Efficacy of an intervention to increase therapeutic adherence in patients with secondary prevention for cardiovascular disease: a study protocol for a randomized controlled trial by Francisco Manuel Lidón-Muñoz, José Antonio Quesada, José Antonio Quesada, José Antonio Quesada, Vicente Francisco Gil-Guillén, Vicente Francisco Gil-Guillén, Vicente Francisco Gil-Guillén, Domingo Orozco-Beltrán, Domingo Orozco-Beltrán, Domingo Orozco-Beltrán

“…This trial has been registered at clinicalTrials.gov, https://clinicaltrials.gov/study/NCT06510946.…”
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Interest, uptake, and feasibility trial of a real-life digital health intervention to improve lifestyle in Brazil by Raquel B De Boni, Jurema C Mota, Michael Duncan, Leonardo Linconl, Giovanna Lucieri Alonso Costa, Sofia Pimentel, Kamila P Sales, Fabiana Gaspar, Fernanda Adaes, Felipe B Schuch, Vicent Balanzá-Martinez, Flavio Kapczinski, Renato S Lima

“…Trial registration The trial was registered at the Brazilian Clinical Trials Registry (Registro Brasileiro de Ensaios Clínicos -REBEC)—number RBR-2ssyb6q.…”
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Movement therapy in advanced heart failure assisted by a lightweight wearable robot: a feasibility pilot study by Isabell Anna Just, Denis Fries, Sina Loewe, Volkmar Falk, Nikola Cesarovic, Frank Edelmann, Anna Feuerstein, Florian L. Haufe, Michele Xiloyannis, Robert Riener, Felix Schoenrath

“…This trial was registered at ClinicalTrials.gov: NCT04839133.…”
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Efficacy of Chinese traditional quadruple single pill combination versus valsartan/hydrochlorothiazide for the treatment of hypertension (COSPQ-BP): study protocol for randomised c... by Kai Liu, Yu Yan, Xin Zhang, Yanan Li, Yuanyuan Yao, Lu Liu, Runyu Ye, Si Wang, Xiangyu Yang, Xiaoping Chen, Shanshan Jia, Qingtao Meng, Xianghao Zuo

“…The findings of this study will be disseminated through conference presentations and peer-reviewed publications.Trial registration This study was registered at the Chinese Clinical Trials Registry (ChiCTR2300067920). The COSPQ-BP trial is currently enrolling. …”
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Using Health Utility Index (HUI) for Measuring the Impact on Health-Related Quality of Life (HRQL) Among Individuals with Chronic Diseases by Frank Mo, Bernard C.K. Choi, Felix C.K. Li, Joav Merrick

“…Using the HUI (constructed based on eight attributes: vision, hearing, speech, mobility, dexterity, cognition, emotion, and pain/discomfort) to measure the HRQL for chronic disease patients and to detect possible associations between HUI system and various chronic conditions, this study provides information to improve the management of chronic diseases.This study is of interest to data analysts, policy makers, and public health practitioners involved in descriptive clinical studies, clinical trials, program evaluation, population health planning, and assessments. …”
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Detecting Deception and Ensuring Data Integrity in a Nationwide mHealth Randomized Controlled Trial: Factorial Design Survey Study by Krista M Kezbers, Michael C Robertson, Emily T Hébert, Audrey Montgomery, Michael S Businelle

“…Trial RegistrationClinicalTrials.gov NCT05194228; https://clinicaltrials.gov/study/NCT05194228…”
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Oncologic oUTcomes of neoadjuvant chemotherapy for obSTructive colon cAncer after steNt decompression (OUTSTAND trial); A study protocol of multicenter non-inferiority randomized c... by Bong-Hyeon Kye, Ji-Hoon Kim, Hyung-Jin Kim, Yoon-Suk Lee, In-Kyu Lee, Won Kyung Kang, Hyeon-Min Cho, Jong-Kyung Park, Chang-Hyeok Ahn, Jae-Im Lee, Seong-Taek Oh, Byung Jo Choi

“…Registration This study is registered on ClinicalTrials.gov Identifier: NCT04889820, registered on May 17, 2021 in clinicaltrials.gov; Protocol ID: XC21MIDI0004.…”
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The Impact of Astaxanthin Supplementation on the Lipid Profile by Filip Arczewski, Michalina Wójcikiewicz, Witold Czyż, Julia Kacperczyk, Karol Dziedzic, Marta Chuncia, Maciej Wojszczyk, Damian Zys, Piotr Pasek, Julia Ryniecka, Wiktor Czaja, Michał Krzciuk

“…Consequently, there is a need for larger, well-standardized clinical trials to accurately assess the efficacy and safety of astaxanthin as a therapeutic agent for lipid modulation and the prevention of metabolic disorders. …”
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Evaluation of the feasibility, acceptability, and impact of Group Antenatal Care at the health post level on continuation in antenatal care and facility based delivery in Ethiopia... by Reena Sethi, Rediet Fasil, Walelegn W. Yallew, Della Berhanu, Yenealem Woldemariam, Gayane Yenokyan, Alemayehu Worku, Dedefo Teshite, Konjit Wolde, Anne Hyre, Stephanie Suhowatsky, Lisa Noguchi

“…Registration NCT05054491, ClinicalTrials.gov (September 23, 2021).…”
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Evaluation of outcome relevance of quality indicators in the emergency department (ENQuIRE): study protocol for a prospective multicentre cohort study by Anna Slagman, Felix Greiner, Martin Möckel, Rainer Röhrig, Susanne Drynda, Wencke Schindler, Johannes Pollmanns, Dirk Horenkamp-Sonntag, Wiebke Schirrmeister, Ronny Otto, Jonas Bienzeisler, Saskia Drösler, Rolf Lefering, Jennifer Hitzek, Enno Swart, Felix Walcher

“…The data collected for this purpose comprise medical records from the ED treatment, discharge (claims) data from hospitalised patients, a patient questionnaire to be answered 6–8 weeks after emergency admission, and outcome measures in a 12-month follow-up obtained as claims data from the SHI.Descriptive and analytical statistics will be applied to provide summaries about the characteristics of QIs and associations between quality measures and patient outcomes.Ethics and dissemination Approval of the leading ethics committee at the Medical Faculty of the University of Magdeburg (reference number 163/18 from 19 November 2018) has been obtained and adapted by responsible local ethics committees.The findings of this work will be disseminated by publication of peer-reviewed manuscripts and presentations as conference contributions (abstracts, poster or oral presentations).Moreover, results will be discussed with clinical experts and medical associations before being proposed for implementation into the quality management of EDs.Trial registration number German Clinical Trials Registry (DRKS00015203); Pre-results.…”
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Tofacitinib Efficacy/Safety in Patients with Ankylosing Spondylitis by Baseline Body Mass Index: A Post Hoc Analysis of Phase 2/3 Trials by Hillary Norton, Paula Sliwinska-Stanczyk, Tomas Hala, Bassel El-Zorkany, Lori Stockert, Rajiv Mundayat, Lisy Wang, Christopher T. Ritchlin

“…Trial Registration ClinicalTrials.gov identifiers, NCT01786668 and NCT03502616.…”
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School-based screening for childhood anxiety problems and intervention delivery: a codesign approach by Tamsin Ford, Alastair Gray, Cathy Creswell, Victoria Williamson, Obioha Ukoumunne, Falko Sniehotta, Mara Violato, Ian McDonald, Paul Brown, Paul Stallard, Michael Larkin, Tessa Reardon, Samantha Pearcey, Claire Hill, Susan H Spence, Maria Breen, Jason Stainer, Michelle Sancho, Roberta Button, Iheoma Green, Fran Morgan, Bec Jasper

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Eating disorders in weight-related therapy (EDIT): Protocol for a systematic review with individual participant data meta-analysis of eating disorder risk in behavioural weight man... by Hiba Jebeile, Natalie B Lister, Sol Libesman, Kylie E Hunter, Caitlin M McMaster, Brittany J Johnson, Louise A Baur, Susan J Paxton, Sarah P Garnett, Amy L Ahern, Denise E Wilfley, Sarah Maguire, Amanda Sainsbury, Katharine Steinbeck, Lisa Askie, Caroline Braet, Andrew J Hill, Dasha Nicholls, Rebecca A Jones, Genevieve Dammery, Alicia M Grunseit, Kelly Cooper, Theodore K Kyle, Faith A Heeren, Fiona Quigley, Rachel D Barnes, Melanie K Bean, Kristine Beaulieu, Maxine Bonham, Kerri N Boutelle, Braulio Henrique Magnani Branco, Simona Calugi, Michelle I Cardel, Kelly Carpenter, Hoi Lun Cheng, Riccardo Dalle Grave, Yngvild S Danielsen, Marcelo Demarzo, Aimee Dordevic, Dawn M Eichen, Andrea B Goldschmidt, Anja Hilbert, Katrijn Houben, Mara Lofrano do Prado, Corby K Martin, Anne McTiernan, Janell L Mensinger, Carly Pacanowski, Wagner Luiz do Prado, Sofia M Ramalho, Hollie A Raynor, Elizabeth Rieger, Eric Robinson, Vera Salvo, Nancy E Sherwood, Sharon A Simpson, Hanna F Skjakodegard, Evelyn Smith, Stephanie Partridge, Marian Tanofsky-Kraff, Rachael W Taylor, Annelies Van Eyck, Krista A Varady, Alaina P Vidmar, Victoria Whitelock, Jack Yanovski, Anna L Seidler, Eating Disorders In weight-related Therapy (EDIT) Collaboration

“…We systematically searched four databases up to March 2022 and clinical trials registries to May 2022 to identify randomised controlled trials of weight management interventions conducted in adolescents or adults with overweight or obesity that measured eating disorder risk at pre- and post-intervention or follow-up. …”
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External beam radiation therapy versus radical prostatectomy for high-risk prostate cancer: protocol of the RECOVER study by Caroline M. van der Starre, Chris H. Bangma, Maarten J. Bijlsma, Alfons C.M. van den Bergh, Lambertus A.L.M. Kiemeney, Wietske Kievit, Kees Vos, Diederik M. Somford, Sally M. Wildeman, Katja K.H. Aben, Igle J. de Jong, Floris J. Pos, Berdine L. Heesterman

“…Trial registration This study is registered at ClinicalTrials.gov (NCT05931419).…”
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The effect of supplementation with type I and type III collagen peptide and type II hydrolyzed collagen on pain, quality of life and physical function in patients with meniscopathy... by Ahmet Serhat Genç, Ali Kerim Yılmaz, Berna Anıl, Esra Korkmaz Salkılıç, Enes Akdemir, Berna Güzel, Ahmet Mor, Hacı Ahmet Yarar, Nizamettin Güzel, Lokman Kehribar

“…Trial registration The study was retrospectively registered in the Iranian Clinical Trials Registry on 14/05/2024 with the number IRCT20240411061470N2.…”
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Effects of Glucagon-Like Peptide-1 Receptor Agonists on Weight Loss in Patients with Type 2 Diabetes: A Systematic Review and Network Meta-Analysis by Feng Sun, Sanbao Chai, Lishi Li, Kai Yu, Zhirong Yang, Shanshan Wu, Yuan Zhang, Linong Ji, Siyan Zhan

“…MEDLINE, EMBASE, Cochrane Library, and ClinicalTrials.gov were searched from 1950 to October 2013. …”
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Two Approaches to Cognitive Evaluation: Assessing the Strengths and Limitations of GPCOG and ACE-III by Magdalena Mąka, Dominik Sikora, Piotr Oleksy, Adam Zając, Karol Zieliński, Łukasz Papież, Ewa Góralczyk, Jakub Kamiński, Bartosz Buczkowski, Dagmara Wochnik

“…Materials and Methods : A review of 37 peer-reviewed studies, including clinical trials and validation research, was conducted using databases like PubMed and Google Scholar. …”
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Prevalence of Coronary Endothelial and Microvascular Dysfunction in Women with Symptoms of Ischemia and No Obstructive Coronary Artery Disease Is Confirmed by a New Cohort: The NHL... by R. David Anderson, John W. Petersen, Puja K. Mehta, Janet Wei, B. Delia Johnson, Eileen M. Handberg, Saibal Kar, Bruce Samuels, Babak Azarbal, Kamlesh Kothawade, Sheryl F. Kelsey, Barry Sharaf, Leslee J. Shaw, George Sopko, C. Noel Bairey Merz, Carl J. Pepine

“…Because these coronary functional abnormalities predict major adverse cardiac events, clinical trials of therapies targeting these abnormalities are indicated.…”
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